-
1
-
-
0031444238
-
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
-
1:CAS:528:DyaK2sXkslShtLc%3D 9230303 10.1016/S0092-8674(00)80314-1
-
Prodromou C, Roe SM, O'Brien R, Ladbury JE, Piper PW, Pearl LH (1997) Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell 90:65-75
-
(1997)
Cell
, vol.90
, pp. 65-75
-
-
Prodromou, C.1
Roe, S.M.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
2
-
-
84860339862
-
The network interaction of the human cytosolic 90 kDa heat shock protein Hsp90: A target for cancer therapeutics
-
22236519 10.1016/j.jprot.2011.12.028
-
da Silva VC, Ramos CH (2012) The network interaction of the human cytosolic 90 kDa heat shock protein Hsp90: a target for cancer therapeutics. J Proteomics 75:2790-2802
-
(2012)
J Proteomics
, vol.75
, pp. 2790-2802
-
-
Da Silva, V.C.1
Ramos, C.H.2
-
3
-
-
77953916528
-
HSP90 at the hub of protein homeostasis: Emerging mechanistic insights
-
1:CAS:528:DC%2BC3cXntFSmt7c%3D 20531426 10.1038/nrm2918
-
Taipale M, Jarosz DF, Lindquist S (2010) HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 11:515-528
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 515-528
-
-
Taipale, M.1
Jarosz, D.F.2
Lindquist, S.3
-
4
-
-
84857060671
-
Quality control and fate determination of Hsp90 client proteins
-
1:CAS:528:DC%2BC38XjtV2rt7g%3D 3242914 21871502 10.1016/j.bbamcr.2011.08. 006
-
Theodoraki MA, Caplan AJ (2012) Quality control and fate determination of Hsp90 client proteins. Biochim Biophys Acta 1823:683-688
-
(2012)
Biochim Biophys Acta
, vol.1823
, pp. 683-688
-
-
Theodoraki, M.A.1
Caplan, A.J.2
-
7
-
-
0742287264
-
Heat shock protein 90
-
1:CAS:528:DC%2BD3sXptVCmsbg%3D 14624223 10.1097/00001622-200311000-00003
-
Neckers L, Ivy SP (2003) Heat shock protein 90. Curr Opin Oncol 15:419-424
-
(2003)
Curr Opin Oncol
, vol.15
, pp. 419-424
-
-
Neckers, L.1
Ivy, S.P.2
-
8
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
1:CAS:528:DC%2BD3sXnsV2kt7w%3D 14508491 10.1038/nature01913
-
Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, Burrows FJ (2003) A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425:407-410
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
Zhang, L.4
Boehm, M.F.5
Fritz, L.C.6
Burrows, F.J.7
-
9
-
-
84862323158
-
Systematic identification of the HSP90 candidate regulated proteome
-
Wu Z, Moghaddas Gholami A, Kuster B (2012) Systematic identification of the HSP90 candidate regulated proteome. Mol Cell Proteomics 11:12
-
(2012)
Mol Cell Proteomics
, vol.11
, pp. 12
-
-
Wu, Z.1
Moghaddas Gholami, A.2
Kuster, B.3
-
10
-
-
77958124439
-
The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1
-
2974653 20977755 10.1186/1756-8722-3-40
-
Usmani SZ, Bona RD, Chiosis G, Li Z (2010) The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1. J Hematol Oncol 3:40
-
(2010)
J Hematol Oncol
, vol.3
, pp. 40
-
-
Usmani, S.Z.1
Bona, R.D.2
Chiosis, G.3
Li, Z.4
-
11
-
-
66249138886
-
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
-
1:CAS:528:DC%2BD1MXmsl2nsr0%3D 19416831 10.1073/pnas.0903392106
-
Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G (2009) Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci USA 106:8368-8373
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8368-8373
-
-
Caldas-Lopes, E.1
Cerchietti, L.2
Ahn, J.H.3
Clement, C.C.4
Robles, A.I.5
Rodina, A.6
Moulick, K.7
Taldone, T.8
Gozman, A.9
Guo, Y.10
Wu, N.11
De Stanchina, E.12
White, J.13
Gross, S.S.14
Ma, Y.15
Varticovski, L.16
Melnick, A.17
Chiosis, G.18
-
12
-
-
39149109163
-
Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects
-
1:CAS:528:DC%2BD1cXoslSm 18172314 10.1158/0008-5472.CAN-07-2268
-
Chan CT, Paulmurugan R, Gheysens OS, Kim J, Chiosis G, Gambhir SS (2008) Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer Res 68:216-226
