Air pollution-mediated susceptibility to inflammation and insulin resistance: Influence of CCR2 pathways in mice

Environmental Health Perspectives

Volumn 122, Issue 1, 2014, Pages 17-26

  Liu, Cuiqing ^a,b   Xu, Xiaohua ^b   Bai, Yuntao ^b   Wang, Tse Yao ^b   Rao, Xiaoquan ^c   Wang, Aixia ^b   Sun, Lixian ^b   Ying, Zhekang ^c   Gushchina, Liubov ^b   Maiseyeu, Andrei ^c   Morishita, Masako ^d   Sun, Qinghua ^b   Harkema, Jack R ^e   Rajagopalan, Sanjay ^c  

^a HANGZHOU NORMAL UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; GAMMA INTERFERON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY LIVER; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; MALE; MOUSE; MYOGRAPHY; NONHUMAN; PARTICULATE MATTER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AIR POLLUTION; ANIMALS; DIETARY FATS; INFLAMMATION; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, CCR2; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84891525636     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1306841     Document Type: Article

References (45)

1. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. 1974. Enzymatic determination of total serum cholesterol. Clin Chem 20(4):470-475.
2. Baeck C, Wehr A, Karlmark KR, Heymann F, Vucur M, Gassler N, et al. 2012. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 61(3):416-426.
3. Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, et al. 2009. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458(7241):1056-1060.
4. Chang L, Karin M. 2001. Mammalian MAP kinase signalling cascades. Nature 410(6824):37-40.
5. Charo IF, Ransohoff RM. 2006. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354(6):610-621.
6. Combadiére C, Potteaux S, Rodero M, Simon T, Pezard A, Esposito B, et al. 2008. Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6Chi and Ly6Clo monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice. Circulation 117(13):1649-1657.
7. Coulthard LR, White DE, Jones DL, McDermott MF, Burchill SA. 2009. p38MAPK: stress responses from molecular mechanisms to therapeutics. Trends Mol Med 15(8):369-379.
8. Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, et al. 2012. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metab 15(5):725-738.
9. Henderson RB, Hobbs JA, Mathies M, Hogg N. 2003. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 102(1):328-335.
10. Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444(7121):860-867.
11. Ito A, Suganami T, Yamauchi A, Degawa-Yamauchi M, Tanaka M, Kouyama R, et al. 2008. Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem 283(51):35715-35723.
12. Jitrapakdee S. 2012. Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis. Int J Biochem Cell Biol 44(1):33-45.
13. Kampfrath T, Maiseyeu A, Ying Z, Shah Z, Deiuliis JA, Xu X, et al. 2011. Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res 108(6):716-726.
14. Lee J, Sun C, Zhou Y, Gokalp D, Herrema H, Park SW, et al. 2011. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med 17(10):1251-1260.
15. Liu CQ, Leung FP, Wong SL, Wong WT, Lau CW, Lu L, et al. 2009. Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: the role of Rho kinase. Biochem Pharmacol 78(4):374-381.
16. Liu Z, Cao W. 2009. p38 Mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus. Endocr Metab Immune Disord Drug Targets 9(1):38-46.
17. Lumeng CN, Bodzin JL, Saltiel AR. 2007a. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117(1):175-184.
18. Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. 2008. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57(12):3239-3246.
19. Lumeng CN, Deyoung SM, Saltiel AR. 2007b. Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab 292(1):E166-E174.
20. Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. 2011. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology 54(6):2185-2197.
21. Martin GG, Atshaves BP, McIntosh AL, Mackie JT, Kier AB, Schroeder F. 2008. Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity. J Nutr 138(10):1859-1865.
22. McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM, et al. 2009. Interferon γ attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem 284(46):31936-31944.
23. McGowan MW, Artiss JD, Strandbergh DR, Zak B. 1983. A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem 29(3):538-542.
24. Morishita M, Keeler GJ, Kamal AS, Wagner JG, Harkema JR, Rohr AC. 2011. Identification of ambient PM2.5 sources and analysis of pollution episodes in Detroit, Michigan using highly time-resolved measurements. Atmos Environ 45(8):1627-1637.
25. Morrison DK, Davis RJ. 2003. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 19:91-118.
26. Obstfeld AE, Sugaru E, Thearle M, Francisco AM, Gayet C, Ginsberg HN, et al. 2010. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 59(4):916-925.
27. Oh DY, Morinaga H, Talukdar S, Bae EJ, Olefsky JM. 2012. Increased macrophage migration into adipose tissue in obese mice. Diabetes 61(2):346-354.
28. Osborn O, Olefsky JM. 2012. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 18(3):363-374.
29. Ouchi N, Parker JL, Lugus JJ, Walsh K. 2011. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11(2):85-97.
30. Proudfoot AE. 2002. Chemokine receptors: multifaceted therapeutic targets. Nat Rev Immunol 2(2):106-115.
31. Rajagopalan S, Brook RD. 2012. Air pollution and type 2 diabetes: mechanistic insights. Diabetes 61(12):3037-3045.
32. Salminen A, Hyttinen JM, Kaarniranta K. 2011. AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) 89(7):667-676.
33. Seo JB, Noh MJ, Yoo EJ, Park SY, Park J, Lee IK, et al. 2003. Functional characterization of the human resistin promoter with adipocyte determination-and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-α. Mol Endocrinol 17(8):1522-1533.
34. Shoelson SE, Lee J, Goldfine AB. 2006. Inflammation and insulin resistance. J Clin Invest 116(7):1793-1801.
35. Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, et al. 2009. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119(4):538-546.
36. Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, et al. 2007. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest 117(4):902-909.
37. Uyeda K, Repa JJ. 2006. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 4(2):107-110.
38. Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, et al. 2006. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116(1):115-124.
39. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. 2003. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112(12):1796-1808.
40. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112(12):1821-1830.
41. Xu X, Liu C, Xu Z, Tzan K, Zhong M, Wang A, et al. 2011. Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicol Sci 124(1):88-98.
42. Xu X, Yavar Z, Verdin M, Ying Z, Mihai G, Kampfrath T, et al. 2010. Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. Arterioscler Thromb Vasc Biol 30(12):2518-2527.
43. Yu LF, Qiu BY, Nan FJ, Li J. 2010. AMPK activators as novel therapeutics for type 2 diabetes. Curr Top Med Chem 10(4):397-410.
44. Zheng Z, Xu X, Zhang X, Wang A, Zhang C, Huttemann M, et al. 2012. Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. J Hepatol 58(1):148-154.
45. Zhong J, Rao X, Deiuliis J, Braunstein Z, Narula V, Hazey J, et al. 2013. A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation. Diabetes 62(1):149-157.