The biological role of carnosine and its possible applications in medicine

Advances in Clinical and Experimental Medicine

Volumn 22, Issue 5, 2013, Pages 739-744

  Budzeń, Sandra ^a   Aszewska, Joanna Rym ^b  

^a UNIVERSITY SCHOOL OF PHYSICAL EDUCATION   (Poland)

^b WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Antioxidant effect; Carnosine; Dementia; Dietary supplementation; Somatic diseases

Indexed keywords

4 HYDROXYNONENAL; ACETALDEHYDE; BETA ALANINE; CARNOSINE; DEXTRO CARNOSINE; MALONALDEHYDE; METHYLGLYOXAL; N ACETYLCARNOSINE; PLACEBO; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ALCOHOL CONSUMPTION; ANAPHYLACTIC SHOCK; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ATHLETE; CATARACT; CENTRAL NERVOUS SYSTEM; CHELATION; DEGENERATIVE DISEASE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIET SUPPLEMENTATION; ENDURANCE; EXPERIMENTAL ANIMAL; EYE DISEASE; FATTY LIVER; GLAUCOMA; GLIOBLASTOMA; GLYCATION; HUMAN; LENS DISEASE; LIFE EXPECTANCY; LIPID PEROXIDATION; LIVER CIRRHOSIS; MEDICAL LITERATURE; METABOLIC SYNDROME X; MUSCLE ISOMETRIC CONTRACTION; MUSCLE MASS; MUSCLE STRENGTH; NEOPLASM; NEUROPROTECTION; NOISE INJURY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHYSICAL ACTIVITY; PROTECTION; RESISTANCE TRAINING; REVIEW; SENSORY DYSFUNCTION; SKELETAL MUSCLE; SMELLING; SPINAL CORD INJURY; SUPPLEMENTATION; VISION; WRESTLING;

ANIMALIA; VERTEBRATA;

ANIMALS; ANTIOXIDANTS; CARNOSINE; EXERCISE; HUMANS; NEUROPROTECTIVE AGENTS;

