Expression loss and Revivification of RhoB gene in ovary carcinoma carcinogenesis and development

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Liu, Yingwei ^a   Song, Na ^b   Ren, Kexing ^b   Meng, Shenglan ^b   Xie, Yao ^a   Long, Qida ^a   Chen, Xiancheng ^b   Zhao, Xia ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; CANCER CELL; CANCER STAGING; CARCINOGENESIS; CYTOPLASM; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE LOSS; GENE SILENCING; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; ONCOGENE; OVARY CARCINOMA; RHOB GENE;

ANTINEOPLASTIC AGENTS; AZACITIDINE; CARCINOGENESIS; CASE-CONTROL STUDIES; CYSTADENOMA, SEROUS; DNA METHYLATION; DNA, NEOPLASM; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; METHYLTRANSFERASES; NEOPLASM STAGING; OVARIAN NEOPLASMS; OVARY; RHOB GTP-BINDING PROTEIN;

EID: 84891469329     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078417     Document Type: Article

References (43)

1. Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer 94: 153-156. doi:10.1002/ijc.1440. PubMed: 11668491.
2. Kaku T, Ogawa S, Kawano Y, Ohishi Y, Kobayashi H et al. (2003) Histological classification of ovarian cancer. Med Electron. Microsc 36: 9-17.
3. Sahai E, Marshall CJ (2002) Rho-GTPases and cancer. Nat Rev Cancer. 21: 133-142.
4. Ridley AJ (2004) Rho proteins and cancer. Breast Cancer Res Treat 84: 13-19. doi:10.1023/B:BREA.0000018423.47497.c6. PubMed: 14999150.
5. Pruitt K, Der CJ (2001) Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett 171: 1-10. doi:10.1016/S0304-3835(01)00528-6. PubMed: 11485822.
6. Kaibuchi K, Kuroda S, Fukata M, Nakagawa M (1999) Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases. Curr Opin Cell Biol 11: 591-596. doi:10.1016/S0955-0674(99)00014-9. PubMed: 10508646.
7. Prendergast GC (2001) Actin' up: RhoB in cancer and apoptosis. Nat Rev Cancer. 1: 162-168. doi:10.1038/35101096. PubMed: 11905808.
8. Mazières J, Tillement V, Allal C, Clanet C, Bobin L et al. (2005) Geranylgeranylated, but not farnesylated, RhoB suppresses Ras transformation of NIH-3T3 cells. Exp Cell Res 304: 354-364. doi: 10.1016/j.yexcr.2004.10.019. PubMed: 15748883.
9. Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M et al. (2001) Differential localization of Rho GTPases in live cells. Regulation by hypervariable regions and rhogdi binding. J Cell Biol 152: 111-126. doi: 10.1083/jcb.152.1.111. PubMed: 11149925.
10. Fritz G, Kaina B, Aktories K (1995) The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments. J Biol Chem 270: 25172-25177. doi:10.1074/jbc.270.42.25172. PubMed: 7559652.
11. Gampel A, Parker PJ, Mellor H (1999) Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB. Curr Biol 9: 955-958. doi:10.1016/S0960-9822(99)80422-9. PubMed: 10508588.
12. Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ (1998) Increasing complexity of Ras signaling. Oncogene. 17: 1395-1413. doi: 10.1038/sj.onc.1202174. PubMed: 9779987.
13. Zohn IM, Campbell SL, Khosravi-Far R, Rossman KL, Der CJ (1998) Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene. 17: 1415-1438. doi:10.1038/sj.onc.1202181. PubMed: 9779988.
14. Liu AX, Rane N, Liu JP, Prendergast GC (2001) RhoB Is Dispensable for Mouse Development, but It Modifies Susceptibility to Tumor Formation as Well as Cell Adhesion and Growth Factor Signaling in Transformed Cells. Mol Cell Biol 21: 6906-6912. doi:10.1128/MCB. 21.20.6906-6912.2001. PubMed: 11564874.
15. Chen Z, Sun J, Pradines A, Favre G, Adnane J, Sebti SM (2000) Both Farnesylated and Geranylgeranylated RhoB Inhibit Malignant Transformation and Suppress Human Tumor Growth in Nude Mice. J Biol Chem 275: 17974-17978. doi:10.1074/jbc.C000145200. PubMed: 10770919.
16. Adnane J, Muro-Cacho C, Mathews L, Sebti SM, Muñoz-Antonia T (2002) Suppression of rho B expression in invasive carcinoma from head and neck cancer patients. Clin Cancer Res 8: 2225-2232. PubMed: 12114424.
17. Forget MA, Desrosiers RR, Del M, Moumdjian R, Shedid D et al. (2002) The expression of rho proteins decreases with human brain tumor progression: potential tumor markers. Clin Exp Metastasis. 19: 9-15. doi:10.1023/A: 1013884426692. PubMed: 11918088.
18. Mazieres J, Antonia T (2004) Loss of RhoB Expression in Human Lung Cancer Progression. Clin Cancer Res 10: 2742-2750. doi: 10.1158/1078-0432.CCR-03-0149. PubMed: 15102679.
19. Suwa H, Ohshio G, Imamura T, Watanabe G, Arii S et al. (1998) Overexpression of the RhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer 77: 147-152. doi: 10.1038/bjc.1998.23. PubMed: 9459160.
20. Delarue FL, Adnane J, Joshi B, Blaskovich MA, Wang DA et al. (2007) Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter. Oncogene. 26: 633-640. doi:10.1038/sj.onc.1209819. PubMed: 16909123.
