Duration of untreated psychosis predicts functional and clinical outcome in children and adolescents with first-episode psychosis: A 2-year longitudinal study

Schizophrenia Research

Volumn 152, Issue 1, 2014, Pages 130-138

  Fraguas, David ^a   del Rey Mejías, Ángel ^a   Moreno, Carmen ^a   Castro Fornieles, Josefina ^b,c   Graell, Montserrat ^d   Otero, Soraya ^e   Gonzalez Pinto, Ana ^f   Moreno, Dolores ^a   Baeza, Inmaculada ^b,c   Martínez Cengotitabengoa, Mónica ^f   Arango, Celso ^a   Parellada, Mara ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d HOSPITAL INFANTIL UNIVERSITARIO NIÑO JESÚS   (Spain)

^e HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^f CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

Author keywords

Adolescent; Affective psychosis; Bipolar disorder; Duration of untreated psychosis (DUP); First episode psychosis (FEP); Outcome; Remission; Schizophrenia

Indexed keywords

CHLORPROMAZINE; NEUROLEPTIC AGENT;

ADOLESCENT; AFFECTIVE PSYCHOSIS; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DSM-IV; FEMALE; FUNCTIONAL ASSESSMENT; GLOBAL ASSESSMENT OF FUNCTIONING; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; PSYCHOSIS; REMISSION; SCHIZOPHRENIA; SCHOOL CHILD; SCORING SYSTEM; FOLLOW UP; OUTCOME ASSESSMENT;

ADOLESCENT; AFFECTIVE PSYCHOSIS; BIPOLAR DISORDER; DURATION OF UNTREATED PSYCHOSIS (DUP); FIRST-EPISODE PSYCHOSIS (FEP); OUTCOME; REMISSION; SCHIZOPHRENIA;

ADOLESCENT; ANALYSIS OF VARIANCE; CHILD; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; REGRESSION ANALYSIS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84891623567     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2013.11.018     Document Type: Article

References (60)

