-
1
-
-
77951755278
-
Pancreatic cancer
-
Hidalgo M. Pancreatic cancer. N Engl J Med. 2010;362:1605-1617.
-
(2010)
N Engl J Med
, vol.362
, pp. 1605-1617
-
-
Hidalgo, M.1
-
2
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first- line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403-2413. (Pubitemid 27251144)
-
(1997)
Journal of Clinical Oncology
, vol.15
, Issue.6
, pp. 2403-2413
-
-
Burris III, H.A.1
Moore, M.J.2
Andersen, J.3
Green, M.R.4
Rothenberg, M.L.5
Modiano, M.R.6
Cripps, M.C.7
Portenoy, R.K.8
Storniolo, A.M.9
Tarassoff, P.10
Nelson, R.11
Dorr, F.A.12
Stephens, C.D.13
Von Hoff, D.D.14
-
3
-
-
67349117952
-
Treatment of advanced pancreatic cancer: From gemcitabine single agent to combinations and targeted therapy
-
Rivera F, Lopez-Tarruella S, Vega-Villegas ME, et al. Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy. Cancer Treat Rev. 2009;35: 335-339.
-
(2009)
Cancer Treat Rev
, vol.35
, pp. 335-339
-
-
Rivera, F.1
Lopez-Tarruella, S.2
Vega-Villegas, M.E.3
-
4
-
-
77951213244
-
Evolution of systemic therapy for advanced pancreatic cancer
-
Renouf D, Moore M. Evolution of systemic therapy for advanced pancreatic cancer. Expert Rev Anticancer Ther. 2010;10:529-540.
-
(2010)
Expert Rev Anticancer Ther
, vol.10
, pp. 529-540
-
-
Renouf, D.1
Moore, M.2
-
5
-
-
77949264996
-
Advanced pancreatic carcinoma: Current treatment and future challenges
-
Stathis A, Moore MJ. Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol. 2010;7:163-172.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 163-172
-
-
Stathis, A.1
Moore, M.J.2
-
6
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
DOI 10.1200/JCO.2006.07.9525
-
Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960-1966. (Pubitemid 46972777)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.15
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
Figer, A.4
Hecht, J.R.5
Gallinger, S.6
Au, H.J.7
Murawa, P.8
Walde, D.9
Wolff, R.A.10
Campos, D.11
Lim, R.12
Ding, K.13
Clark, G.14
Voskoglou-Nomikos, T.15
Ptasynski, M.16
Parulekar, W.17
-
7
-
-
79955921754
-
Folfirinox versus gemcitabine for metastatic pancreatic cancer
-
Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011; 364:1817-1825.
-
(2011)
N Engl J Med
, vol.364
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
-
8
-
-
0038621384
-
Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
-
DOI 10.1038/sj.onc.1206390
-
Arlt A, Gehrz A, Muerkoster S, et al. Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene. 2003;22:3243-3251. (Pubitemid 36712936)
-
(2003)
Oncogene
, vol.22
, Issue.21
, pp. 3243-3251
-
-
Arlt, A.1
Gehrz, A.2
Muerkoster, S.3
Vorndamm, J.4
Kruse, M.-L.5
Folsch, U.R.6
Schafer, H.7
-
9
-
-
0032943591
-
The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
-
Wang W, Abbruzzese JL, Evans DB, et al. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res. 1999;5:119-127. (Pubitemid 29045184)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.1
, pp. 119-127
-
-
Wang, W.1
Abbruzzese, J.L.2
Evans, D.B.3
Larry, L.4
Cleary, K.R.5
Chiao, P.J.6
-
10
-
-
0037242595
-
Function of nuclear factor κB in pancreatic cancer metastasis
-
Fujioka S, Sclabas GM, Schmidt C, et al. Function of nuclear factor kappaB in pancreatic cancer metastasis. Clin Cancer Res. 2003;9: 346-354. (Pubitemid 36109751)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.1