21. Wang S, Yan-Neale Y, Fischer D, Zeremski M, Cai R et al. (2003) Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. Oncogene. 22: 6204-6213. doi:10.1038/sj.onc.1206653. PubMed: 13679859.
22. Momtahen S, Kazzazi AS, Kadivar M (2007) Assessment of gynecological malignancies based on pathologic reports in five general hospitals in Tehran (1995-2005). ASCO Meeting Abstracts. 25. p. 5550.
23. Harter P, Gnauert K, Hils R, Lehmann TG, Fisseler-Eckhoff A et al. (2007) Pattern and clinical predictors of lymph node metastases in epithelial ovarian cancer. Int J Gynecol Cancer. 17: 1238-1244. doi: 10.1111/j.1525-1438.2007. 00931.x. PubMed: 17433064.
24. Caslini C, Capo-chichi CD, Roland IH, Nicolas E, Yeung AT et al. (2006) Histone modifications silence the GATA transcription factor genes in ovarian cancer. Oncogene. 25: 5446-5461. doi:10.1038/sj.onc.1209533. PubMed: 16607277.
25. Simpson KJ, Dugan AS, Mercurio AM (2004) Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res 64: 8694-8701. doi:10.1158/0008-5472.CAN-04-2247. PubMed: 15574779.
26. Boulter E, Garcia-Mata R, Guilluy C, Dubash A, Rossi G et al. (2010) Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol 12(5): 477-483. doi:10.1038/ncb2049. PubMed: 20400958.
27. Ho TT, Merajver SD, Lapière CM, Nusgens BV, Deroanne CF (2008) RhoA-GDP regulates RhoB protein stability: potential involvement of RhoGDIá. J Biol Chem 283: 21588-21598. doi:10.1074/jbc.M710033200. PubMed: 18524772.
28. Bellovin DI, Simpson KJ, Danilov T, Maynard E, Rimm DL et al. (2006) Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene 25: 6959-6967. doi:10.1038/sj.onc.1209682. PubMed: 16715134.
29. Stamatakis K, Cernuda-Morollón E, Hernández-Perera O, Pérez-Sala D (2002) Isoprenylation of RhoB is necessary for its degradation: a novel determinant in the complex regulation of RhoB expression by the mevalonate pathway. J Biol Chem 277: 49389-49396. doi:10.1074/jbc. M204049200. PubMed: 12384510.
30. Huang M, Prendergast GC (2006) RhoB in cancer suppression. Histol Histopathol 21: 213-218. PubMed: 16329046.
31. Wheeler AP, Ridley AJ (2007) RhoB affects macrophage adhesion, integrin expression and migration. Exp Cell Res 313: 3505-3516. doi: 10.1016/j.yexcr. 2007.07.014. PubMed: 17692842.
32. DeWard AD, Leali K, West RA, Prendergast GC, Alberts AS (2009) Loss of RhoB Expression Enhances the Myelodysplastic Phenotype of Mammalian Diaphanous-Related Formin mDia1 Knockout Mice. PLOS ONE. 4: 7102-7110. doi:10.1371/journal.pone.0007102. PubMed: 19768111.
33. Liu Ax, Du W, Liu JP, Jessell TM, Prendergast GC (2000) RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors. Mol Cell Biol 20: 6105-6113. doi: 10.1128/MCB.20.16.6105-6113.2000. PubMed: 10913192.
34. Mant JWF, Vessey MP (1994) Ovarian and endometrial cancers. In: R DollJJF FraumeniCS Muir, Trends in Cancer Incidence and Mortality. Plainview, NY: Cold Spring Harbor Laboratory. pp. 287-307.
35. Weidle UH, Grossmann A (2000) Inhibition of histone deacetylase: a new strategy to target epigenetic modifications for anticancer treatment. Anticancer Res 20: 1471-1486. PubMed: 10928059.
36. Couderc B, Pradines A, Rafii A, Golzio M, Deviers A et al. (2008) In vivo restoration of RhoB expression leads to ovarian tumor regression. Cancer Gene Ther 15: 456-464. doi:10.1038/cgt.2008.12. PubMed: 18340357.
37. Marks PA, Miller T, Richon VM (2003) Histone deacetylases. Curr Opin Pharmacol 3: 344-351. doi:10.1016/S1471-4892(03)00084-5. PubMed: 12901942.
38. Eickhoff B, Ruller S, Laue T, Kohler G, Stahl C et al. (2000) Trichostatin A modulates expression of p21waf1/cip1, Bcl-xL. ID: 1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFIID/TAFII31 mRNA in human lung adenocarcinoma cells. Biol Chem. 381:107-112.
39. Della Ragione F, Criniti V, Della Pietra V, Borriello A, Oliva A et al. (2001) Genes modulated by histone acetylation as new effectors of butyrate activity. FEBS Lett 499: 199-204. doi:10.1016/S0014-5793(01)02539-X. PubMed: 11423116.
40. Vigushin DM, Ali S, Pace PE, Mirsaidi N, Ito K et al. (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res 7: 971-976. PubMed: 11309348.
41. Ferrara FF, Fazi F, Bianchini A, Padula F, Gelmetti V et al. (2001) Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. Cancer Res 61: 2-7. PubMed: 11196162.
42. Allal C, Pradines A, Hamilton AD, Sebti SM, Favre G (2002) Farnesylated RhoB prevents cell cycle arrest and actin cytoskeleton disruption caused by the geranylgeranyltransferase I inhibitor GGTI. Cell Cycle- 298: 1:430-37.
43. Huelsenbeck J, Dreger SC, Gerhard R, Fritz G, Just I et al. (2007) Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile. Biochemistry 46: 4923-4931. doi:10.1021/bi602465z. PubMed: 17397186.