Effects of aescin on cytochrome P450 enzymes in rats

Journal of Ethnopharmacology

Volumn 151, Issue 1, 2014, Pages 583-590

  Huang, Yi ^a   Zheng, Shuang Li ^b   Zhu, Hai Yan ^c   Xu, Zhi Sheng ^b   Xu, Ren Ai ^c  

^a WENZHOU PEOPLE'S HOSPITAL   (China)

^b THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Aescin; Cocktail; CYP; Herb drug interaction; mRNA

Indexed keywords

CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; ESCIN; MESSENGER RNA; MIDAZOLAM; PHENACETIN; TOLBUTAMIDE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HERB DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MULTIPLE DRUG DOSE; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

AESCULUS; AESCULUS HIPPOCASTANUM; RATTUS;

AESCIN; COCKTAIL; CYP; HERB-DRUG INTERACTION; MRNA;

ANIMALS; AREA UNDER CURVE; CHLORZOXAZONE; CYTOCHROME P-450 ENZYME SYSTEM; ESCIN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HALF-LIFE; HERB-DRUG INTERACTIONS; HYPNOTICS AND SEDATIVES; HYPOGLYCEMIC AGENTS; LIVER; MALE; MIDAZOLAM; MUSCLE RELAXANTS, CENTRAL; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TOLBUTAMIDE;

EID: 84891491520     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.11.016     Document Type: Article

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