SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II-infused mice via activation of iNOS

Journal of the American Heart Association

Volumn 2, Issue 3, 2013, Pages

  Tan, Chek K ^a   Tan, Eddie H ^a   Luo, Baiwen ^b   Huang, Charlotte L ^b   Loo, Joachim S ^b   Choong, Cleo ^b   Tan, Nguan S ^a,c  

^a Schools of Biological Sciences Nanyang ^*  (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Aneurysm; Inflammation; Inos; SMAD3; TGF

Indexed keywords

ACETYLSALICYLIC ACID; AMINOGUANIDINE; ANGIOTENSIN II; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLODRONIC ACID; DEXAMETHASONE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GELATINASE A; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; SMAD3 PROTEIN; SMAD3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; AORTA DISSECTION; AORTA MEDIA; AORTA RUPTURE; ARTICLE; CONTROLLED STUDY; DEATH; ENZYME ACTIVATION; EX VIVO STUDY; HYPERTENSION; INFLAMMATION; LEUKOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; TENSILE STRENGTH; UPREGULATION; VASCULITIS; ANIMAL; AORTIC ANEURYSM; AORTITIS; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; MALE; PHENOTYPE; PHYSIOLOGY; ANEURYSM; INOS; SMAD3; TGF-Β;

ANGIOTENSIN II; ANIMALS; AORTIC ANEURYSM; AORTITIS; MALE; MICE; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE TYPE II; PHENOTYPE; SMAD3 PROTEIN;

ANEURYSM; INFLAMMATION; INOS; SMAD3; TGF-Β;

EID: 84891402310     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000269     Document Type: Article

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