Effect of HIV clade differences on the onset and severity of HIV-associated neurocognitive disorders

Journal of NeuroVirology

Volumn 19, Issue 6, 2013, Pages 515-522

  Tyor, William ^a,c   Fritz French, Cari ^a   Nath, Avindra ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Encephalitis; HIV clades; HIV encephalitis; HIV associated neurocognitive disorders

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MICROTUBULE ASSOCIATED PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRANSACTIVATOR PROTEIN;

AFRICA; BEHAVIOR DISORDER; CLADISTICS; CLINICAL STUDY; GEOGRAPHIC DISTRIBUTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; INCIDENCE; INDIA; MONOCYTE; MOUSE MODEL; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; REVIEW; VIRUS CHARACTERIZATION; VIRUS VIRULENCE;

AGE OF ONSET; AIDS DEMENTIA COMPLEX; ANIMALS; ANTI-HIV AGENTS; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FEMALE; HIV-1; HUMANS; MALE; MICE; NEUROPSYCHOLOGICAL TESTS; PATIENT SELECTION; SAMPLE SIZE; SEVERITY OF ILLNESS INDEX;

EID: 84891433871     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-013-0206-6     Document Type: Review

References (49)

1. Boivin MJ, Ruel TD, Boal HE, Bangirana P, Cao H, Eller LA, Charlebois E, Havlir DV, Kamya MR, Achan J, Akello C, Wong JK (2010) HIV-subtype A is associated with poorer neuropsychological performance compared with subtype D in antiretroviral therapy-naive Ugandan children. AIDS 24(8):1163-1170
2. Campbell GR, Watkins JD, Loret EP, Spector SA (2011) Differential induction of rat neuronal excitotoxic cell death by human immunodeficiency virus type 1 clade B and C tat proteins. AIDS Res Hum Retroviruses 27(6):647-654
3. Cheng J, Nath A, Knudsen B, Hochman S, Geiger JD, Ma M, Magnuson DS (1998) Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein. Neuroscience 82(1):97-106
4. Choi Y, Townend J, Vincent T, Zaidi I, Sarge-Njie R, Jaye A, Clifford DB (2011) Neurologic manifestations of human immunodeficiency virus-2: dementia, myelopathy, and neuropathy in West Africa. J Neurovirol 17(2):166-175
5. Clifford DB, Mitike MT, Mekonnen Y, Zhang J, Zenebe G, Melaku Z, Zewde A, Gessesse N, Wolday D, Messele T, Teshome M, Evans S (2007) Neurological evaluation of untreated human immunodeficiency virus infected adults in Ethiopia. J Neurovirol 13(1):67-72
6. Gandhi N, Saiyed Z, Thangavel S, Rodriguez J, Rao KV, Nair MP (2009) Differential effects of HIV type 1 clade B and clade C Tat protein on expression of proinflammatory and antiinflammatory cytokines by primary monocytes. AIDS Res Hum Retroviruses 25(7):691-699
7. Gandhi N, Saiyed ZM, Napuri J, Samikkannu T, Reddy PV, Agudelo M, Khatavkar P, Saxena SK, Nair MP (2010) Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: implications for HIV-1-associated neurocognitive disorder. J Neurovirol 16(4):294-305
8. Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ et al (1992) Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 176(6):1703-1718
9. Glass JD, Wesselingh SL, Selnes OA, McArthur JC (1993) Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 43(11):2230-2237
10. Gupta JD, Satishchandra P, Gopukumar K, Wilkie F, Waldrop-Valverde D, Ellis R, Ownby R, Subbakrishna DK, Desai A, Kamat A, Ravi V, Rao BS, Satish KS, Kumar M (2007) Neuropsychological deficits in human immunodeficiency virus type 1 clade C-seropositive adults from South India. J Neurovirol 13(3):195-202
11. Heaps JM, Joska J, Hoare J, Ortega M, Agrawal A, Seedat S, Ances BM, Stein DJ, Paul R (2012) Neuroimaging markers of human immunodeficiency virus infection in South Africa. J Neurovirol 18(3):151-156
12. Hemelaar J, Gouws E, Ghys PD, Osmanov S (2006) Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. AIDS 20(16):W13-23