-
(2008)
Cancer Res
, vol.68
, pp. 216-226
-
-
Chan, C.T.1
Paulmurugan, R.2
Gheysens, O.S.3
Kim, J.4
Chiosis, G.5
Gambhir, S.S.6
-
13
-
-
85047692516
-
Signaling pathways of the TNF superfamily: A double-edged sword
-
1:CAS:528:DC%2BD3sXmvVWmtb0%3D 12949498 10.1038/nri1184
-
Aggarwal BB (2003) Signaling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3:745-756
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 745-756
-
-
Aggarwal, B.B.1
-
14
-
-
0037276438
-
Tumor necrosis factor signaling
-
1:CAS:528:DC%2BD3sXit12mu7s%3D 12655295 10.1038/sj.cdd.4401189
-
Wajant H, Pfizenmaier K, Scheurich P (2003) Tumor necrosis factor signaling. Cell Death Differ 10:45-65
-
(2003)
Cell Death Differ
, vol.10
, pp. 45-65
-
-
Wajant, H.1
Pfizenmaier, K.2
Scheurich, P.3
-
15
-
-
0032033132
-
The death domain kinase RIP mediates the TNF-induced NF-κB signal
-
1:CAS:528:DyaK1cXitFGgsLk%3D 9529147 10.1016/S1074-7613(00)80535-X
-
Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Leder P (1998) The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8:297-303
-
(1998)
Immunity
, vol.8
, pp. 297-303
-
-
Kelliher, M.A.1
Grimm, S.2
Ishida, Y.3
Kuo, F.4
Stanger, B.Z.5
Leder, P.6
-
16
-
-
0029858348
-
RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis
-
1:CAS:528:DyaK28XnsFKrtLg%3D 8947041
-
Ting AT, Pimentel-Muinos FX, Seed B (1996) RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis. EMBO J 15:6189-6196
-
(1996)
EMBO J
, vol.15
, pp. 6189-6196
-
-
Ting, A.T.1
Pimentel-Muinos, F.X.2
Seed, B.3
-
17
-
-
0030001051
-
A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis
-
1:CAS:528:DyaK28XjtFCqs70%3D 231266 8649383
-
Zhang J, Winoto A (1996) A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis. Mol Cell Biol 16:2756-2763
-
(1996)
Mol Cell Biol
, vol.16
, pp. 2756-2763
-
-
Zhang, J.1
Winoto, A.2
-
18
-
-
0346505340
-
The IKK NF-κB system: A treasure trove for drug development
-
1:CAS:528:DC%2BD2cXpvFKqug%3D%3D 14708018 10.1038/nrd1279
-
Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-κB system: a treasure trove for drug development. Nat Rev Drug Discov 3:17-26
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 17-26
-
-
Karin, M.1
Yamamoto, Y.2
Wang, Q.M.3
-
19
-
-
0034922161
-
The essential role of MEKK3 in TNF-induced NFκB activation
-
1:CAS:528:DC%2BD3MXltFSltLo%3D 11429546 10.1038/89769
-
Yang J, Lin Y, Guo Z, et al. (2001) The essential role of MEKK3 in TNF-induced NFκB activation. Nat Immunol 2:620-624
-
(2001)
Nat Immunol
, vol.2
, pp. 620-624
-
-
Yang, J.1
Lin, Y.2
Guo, Z.3
-
20
-
-
0032516651
-
IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival
-
1:CAS:528:DyaK1cXlsVCjsro%3D 9703517 10.1126/science.281.5379.998
-
Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (1998) IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival. Science 281:998-1001
-
(1998)
Science
, vol.281
, pp. 998-1001
-
-
Wu, M.X.1
Ao, Z.2
Prasad, K.V.3
Wu, R.4
Schlossman, S.F.5
-
21
-
-
0032508414
-
NFκB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
1:CAS:528:DyaK1cXmtVWhurk%3D 9733516 10.1126/science.281.5383.1680
-
Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS (1998) NFκB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680-1683
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin, A.S.5
-
22
-
-
14844327760
-
Reactive oxygen species promote TNFa induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
-
1:CAS:528:DC%2BD2MXis1yhsbg%3D 15766528 10.1016/j.cell.2004.12.041
-
Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M (2005) Reactive oxygen species promote TNFa induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120:649-661
-
(2005)
Cell
, vol.120
, pp. 649-661
-
