Duration of untreated psychosis: Relationship with baseline characteristics and three-year outcome in first-episode psychosis

Psychiatry Research

Volumn 198, Issue 3, 2012, Pages 360-365

  Chang, Wing Chung ^a   Tang, Jennifer Yee Man ^a   Hui, Christy Lai Ming ^a   Lam, May Mei Ling ^a   Wong, Gloria Hoi Yan ^a   Chan, Sherry Kit Wa ^a   Chiu, Cindy Pui Yu ^a   Chung, Dicky Wai Sau ^b   Law, Chi Wing ^c   Tso, Steve ^d   Chan, Kathy ^e   Hung, Se Fong ^e   Chen, Eric Yu Hai ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b TAI PO HOSPITAL   (Hong Kong)

^c QUEEN MARY HOSPITAL   (Hong Kong)

^d CASTLE PEAK HOSPITAL   (Hong Kong)

^e KWAI CHUNG HOSPITAL   (Hong Kong)

Author keywords

Duration of untreated psychosis; Employment; First episode psychosis; Mode of onset; Outcome

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; EMPLOYMENT; FEMALE; HONG KONG; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH SERVICE; ONSET AGE; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PSYCHOSIS; SYMPTOM;

ADULT; AGE OF ONSET; EMPLOYMENT; FEMALE; HOSPITALIZATION; HUMANS; MALE; PROGNOSIS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; SCHIZOPHRENIC PSYCHOLOGY; SEX CHARACTERISTICS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84868665081     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2011.09.006     Document Type: Article

References (40)

