Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders

British Journal of Psychiatry

Volumn 185, Issue JULY, 2004, Pages 18-24

  Perkins, Diana O ^a   Lieberman, Jeffrey A ^a   Gu, Hongbin ^a   Tohen, Mauricio ^b   McEvoy, Joseph ^c   Green, Alan I ^d   Zipursky, Robert B ^e   Strakowski, Stephen M ^f   Sharma, Tonmoy ^g   Kahn, René S ^h   Gur, Raquel ⁱ   Tollefson, Gary ^j  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^g NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^h UTRECHT UNIVERSITY   (Netherlands)

ⁱ UNIVERSITY OF PENNSYLVANIA   (United States)

^j ELI LILLY AND COMPANY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; HUMAN; MALE; MENTAL DISEASE; PREDICTION; PROSPECTIVE STUDY; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCHIZOPHRENIFORM DISORDER; SIDE EFFECT; SOCIAL ASPECT; TREATMENT OUTCOME; VOCATION;

ADOLESCENT; ADULT; AGE OF ONSET; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; DOUBLE-BLIND METHOD; FEMALE; HALOPERIDOL; HUMANS; MALE; PROGNOSIS; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; REMISSION INDUCTION; SCHIZOPHRENIA; TREATMENT OUTCOME;

EID: 3242687762     PISSN: 00071250     EISSN: None     Source Type: Journal    
DOI: 10.1192/bjp.185.1.18     Document Type: Article

References (24)

1. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington, DC: APA.
2. Cahn, W., Pol, H. E., Lems, E. B., et al (2002) Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Archives of General Psychiatry, 59, 1002-1010.
3. Cannon-Spoor, H. E., Potkin, S. G. & Wyatt, R. J. (1982) Measurement of premorbid adjustment in schizophrenia. Schizophrenia Bulletin, 8, 470-484.
4. Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology. Publication ADM 76-338, pp. 218-222. Washington, DC: US Department of Health, Education and Welfare.
5. Haas, G. L., Garratt, L. S. & Sweeney, J. A. (1998) Delay to first antipsychotic medication in schizophrenia: impact on symptomatology and clinical course of illness. Journal of Psychiatric Research, 32, 151-159.
6. Harrigan, S. M., McGorry, P. D. & Krstev, H. (2000) Does treatment delay in first-episode psychosis really matter? Schizophrenia Research, 41, 97-110.
7. Heinrichs, D.W., Hanlan, T. E. & Carpenter, W.T. Jr (1984) The Quality of Life Scale: an instrument for rating the schizophrenia deficit syndrome. Schizophrenia Bulletin, 10, 388-398.
8. Ho, B. C., Andreasen, N. C., Nopoulos, P., et al (1003) Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia. Archives of General Psychiatry, 60, 585-594.
9. Johnstone, E. C., Macmillan, J. F., Frith, C. D., et al (1990) Further investigation of the predictors of outcome following first schizophrenic episodes. British Journal of Psychiatry, 157, 182-189.
10. Kay, S. R., Opler, L. A. & Lindenmayer, J. P. (1988) Reliability and validity of the positive and negative syndrome scale for schizophrenics. Psychiatry Research, 23, 99-110.
11. Larsen, T. K., Moe, L. C., Vibe-Hansen, L., et al (2000) Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis. Schizophrenia Research, 45, 1-9.
12. Lieberman, J., Chakos, M., Wu, H., et al (2001a) Longitudinal study of brain morphology in first-episode schizophrenia. Biological Psychiatry, 49, 487-499.
13. Lieberman, J. A., Perkins, D., Belger, A., et al (2001b) The early stages of schizophrenia: speculations on pathogenesis, pathophysiology and therapeutic approaches. Biological Psychiatry, 50, 884-897.
14. Lieberman, J. A., Tollefson, G., Tohen, M., et al (2003) Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol. American Journal of Psychiatry, 160, 1396-1404.
15. Loebel, A. D., Lieberman, J. A., Alvir, J. M., et al (1992) Duration of psychosis and outcome in first-episode schizophrenia. American Journal of Psychiatry, 149, 1183-1188.
16. Malla, A. K., Norman, R. M. G., Manchanda, R., et al (2002) One year outcome in first-episode psychosis: influence of DUP and other predictors. Schizophrenia Research, 54, 231-242.
17. McGlashan, T. H. (1986) The prediction of outcome in chronic schizophrenia. IV. The Chestnut Lodge follow-up study. Archives of General Psychiatry, 43, 167-176.
18. McGlashan, T. H. (1999) Duration of untreated psychosis in first-episode schizophrenia: marker or determinant of course? Biological Psychiatry, 46, 899-907.
19. Montgomery, S. A. & Åsberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382-389.
20. Ott, S. L., Spinelli, S., Rock, D., et al (1998) The New York High-Risk Project: social and general intelligence in children at risk for schizophrenia. Schizophrenia Research, 31, 1-11.
21. Perkins, D. O., Leserman, J., Jarskog, L. F., et al (2000) Characterizing and dating the onset of symptoms in psychotic illness: the Symptom Onset in Schizophrenia (SOS) inventory. Schizophrenia Research, 44, 1-10.
22. Robinson, D. G., Woerner, M. G., Alvir, J. M., et al (1999) Predictors of treatment response from a first-episode of schizophrenia or schizoaffective disorder. American Journal of Psychiatry, 156, 544-549.
23. Weinberger, D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660-669.
24. Wiersma, D., Nienhuis, F. J., Slooff, C. J., et al (1998) Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort. Schizophrenia Bulletin, 24, 75-85.