Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model

Journal of Hepatology

Volumn 58, Issue 1, 2013, Pages 148-154

  Zheng, Ze ^a   Xu, Xiaohua ^c   Zhang, Xuebao ^a   Wang, Aixia ^b,c   Zhang, Chunbin ^a   Hüttemann, Maik ^a   Grossman, Lawrence I ^a   Chen, Lung Chi ^d   Rajagopalan, Sanjay ^b   Sun, Qinghua ^b,c   Zhang, Kezhong ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d NEW YORK UNIVERSITY   (United States)

Author keywords

Air pollution; Glucose metabolism; Liver disease; NASH

Indexed keywords

GLUCOSE; GLYCOGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4;

AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FATTY LIVER; GENE EXPRESSION; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HISTOPATHOLOGY; HOMEOSTASIS; INFLAMMATION; INSULIN RESISTANCE; LIVER FIBROSIS; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PARTICULATE MATTER; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; FATTY LIVER; GLUCOSE; GLUCOSE INTOLERANCE; GLYCOGEN; HEPATITIS; HOMEOSTASIS; INHALATION EXPOSURE; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; LIVER CIRRHOSIS; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PARTICULATE MATTER; PHENOTYPE; PPAR ALPHA; PPAR GAMMA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84871231019     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.08.009     Document Type: Article

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