13. Holguin A, Banda M, Willen EJ, Malama C, Chiyenu KO, Mudenda VC, Wood C (2011) HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia. AIDS Behav 15(8):1895-1901
14. Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W 3rd, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C (2013) Global NeuroAIDS roundtable. J Neurovirol 19(1):1-9
15. Joska JA, Fincham DS, Stein DJ, Paul RH, Seedat S (2010) Clinical correlates of HIV-associated neurocognitive disorders in South Africa. AIDS Behav 14(2):371-378
16. Joska JA, Westgarth-Taylor J, Hoare J, Thomas KG, Paul R, Myer L, Stein DJ (2011a) Validity of the International HIV Dementia Scale in South Africa. AIDS Patient Care STDS 25(2):95-101
17. Joska JA, Westgarth-Taylor J, Myer L, Hoare J, Thomas KG, Combrinck M, Paul RH, Stein DJ, Flisher AJ (2011b) Characterization of HIV-associated neurocognitive disorders among individuals starting antiretroviral therapy in South Africa. AIDS Behav 15(6):1197-1203
18. Lamers SL, Poon AF, McGrath MS (2011) HIV-1 nef protein structures associated with brain infection and dementia pathogenesis. PLoS One 6(2):e16659
19. Lawler K, Mosepele M, Ratcliffe S, Seloilwe E, Steele K, Nthobatsang R, Steenhoff A (2010) Neurocognitive impairment among HIV-positive individuals in Botswana: a pilot study. J Int AIDS Soc 13:15
20. Li W, Huang Y, Reid R, Steiner J, Malpica-Llanos T, Darden TA, Shankar SK, Mahadevan A, Satishchandra P, Nath A (2008) NMDA receptor activation by HIV-Tat protein is clade dependent. J Neurosci 28(47):12190-12198
21. Liner KJ 2nd, Ro MJ, Robertson KR (2010) HIV, antiretroviral therapies, and the brain. Curr HIV/AIDS Rep 7(2):85-91
22. Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995) Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 37(3):373-380
23. Maj M, Satz P, Janssen R, Zaudig M, Starace F, D'Elia L, Sughondhabirom B, Mussa M, Naber D, Ndetei D et al (1994) WHO Neuropsychiatric AIDS study, cross-sectional phase II. Neuropsychological and neurological findings. Arch Gen Psychiatry 51(1):51-61
24. McArthur JC, Hoover DR, Bacellar H, Miller EN, Cohen BA, Becker JT, Graham NM, McArthur JH, Selnes OA, Jacobson LP et al (1993) Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study. Neurology 43(11):2245-2252
25. McArthur JC, Steiner J, Sacktor N, Nath A (2010) Human immunodeficiency virus-associated neurocognitive disorders: mind the gap. Ann Neurol 67(6):699-714
26. Mishra M, Vetrivel S, Siddappa NB, Ranga U, Seth P (2008) Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif. Ann Neurol 63(3):366-376
27. Nath A, Psooy K, Martin C, Knudsen B, Magnuson DS, Haughey N, Geiger JD (1996) Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 70(3):1475-1480
28. Olivieri KC, Agopian KA, Mukerji J, Gabuzda D (2010) Evidence for adaptive evolution at the divergence between lymphoid and brain HIV-1 nef genes. AIDS Res Hum Retroviruses 26(4):495-500
29. Power C, McArthur JC, Nath A, Wehrly K, Mayne M, Nishio J, Langelier T, Johnson RT, Chesebro B (1998) Neuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patients. J Virol 72(11):9045-9053
30. Power C, Selnes OA, Grim JA, McArthur JC (1995) HIV dementia scale: a rapid screening test. J Acquir Immune Defic Syndr Hum Retrovirol 8(3):273-278
31. Ragin AB, Du H, Ochs R, Wu Y, Sammet CL, Shoukry A, Epstein LG (2012) Structural brain alterations can be detected early in HIV infection. Neurology 79(24):2328-2334
32. Ranga U, Shankarappa R, Siddappa NB, Ramakrishna L, Nagendran R, Mahalingam M, Mahadevan A, Jayasuryan N, Satishchandra P, Shankar SK, Prasad VR (2004) Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine. J Virol 78(5):2586-2590