1. Aas I.H. Global Assessment of Functioning (GAF): properties and frontier of current knowledge. Ann. Gen. Psychiatry 2010, 9:20.
2. Addington J., Addington D. Symptom remission in first episode patients. Schizophr. Res. 2008, 106(2-3):281-285.
3. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2000, text rev., Author, Washington, DC. fourth ed.
4. Amminger G.P., Henry L.P., Harrigan S.M., Harris M.G., Alvarez-Jimenez M., Herrman H., Jackson H.J., McGorry P.D. Outcome in early-onset schizophrenia revisited: findings from the early psychosis prevention and intervention centre long-term follow-up study. Schizophr. Res. 2011, 131(1-3):112-119.
5. Andreasen N.C., Carpenter W.T., Kane J.M., Lasser R.A., Marder S.R., Weinberger D.R. Remission in schizophrenia: proposed criteria and rationale for consensus. Am. J. Psychiatry 2005, 162(3):441-449.
6. Andreasen N.C., Pressler M., Nopoulos P., Miller D., Ho B.C. Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs. Biol. Psychiatry 2010, 67(3):255-262.
7. Arango C., Fraguas D., Parellada M. Differential neurodevelopmental trajectories in patients with early-onset bipolar and schizophrenia disorders. Schizophr. Bull. 2013, (in press).
8. Barnes T.R., Leeson V.C., Mutsatsa S.H., Watt H.C., Hutton S.B., Joyce E.M. Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia. Br. J. Psychiatry 2008, 193(3):203-209.
9. Boonstra N., Klaassen R., Sytema S., Marshall M., De Haan L., Wunderink L., Wiersma D. Duration of untreated psychosis and negative symptoms-a systematic review and meta-analysis of individual patient data. Schizophr. Res. 2012, 142(1-3):12-19.
10. Cannon-Spoor H.E., Potkin S.G., Wyatt R.J. Measurement of premorbid adjustment in chronic schizophrenia. Schizophr. Bull. 1982, 8(3):470-484.
11. Castro-Fornieles J., Baeza I., de la Serna E., Gonzalez-Pinto A., Parellada M., Graell M., Moreno D., Otero S., Arango C. Two-year diagnostic stability in early-onset first-episode psychosis. J. Child Psychol. Psychiatry 2011, 52(10):1089-1098.
12. Castro-Fornieles J., Parellada M., Gonzalez-Pinto A., Moreno D., Graell M., Baeza I., Otero S., Soutullo C.A., Crespo-Facorro B., Ruiz-Sancho A., Desco M., Rojas-Corrales O., Patino A., Carrasco-Marin E., Arango C. The child and adolescent first-episode psychosis study (CAFEPS): design and baseline results. Schizophr. Res. 2007, 91(1-3):226-237.
13. Cechnicki A., Hanuszkiewicz I., Polczyk R., Bielanska A. Prognostic value of duration of untreated psychosis in long-term outcome of schizophrenia. Med. Sci. Monit. 2011, 17(5):CR277-CR283.
14. Compton M.T., Carter T., Bergner E., Franz L., Stewart T., Trotman H., McGlashan T.H., McGorry P.D. Defining, operationalizing and measuring the duration of untreated psychosis: advances, limitations and future directions. Early Interv. Psychiatry 2007, 1:236-250.
15. Cuesta M.J., Garcia de Jalon E., Campos M.S., Ibanez B., Sanchez-Torres A.M., Peralta V. Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis. Schizophr. Res. 2012, 141(2-3):222-227.
16. Chang W.C., Tang J.Y., Hui C.L., Lam M.M., Wong G.H., Chan S.K., Chiu C.P., Chung D.W., Law C.W., Tso S., Chan K., Hung S.F., Chen E.Y. Duration of untreated psychosis: relationship with baseline characteristics and three-year outcome in first-episode psychosis. Psychiatry Res. 2012, 198(3):360-365.
17. Dominguez M.D., Fisher H.L., Major B., Chisholm B., Rahaman N., Joyce J., Woolley J., Lawrence J., Hinton M., Marlowe K., Aitchison K., Johnson S., Hodes M. Duration of untreated psychosis in adolescents: ethnic differences and clinical profiles. Schizophr. Res. 2013, 150(2-3):526-532.
18. Emsley R., Rabinowitz J., Medori R. Remission in early psychosis: rates, predictors, and clinical and functional outcome correlates. Schizophr. Res. 2007, 89(1-3):129-139.
19. Ezpeleta L., Granero R., de la Osa N. Evaluación del deterioro en niños y adolescentes a través de la Children's Global Assessment Scale (CGAS). Rev. psiquiatr. infanto-juv. 1999, 1:18-26.
20. Gelman A., Hill J., Yajima M. Why we (usually) don't have to worry about multiple comparisons. J. Res. Educ. Eff. 2012, 5:189-211.