, pp. 346-354
-
-
Fujioka, S.1
Sclabas, G.M.2
Schmidt, C.3
Frederick, W.A.4
Dong, Q.G.5
Abbruzzese, J.L.6
Evans, D.B.7
Baker, C.8
Chiao, P.J.9
-
11
-
-
41149089359
-
The role of nuclear factor κB in pancreatic cancer and the clinical applications of targeted therapy
-
DOI 10.1097/MPA.0b013e31815b3207, PII 0000667620080400000001
-
Holcomb B, Yip-Schneider M, Schmidt CM. The role of nuclear factor kappaB in pancreatic cancer and the clinical applications of targeted therapy. Pancreas. 2008;36:225-235. (Pubitemid 351440925)
-
(2008)
Pancreas
, vol.36
, Issue.3
, pp. 225-235
-
-
Holcomb, B.1
Yip-Schneider, M.2
Schmidt, C.M.3
-
12
-
-
0034933389
-
Successful treatment of DIC with a serine proteinase inhibitor [19]
-
Yokota T, Yamada Y, Takahashi M, et al. Successful treatment of DIC with a serine proteinase inhibitor. Am J Emerg Med. 2001;19:334-335. (Pubitemid 32642180)
-
(2001)
American Journal of Emergency Medicine
, vol.19
, Issue.4
, pp. 334-335
-
-
Yokota, T.1
Yamada, Y.2
Takahashi, M.3
Kunii, Y.4
Iwamoto, K.5
Kagami, M.6
Kikuchi, S.7
Yamauchi, H.8
Yoshikawa, K.9
-
13
-
-
10344253359
-
Treatment of acute pancreatitis with protease inhibitors: A meta-analysis
-
DOI 10.1097/00042737-200412000-00009
-
Seta T, Noguchi Y, Shimada T, et al. Treatment of acute pancreatitis with protease inhibitors: a meta-analysis. Eur J Gastroenterol Hepatol. 2004;16:1287-1293. (Pubitemid 39627527)
-
(2004)
European Journal of Gastroenterology and Hepatology
, vol.16
, Issue.12
, pp. 1287-1293
-
-
Seta, T.1
Noguchi, Y.2
Shimada, T.3
Shikata, S.4
Fukui, T.5
-
14
-
-
79953238453
-
Protease inhibitors for preventing complications associated with ercp: An update meta-analysis
-
Seta T, Noguchi Y. Protease inhibitors for preventing complications associated with ERCP: an update meta-analysis. Gastrointest Endosc. 2011;73:700-706.
-
(2011)
Gastrointest Endosc
, vol.73
, pp. 700-706
-
-
Seta, T.1
Noguchi, Y.2
-
15
-
-
34547947985
-
Synthetic serine protease inhibitor, gabexate mesilate, prevents nuclear factor-κB activation and increases TNF-α-mediated apoptosis in human pancreatic cancer cells
-
DOI 10.1007/s10620-006-9654-7
-
Takahashi H, Funahashi H, Sawai H, et al. Synthetic serine protease inhibitor, gabexate mesilate, prevents nuclear factor-kappaB activation and increases TNF-alphaYmediated apoptosis in human pancreatic cancer cells. Dig Dis Sci. 2007;52:2646-2652. (Pubitemid 47373891)
-
(2007)
Digestive Diseases and Sciences
, vol.52
, Issue.10
, pp. 2646-2652
-
-
Takahashi, H.1
Funahashi, H.2
Sawai, H.3
Matsuo, Y.4
Yamamoto, M.5
Okada, Y.6
Takeyama, H.7
Manabe, T.8
-
17
-
-
0020520088
-
Application of HPLC measurement of plasma concentration of gabexate mesilate
-
Nishijima MK, Takezawa J, Taenaka N, et al. Application of HPLC measurement of plasma concentration of gabexate mesilate. Thromb Res. 1983;31:279-284. (Pubitemid 13023145)
-
(1983)
Thrombosis Research
, vol.31
, Issue.2
, pp. 279-284
-
-
Nishijima, M.K.1
Takezawa, J.2
Taenaka, N.3
-
18
-
-
0026101039
-
Saturation of 2¶,2¶-difluorodeoxycytidine 5¶-triphosphate accumulation by mononuclear cells during a phase i trial of gemcitabine
-
Grunewald R, Abbruzzese JL, Tarassoff P, et al. Saturation of 2¶,2¶-difluorodeoxycytidine 5¶-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine. Cancer Chemother Pharmacol. 1991;27:258-262.
