Expression of SOX9 in intraductal papillary mucinous neoplasms of the pancreas

Pancreas

Volumn 43, Issue 1, 2014, Pages 7-14

  Meng, Fanbin ^a,b   Takaori, Kyoichi ^a   Ito, Tatsuo ^a   Masui, Toshihiko ^a   Kawaguchi, Michiya ^a   Kawaguchi, Yoshiya ^c   Uemoto, Shinji ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

intraductal papillary mucinous neoplasm; IPMN; pancreas; SOX9

Indexed keywords

HERMES ANTIGEN; MUCIN 1; MUCIN 2; MUCIN 5AC; TRANSCRIPTION FACTOR SOX9;

ADULT; AGED; ARTICLE; CARCINOMA CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPLASIA; EPITHELIUM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY MUCINOUS TUMOR; INVASIVE CARCINOMA; MALE; MIDDLE AGED; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; YOUNG ADULT;

ADENOCARCINOMA, MUCINOUS; AGED; ANTIGENS, CD44; CARCINOMA, PANCREATIC DUCTAL; CARCINOMA, PAPILLARY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; SOX9 TRANSCRIPTION FACTOR;

EID: 84891528892     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3182a70b2f     Document Type: Article

References (41)

1. Adsay NV, Fukushima N, Furukawa T, et al. Intraductal neoplasms of the pancreas. In: Theise ND, Nakashima O, Park YN, et al. WHO Classification of Tumors of the Digestive System. Lyon: IARC Press. 2010:304-331.
2. Kimura W, Sasahira N, Yoshikawa T, et al. Duct-ectatic type of mucin producing tumor of the pancreasVnew concept of pancreatic neoplasia. Hepatogastroenterology. 1996;43:692-709. (Pubitemid 26190131)
3. Nara S, Shimada K, Kosuge T, et al. Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms. Am J Surg Pathol. 2008;32:243-255. (Pubitemid 351172139)
4. Schnelldorfer T, Sarr MG, Nagorney DM, et al. Experience with 208 resections for intraductal papillary mucinous neoplasm of the pancreas. Arch Surg. 2008;143:639-646. (Pubitemid 352040228)
5. Schonleben F, Qiu W, Bruckman KC, et al. BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Lett. 2007;249:242-248. (Pubitemid 46452934)
6. Wu J, Matthaei H, Maitra A, et al. Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med. 2011;3:92ra66.
7. Uemura K, Hiyama E, Murakami Y, et al. Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours. Oncol Rep. 2003;10:277-283.
8. Schonleben F, Qiu W, Ciau NT, et al. PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin Cancer Res. 2006;12:3851-3855. (Pubitemid 44000267)
9. Wada K. p16 and p53 gene alterations and accumulations in the malignant evolution of intraductal papillary-mucinous tumors of the pancreas. J Hepatobiliary Pancreat Surg. 2002;9:76-85. (Pubitemid 34477373)
10. Bardeesy N, Cheng KH, Berger JH, et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 2006;20:3130-3146. (Pubitemid 44790628)
11. Takeshita A, Kimura W, Hirai I, et al. Clinicopathologic study of the MIB-1 labeling index (Ki67) and postoperative prognosis for intraductal papillary mucinous neoplasms and ordinary ductal adenocarcinoma. Pancreas. 2012;41:114-120.
12. Miyasaka Y, Nagai E, Ohuchida K, et al. CD44v6 expression in intraductal papillary mucinous neoplasms of the pancreas. Pancreas. 2010;39:31-35.
13. Akiyama H. Control of chondrogenesis by the transcription factor SOX9. Mod Rheumatol. 2008;18:213-219.
14. Antoniou A, Raynaud P, Cordi S, et al. Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology. 2009;136:2325-2333.
15. Stolt CC, Lommes P, Sock E, et al. The SOX9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003;17:1677-1689. (Pubitemid 36828793)
16. Vidal VP, Chaboissier MC, Lutzkendorf S, et al. SOX9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol. 2005;15:1340-1351. (Pubitemid 41097538)