EID: 84891447310     PISSN: 18995276     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Hipkiss AR, Preston JE, Himsworth DT, Worthington VC, Keown M, Michaelis J, Lawrence J, Mateen A, Allende L, Eagles PA, Abbott NJ: Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann N Y Acad Sci 1998, 20, 854, 37-53. (Pubitemid 29022791)
2. Gariballa AE, Sinclair AJ: Carnosine: physiological properties and therapeutic potential. Age Ageing 2000, 29, 207-210.
3. Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA: Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007, 32, 225-233. (Pubitemid 46198746)
4. Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, Taes Y, De Heer E, Derave W: Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans. Amino Acids 2011, 40, 1221-1229.
5. Derave W, Everaert I, Beeckman S, Baguet A: Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training. Sports Med 2010, 1, 40, 247-263.
6. Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr: Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc 2010, 42, 1162-1173.
7. Bakardjiev A, Bauer K: Biosynthesis, release, and uptake of carnosine in primary cultures. Biochemistry (Mosc) 2000, 65, 779-782.
8. Guney Y, Turkcu UO, Hicsonmez A, Andrieu MN, Guney HZ, Bilgihan A, Kurtman C: Carnosine may reduce lung injury caused by radiation therapy. Med Hypotheses 2006, 66, 957-959.
9. Hipkiss AR: Carnosine and its possible roles in nutrition and health. Adv Food Nutr Res 2009, 57, 87-154.
10. Babizhayev MA, Deyev AI, Savel'yeva EL, Lankin VZ, Yegorov YE: Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging. J Dermatolog Treat 2011, 7, 14.
11. Boldyrev AA, Gallant SC, Sukhich GT: Carnosine, the protective, anti-aging peptide. Biosci Rep 1999, 19, 581-587. (Pubitemid 30351189)
12. Kozan R, Sefil F, Baǧirici F: Anticonvulsant effect of carnosine on penicillin-induced epileptiform activity in rats. Brain Res 2008, 6, 1239, 249-255.
13. Boldyrev A, Fedorova T, Stepanova M, Dobrotvorskaya I, Kozlova E, Boldanova N, Bagyeva G, Ivanova-Smolenskaya I, Illarioshkin S: Carnosine increases efficiency of DOPA therapy of Parkinson's disease: a pilot study. Rejuvenation Res 2008, 1, 821-827.
14. Tsai SJ, Kuo WW, Liu WH, Yin MC: Antioxidative and Anti-Inflammatory Protection from Carnosine in the Striatum of MPTP-Treated Mice. J Agric Food Chem 2010, 10, 6.
15. Cheng J, Wang F, Yu DF, Wu PF, Chen JG: The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons. Eur J Pharmacol 2011, 10, 650, 184-194.
16. Di Paola R, Impellizzeri D, Salinaro AT, Mazzon E, Bellia F, Cavallaro M, Cornelius C, Vecchio G, Calabrese V, Rizzarelli E, Cuzzocrea S: Administration of carnosine in the treatment of acute spinal cord injury. Biochem Pharmacol 2011, 15, 82, 1478-1489.
17. Stvolinsky SL, Dobrota D: Anti-ischemic activity of carnosine. Biochemistry (Mosc) 2000, 65, 849-855.
18. Min J, Senut MC, Rajanikant K, Greenberg E, Bandagi R, Zemke D, Mousa A, Kassab M, Farooq MU, Gupta R, Majid A: Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia. J Neurosci Res 2008, 86, 2984-2991.
19. Ozdoǧan K, Taşkin E, Dursun N: Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats. Anadolu Kardiyol Derg. 2011, 11, 3-10.
20. Naghshvar F, Abianeh SM, Ahmadashrafi S, Hosseinimehr SJ: Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells. Cell Biochem Funct 2012, 30, 569-573.
21. Artun BC, Küskü-Kiraz Z, Güllüoǧlu M, Cevikbaş U, Koçak-Toker N, Uysal M: The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats. Hum Exp Toxicol 2010, 29, 659-665.
22. Liu WH, Liu TC, Yin MC: Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury. Food Chem Toxicol 2008, 46, 1503-1509.
23. Pfister F, Riedl E, Wang Q, vom Hagen F, Deinzer M, Harmsen MC, Molema G, Yard B, Feng Y, Hammes HP: Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy. Cell Physiol Biochem 2011, 28, 125-136.
24. Babizhayev MA, Micans P, Guiotto A, Kasus-Jacobi A: N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients. Am J Ther 2009, 16, 517-533.
25. Zhuravskii SG, Aleksandrova LA, Ivanov SA, Sirot VS, Lopotko AI, Zhloba AA: Protective effect of carnosine on excitable structures of the auditory apparatus in albino rats with acute acoustic trauma. Bull Exp Biol Med 2004, 137, 98-102. (Pubitemid 39137268)
26. Bonfanti L, Peretto P, De Marchis S, Fasolo A: Carnosine-related dipeptides in the mammalian brain. Prog Neurobiol 1999, 59, 333-353. (Pubitemid 29352340)
27. Ansurudeen I, Sunkari VG, Grunler J, Peters V, Schmitt CP, Catrina SB, Brismar K, Forsberg EA: Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes. Amino Acids 2012, 43, 127-134.
28. Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de Heer E, Baelde H, Bakker SJ, Zirie M, Rondeau E,Mathieson P, Saleem MA, Meyer J, Koppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschocke J, van der Woude FJ: Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. Diabetes 2005, 54, 2320-2327. (Pubitemid 41134258)
29. Nagai K, Niijima A, Yamano T, Otani H, Okumra N, Tsuruoka N, Nakai M, Kiso Y: Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves. Exp Biol Med (Maywood) 2003, 228, 1138-1145. (Pubitemid 37413671)
30. Horii Y, Shen J, Fujisaki Y, Yoshida K, Nagai K: Effects of l-carnosine on splenic sympathetic nerve activity and tumor proliferation. Neurosci Lett 2012, 21, 510, 1-5.
31. Renner C, Asperger A, Seyffarth A, Meixensberger J, Gebhardt R, Gaunitz F: Carnosine inhibits ATP production in cells from malignant glioma. Neurol Res 2010, 32, 101-105.
32. Aldini G, Orioli M, Rossoni G, Savi F, Braidotti P, Vistoli G, Yeum KJ, Negrisoli G, Carini M: The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats. J Cell Mol Med 2011, 15, 1339-1354.
33. Babizhayev MA, Deyev AI: Management of the virulent influenza virus infection by oral formulation of nonhydrolizedcarnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production. Am J Ther 2012, 19, e25-e47.
34. Baguet A, Everaert I, De Naeyer H, Reyngoudt H, Stegen S, Beeckman S, Achten E, Vanhee L, Volkaert A, Petrovic M, Taes Y, Derave W: Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacity. Eur J Appl Physiol 2011, 111, 2571-2580.
35. Derave W, Ozdemir MS, Harris RC, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten E: Beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters. J Appl Physiol 2007, 103, 1736-1743. (Pubitemid 350033860)
36. Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K: High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting. Jpn J Physiol 2002, 52, 199-205. (Pubitemid 34857605)
37. Goto K, Maemura H, Takamatsu K, Ishii N: Hormonal responses to resistance exercise after ingestion of carnosine and anserine. J Strength Cond Res 2011, 25, 398-405.
38. Kendrick IP, Harris RC, Kim HJ, Kim CK, Dang VH, Lam TQ, Bui TT, Smith M, Wise JA: The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids 2008, 34, 547-554.
39. Del Favero S, Roschel H, Solis MY, Hayashi AP, Artioli GG, Otaduy MC, Benatti FB, Harris RC, Wise J A, Leite CC, Pereira RM, de Sa-Pinto AL, Lancha-Junior AH, Gualano B: Beta-alanine (Carnosyn™) supplementation in elderly subjects (60-80 years): effects on musclecarnosine content and physical capacity. Amino Acids 2012, 43, 49-56.
40. Jagim AR, Wright GA, Brice AG, Doberstein ST: Effects of beta-alanine supplementation on sprint endurance. J Strength Cond Res 2012, 3 [E-pub ahead of print].