Digoxin reduces cardiac sympathetic activity in severe congestive heart failure

Journal of the American College of Cardiology

Volumn 28, Issue 1, 1996, Pages 155-161

  Newton, Gary E ^a   Tong, Jeffrey H ^b   Schofield, Anne M ^a   Baines, Andrew D ^b   Floras, John S ^a   Parker, John D ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLETHYLENE GLYCOL; AMIODARONE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; NORADRENALIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; FEMALE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FILLING PRESSURE; HEART VENTRICLE FUNCTION; HEMODYNAMICS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; SYMPATHETIC TONE;

EID: 0030199274     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0735-1097(96)00120-9     Document Type: Article

References (36)

1. 1. Hasking GJ, Esler MD, Jennings GJ, Burton D, Johns JA, Korner PI. Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 1986;73:615-21.
2. 1-receptor down-regulation in heart failure. Circ Res 1986;59:297-309.
3. 3. Mann DL, Kent RL, Parsons B, Cooper G. Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 1992;85:790-804.
4. 4. Meredith IT, Broughton A, Jennings GL, Esler MD. Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias. N Engl J Med 1991;325:618-24.
5. 5. Kaye DM, Lefkovits J, Jennings GL, Bergin P, Broughton A, Esler MD. Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol 1995;26:1257-63.
6. 6. Quest JA, Gillis RA. Effect of digitalis on carotid sinus baroreceptor activity. Circ Res 1974;35:247-55.
7. 7. Thames MD, Waickman LA, Abboud FM. Senstization of cardiac receptors (vagal afferents) by intracoronary acetylstrophanthidin. Am J Physiol 1980; 239:H628-35.
8. 8. Lopez JA, Timmis AD, Garan H, Homey CJ, Powell WJ. Effect of intracarotid administration of ouabain in dogs. Am J Physiol 1988;254: H148-55.
9. 9. Ferrari A, Gregorini L, Ferrari MC, Preti L, Mancia G. Digitalis and baroreceptor reflexes in man. Circulation 1981;63:279-85.
10. 10. Schobel HP, Oren RM, Roach PJ, Mark AL, Ferguson DW. Contrasting effects of digitalis and dobutamine on baroreflex sympathetic control in normal humans. Circulation 1991;84:1118-29.
11. 11. Ferguson DW, Abboud FM, Mark AL. Selective impairement of baroreflex-mediated vasoconstrictor responses in patients with ventricular dysfunction. Circulation 1984;69:451-60.
12. 12. Watanabe AM. Digitalis and the autonomic nervous system. J Am Coll Cardiol 1985;5:35A-42A.
13. 13. Gillis RA. Cardiac sympathetic nerve activity: changes induced by ouabain and propranolol. Science 1969;166:508-10.
14. 14. Rebagay WR, Caldwell RW. Different patterns of autonomic nerve activity produced by a polar vs. a neutral cardiac glycoside. J Pharmacol Exp Ther 1990;253:180-4.
15. 15. Sole MJ, Benedict CR, Versteeg DHG, de Kloet ER. Digitoxin therapy partially restores cardiac catecholamine and brain serotonin metabolism in congestive heart failure. J Mol Cell Cardiol 1985;17:1055-63.
16. 16. Ribner HS, Plucinski DA, Hsieh A, et al. Acute effects of digoxin on total systemic vascular resistance in congestive heart failure due to dilated cardiomyopathy: a hemodynamic-hormonal study. Am J Cardiol 1985;56: 896-904.
17. 17. Gheorghiade M, Hall V, Lakier JB, Goldstein S. Comparative hemodynamic and neurohormonal effects of intravenous captopril and digoxin and their combinations in patients with severe heart failure. J Am Coll Cardiol 1989;13:134-42.