21. Harris M.G., Henry L.P., Harrigan S.M., Purcell R., Schwartz O.S., Farrelly S.E., Prosser A.L., Jackson H.J., McGorry P.D. The relationship between duration of untreated psychosis and outcome: an eight-year prospective study. Schizophr. Res. 2005, 79(1):85-93.
22. Hill M., Crumlish N., Clarke M., Whitty P., Owens E., Renwick L., Browne S., Macklin E.A., Kinsella A., Larkin C., Waddington J.L., O'Callaghan E. Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12years. Schizophr. Res. 2012, 141(2-3):215-221.
23. Huber G. The heterogeneous course of schizophrenia. Schizophr. Res. 1997, 28(2-3):177-185.
24. Jeppesen P., Petersen L., Thorup A., Abel M.B., Ohlenschlaeger J., Christensen T.O., Krarup G., Jorgensen P., Nordentoft M. The association between pre-morbid adjustment, duration of untreated psychosis and outcome in first-episode psychosis. Psychol. Med. 2008, 38(8):1157-1166.
25. Johnson D.H. The insignificance of statistical significance testing. J. Wildl. Manag. 1999, 63(3):763-772.
26. Juola P., Miettunen J., Veijola J., Isohanni M., Jaaskelainen E. Predictors of short- and long-term clinical outcome in schizophrenic psychosis-the Northern Finland 1966 Birth Cohort study. Eur. Psychiatry 2013, 28(5):263-268.
27. Kaufman J., Birmaher B., Brent D., Rao U., Flynn C., Moreci P., Williamson D., Ryan N. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J. Am. Acad. Child Adolesc. Psychiatry 1997, 36(7):980-988.
28. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr. Bull. 1987, 13(2):261-276.
29. Larsen T.K., Friis S., Haahr U., Johannessen J.O., Melle I., Opjordsmoen S., Rund B.R., Simonsen E., Vaglum P.V., McGlashan T.H. Premorbid adjustment in first-episode non-affective psychosis: distinct patterns of pre-onset course. Br. J. Psychiatry 2004, 185:108-115.
30. Larsen T.K., McGlashan T.H., Johannessen J.O., Friis S., Guldberg C., Haahr U., Horneland M., Melle I., Moe L.C., Opjordsmoen S., Simonsen E., Vaglum P. Shortened duration of untreated first episode of psychosis: changes in patient characteristics at treatment. Am. J. Psychiatry 2001, 158(11):1917-1919.
31. Larsen T.K., Melle I., Auestad B., Friis S., Haahr U., Johannessen J.O., Opjordsmoen S., Rund B.R., Simonsen E., Vaglum P., McGlashan T. Early detection of first-episode psychosis: the effect on 1-year outcome. Schizophr. Bull. 2006, 32(4):758-764.
32. Larsen T.K., Moe L.C., Vibe-Hansen L., Johannessen J.O. Premorbid functioning versus duration of untreated psychosis in 1year outcome in first-episode psychosis. Schizophr. Res. 2000, 45(1-2):1-9.
33. Leeson V.C., Barnes T.R., Hutton S.B., Ron M.A., Joyce E.M. IQ as a predictor of functional outcome in schizophrenia: a longitudinal, four-year study of first-episode psychosis. Schizophr. Res. 2009, 107(1):55-60.
34. Malla A.K., Bodnar M., Joober R., Lepage M. Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosis. Schizophr. Res. 2011, 125(1):13-20.
35. Marshall M., Lewis S., Lockwood A., Drake R., Jones P., Croudace T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch. Gen. Psychiatry 2005, 62(9):975-983.
36. McGlashan T.H. Duration of untreated psychosis in first-episode schizophrenia: marker or determinant of course?. Biol. Psychiatry 1999, 46(7):899-907.
37. Melle I., Larsen T.K., Haahr U., Friis S., Johannesen J.O., Opjordsmoen S., Rund B.R., Simonsen E., Vaglum P., McGlashan T. Prevention of negative symptom psychopathologies in first-episode schizophrenia: two-year effects of reducing the duration of untreated psychosis. Arch. Gen. Psychiatry 2008, 65(6):634-640.
38. Morgan C., Abdul-Al R., Lappin J.M., Jones P., Fearon P., Leese M., Croudace T., Morgan K., Dazzan P., Craig T., Leff J., Murray R. Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study. Br. J. Psychiatry 2006, 189:446-452.
39. Pedersen G., Karterud S. The symptom and function dimensions of the Global Assessment of Functioning (GAF) scale. Compr. Psychiatry 2012, 53(3):292-298.
