메뉴 건너뛰기




Volumn 4, Issue 11-12, 2013, Pages 501-512

BaxΔ2 Family Alternative Splicing Salvages Bax Microsatellite-Frameshift Mutations

Author keywords

alternative splicing; Bax; microsatellite instability; microsatellite mutation; tumor suppressor

Indexed keywords

PROTEIN BAX; RNA;

EID: 84891517135     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601913515906     Document Type: Article
Times cited : (11)

References (37)
  • 1
    • 0037445248 scopus 로고    scopus 로고
    • Role of DNA mismatch repair defects in the pathogenesis of human cancer
    • Peltomaki P.Role of DNA mismatch repair defects in the pathogenesis of human cancer.J Clin Oncol. 2003;21 (6): 1174-9.
    • (2003) J Clin Oncol , vol.21 , Issue.6 , pp. 1174-1179
    • Peltomaki, P.1
  • 2
    • 0030250603 scopus 로고    scopus 로고
    • Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3
    • Habraken Y,Sung P,Prakash L,Prakash S.Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3.Curr Biol. 1996;6 (9): 1185-7.
    • (1996) Curr Biol , vol.6 , Issue.9 , pp. 1185-1187
    • Habraken, Y.1    Sung, P.2    Prakash, L.3    Prakash, S.4
  • 3
    • 0035081417 scopus 로고    scopus 로고
    • Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells
    • Elliott B,Jasin M.Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells.Mol Cell Biol. 2001;21 (8): 2671-82.
    • (2001) Mol Cell Biol , vol.21 , Issue.8 , pp. 2671-2682
    • Elliott, B.1    Jasin, M.2
  • 4
    • 0031048652 scopus 로고    scopus 로고
    • Genetic control of microsatellite stability
    • Sia EA,Jinks-Robertson S,Petes TD.Genetic control of microsatellite stability.Mutat Res. 1997;383 (1): 61-70.
    • (1997) Mutat Res , vol.383 , Issue.1 , pp. 61-70
    • Sia, E.A.1    Jinks-Robertson, S.2    Petes, T.D.3
  • 5
    • 0033914750 scopus 로고    scopus 로고
    • DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer
    • Iino H,Simms L,Young J, et al.DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer.Gut. 2000;47 (1): 37-42.
    • (2000) Gut , vol.47 , Issue.1 , pp. 37-42
    • Iino, H.1    Simms, L.2    Young, J.3
  • 6
    • 0033630042 scopus 로고    scopus 로고
    • The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences
    • Johannsdottir JT,Jonasson JG,Bergthorsson JT, et al.The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences.Int J Oncol. 2000;16 (1): 133-9.
    • (2000) Int J Oncol , vol.16 , Issue.1 , pp. 133-139
    • Johannsdottir, J.T.1    Jonasson, J.G.2    Bergthorsson, J.T.3
  • 7
    • 26444532936 scopus 로고    scopus 로고
    • Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers
    • El-Bchiri J,Buhard O,Penard-Lacronique V,Thomas G,Hamelin R,Duval A.Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers.Hum Mol Genet. 2005;14 (16): 2435-42.
    • (2005) Hum Mol Genet , vol.14 , Issue.16 , pp. 2435-2442
    • El-Bchiri, J.1    Buhard, O.2    Penard-Lacronique, V.3    Thomas, G.4    Hamelin, R.5    Duval, A.6
  • 8
    • 0037099597 scopus 로고    scopus 로고
    • Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability
    • Vassileva V,Millar A,Briollais L,Chapman W,Bapat B.Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability.Cancer Res. 2002;62 (14): 4095-9.
    • (2002) Cancer Res , vol.62 , Issue.14 , pp. 4095-4099
    • Vassileva, V.1    Millar, A.2    Briollais, L.3    Chapman, W.4    Bapat, B.5
  • 9
    • 0036087401 scopus 로고    scopus 로고
    • Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability
    • Kuismanen SA,Moisio AL,Schweizer P, et al.Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.Am J Pathol. 2002;160 (6): 1953-8.
    • (2002) Am J Pathol , vol.160 , Issue.6 , pp. 1953-1958
    • Kuismanen, S.A.1    Moisio, A.L.2    Schweizer, P.3
  • 10
    • 33644972891 scopus 로고    scopus 로고
    • Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer
    • Yamaguchi T,Iijima T,Mori T, et al.Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer.Dis Colon Rectum. 2006;49 (3): 399-406.
    • (2006) Dis Colon Rectum , vol.49 , Issue.3 , pp. 399-406
    • Yamaguchi, T.1    Iijima, T.2    Mori, T.3
  • 11
    • 35148887112 scopus 로고    scopus 로고
    • Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability
    • Miquel C,Jacob S,Grandjouan S, et al.Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.Oncogene. 2007;26 (40): 5919-26.
    • (2007) Oncogene , vol.26 , Issue.40 , pp. 5919-5926
    • Miquel, C.1    Jacob, S.2    Grandjouan, S.3
  • 12
    • 33646009986 scopus 로고    scopus 로고
    • Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability
    • Ham MF,Takakuwa T,Luo WJ,Liu A,Horii A,Aozasa K.Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability.Cancer Sci. 2006;97 (3): 226-34.
    • (2006) Cancer Sci , vol.97 , Issue.3 , pp. 226-234
    • Ham, M.F.1    Takakuwa, T.2    Luo, W.J.3    Liu, A.4    Horii, A.5    Aozasa, K.6
  • 13
    • 0344417114 scopus 로고    scopus 로고
    • Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype
    • Schwartz S,Yamamoto H,Navarro M,Maestro M,Reventos J,Perucho M.Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.Cancer Res. 1999;59 (12): 2995-3002.
    • (1999) Cancer Res , vol.59 , Issue.12 , pp. 2995-3002
    • Schwartz, S.1    Yamamoto, H.2    Navarro, M.3    Maestro, M.4    Reventos, J.5    Perucho, M.6
  • 14
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N,Yamamoto H,Ionov Y, et al.Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.Science. 1997;275 (5302): 967-9.
    • (1997) Science , vol.275 , Issue.5302 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3
  • 15
    • 0141731323 scopus 로고    scopus 로고
    • Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer
    • Fallik D,Borrini F,Boige V, et al.Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer.Cancer Res. 2003;63 (18): 5738-44.
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 5738-5744
    • Fallik, D.1    Borrini, F.2    Boige, V.3
  • 16
    • 54949143174 scopus 로고    scopus 로고
    • Low expression of Bax predicts poor prognosis in resected non-small cell lung cancer patients with non-squamous histology
    • Jeong SH,Lee HW,Han JH, et al.Low expression of Bax predicts poor prognosis in resected non-small cell lung cancer patients with non-squamous histology.Jpn J Clin Oncol. 2008;38 (10): 661-9.
    • (2008) Jpn J Clin Oncol , vol.38 , Issue.10 , pp. 661-669
    • Jeong, S.H.1    Lee, H.W.2    Han, J.H.3
  • 17
    • 0038075337 scopus 로고    scopus 로고
    • Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability
    • Mrozek A,Petrowsky H,Sturm I, et al.Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability.Cell Death Differ. 2003;10 (4): 461-7.
    • (2003) Cell Death Differ , vol.10 , Issue.4 , pp. 461-467
    • Mrozek, A.1    Petrowsky, H.2    Sturm, I.3
  • 18
    • 67349213603 scopus 로고    scopus 로고
    • Prognostic implications of BAX protein expression and microsatellite instability in all non-metastatic stages of primary colon cancer treated by surgery alone
