Association of liver X receptors (LXRs) genetic variants to gallbladder cancer susceptibility

Tumor Biology

Volumn 34, Issue 6, 2013, Pages 3959-3966

  Sharma, Kiran Lata ^a   Misra, Sanjeev ^b   Kumar, Ashok ^a   Mittal, Balraj ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^b KING GEORGE'S MEDICAL UNIVERSITY   (India)

Author keywords

Case control association study; Gallbladder cancer; Gallstone; Genetic susceptibility; Liver X receptors; SNPs

Indexed keywords

LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA;

ADULT; AGED; ARTICLE; CANCER INCIDENCE; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CLINICAL EVALUATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GALLBLADDER CARCINOMA; GALLSTONE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HIGH RISK POPULATION; HUMAN; INDIA; LXR ALPHA GENE; LXR BETA GENE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE; TOBACCO CONSUMPTION;

EID: 84891490235     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0984-8     Document Type: Article

References (39)

1. Misra S, Chaturvedi A, Misra NC, Sharma ID. Carcinoma of the gallbladder. Lancet Oncol. 2003;4:167-76.
2. Roa I, Araya JC, Villaseca M, De Aretxabala X, Riedemann P, Endoh K, et al. Preneoplastic lesions and gallbladder cancer: an estimate of the period required for progression. Gastroenterology. 1996;111:232-6.
3. Wistuba II, Gazdar AF. Gallbladder cancer: lessons from a rare tumour. Nat Rev Cancer. 2004;4:695-706.
4. Kozuka S, Tsubone N, Yasui A, Hachisuka K. Relation of adenoma to carcinoma in the gallbladder. Cancer. 1982;50:2226-34.
5. Lazcano-Ponce EC, Miquel JF, Munoz N, Herrero R, Ferrecio C, Wistuba II, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 2001;51:349-64.
6. Henson DE, Albores-Saavedra J, Corle D. Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates. Cancer. 1992;70:1493-7.
7. Lowenfels AB, Walker AM, Althaus DP, Townsend G, Domellof L. Gallstone growth, size, and risk of gallbladder cancer: an interracial study. Int J Epidemiol. 1989;18:50-4.
8. Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006;116:607-14.
9. Xing Y, Fan X, Ying D. Liver X receptor agonist treatment promotes the migration of granule neurons during cerebellar development. J Neurochem. 2010;115:1486-94.
10. Steffensen KR, Gustafsson JA. Putative metabolic effects of the liver X receptor (LXR). Diabetes. 2004;53 Suppl 1:S36-42.
11. Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, et al. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem. 2002;277:11019-25.
12. Mak PA, Kast-Woelbern HR, Anisfeld AM, Edwards PA. Identification of PLTP as an LXR target gene and apoe as an FXR target gene reveals overlapping targets for the two nuclear receptors. J Lipid Res. 2002;43:2037-41.
13. Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282:743-51.
14. Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, et al. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol. 2001;21:2991-3000.
15. Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab. 2007;5:73-9.
16. -/- female mice. Proc Natl Acad Sci U S A. 2010;107:14763-8.
17. Dahlman I, Nilsson M, Gu HF, Lecoeur C, Efendic S, Ostenson CG, et al. Functional and genetic analysis in type 2 diabetes of liver X receptor alleles - a cohort study. BMC Med Genet. 2009;10:27.
18. Dahlman I, Nilsson M, Jiao H, Hoffstedt J, Lindgren CM, Humphreys K, et al. Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity. Pharmacogenet Genomics. 2006;16:881-9.
19. Solaas K, Legry V, Retterstol K, Berg PR, Holven KB, Ferrieres J, et al. Suggestive evidence of associations between liver X receptor beta polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: Hunt2 (Norway), monica (France) and helena (Europe). BMC Med Genet. 2010;11:144.