-
Kamata, H.1
Honda, S.2
Maeda, S.3
Chang, L.4
Hirata, H.5
Karin, M.6
-
23
-
-
3142719113
-
Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation
-
1:CAS:528:DC%2BD2cXlsVOmsbw%3D 15077173 10.1038/sj.onc.1207705
-
Broemer M, Krappmann D, Scheidereit C (2004) Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation. Oncogene 23:5378-5386
-
(2004)
Oncogene
, vol.23
, pp. 5378-5386
-
-
Broemer, M.1
Krappmann, D.2
Scheidereit, C.3
-
24
-
-
0034615701
-
Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-κB activation
-
1:CAS:528:DC%2BD3cXisFWjtLY%3D 10744744 10.1074/jbc.275.14.10519
-
Lewis J, Devin A, Miller A, et al. (2000) Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-κB activation. J Biol Chem 275:10519-10526
-
(2000)
J Biol Chem
, vol.275
, pp. 10519-10526
-
-
Lewis, J.1
Devin, A.2
Miller, A.3
-
25
-
-
84868486281
-
Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base-copper complexes
-
1:CAS:528:DC%2BC38XhslKqt7bL 3676669 23142973 10.1016/j.jinorgbio.2012. 10.006
-
Zuo J, Bi C, Fan Y, et al. (2013) Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base-copper complexes. J Inorg Biochem 118:83-93
-
(2013)
J Inorg Biochem
, vol.118
, pp. 83-93
-
-
Zuo, J.1
Bi, C.2
Fan, Y.3
-
26
-
-
20044384168
-
Phase i trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer
-
1:CAS:528:DC%2BD2MXitl2gtbw%3D 15718306 10.1200/JCO.2005.09.119
-
Goetz MP, Toft D, Reid J, et al. (2005) Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. J Clin Oncol 23:1078-1087
-
(2005)
J Clin Oncol
, vol.23
, pp. 1078-1087
-
-
Goetz, M.P.1
Toft, D.2
Reid, J.3
-
27
-
-
33745174538
-
Heat shock protein-90 inhibitors: A chronicle from geldanamycin to today's agents
-
1:CAS:528:DC%2BD28XmsFyqtbk%3D 16784024
-
Chiosis G, Caldas Lopes E, Solit D (2006) Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents. Curr Opin Investig Drugs 7:534-541
-
(2006)
Curr Opin Investig Drugs
, vol.7
, pp. 534-541
-
-
Chiosis, G.1
Caldas Lopes, E.2
Solit, D.3
-
28
-
-
80052179384
-
Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation
-
1:CAS:528:DC%2BC3MXhtFeqtrzL 21663398 10.1667/RR2534.1
-
Fukumoto R, Kiang JG (2011) Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation. Radiat Res 176:333-345
-
(2011)
Radiat Res
, vol.176
, pp. 333-345
-
-
Fukumoto, R.1
Kiang, J.G.2
-
29
-
-
77950929054
-
Phase i study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia
-
1:CAS:528:DC%2BC3cXks1Kls7o%3D 20111068 10.1038/leu.2009.292
-
Lancet JE, Gojo I, Burton M, Quinn M, Tighe SM, Kersey K, Zhong Z, Albitar MX, Bhalla K, Hannah AL, Baer MR (2010) Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia. Leukemia 24:699-705
-
(2010)
Leukemia
, vol.24
, pp. 699-705
-
-
Lancet, J.E.1
Gojo, I.2
Burton, M.3
Quinn, M.4
Tighe, S.M.5
Kersey, K.6
Zhong, Z.7
Albitar, M.X.8
Bhalla, K.9
Hannah, A.L.10
Baer, M.R.11
-
30
-
-
84866375177
-
A phase i dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors
-
1:CAS:528:DC%2BC38Xhtl2lt7vJ 22781552 10.1158/1078-0432.CCR-11-3200
-
Jhaveri K, Miller K, Rosen L, Schneider B, Chap L, Hannah A, Zhong Z, Ma W, Hudis C, Modi S (2012) A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors. Clin Cancer Res 18:5090-5098
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5090-5098
-
-
Jhaveri, K.1
Miller, K.2
Rosen, L.3
Schneider, B.4
Chap, L.5
Hannah, A.6
Zhong, Z.7
Ma, W.8
Hudis, C.9
Modi, S.10
-
31
-
-
77957021127
-
Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis
-
1:CAS:528:DC%2BC3cXht1WmurzE 20667592 10.1016/j.leukres.2010.07.002
-
Palacios C, Martín-Pérez R, López-Pérez AI, Pandiella A, López-Rivas A (2010) Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin- induced apoptosis. Leuk Res 34:1533-1538
-
(2010)
Leuk Res
, vol.34
, pp. 1533-1538