40. Penttila M., Miettunen J., Koponen H., Kyllonen M., Veijola J., Isohanni M., Jaaskelainen E. Association between the duration of untreated psychosis and short- and long-term outcome in schizophrenia within the Northern Finland 1966 Birth Cohort. Schizophr. Res. 2013, 143(1):3-10.
41. Peralta Martín V., Cuesta Zorita M.J. Validation of positive and negative symptom scale (PANSS) in a sample of Spanish schizophrenic patients. Actas Luso Esp. Neurol. Psiquiatr. Cienc. Afines 1994, 22:171-177.
42. Perkins D., Lieberman J., Gu H., Tohen M., McEvoy J., Green A., Zipursky R., Strakowski S., Sharma T., Kahn R., Gur R., Tollefson G. Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders. Br. J. Psychiatry 2004, 185:18-24.
43. Perkins D.O., Gu H., Boteva K., Lieberman J.A. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am. J. Psychiatry 2005, 162(10):1785-1804.
44. Robertson D.A., Hargreaves A., Kelleher E.B., Morris D., Gill M., Corvin A., Donohoe G. Social dysfunction in schizophrenia: an investigation of the GAF scale's sensitivity to deficits in social cognition. Schizophr. Res. 2013, 146(1-3):363-365.
45. Ropcke B., Eggers C. Early-onset schizophrenia: a 15-year follow-up. Eur. Child Adolesc. Psychiatry 2005, 14(6):341-350.
46. Roy-Byrne P., Dagadakis C., Unutzer J., Ries R. Evidence for limited validity of the revised global assessment of functioning scale. Psychiatr. Serv. 1996, 47(8):864-866.
47. Rund B.R. Does active psychosis cause neurobiological pathology? A critical review of the neurotoxicity hypothesis. Psychol. Med. 2013, 1-14.
48. Satler J. Assessment of Children Cognitive Applications 2001, San Diego State University Publisher Inc., San Diego, CA. fourth ed.
49. Schennach-Wolff R., Jager M., Mayr A., Meyer S., Kuhn K.U., Klingberg S., Heuser I., Klosterkotter J., Gastpar M., Schmitt A., Schlosser R., Schneider F., Gaebel W., Seemuller F., Moller H.J., Riedel M. Predictors of response and remission in the acute treatment of first-episode schizophrenia patients-is it all about early response?. Eur. Neuropsychopharmacol. 2011, 21(5):370-378.
50. Schimmelmann B.G., Huber C.G., Lambert M., Cotton S., McGorry P.D., Conus P. Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort. J. Psychiatr. Res. 2008, 42(12):982-990.
51. Schottle D., Schimmelmann B.G., Conus P., Cotton S.M., Michel C., McGorry P.D., Karow A., Naber D., Lambert M. Differentiating schizoaffective and bipolar I disorder in first-episode psychotic mania. Schizophr. Res. 2012, 140(1-3):31-36.
52. Schwartz R.C. Concurrent validity of the global assessment of functioning scale for clients with schizophrenia. Psychol. Rep. 2007, 100(2):571-574.
53. Shaffer D., Gould M.S., Brasic J., Ambrosini P., Fisher P., Bird H., Aluwahlia S. A children's global assessment scale (CGAS). Arch. Gen. Psychiatry 1983, 40(11):1228-1231.
54. Soutullo C. Traducción al Español de la Entrevista Diagnóstica: Kiddie-Schedule for Affective Disorders& Schizophrenia, Present& Lifetime Version (K-SADS-PL, 1996) http://www.cun.es/la-clinica/departamentos-yservicios-medicos/psiquiatria-y-psicologia-medica/mas-sobreel-departamento/unidades/psiquiatria-infantil-y-adolescente.
55. van Os J., Burns T., Cavallaro R., Leucht S., Peuskens J., Helldin L., Bernardo M., Arango C., Fleischhacker W., Lachaux B., Kane J.M. Standardized remission criteria in schizophrenia. Acta Psychiatr. Scand. 2006, 113(2):91-95.
56. van Os J., Kenis G., Rutten B.P. The environment and schizophrenia. Nature 2010, 468(7321):203-212.
57. Verdoux H., Liraud F., Bergey C., Assens F., Abalan F., van Os J. Is the association between duration of untreated psychosis and outcome confounded? A two year follow-up study of first-admitted patients. Schizophr. Res. 2001, 49(3):231-241.
58. Wiersma D., Nienhuis F.J., Slooff C.J., Giel R. Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort. Schizophr. Bull. 1998, 24(1):75-85.
59. Wunderink L., Sytema S., Nienhuis F.J., Wiersma D. Clinical recovery in first-episode psychosis. Schizophr. Bull. 2009, 35(2):362-369.
60. Zipursky R.B., Reilly T.J., Murray R.M. The myth of schizophrenia as a progressive brain disease. Schizophr. Bull. 2013, 39(6):1363-1372.