Transcriptomic analysis of the host response to Giardia duodenalis infection reveals redundant mechanisms for parasite control

mBio

Volumn 4, Issue 6, 2013, Pages

  Tako, Ernest A ^a,c   Hassimi, Maryam F ^b,d   Li, Erqiu ^a   Singer, Steven M ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b AGILENT TECHNOLOGIES   (United States)

^c BRONX LEBANON HOSPITAL CENTER   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MATRILYSIN; PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY GENE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ANALYSIS; GIARDIA LAMBLIA; GIARDIASIS; GROWTH RATE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MAST CELL; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PARASITE CONTROL; PARASITE IDENTIFICATION; PARASITE LOAD; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSCRIPTOMICS; UPREGULATION;

ANIMALS; FEMALE; GENE EXPRESSION PROFILING; GIARDIA LAMBLIA; HOST-PARASITE INTERACTIONS; INTESTINE, SMALL; MICE; MICE, INBRED C57BL; MICROARRAY ANALYSIS;

EID: 84891610703     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00660-13     Document Type: Article

References (36)

1. Farthing MJ. 1997. The molecular pathogenesis of giardiasis. J. Pediatr. Gastroenterol. Nutr. 24:79-88.
2. Flanagan PA. 1992. Giardia-diagnosis, clinical course and epidemiology. A review. Epidemiol. Infect. 109:1-22.
3. Wolfe MS. 1984. Symptomatology, diagnosis, and treatment, p 147-161. In Erlandsen SL, Meyer EA (ed), Giardia and giardiasis. Plenum Press, New York, NY.
4. Eckmann L. 2003. Mucosal defences against Giardia. Parasite Immunol. 25:259-270.
5. Thompson RC, Reynoldson JA, Mendis AH. 1993. Giardia and giardiasis. Adv. Parasitol. 32:71-160.
6. Simsek Z, Zeyrek FY, Kurcer MA. 2004. Effect of giardia infection on growth and psychomotor development of children aged 0-5 years. J. Trop. Pediatr. 50:90-93.
7. Solaymani-Mohammadi S, Singer SM. 2010. Giardia duodenalis: the double-edged sword of immune responses in giardiasis. Exp. Parasitol. 126:292-297.
8. Robertson LJ, Hanevik K, Escobedo AA, Mørch K, Langeland N. 2010. Giardiasis-why do the symptoms sometimes never stop? Trends Parasitol. 26:75-82.
9. Adam RD. 2001. Biology of Giardia lamblia. Clin. Microbiol. Rev. 14: 447-475.
10. Davids BJ, Palm JE, Housley MP, Smith JR, Andersen YS, Martin MG, Hendrickson BA, Johansen FE, Svärd SG, Gillin FD, Eckmann L. 2006. Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia. J. Immunol. 177: 6281-6290.
11. Langford TD, Housley MP, Boes M, Chen J, Kagnoff MF, Gillin FD, Eckmann L. 2002. Central importance of immunoglobulin A in host defense against Giardia spp. Infect. Immun. 70:11-18.
12. LoGalbo PR, Sampson HA, Buckley RH. 1982. Symptomatic giardiasis in three patients with X-linked agammaglobulinemia. J. Pediatr. 101:78-80.
13. Stager S, Muller N. 1997. Giardia lamblia infections in B-cell-deficient transgenic mice. Infect. Immun. 65:3944-3946.
14. Singer SM, Nash TE. 2000. T-cell-dependent control of acute Giardia lamblia infections in mice. Infect. Immun. 68:170-175.
15. Roxström-Lindquist K, Ringqvist E, Palm D, Svärd S. 2005. Giardia lamblia-induced changes in gene expression in differentiated Caco-2 human intestinal epithelial cells. Infect. Immun. 73:8204-8208.
16. Kamda JD, Singer SM. 2009. Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77:685-693.
17. Scott KG, Logan MR, Klammer GM, Teoh DA, Buret AG. 2000. Jejunal brush border microvillous alterations in Giardia muris-infected mice: role of T lymphocytes and interleukin-6. Infect. Immun. 68:3412-3418.
18. Zhou P, Li E, Shea-Donohue T, Singer SM. 2007. Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice. Parasite Immunol. 29:367-374.
19. Aley SB, Zimmerman M, Hetsko M, Selsted ME, Gillin FD. 1994. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect. Immun. 62:5397-5403.
20. Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, López-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. 1999. Regulation of intestinal alpha α-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286:113-117.
21. Li E, Zhou P, Singer SM. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. J. Immunol. 176:516-521.
22. Evans-Osses I, Ansa-Addo, EA, Inal JM, Ramirez MI. 2010. Involvement of lectin pathway activation in the complement killing of Giardia intestinalis. Biochem. Biophys. Res. Commun. 395:382-386.
23. Roxström-Lindquist K, Palm D, Reiner D, Ringqvist E, Svärd SG. 2006. Giardia immunity-an update. Trends Parasitol. 22:26-31.
24. Li E, Zhou P, Petrin Z, Singer SM. 2004. Mast cell-dependent control of Giardia lamblia infections in mice. Infect. Immun. 72:6642-6649.
25. Troeger H, Epple HJ, Schneider T, Wahnschaffe U, Ullrich R, Burchard GD, Jelinek T, Zeitz M, Fromm M, Schulzke JD. 2007. Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. Gut 56:328-335.
26. Scott KG, Yu LC, Buret AG. 2004. Role of CD8 and CD4 T lymphocytes in jejunal mucosal injury during murine giardiasis. Infect. Immun. 72:3536-3542.
27. Eckmann L, Laurent F, Langford TD, Hetsko ML, Smith JR, Kagnoff MF, Gillin FD. 2000. Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia. J. Immunol. 164:1478-1487.
28. Li E, Zhao A, Shea-Donohue T, Singer SM. 2007. Mast cell mediated changes in smooth muscle contractility during mouse giardiasis. Infect. Immun. 75:4514-4518.
29. Muhsen K, Levine MM. 2012. A systematic review and meta-analysis of the association between Giardia lamblia and endemic pediatric diarrhea in developing countries. Clin. Infect. Dis. 55(Suppl 4):S271-S293.
30. Veenemans J, Mank T, Ottenhof M, Baidjoe A, Mbugi EV, Demir AY, Wielders JP, Savelkoul HF, Verhoef H. 2011. Protection against diarrhea associated with Giardia intestinalis is lost with multi-nutrient supplementation: a study in Tanzanian children. PLOS Negl. Trop Dis. 5:e1158. doi:10.1371/journal.pntd.0001158.
31. Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL. 2003. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422:522-526.
32. Umezawa K, Akaike T, Fujii S, Suga M, Setoguchi K, Ozawa A, Maeda H. 1997. Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice. Infect. Immun. 65:2932-2940.
33. Zhou P, Li E, Zhu N, Robertson J, Nash T, Singer SM. 2003. Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice. Infect. Immun. 71:1566-1568.
34. Beissbarth T, Speed TP. 2004. GOstat: find statistically overrepresented Gene Ontologies within a group of genes. Bioinformatics 20:1464-1465.
35. Overbergh L, Valckx D, Waer M, Mathieu C. 1999. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 11:305-312.
36. Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate-a practical and powerful approach to multiple testing. J. R. Stat. Soc. B Stat. Methodol. 57:289-300.