-
-
Palacios, C.1
Martín-Pérez, R.2
López-Pérez, A.I.3
Pandiella, A.4
López-Rivas, A.5
-
32
-
-
79952847290
-
In vitro metabolism of 17-(dimethylaminoethylamino)-17- demethoxygeldanamycin in human liver microsomes
-
1:CAS:528:DC%2BC3MXkslSlsb8%3D 21177985 10.1124/dmd.110.036418
-
Zheng N, Zou P, Wang S, Sun D (2011) In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes. Drug Metab Dispos 39:627-635
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 627-635
-
-
Zheng, N.1
Zou, P.2
Wang, S.3
Sun, D.4
-
33
-
-
33746365169
-
Discovery and development of purine scaffold Hsp90 inhibitors
-
1:CAS:528:DC%2BD28Xpt1ejtLw%3D 16842155 10.2174/156802606777812013
-
Chiosis G (2006) Discovery and development of purine scaffold Hsp90 inhibitors. Curr Top Med Chem 6:1183-1191
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 1183-1191
-
-
Chiosis, G.1
-
34
-
-
0024421221
-
Hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures
-
1:CAS:528:DyaK3cXpt1yksw%3D%3D 362454 2674684
-
Borkovich KA, Farrelly FW, Finkelstein DB, Taulien J, Lindquist S (1989) Hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures. Mol Cell Biol 9:3919-3930
-
(1989)
Mol Cell Biol
, vol.9
, pp. 3919-3930
-
-
Borkovich, K.A.1
Farrelly, F.W.2
Finkelstein, D.B.3
Taulien, J.4
Lindquist, S.5
-
35
-
-
0026731880
-
Evidence for reversible, non-microtubule and non-microfilament-dependent nuclear translocation of hsp90 after heat shock in human fibroblasts
-
1:CAS:528:DyaK38XmsV2isb4%3D 1425772
-
Akner G, Mossberg K, Sundqvist KG, Gustafsson JA, Wikstrom AC (1992) Evidence for reversible, non-microtubule and non-microfilament-dependent nuclear translocation of hsp90 after heat shock in human fibroblasts. Eur J Cell Biol 58:356-364
-
(1992)
Eur J Cell Biol
, vol.58
, pp. 356-364
-
-
Akner, G.1
Mossberg, K.2
Sundqvist, K.G.3
Gustafsson, J.A.4
Wikstrom, A.C.5
-
36
-
-
0030601988
-
Localization of heat shock proteins in mouse male germ cells: An immunoelectron microscopical study
-
1:CAS:528:DyaK28XntlegtrY%3D 8940251 10.1006/excr.1996.0345
-
Biggiogera M, Tanguay RM, Marin R, Wu Y, Martin TE, Fakan S (1996) Localization of heat shock proteins in mouse male germ cells: an immunoelectron microscopical study. Exp Cell Res 229:77-85
-
(1996)
Exp Cell Res
, vol.229
, pp. 77-85
-
-
Biggiogera, M.1
Tanguay, R.M.2
Marin, R.3
Wu, Y.4
Martin, T.E.5
Fakan, S.6
-
37
-
-
0037258854
-
Intracellular localization of the 90 kDA heat shock protein (HSP90α) determined by expression of a EGFP-HSP90α-fusion protein in unstressed and heat stressed 3T3 cells
-
1:CAS:528:DC%2BD3sXitlWjsb8%3D 12713799 10.1016/S1065-6995(02)00256-1
-
Langer T, Rosmus S, Fasold H (2003) Intracellular localization of the 90 kDA heat shock protein (HSP90α) determined by expression of a EGFP-HSP90α-fusion protein in unstressed and heat stressed 3T3 cells. Cell Biol Int 27:47-52
-
(2003)
Cell Biol Int
, vol.27
, pp. 47-52
-
-
Langer, T.1
Rosmus, S.2
Fasold, H.3
-
38
-
-
0030925683
-
Steroid receptor interactions with heat shock protein and immunophilin chaperones
-
1:CAS:528:DyaK2sXktV2qsrs%3D 9183567 10.1210/er.18.3.306
-
Pratt WB, Toft DO (1997) Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 18:306-360
-
(1997)
Endocr Rev
, vol.18
, pp. 306-360
-
-
Pratt, W.B.1
Toft, D.O.2
-
39
-
-
0034353454
-
Inhibition of NF-κB activity enhances TRAIL mediated apoptosis in breast cancer cell lines
-
1:CAS:528:DC%2BD3MXlt1GmsQ%3D%3D 11194457 10.1023/A:1006458407515
-
Keane MM, Rubinstein Y, Cuello M, et al. (2000) Inhibition of NF-κB activity enhances TRAIL mediated apoptosis in breast cancer cell lines. Breast Cancer Res Treat 64:211-219
-
(2000)
Breast Cancer Res Treat
, vol.64
, pp. 211-219
-
-
Keane, M.M.1
Rubinstein, Y.2
Cuello, M.3
|