33. Rao VR, Neogi U, Talboom JS, Padilla L, Rahman M, Fritz-French C, Gonzalez-Ramirez S, Verma A, Wood C, Ruprecht RM, Ranga U, Azim T, Joska J, Eugenin E, Shet A, Bimonte-Nelson H, Tyor WR, Prasad VR (2013) Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence. Retrovirology 10:61
34. Rao VR, Sas AR, Eugenin EA, Siddappa NB, Bimonte-Nelson H, Berman JW, Ranga U, Tyor WR, Prasad VR (2008) HIV-1 clade-specific differences in the induction of neuropathogenesis. J Neurosci 28(40):10010-10016
35. Robertson K, Liner J, Hakim J, Sankale JL, Grant I, Letendre S, Clifford D, Diop AG, Jaye A, Kanmogne G, Njamnshi A, Langford TD, Weyessa TG, Wood C, Banda M, Hosseinipour M, Sacktor N, Nakasuja N, Bangirana P, Paul R, Joska J, Wong J, Boivin M, Holding P, Kammerer B, Van Rie A, Ive P, Nath A, Lawler K, Adebamowo C, Royal W 3rd, Joseph J (2010) NeuroAIDS in Africa. J Neurovirol 16(3):189-202
36. Royal W 3rd, Cherner M, Carr J, Habib AG, Akomolafe A, Abimiku A, Charurat M, Farley J, Oluyemisi A, Mamadu I, Johnson J, Ellis R, McCutchan JA, Grant I, Blattner WA (2012) Clinical features and preliminary studies of virological correlates of neurocognitive impairment among HIV-infected individuals in Nigeria. J Neurovirol 18(3):191-199
37. Sacktor N, Nakasujja N, Robertson K, Clifford DB (2007a) HIV-associated cognitive impairment in sub-Saharan Africa - the potential effect of clade diversity. Nat Clin Pract Neurol 3(8):436-443
38. Sacktor N, Nakasujja N, Skolasky RL, Rezapour M, Robertson K, Musisi S, Katabira E, Ronald A, Clifford DB, Laeyendecker O, Quinn TC (2009) HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda. Clin Infect Dis 49(5):780-786
39. Sacktor N, Skolasky R, Selnes OA, Watters M, Poff P, Shiramizu B, Shikuma C, Valcour V (2007b) Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals. J Neurovirol 13(3):203-209
40. Sacktor NC, Wong M, Nakasujja N, Skolasky RL, Selnes OA, Musisi S, Robertson K, McArthur JC, Ronald A, Katabira E (2005) The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 19(13):1367-1374
41. Samikkannu T, Agudelo M, Gandhi N, Reddy PV, Saiyed ZM, Nwankwo D, Nair MP (2011) Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS. J Neurovirol 17(3):230-238
42. Satishchandra P, Nalini A, Gourie-Devi M, Khanna N, Santosh V, Ravi V, Desai A, Chandramuki A, Jayakumar PN, Shankar SK (2000) Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96). Indian J Med Res 111:14-23
43. Self RL, Mulholland PJ, Nath A, Harris BR, Prendergast MA (2004) The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site. Brain Res 995(1):39-45
44. Spira S, Wainberg MA, Loemba H, Turner D, Brenner BG (2003) Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance. J Antimicrob Chemother 51(2):229-240
45. Tyor WR (2009) Pathogenesis and treatment of HIV-associated dementia: recent studies in a SCID mouse model. In: Lajtha A, Banik N, Ray S (eds) Handbook of neurochemistry and molecular neurobiology. Springer, New York, pp 471-489
46. Wadia RS, Pujari SN, Kothari S, Udhar M, Kulkarni S, Bhagat S, Nanivadekar A (2001) Neurological manifestations of HIV disease. J Assoc Physicians India 49:343-348
47. Wong MH, Robertson K, Nakasujja N, Skolasky R, Musisi S, Katabira E, McArthur JC, Ronald A, Sacktor N (2007) Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology 68(5):350-355
48. Yepthomi T, Paul R, Vallabhaneni S, Kumarasamy N, Tate DF, Solomon S, Flanigan T (2006) Neurocognitive consequences of HIV in southern India: a preliminary study of clade C virus. J Int Neuropsychol Soc 12(3):424-430
49. Zhang Y, Qiao L, Ding W, Wei F, Zhao Q, Wang X, Shi Y, Li N, Smith D, Chen D (2012) An initial screening for HIV-associated neurocognitive disorders of HIV-1 infected patients in China. J Neurovirol 18(2):120-126