-
(1991)
Cancer Chemother Pharmacol
, vol.27
, pp. 258-262
-
-
Grunewald, R.1
Abbruzzese, J.L.2
Tarassoff, P.3
-
19
-
-
43549110055
-
Prolonged versus standard gemcitabine infusion: Translation of molecular pharmacology to new treatment strategy
-
DOI 10.1634/theoncologist.2007-0215
-
Veltkamp SA, Beijnen JH, Schellens JH. Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy. Oncologist. 2008;13:261-276. (Pubitemid 351679901)
-
(2008)
Oncologist
, vol.13
, Issue.3
, pp. 261-276
-
-
Veltkamp, S.A.1
Beijnen, J.H.2
Schellens, J.H.M.3
-
20
-
-
34347234200
-
The chemoinvasion assay: A method to assess tumor and endothelial cell invasion and its modulation
-
DOI 10.1038/nprot.2006.466, PII NPROT.2006.466
-
Albini A, Benelli R. The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Nat Protoc. 2007;2:504-511. (Pubitemid 47040014)
-
(2007)
Nature Protocols
, vol.2
, Issue.3
, pp. 504-511
-
-
Albini, A.1
Benelli, R.2
-
21
-
-
4544326176
-
Evidence for the notch signaling pathway on the role of estrogen in angiogenesis
-
DOI 10.1210/me.2003-0362
-
Soares R, Balogh G, Guo S, et al. Evidence for the notch signaling pathway on the role of estrogen in angiogenesis. Mol Endocrinol. 2004;18:2333-2343. (Pubitemid 39215261)
-
(2004)
Molecular Endocrinology
, vol.18
, Issue.9
, pp. 2333-2343
-
-
Soares, R.1
Balogh, G.2
Guo, S.3
Gartner, F.4
Russo, J.5
Schmitt, F.6
-
22
-
-
33750466230
-
Introduction to NF-κB: Players, pathways, perspectives
-
DOI 10.1038/sj.onc.1209954, PII 1209954
-
Gilmore TD. Introduction to NF-JB: players, pathways, perspectives. Oncogene. 2006;25:6680-6684. (Pubitemid 44657845)
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6680-6684
-
-
Gilmore, T.D.1
-
23
-
-
33750432183
-
Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression
-
DOI 10.1038/sj.onc.1209942, PII 1209942
-
Basseres DS, Baldwin AS. Nuclear factor-JB and inhibitor of IKB kinase pathways in oncogenic initiation and progression. Oncogene. 2006;25:6817-6830. (Pubitemid 44657854)
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6817-6830
-
-
Basseres, D.S.1
Baldwin, A.S.2
-
24
-
-
4444376712
-
Signaling to nf-jb
-
Hayden MS, Ghosh S. Signaling to NF-JB. Genes Dev. 2004;18: 2195-2224.
-
(2004)
Genes Dev
, vol.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
25
-
-
9644253003
-
The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells
-
DOI 10.1038/sj.onc.1207902
-
Asano T, Yao Y, Zhu J, et al. The PI 3-kinase/Akt signaling pathway is activated due to aberrant PTEN expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene. 2004;23:8571-8580. (Pubitemid 39576463)
-
(2004)
Oncogene
, vol.23
, Issue.53
, pp. 8571-8580
-
-
Asano, T.1
Yao, Y.2
Zhu, J.3
Li, D.4
Abbruzzese, J.L.5
Reddy, S.A.G.6
-
26
-
-
78649265598
-
Loss of raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma
-
Kim HS, Kim GY, Lim SJ, et al. Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma. Pathology. 2010;42:655-660.
-
(2010)
Pathology
, vol.42
, pp. 655-660
-
-
Kim, H.S.1
Kim, G.Y.2
Lim, S.J.3
-
27
-
-
0037422205
-
Inhibition of constitutive NF-κB activity by IκBαM suppresses tumorigenesis
-
DOI 10.1038/sj.onc.1206323
-
Fujioka S, Sclabas GM, Schmidt C, et al. Inhibition of constitutive NF-kappa B activity by Ikappa B alpha M suppresses tumorigenesis. Oncogene. 2003;22:1365-1370. (Pubitemid 36384598)
-
(2003)
Oncogene
, vol.22
, Issue.9
, pp. 1365-1370
-
-
Fujioka, S.1
Sclabas, G.M.2
Schmidt, C.3
Niu, J.4
Frederick, W.A.5
Dong, Q.G.6
Abbruzzese, J.L.7
Evans, D.B.8
Baker, C.9
Chiao, P.J.10
-
28
-
-
0348012946
-
NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells
-
DOI 10.1002/ijc.11562
-
Xiong HQ, Abbruzzese JL, Lin E, et al. NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Int J Cancer. 2004;108:181-188. (Pubitemid 37541768)
-
(2004)
International Journal of Cancer
, vol.108
, Issue.2
, pp. 181-188
-
-
Xiong, H.Q.1
Abbruzzese, J.L.2
Lin, E.3
Wang, L.4
Zheng, L.5
Xie, K.6
-
29
-
-
0035342593
-
Pancreatic cancer cell-derived vascular endothelial growth factor is biologically active in vitro and enhances tumorigenicity in vivo
-
DOI 10.1002/ijc.1202
-
Luo J, Guo P, Matsuda K, et al. Pancreatic cancer cell-derived vascular endothelial growth factor is biologically active in vitro and enhances tumorigenicity in vivo. Int J Cancer. 2001;92:361-369. (Pubitemid 32249712)
-
(2001)
International Journal of Cancer
, vol.92
, Issue.3
, pp. 361-369
-
-
Luo, J.1
Guo, P.2
Matsuda, K.3
Truong, N.4
Lee, A.5
Chun, C.6
Cheng, S.-Y.7
Korc, M.8
-
30
-
-
58149465757
-
Cxcl8/il-8 and cxcl12/ sdf-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer
-
Matsuo Y, Ochi N, Sawai H, et al. CXCL8/IL-8 and CXCL12/ SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer. 2009;124:853-861.