    • Nehls O,Hass HG,Okech T, et al.Prognostic implications of BAX protein expression and microsatellite instability in all non-metastatic stages of primary colon cancer treated by surgery alone.Int J Colorectal Dis. 2009;24 (6): 655-63.
    • (2009) Int J Colorectal Dis , vol.24 , Issue.6 , pp. 655-663
    • Nehls, O.1    Hass, H.G.2    Okech, T.3
  • 19
    • 34247577671 scopus 로고    scopus 로고
    • Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX
    • Nehls O,Okech T,Hsieh CJ, et al.Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX.Br J Cancer. 2007;96 (9): 1409-18.
    • (2007) Br J Cancer , vol.96 , Issue.9 , pp. 1409-1418
    • Nehls, O.1    Okech, T.2    Hsieh, C.J.3
  • 20
    • 40949083386 scopus 로고    scopus 로고
    • Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression
    • Olejniczak SH,Hernandez-Ilizaliturri FJ,Clements JL,Czuczman MS.Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression.Clin Cancer Res. 2008;14 (5): 1550-60.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1550-1560
    • Olejniczak, S.H.1    Hernandez-Ilizaliturri, F.J.2    Clements, J.L.3    Czuczman, M.S.4
  • 21
    • 33646391241 scopus 로고    scopus 로고
    • Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers
    • Jung B,Smith EJ,Doctolero RT, et al.Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers.Int J Cancer. 2006;118 (10): 2509-13.
    • (2006) Int J Cancer , vol.118 , Issue.10 , pp. 2509-2513
    • Jung, B.1    Smith, E.J.2    Doctolero, R.T.3
  • 22
    • 33745899048 scopus 로고    scopus 로고
    • Alternative splicing: new insights from global analyses
    • Blencowe BJ.Alternative splicing: new insights from global analyses.Cell. 2006;126 (1): 37-47.
    • (2006) Cell , vol.126 , Issue.1 , pp. 37-47
    • Blencowe, B.J.1
  • 23
    • 66049085709 scopus 로고    scopus 로고
    • Alternative splicing and tumor progression
    • Ghigna C,Valacca C,Biamonti G.Alternative splicing and tumor progression.Curr Genomics. 2008;9 (8): 556-70.
    • (2008) Curr Genomics , vol.9 , Issue.8 , pp. 556-570
    • Ghigna, C.1    Valacca, C.2    Biamonti, G.3
  • 24
    • 84867369525 scopus 로고    scopus 로고
    • Alternative splicing in oncogenic kinases: from physiological functions to cancer
    • Druillennec S,Dorard C,Eychene A.Alternative splicing in oncogenic kinases: from physiological functions to cancer.J Nucleic Acids. 2011;2012:639062.
    • (2011) J Nucleic Acids , vol.2012 , pp. 639062
    • Druillennec, S.1    Dorard, C.2    Eychene, A.3
  • 25
    • 64249084287 scopus 로고    scopus 로고
    • Aberrant RNA splicing and its functional consequences in cancer cells
    • Fackenthal JD,Godley LA.Aberrant RNA splicing and its functional consequences in cancer cells.Dis Model Mech. 2008;1 (1): 37-42.
    • (2008) Dis Model Mech , vol.1 , Issue.1 , pp. 37-42
    • Fackenthal, J.D.1    Godley, L.A.2
  • 26
    • 37349089805 scopus 로고    scopus 로고
    • Insights into the connection between cancer and alternative splicing
    • Kim E,Goren A,Ast G.Insights into the connection between cancer and alternative splicing.Trends Genet. 2008;24 (1): 7-10.
    • (2008) Trends Genet , vol.24 , Issue.1 , pp. 7-10
    • Kim, E.1    Goren, A.2    Ast, G.3
  • 27
    • 48149095822 scopus 로고    scopus 로고
    • Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?
    • McGlincy NJ,Smith CW.Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?.Trends Biochem Sci. 2008;33 (8): 385-93.
    • (2008) Trends Biochem Sci , vol.33 , Issue.8 , pp. 385-393
    • McGlincy, N.J.1    Smith, C.W.2
  • 28
    • 58249090764 scopus 로고    scopus 로고
    • Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1
    • Carvalho M,Pino MA,Karchin R, et al.Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1.Mutat Res. 2009;660 (1-2): 1-11.
    • (2009) Mutat Res , vol.660 , Issue.1-2 , pp. 1-11
    • Carvalho, M.1    Pino, M.A.2    Karchin, R.3
  • 29
    • 0036207384 scopus 로고    scopus 로고
    • Listening to silence and understanding nonsense: exonic mutations that affect splicing
    • Cartegni L,Chew SL,Krainer AR.Listening to silence and understanding nonsense: exonic mutations that affect splicing.Nat Rev Genet. 2002;3 (4): 285-98.
    • (2002) Nat Rev Genet , vol.3 , Issue.4 , pp. 285-298
    • Cartegni, L.1    Chew, S.L.2    Krainer, A.R.3
  • 30
    • 77949811343 scopus 로고    scopus 로고
    • Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis
    • Gardner LB.Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.Mol Cancer Res. 2010;8 (3): 295-308.
    • (2010) Mol Cancer Res , vol.8 , Issue.3 , pp. 295-308
    • Gardner, L.B.1
  • 31
    • 84867264063 scopus 로고    scopus 로고
    • BaxDelta2 is a novel bax isoform unique to microsatellite unstable tumors
    • Haferkamp B,Zhang H,Lin Y, et al.BaxDelta2 is a novel bax isoform unique to microsatellite unstable tumors.J Biol Chem. 2012;287 (41): 34722-9.
    • (2012) J Biol Chem , vol.287 , Issue.41 , pp. 34722-34729
    • Haferkamp, B.1    Zhang, H.2    Lin, Y.3
  • 32
    • 0032496238 scopus 로고    scopus 로고
    • A novel splice variant of the cell death-promoting protein BAX
    • Zhou M,Demo SD,McClure TN,Crea R,Bitler CM.A novel splice variant of the cell death-promoting protein BAX.J Biol Chem. 1998;273 (19): 11930-6.
    • (1998) J Biol Chem , vol.273 , Issue.19 , pp. 11930-11936
    • Zhou, M.1    Demo, S.D.2    McClure, T.N.3    Crea, R.4    Bitler, C.M.5
  • 33
    • 32544456772 scopus 로고    scopus 로고
    • Characterization and prediction of alternative splice sites
    • Wang M,Marin A.Characterization and prediction of alternative splice sites.Gene. 2006;366 (2): 219-27.
    • (2006) Gene , vol.366 , Issue.2 , pp. 219-227
    • Wang, M.1    Marin, A.2
  • 34
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN,Milliman CL,Korsmeyer SJ.Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.Cell. 1993;74 (4): 609-19.
    • (1993) Cell , vol.74 , Issue.4 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 35
    • 47249105254 scopus 로고    scopus 로고
    • Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms
    • Valentijn AJ,Upton JP,Bates N,Gilmore AP.Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms.Cell Death Differ. 2008;15 (8): 1243-54.
    • (2008) Cell Death Differ , vol.15 , Issue.8 , pp. 1243-1254
    • Valentijn, A.J.1    Upton, J.P.2    Bates, N.3    Gilmore, A.P.4
  • 36
    • 58149299435 scopus 로고    scopus 로고
    • Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism
    • Fu NY,Sukumaran SK,Kerk SY,Yu VC.Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism.Mol Cell. 2009;33 (1): 15-29.
    • (2009) Mol Cell , vol.33 , Issue.1 , pp. 15-29
    • Fu, N.Y.1    Sukumaran, S.K.2    Kerk, S.Y.3    Yu, V.C.4
  • 37
    • 0037087706 scopus 로고    scopus 로고
    • The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients
    • Cartron PF,Oliver L,Martin S, et al.The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients.Hum Mol Genet. 2002;11 (6): 675-87.
    • (2002) Hum Mol Genet , vol.11 , Issue.6 , pp. 675-687
    • Cartron, P.F.1    Oliver, L.2    Martin, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.