Digoxin and 30-day all-cause hospital admission in older patients with chronic diastolic heart failure

American Journal of Medicine

Volumn 127, Issue 2, 2014, Pages 132-139

  Hashim, Taimoor ^a   Elbaz, Shereen ^a   Patel, Kanan ^a   Morgan, Charity J ^a   Fonarow, Gregg C ^b   Fleg, Jerome L ^c   McGwin, Gerald ^a   Cutter, Gary R ^a   Allman, Richard M ^a,d   Prabhu, Sumanth D ^a,d   Zile, Michael R ^e,f   Bourge, Robert C ^a   Ahmed, Ali ^a,d  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d BIRMINGHAM VA MEDICAL CENTER   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

30 day all cause hospital admission; Diastolic heart failure; Digoxin

Indexed keywords

DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; NITRATE; PLACEBO;

AGED; CHRONIC DIASTOLIC HEART FAILURE; CONFERENCE PAPER; CONTROLLED STUDY; DEATH; DIASTOLIC HEART FAILURE; FEMALE; HAZARD RATIO; HEART EJECTION FRACTION; HEART FAILURE; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; UNSTABLE ANGINA PECTORIS;

30-DAY ALL-CAUSE HOSPITAL ADMISSION; DIASTOLIC HEART FAILURE; DIGOXIN;

AGED; AGED, 80 AND OVER; CANADA; CARDIOTONIC AGENTS; CARDIOVASCULAR AGENTS; CHRONIC DISEASE; DIGOXIN; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE, DIASTOLIC; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; ODDS RATIO; PATIENT ADMISSION; PATIENT READMISSION; PROPORTIONAL HAZARDS MODELS; SAMPLE SIZE; TREATMENT OUTCOME; UNITED STATES;

EID: 84892962784     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2013.08.006     Document Type: Conference Paper

References (15)

1. S.F. Jencks, M.V. Williams, and E.A. Coleman Rehospitalizations among patients in the Medicare fee-for-service program N Engl J Med 360 2009 1418 1428
2. J. Butler, and A. Kalogeropoulos Hospital strategies to reduce heart failure readmissions: where is the evidence? J Am Coll Cardiol 60 2012 615 617
3. M.A. Konstam Heart failure in the lifetime of Musca Domestica (the common housefly) JACC Heart Fail 1 2013 178 180
4. J. Rau Hospitals face pressure to avert readmissions 2012 New York The New York Times Available at: http://www.nytimes.com/2012/11/27/health/hospitals- face-pressure-from-medicare-to-avert-readmissions.html?-r=0 Accessed December 2, 2012
5. R.C. Bourge, J.L. Fleg, and G.C. Fonarow et al. Digoxin reduces 30-day all-cause hospital admission in older patients with chronic systolic heart failure Am J Med 126 2013 701 708
6. The Digitalis Investigation Group Investigators The effect of digoxin on mortality and morbidity in patients with heart failure N Engl J Med 336 1997 525 533
7. A. Ahmed, M.W. Rich, and J.L. Fleg et al. Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial Circulation 114 2006 397 403
8. A. Ahmed, M.R. Zile, and M.W. Rich et al. Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failure Am J Cardiol 99 2007 460 464
9. M. Iriarte, R. Caso, and N. Murga et al. Microvascular angina pectoris in hypertensive patients with left ventricular hypertrophy and diagnostic value of exercise thallium-201 scintigraphy Am J Cardiol 75 1995 335 339
10. M.L. Marcus, S. Koyanagi, D.G. Harrison, D.B. Doty, L.F. Hiratzka, and C.L. Eastham Abnormalities in the coronary circulation that occur as a consequence of cardiac hypertrophy Am J Med 75 1983 62 66
11. F. Nijland, O. Kamp, P.M. Verhorst, W.G. de Voogt, and C.A. Visser In-hospital and long-term prognostic value of viable myocardium detected by dobutamine echocardiography early after acute myocardial infarction and its relation to indicators of left ventricular systolic dysfunction Am J Cardiol 88 2001 949 955
12. Ahmed A, Bourge RC, Fonarow GC, et al. Digoxin use and lower 30-day all-cause readmission for Medicare beneficiaries hospitalized for heart failure. Am J Med. In press.
13. M. Gheorghiade, G.C. Fonarow, and D.J. van Veldhuisen et al. Lack of evidence of increased mortality among patients with atrial fibrillation taking digoxin: findings from post hoc propensity-matched analysis of the AFFIRM trial Eur Heart J 34 2013 1489 1497
14. A.F. Hernandez, B.G. Hammill, C.M. O'Connor, K.A. Schulman, L.H. Curtis, and G.C. Fonarow Clinical effectiveness of beta-blockers in heart failure: findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) Registry J Am Coll Cardiol 53 2009 184 192
15. A. Ahmed, M.W. Rich, and T.E. Love et al. Digoxin and reduction in mortality and hospitalization in heart failure: a comprehensive post hoc analysis of the DIG trial Eur Heart J 27 2006 178 186