20. Lee PH, Shatkay H. F-SNP: computationally predicted functional SNPS for disease association studies. Nucleic Acids Res. 2008;36:D820-4.
21. Yuan HY, Chiou JJ, Tseng WH, Liu CH, Liu CK, Lin YJ, et al. FastSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res. 2006;34:W635-41.
22. Sharma KL, Misra S, Kumar A, Mittal B. Higher risk of matrix metalloproteinase (mmp-2, 7, 9) and tissue inhibitor of metalloproteinase (timp-2) genetic variants to gallbladder cancer. Liver Int. 2012;32:1278-86.
23. Corradini SG, Elisei W, Giovannelli L, Ripani C, Della Guardia P, Corsi A, et al. Impaired human gallbladder lipid absorption in cholesterol gallstone disease and its effect on cholesterol solubility in bile. Gastroenterology. 2000;118:912-20.
24. Buch S, Schafmayer C, Volzke H, Becker C, Franke A, von Eller-Eberstein H, et al. A genome-wide association scan identifies the hepatic cholesterol transporter abcg8 as a susceptibility factor for human gallstone disease. Nat Genet. 2007;39:995-9.
25. Yu L, York J, von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH. Stimulation of cholesterol excretion by the liver x receptor agonist requires atp-binding cassette transporters g5 and g8. J Biol Chem. 2003;278:15565-70.
26. Plosch T, Bloks VW, Terasawa Y, Berdy S, Siegler K, Van Der Sluijs F, et al. Sitosterolemia in abc-transporter g5-deficient mice is aggravated on activation of the liver X receptor. Gastroenterology. 2004;126:290-300.
27. Mouzat K, Mercier E, Polge A, Evrard A, Baron S, Balducchi JP, et al. A common polymorphism in nr1h2 (LXR-β) is associated with preeclampsia. BMC Med Genet. 2011;12:145.
28. Myers SA, Wang SC, Muscat GE. The chicken ovalbumin upstream promoter-transcription factors modulate genes and pathways involved in skeletal muscle cell metabolism. J Biol Chem. 2006;281:24149-60.
29. Infante J, Rodriguez-Rodriguez E, Mateo I, Llorca J, Vazquez-Higuera JL, Berciano J, et al. Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk. Neurobiol Aging. 2010;31:710-4.
30. Lund EG, Menke JG, Sparrow CP. Liver X receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol. 2003;23:1169-77.
31. Kalaany NY, Mangelsdorf DJ. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu Rev Physiol. 2006;68:159-91.
32. Moschetta A, Bookout AL, Mangelsdorf DJ. Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med. 2004;10:1352-8.
33. Uppal H, Zhai Y, Gangopadhyay A, Khadem S, Ren S, Moser JA, et al. Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization. Hepatology. 2008;47:1331-42.
34. von Kampen O, Buch S, Nothnagel M, Azocar L, Molina H, Brosch M, et al. Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus. Hepatology. 2013;57(6):2407-17.
35. Srivastava A, Srivastava K, Choudhuri G, Mittal B. Role of ABCG8 D19H (rs11887534) variant in gallstone susceptibility in northern India. J Gastroenterol Hepatol. 2010;25:1758-62.
36. Srivastava A, Tulsyan S, Pandey SN, Choudhuri G, Mittal B. Single nucleotide polymorphism in the ABCG8 transporter gene is associated with gallbladder cancer susceptibility. Liver Int. 2009;29:831-7.
37. Schafmayer C, Tepel J, Franke A, Buch S, Lieb S, Seeger M, et al. Investigation of the lith1 candidate genes abcb11 and LXRA in human gallstone disease. Hepatology. 2006;44:650-7.
38. Andersen V, Christensen J, Ernst A, Jacobsen BA, Tjonneland A, Krarup HB, et al. Polymorphisms in nf-kappab, PXR, LXR, PPARgamma and risk of inflammatory bowel disease. World J Gastroenterol. 2011;17:197-206.
39. Andersen V, Christensen J, Overvad K, Tjonneland A, Vogel U. Polymorphisms in nfkb, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. BMC Cancer. 2010;10:484. Technology