Design, synthesis and evaluation of novel indole derivatives as AKT inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 366-373

  Yang, Dezhi ^a   Wang, Peng ^a   Liu, Jianzhen ^a   Xing, Hualu ^a   Liu, Yang ^a   Xie, Wencheng ^a   Zhao, Guisen ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

AKT inhibitors; GSK3 ; Inhibition rate; Tetra substituted indoles

Indexed keywords

1 (1H INDOL 3 YL) 3 [[7 METHOXY 1 METHYL 2 (3 METHYL 1,2,4 OXADIAZOL 5 YL) 1H INDOL 4 YL]OXY]PROPAN 2 AMINE; 1 [[7 METHOXY 1 METHYL 2 (3 METHYL 1,2,4 OXADIAZOL 5 YL) 1H INDOL 4 YL]OXY] 3 PHENYLPROPAN 2 AMINE; 1 [[7 METHOXY 1 METHYL 2 (3 METHYL 1,2,4 OXADIAZOL 5 YL) 1H INDOL 4 YL]OXY] 4 (METHYLTHIO)BUTAN 2 AMINE; 1 [[7 METHOXY 1 METHYL 2 (3 METHYL 1,2,4 OXAOXADIAZOL 5 YL) 1H INDOL 4 YL]OXY] 3 PHENYLPROPAN 2 AMINE; 1,2,4,7 TETRA SUBSTITUTED INDOLE DERIVATIVE; METHYL 4 (2 AMINO 3 PHENYLPROPOXY) 7 BROMO 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 4 (2 AMINO 3 PHENYLPROPOXY) 7 CHLORO 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 4 (2 AMINO 3 PHENYLPROPOXY) 7 METHOXY 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 4 [(2 AMINO 4 METHYLPENTYL)OXY] 7 METHOXY 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 4 [2 AMINO 3 (1H INDOL 3 YL)PROPOXY] 7 BROMO 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 4 [2 AMINO 3 (1H INDOL 3 YL)PROPOXY] 7 CHLORO 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 4 [2 AMINO 4 (METHYLTHIO)BUTOXY] 7 METHOXY 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 4 HYDROXY 7 METHOXY 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 4[(2 AMINO 3 METHYLPENTYL)OXY] 7 METHOXY 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 7 BROMO 4 HYDROXY 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; METHYL 7 CHLORO 4 HYDROXY 1 METHYL 1H INDOLE 2 CARBOXYLIC ACID; PROTEIN KINASE B INHIBITOR; TERT BUTYL (1 HYDROXY 3 METHYLPENTAN 2 YL)CARBAMIC ACID; TERT BUTYL (1 HYDROXY 3 PHENYLPROPAN 2 YL)CARBAMIC ACID; TERT BUTYL (1 HYDROXY 4 METHYLPENTAN 2 YL)CARBAMIC ACID; TERT BUTYL [1 HYDROXY 3 (1H INDOL 3 YL)PROPAN 2 YL]CARBAMIC ACID; TERT BUTYL [1 HYDROXY 4 (METHYLTHIO)BUTAN 2 YL]CARBAMIC ACID; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL LINE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; PC 3 CELL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

TETRA;

AKT INHIBITORS; GSK3Β; INHIBITION RATE; TETRA-SUBSTITUTED INDOLES;

GLYCOGEN SYNTHASE KINASE 3; HUMANS; INDOLES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891491552     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.022     Document Type: Article

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