The synthesis of novel taxoids for oral administration

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 194-203

  Jing, Yun Rong ^a   Zhou, Wei ^b   Li, Wan Liang ^b   Zhao, Lin Xiang ^a   Wang, Yong Feng ^b,c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Tianjin Tasly Group Co Ltd   (China)

^c Zhuhai Oxforston PharmTech Co Ltd   (China)

Author keywords

1,14 Carbonate baccatin III; Bi directional Caco 2 cells permeability; MDCK MDR1 monolayers; Oral bioavailability; P gp substrate; Paclitaxel

Indexed keywords

DIGOXIN; ERYTHROMYCIN; MULTIDRUG RESISTANCE PROTEIN 1; ORTATAXEL; PACLITAXEL; TAXOID; VERAPAMIL;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; MDCK CELL; NONHUMAN; TRANSCYTOSIS;

1,14-CARBONATE BACCATIN III; BI-DIRECTIONAL CACO-2 CELLS PERMEABILITY; MDCK-MDR1 MONOLAYERS; ORAL BIOAVAILABILITY; P-GP SUBSTRATE; PACLITAXEL;

ADMINISTRATION, ORAL; ANIMALS; DOGS; HUMANS; PACLITAXEL; TAXOIDS;

EID: 84891491534     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.037     Document Type: Article

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