-
(2009)
Int J Cancer
, vol.124
, pp. 853-861
-
-
Matsuo, Y.1
Ochi, N.2
Sawai, H.3
-
31
-
-
0033999274
-
Expression of matrix metalloproteinases and the tissue inhibitors of metalloproteinases and their local invasiveness and metastasis in chinese human pancreatic cancer
-
DOI 10.1002/(SICI)1096-9098(200002)73:2<95::AID-JSO7>3.0.CO;2-R
-
Gong YL, Xu GM, Huang WD, et al. Expression of matrix metalloproteinases and the tissue inhibitors of metalloproteinases and their local invasiveness and metastasis in Chinese human pancreatic cancer. J Surg Oncol. 2000;73:95-99. (Pubitemid 30123732)
-
(2000)
Journal of Surgical Oncology
, vol.73
, Issue.2
, pp. 95-99
-
-
Gong, Y.L.1
Xu, G.M.2
Huang, W.D.3
Chen, L.B.4
-
32
-
-
0036177290
-
Histologic features of venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer
-
DOI 10.1097/00006676-200203000-00008
-
Nagakawa Y, Aoki T, Kasuya K, et al. Histologic features of venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer. Pancreas. 2002;24:169-178. (Pubitemid 34171293)
-
(2002)
Pancreas
, vol.24
, Issue.2
, pp. 169-178
-
-
Nagakawa, Y.1
Aoki, T.2
Kasuya, K.3
Tsuchida, A.4
Koyanagi, Y.5
-
33
-
-
0036334059
-
Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials
-
DOI 10.1245/aso.2002.9.7.668
-
Bloomston M, Zervos EE, Rosemurgy AS. Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials. Ann Surg Oncol. 2002;9:668-674. (Pubitemid 34857984)
-
(2002)
Annals of Surgical Oncology
, vol.9
, Issue.7
, pp. 668-674
-
-
Bloomston, M.1
Zervos, E.E.2
Rosemurgy II, A.S.3
-
34
-
-
2942536487
-
Invasion and metastasis in pancreatic cancer
-
Keleg S, Buchler P, Ludwig R, et al. Invasion and metastasis in pancreatic cancer. Mol Cancer. 2003;2:14.
-
(2003)
Mol Cancer
, vol.2
, pp. 14
-
-
Keleg, S.1
Buchler, P.2
Ludwig, R.3
-
35
-
-
84866742346
-
A phase ii randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma
-
Ko AH, Youssoufian H, Gurtler J, et al. A phase II randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma. Invest New Drugs. 2011;30:1597-1006.
-
(2011)
Invest New Drugs
, vol.30
, pp. 1597-1006
-
-
Ko, A.H.1
Youssoufian, H.2
Gurtler, J.3
-
36
-
-
33750432183
-
Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression
-
DOI 10.1038/sj.onc.1209942, PII 1209942
-
Basseres DS, Baldwin AS. Nuclear factor-JB and inhibitor of IKB kinase pathways in oncogenic initiation and progression. Oncogene. 2006;25:6817-6830. (Pubitemid 44657854)
-
(2006)
Oncogene
, vol.25
, Issue.51
, pp. 6817-6830
-
-
Basseres, D.S.1
Baldwin, A.S.2
-
37
-
-
77649272556
-
Rkip inhibits nf-kappab in cancer cells by regulating upstream signalling components of the ikappab kinase complex
-
Tang H, Park S, Sun SC, et al. RKIP inhibits NF-kappaB in cancer cells by regulating upstream signalling components of the IkappaB kinase complex. FEBS Lett. 2010;584:662-668.
-
(2010)
FEBS Lett
, vol.584
, pp. 662-668
-
-
Tang, H.1
Park, S.2
Sun, S.C.3
-
38
-
-
77954656531
-
Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer
-
Takano S, Sogawa K, Yoshitomi H, et al. Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer. Br J Cancer. 2010;103:223-231.
-
(2010)
Br J Cancer
, vol.103
, pp. 223-231
-
-
Takano, S.1
Sogawa, K.2
Yoshitomi, H.3
|