1. Addington J., van Mastrigt S., Addington D. Duration of untreated psychosis: impact on 2-year outcome. Psychological Medicine 2004, 34:277-284.
2. Ballageer T., Malla A., Manchanda R., Takhar J., Haricharan R. Is adolescent-onset first-episode psychosis different from adult onset?. Journal of the American Academy of Child and Adolescent Psychiatry 2005, 44:782-789.
3. Barnes T.R.E., Leeson V.C., Mutsatsa S.H., Watt H.C., Hutton S.B., Joyce E.M. Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia. The British Journal of Psychiatry 2008, 193:203-209.
4. Bosanac P., Patton G.C., Castle D.J. Early intervention in psychotic disorders: faith before facts?. Psychological Medicine 2010, 40:353-358.
5. Bottlender R., Sato T., Jager M., Wegener U., Wittmann J., Strauß A., Moller H.J. The impact of the duration of untreated psychosis prior to first psychiatric admission on the 15-year outcome in schizophrenia. Schizophrenia Research 2003, 62:37-44.
6. Chang W.C., Pang S.L.K., Chung D.W.S., Chan S.S.M. Five-year stability of ICD-10 diagnoses among Chinese patients presented with first-episode psychosis in Hong Kong. Schizophrenia Research 2009, 115:351-357.
7. Chen E.Y.H., Dunn E.L.W., Miao M.Y.K., Yeung W.S., Wong C.K., Chan W.F., Chen R.Y.L., Chung K.F., Tang W.N. The impact of family experience on the duration of untreated psychosis in Hong Kong. Social Psychiatry and Psychiatric Epidemiology 2005, 40:350-356.
8. Chen E.Y.H., Tang J.Y.M., Hui C.L.M., Chiu C.P.Y., Lam M.L.M., Law C.W., Yew C.W.S., Wong G.H.Y., Chung D.W.S., Tso S., Chan K.P.M., Yip K.C., Hung S.F., Honer W.G. Three-year outcome of phase-specific early intervention for first-episode psychosis: a cohort study in Hong Kong. Early Intervention in Psychiatry 2011, 5:315-323.
9. Crumlish N., Whitty P., Clarke M., Browne S., Kamali M., Gervin M., McTigue O., Kinsella A., Waddington J.L., Larkin C., O'Callaghan E. Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis. The British Journal of Psychiatry 2009, 194:18-24.
10. de Haan L., Linszen D.H., Lenior M.E., Doberlein de Win E., Gorsira R. Duration of untreated psychosis and outcome of schizophrenia: delay in intensive psychosocial treatment versus delay in treatment with antipsychotic medication. Schizophrenia Bulletin 2003, 29:341-348.
11. Edwards J., Harrigan S.M., McGorry P.D., Amminger G.P. DUP and enduring negative symptoms in first episode schizophrenia. Psychological Medicine 2002, 32:563-564.
12. Farooq S., Large M., Nielssen O., Waheed W. The relationship between the duration of untreated psychosis and outcome in low-and-middle income countries: a systematic review and meta-analysis. Schizophrenia Research 2009, 109:15-23.
13. Green M.F., Kern R.S., Braff D.L., Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?. Schizophrenia Bulletin 2000, 26:119-136.
14. Hafner H., Loffler W., Hambrecht M., der Heiden W. Depression, negative symptoms, social stagnation and social decline in the early course of schizophrenia. Acta Psychiatrica Scandinavica 1999, 100:105-118.
15. Harrigan S.M., McGorry P.D., Krstev H. Dose treatment delay in first-episode psychosis really matter?. Psychological Medicine 2003, 33:97-110.
16. Harris M.G., Henry L.P., Harrigan S.M., Purcell R., Schwartz O.S., Farrelly S.E., Prosser A.L., Jackson H.J., McGorry D.P. The relationship between duration of untreated psychosis and outcome: an eight-year prospective study. Schizophrenia Research 2005, 79:85-93.
17. Harrison G., Croudace T., Manson P., Glazebrook C., Medley I. Predicting long-term outcome in schizophrenia. Psychological Medicine 1996, 26:697-705.
18. Hoff A.L., Sakuma M., Heydebrand G., Csernansky J.G., DeLisi L.E. Lack of association between duration of untreated illness and severity of cognitive and structural brain deficits at the first episode of schizophrenia. The American Journal of Psychiatry 2000, 157:1824-1828.
19. Jablensky A., Sartorius N., Ernberg G., Anker M., Korten A., Cooper J.E., Day R., Bertelsen A. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychological Medicine. Monograph Supplement 1992, 20:1-97.
20. Jeppesen P., Petersen L., Thorup A., Abel M.B., Øhlenschlæger J., Christensen T.Ø., Krarup G., Jørgensen P., Nordentoft M. The association between pre-morbid adjustment, duration of untreated psychosis and outcome in first-episode psychosis. Psychological Medicine 2008, 38:1157-1166.
21. Keshavan M.S., Haas G., Miewald J., Montrose D.M., Reddy R., Schooler N.R., Sweeney J.A. Prolonged untreated illness duration from prodromal onset predicts outcome in first episode psychosis. Schizophrenia Bulletin 2003, 29:757-769.
22. Malla A.K., Takhar J.J., Norman R.M.G., Manchanda R., Cortese L., Haricharan R., Verdi M., Ahmed R. Negative symptoms in first episode non-affective psycohsis. Acta Psychiatrica Scandinavica 2002, 105:431-439.
23. Malla A.K., Norman R.M.G., Takhar J., Manchanda R., Townsend L., Scholten D., Haricharan R. Can patients at risk for persistent negative symptoms be identified during their first episode of psychosis?. The Journal of Nervous and Mental Disease 2004, 192:455-463.
24. Marshall M., Lewis S., Lockwood A., Drake R., Jones P., Croudace T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Archives of General Psychiatry 2005, 62:975-983.
25. Marshall M., Harrigan S., Lewis S. Duration of untreated psychosis: definition, measurement and association with outcome. The recognition and management of Early Psychosis: a Preventive Approach 2009, 125-145. Cambridge University Press, Cambridge. H.J. Jackson, P.D. McGorry (Eds.).
26. Melle I., Larsen T.K., Haahr U., Friis S., Johannessen J.O., Opjordsmoen S., Simonsen E., Rund B.R., Vaglum P., McGlashan T. Reducing the duration of untreated first-episode psychosis: effects on clinical presentation. Archives of General Psychiatry 2004, 61:143-150.
27. Melle I., Larsen T.K., Haahr U., Friis S., Johannessen J.O., Opjordsmoen S., Rund B.R., Simonsen E., Vaglum P., McGlashan T. Prevention of negative symptom psychopathologies in first-episode schizophrenia: two-year effects of reducing the duration of untreated psychosis. Archives of General Psychiatry 2008, 65:634-640.
28. Morgan C., Abdul-Al R., Lappin J.M., Jones P., Fearon P., Leese M., Croudace T., Morgan K., Dazzan P., Craig T., Leff J., Murray R. Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study. The British Journal of Psychiatry 2006, 189:446-452.
29. Norman R.M.G., Townsend L., Malla A.K. Duration of untreated psychosis and cognitive functioning in first-episode patients. The British Journal of Psychiatry 2001, 179:340-345.
30. Norman R.M.G., Malla A.K., Manchanda R., Windell D., Harricharan R., Takhar J., Northcott S. Does treatment delay predict occupational functioning in first-episode psychosis?. Schizophrenia Research 2007, 91:259-262.
31. Pek E., Mythily S., Chong S.A. Clinical and social correlates of duration of untreated psychosis in first-episode psychosis patients. Annals of the Academy of Medicine, Singapore 2006, 35:24-26.
32. Perkins D.O., Gu H., Boteva K., Lieberman J. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. The American Journal of Psychiatry 2005, 162:1785-1804.
33. Rinaldi M., Killackey E., Smith J., Shepherd G., Singh S.P., Craig T. First episode psychosis and employment: a review. International Review of Psychiatry 2010, 22:148-162.
34. Schimmelmann B.G., Huber C.G., Lambert M., Cotton S., McGorry P.D., Conus P. Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort. Schizophrenia Research 2008, 42:982-990.
35. Schmitz N., Malla A., Norman R., Archie S., Zipursky R. Inconsistency in the relationship between duration of untreated psychosis and negative symptoms: sorting out the problem of heterogeneity. Schizophrenia Research 2007, 93:152-159.
36. Tulloch A.D., Fearon P., David A.S. Social outcomes in schizophrenia: from description to action. Current Opinion in Psychiatry 2006, 19:140-144.
37. Ventura J., Hellemann G.S., Thames A.D., Koellner V., Nuechterlein K.H. Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophrenia Research 2009, 113:189-199.
38. Wong G.H.Y., Hui C.L.M., Chiu C.P.Y., Lam M.L.M., Chung D.W.S., Tso S., Chan K., Yip K.C., Hung S.F., Chen E.Y.H. Early detection and intervention of psychosis in Hong Kong: experience of a population-based intervention programme. Clinical Neuropsychiatry 2008, 5:286-289.
39. World Health Organization The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Description and Diagnostic Guidelines 1992, WHO, Geneva.
40. Wunderink A., Nienhuis F.J., Sytema S., Wiersma D. Treatment delay and response rate in first episode psychosis. Acta Psychiatrica Scandinavica 2006, 113:332-339.