The preventive role of breadfruit against inflammation-associated epithelial carcinogenesis in mice

Molecular Nutrition and Food Research

Volumn 58, Issue 1, 2014, Pages 206-210

  Lin, Jer An ^a   Chen, Hsiang Chi ^a   Yen, Gow Chin ^a,b  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

12 O tetradecanoylphorbol 13 acetate; Artocarpus communis; Flavonoids; Inflammation; Skin tumorigenesis

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2; FLAVONOID; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; PTGS2 PROTEIN, MOUSE;

12-O-TETRADECANOYLPHORBOL-13-ACETATE; ANIMAL; ARTICLE; ARTOCARPUS; ARTOCARPUS COMMUNIS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; EPITHELIUM CELL; EXPERIMENTAL NEOPLASM; FEMALE; INFLAMMATION; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOUSE; PATHOLOGY; SKIN TUMORIGENESIS;

12-O-TETRADECANOYLPHORBOL-13-ACETATE; ARTOCARPUS COMMUNIS; FLAVONOIDS; INFLAMMATION; SKIN TUMORIGENESIS;

ANIMALS; ANTICARCINOGENIC AGENTS; ARTOCARPUS; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FEMALE; INFLAMMATION; MICE; MICE, INBRED ICR; NEOPLASMS, EXPERIMENTAL; PLANT EXTRACTS; TETRADECANOYLPHORBOL ACETATE;

EID: 84891404055     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300248     Document Type: Article

References (19)

1. Rundhaug, J. E., Fischer, S. M., Molecular mechanisms of mouse skin tumor promotion. Cancers (Basel) 2010, 2, 436-482.
2. Nickoloff, B. J., Ben-Neriah, Y., Pikarsky, E., Inflammation and cancer: is the link as simple as we think? J. Invest. Dermatol. 2005, 124, x-xiv.
3. Prado, R., Francis, S. O., Mason, M. N., Wing, G. et al., Nonmelanoma skin cancer chemoprevention. Dermatol. Surg. 2011, 37, 1566-1578.
4. Katiyar, S. K., Agarwal, R., Wood, G. S., Mukhtar, H., Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7, 12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea. Cancer Res. 1992, 52, 6890-6897.
5. Lai, C. S., Li, S., Chai, C. Y., Lo, C. Y. et al., Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3', 4'-didemethylnobiletin, derived from nobiletin. Carcinogenesis 2008, 29, 2415-2424.
6. Aravindaram, K., Yang, N. S., Anti-inflammatory plant natural products for cancer therapy. Planta Med. 2010, 76, 1103-1117.
7. Jagtap, U. B., Bapat, V. A., Artocarpus: a review of its traditional uses, phytochemistry and pharmacology. J. Ethnopharmacol. 2010, 129, 142-166.
8. Wei, B. L., Weng, J. R., Chiu, P. H., Hung, C. F. et al., Anti-inflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis. J. Agric. Food Chem. 2005, 53, 3867-3871.
9. Lin, J. A., Fang, S. C., Wu, C. H., Huang, S. M. et al., Anti-inflammatory effect of the 5, 7, 4'-trihydroxy-6-geranylflavanone isolated from the fruit of Artocarpus communis in S100B-induced human monocytes. J. Agric. Food Chem. 2011, 59, 105-111.
10. Lin, J. A., Wu, C. H., Fang, S. C., Yen, G. C., Combining the observation of cell morphology with the evaluation of key inflammatory mediators to assess the anti-inflammatory effects of geranyl flavonoid derivatives in breadfruit. Food Chem. 2012, 132, 2118-2125.
11. Hsu, C. L., Shyu, M. H., Lin, J. A., Yen, G. C. et al., Cytotoxic effects of geranyl flavonoid derivatives from the fruit of Artocarpus communis in SK-Hep-1 human hepatocellular carcinoma cells. Food Chem. 2011, 127, 127-134.
12. Fang, S. C., Hsu, C. L., Yu, Y. S., Yen, G. C., Cytotoxic effects of new geranyl chalcone derivatives isolated from the leaves of Artocarpus communis in SW 872 human liposarcoma cells. J. Agric. Food Chem. 2008, 56, 8859-8868.
13. Kundu, J. K., Shin, Y. K., Kim, S. H., Surh, Y. J., Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis 2006, 27, 1465-1474.
14. Shrotriya, S., Kundu, J. K., Na, H. K., Surh, Y. J., Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling. Cancer Res. 2010, 70, 1932-1940.
15. Wu, H., Hsieh, M. C., Lo, C. Y., Liu, C. B. et al., 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. Mol. Nutr. Food Res. 2010, 54, 1296-1306.
16. Gosslau, A., En Jao, D. L., Huang, M. T., Ho, C. T. et al., Effects of the black tea polyphenol theaflavin-2 on apoptotic and inflammatory pathways in vitro and in vivo. Mol. Nutr. Food Res. 2011, 55, 198-208.
17. Ho, Y. S., Lai, C. S., Liu, H. I., Ho, S. Y. et al., Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation. Biochem. Pharmacol. 2007, 73, 1786-1795.
18. Pai, R., Szabo, I. L., Soreghan, B. A., Atay, S. et al., PGE2 stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways. Biochem. Biophys. Res. Commun. 2001, 286, 923-928.
19. Orlikova, B., Tasdemir, D., Golais, F., Dicato, M. et al., Dietary chalcones with chemopreventive and chemotherapeutic potential. Genes Nutr. 2011, 6, 125-147.