Synthesis and biological evaluation of the pirfenidone derivatives as antifibrotic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 1, 2014, Pages 220-223

  Ma, Zhen ^a   Pan, Youlu ^a   Huang, Wenhai ^a   Yang, Yewei ^a   Wang, Zunyuan ^a   Li, Qin ^a   Zhao, Yin ^a   Zhang, Xinyue ^a   Shen, Zhengrong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antifibrotic; Derivatives; IPF; p38; Pirfenidone

Indexed keywords

ANTIFIBROTIC AGENT; CARBONYL DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHENYL GROUP; PIRFENIDONE; PIRFENIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; LUNG FIBROBLAST; MOLECULAR DOCKING; AMINATION; ANTIPROLIFERATIVE ACTIVITY; DRUG PROTEIN BINDING; IN VITRO STUDY; SIGNAL TRANSDUCTION;

ANTIFIBROTIC; DERIVATIVES; IPF; P38; PIRFENIDONE;

CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROSIS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRIDONES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891490618     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.11.038     Document Type: Article

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