18. 18. Van Veldhuisen DJ, Man In't Veld AJ, Dunselman PHJM, et al. Double-blind placebo-controlled study of ibopamine and digoxin in patients with mild to moderate heart failure: results of the Dutch Ibopamine Multicenter Trial. J Am Coll Cardiol 1993;22:1564-73.
19. 19. Krum H, Bigger JT, Goldsmith RL, Packer M. Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure. J Am Coll Cardiol 1995;25:289-94.
20. 20. Ferguson DW, Berg WJ, Sanders JS, Roach PJ, Kempf JS, Kienzle MG. Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings. Circulation 1989;80: 65-77.
21. 21. Kaye DM, Lambert GW, Lefkovits J, Morris M, Jennings G, Esler MD. Neurocheraical evidence of cardiac sympathetic activation and increased central nervous system norepinephrine turnover in severe congestive heart failure. J Am Coll Cardiol 1994;23:570-8.
22. 22. Ferguson DW, Berg WJ, Sanders JS. Clinical and hemodynamic correlates of sympathetic nerve activity in normal humans and patients with heart failure: evidence from direct microneurographic recordings. J Am Coll Cardiol 1990;16:1125-34.
23. 23. Leimbach WN, Wallin BG, Victor RG, Aylward PE, Sundlof G, Mark AL. Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure. Circulation 1986;73:913-9.
24. 24. Esler M, Jennings G, Korner P, Blombery P, Sacharias N, Leonard P. Measurement of total and organ-specific norepinephrine kinetics in humans. Am J Physiol 1984;247:E21-8.
25. 25. Meredith IT, Eisenhofer G, Lambert GW, Dewar EM, Jennings GL, Esler MD. Cardiac sympathetic nervous activity in congestive heart failure: evidence for increased neuronal norepinephrine release and preserved neuronal uptake. Circulation 1993;88:136-45.
26. 26. Eisenhofer G, Smolich JJ, Cox HS, Esler MD. Neuronal reuptake of norepinephrine and production of dihydroxyphenylglycol by cardiac sympathetic nerves in the anaesthetized dog. Circulation 1991;84:1354-63.
27. 27. Esler M, Jackman G, Bobik A, et al. Determination of norepinephrine apparent release rate and clearance in humans. Life Sci 1979;25:1461-70.
28. 28. Mathey DG, Chatterjee K, Tyberg JV, Lekven J, Brundage B, Parmeley WW. Coronary sinus reflux: a source of error in the measurement of thermodilution coronary sinus flow. Circulation 1971;57:778-86.
29. 29. Ganz W, Tamura K, Marcus HS, Donoso R, Swan HJC. Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation 1971;44:181-95.
30. 30. Lee DC, Johnson RA, Bingham JB, et al. Heart failure in outpatients: a randomized trial of digoxin versus placebo. N Engl J Med 1982;306:699-705.
31. 31. Goldsmith SR, Simon AB, Miller E. Effect of digitalis on norepinephrine kinetics in congestive heart failure. J Am Coll Cardiol 1992;20:858-63.
32. 32. Garan H, Smith TW, Powell WJ. The central nervous system as a site of action for the coronary vasoconstrictor effect of digoxin. J Clin Invest 1974;54:1365-72.
33. 33. Kranzhofer R, Haass M, Kurz T, Richardt G, Schomig A. Effect of digitalis glycosides on norepinephrine release in the heart. Dual mechanism of action. Circ Res 1991;68:1628-37.
34. 34. Grima AE, Moe GW, Howard RJ, Armstrong PW. Recovery of attenuated baroreflex sensitivity in conscious dogs after reversal of pacing induced heart failure. Cardiovasc Res 1994;28:384-90.
35. 35. Cousineau D, Goresky CA, Bach GG, Rose CP. Effect of b-adrenergic blockade on in vivo norepinephrine release in canine heart. Am J Physiol 1984;246:H283-92.
36. 36. Goldstein DS, Brush JE, Eisenhofer G, Stull R, Esler M. In vivo measurement of neuronal uptake of norepinephrine in the human heart. Circulation 1988;78:41-8.