17. Seymour PA, Freude KK, Tran MN, et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007;104:1865-1870. (Pubitemid 46239870)
18. Blache P, van de Wetering M, Duluc I, et al. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol. 2004;166:37-47. (Pubitemid 38931915)
19. Furuyama K, Kawaguchi Y, Akiyama H, et al. Continuous cell supply from a SOX9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2011;43:34-41.
20. Moniot B, Biau S, Faure S, et al. SOX9 specifies the pyloric sphincter epithelium through mesenchymal-epithelial signals. Development. 2004;131:3795-3804. (Pubitemid 39199386)
21. Ling S, Chang X, Schultz L, et al. An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer. Cancer Res. 2011;71:3812-3821.
22. Cajaiba MM, Jianhua L, Goodman MA, et al. SOX9 expression is not limited to chondroid neoplasms: variable occurrence in other soft tissue and bone tumors with frequent expression by synovial sarcomas. Int J Surg Pathol. 2010; 18:319-323.
23. Jay P, Berta P, Blache P. Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells. Cancer Res. 2005;65:2193-2198. (Pubitemid 40490127)
24. Zalzali H, Naudin C, Bastide P, et al. CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium. Oncogene. 2008;27:7131-7138.
25. Chakravarty G, Moroz K, Makridakis NM, et al. Prognostic significance of cytoplasmic SOX9 in invasive ductal carcinoma and metastatic breast cancer. Exp Biol Med (Maywood). 2011;236:145-155.
26. Sashikawa Kimura M, Mutoh H, Sugano K. SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans. J Gastroenterol. 2011;46:1292-1299.
27. Mazur PK, Riener MO, Jochum W, et al. Expression and clinicopathological significance of notch signaling and cell-fate genes in biliary tract cancer. Am J Gastroenterol. 2012;107:126-135.
28. Jiang SS, Fang WT, Hou YH, et al. Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin Cancer Res. 2010;16:4363-4373.
29. Gracz AD, Ramalingam S, Magness ST. SOX9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol. 2010;298:G590-G600.
30. Kim TH, Escudero S, Shivdasani RA. Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci U S A. 2012;109:3932-3937.
31. Li C, Lee CJ, Simeone DM. Identification of human pancreatic cancer stem cells. Methods Mol Biol. 2009;568:161-173.
32. Hou NY, Yang K, Chen T, et al. CD133+ CD44+ subgroups may be human small intestinal stem cells. Mol Biol Rep. 2011;38:997-1004.
33. Ban S, Naitoh Y, Mino-Kenudson M, et al. Intraductal papillary mucinous neoplasm (IPMN) of the pancreas: its histopathologic difference between 2 major types. Am J Surg Pathol. 2006;30: 1561-1569. (Pubitemid 44808792)
34. Adsay NV, Merati K, Basturk O, et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an ''intestinal'' pathway of carcinogenesis in the pancreas. Am J Surg Pathol. 2004;28:839-848. (Pubitemid 38856838)
35. Potten CS. Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos Trans R Soc Lond B Biol Sci. 1998;353:821-830. (Pubitemid 28314364)
36. Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003-1007. (Pubitemid 350014593)
37. Bjerknes M, Cheng H. Intestinal epithelial stem cells and progenitors. Methods Enzymol. 2006;419:337-383. (Pubitemid 44820373)
38. Itzkovitz S, Lyubimova A, Blat IC, et al. Single-molecule transcript counting of stem-cell markers in the mouse. Nat Cell Biol. 2011;14: 106-114.
39. Barker N, van de Wetering M, Clevers H. The intestinal stem cell. Genes Dev. 2008;22:1856-1864. (Pubitemid 352008634)
40. Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009;459:262-265.
41. Kopp JL, von Figura G, Mayes E, et al. Identification of SOX9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell. 2012;22:737-750.