Induction by staurosporine of nitric oxide synthase expression in vascular smooth muscle cells: Role of NF-κB, CREB and C/EBPβ

British Journal of Pharmacology

Volumn 120, Issue 6, 1997, Pages 1067-1074

  Hecker, Markus ^a,b   Preiß, Christiane ^a   Schini Kerth, Valérie B ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

C EBP; CREB; Cyclic AMP; Gene expression; Inducible NO synthase; Interleukin 1 ; NF B; Protein kinase C; Staurosporine; Tyrosine kinase(s); Vascular smooth muscle cells

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CALPHOSTIN C; CYCLOHEXIMIDE; DACTINOMYCIN; ERBSTATIN; ERBSTATIN A; FORSKOLIN; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE SYNTHASE; NITRITE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; STAUROSPORINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DNA TRANSCRIPTION; ENZYME INDUCTION; GENE EXPRESSION; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; ROLE PLAYING; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; ENZYME INDUCTION; ENZYME INHIBITORS; FORSKOLIN; INTERLEUKIN-1; MALE; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NUCLEAR PROTEINS; PROTEIN KINASE C; RATS; RATS, INBRED WKY; RNA, MESSENGER; STAUROSPORINE; TRANSCRIPTION FACTORS;

EID: 0031002134     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701026     Document Type: Article

References (32)

1. BOESE, M., BUSSE, R., MÜLSCH, A. & SCHINI-KERTH, V.B. (1996). Effect of cyclic GMP-dependent vasodilators on the expression of the inducible nitric oxide synthase in vascular smooth muscle cells: role of cyclic AMP. Br. J. Pharmacol., 119, 707-715.
2. CHARTRAIN, N.A., GELLER, D.A., KOTY, P.P. SITRIN, N.F., NÜSSLER, A.K., HOFFMAN, E.P., BILLIAR, T.R., HUTCHINSON, N.I. & MUDGETT, J.S. (1994). Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. J. Biol. Chem., 269, 6765-6772.
3. CHOMCZYNSKI, P. & SACCHI, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
4. EBERHARDT, W., KUNZ, D., HUMMEL, R. & PFEILSCHIFTER, J. (1996). Molecular cloning of the rat inducible nitric oxide synthase gene promoter. Biochem. Biophys. Res. Commun., 223, 752-756.
5. EBERHARDT, W., KUNZ, D. & PFEILSCHIFTER, J. (1994). Pyrrolidine dithiocarbamate differently affects interleukin-1β and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. Biochem. Biophys. Res. Commun., 200, 163-170.
6. GENG, Y.J., WU, Q. & HANSSON, G.K. (1994). Protein kinase C activation inhibits cytokine-induced nitric oxide synthesis in vascular smooth muscle cells. Biochim. Biophys. Acta, 1223, 125-132.
7. GORDON, D., MOHAI, L.G. & SCHWARTZ, S.M. (1986). Induction of polyploidy in cultures of neonatal rat aortic smooth muscle cells. Circ. Res., 59, 633-644.
8. HECKER, M., PREISS, C., KLEMM, P. & BUSSE, R. (1996a). Inhibition by antioxidants of nitric oxide synthase expression in macrophages: Role of nuclear factor κB and interferon regulatory factor 1. Br. J. Pharmacol., 118, 2178-2184.
9. HECKER, M., PREISS, C., SCHINI-KERTH, V.B. & BUSSE, R. (1996b). Antioxidants differentially affect nuclear factor κB-mediated nitric oxide synthase expression in vascular smooth muscle cells. FEBS Lett., 380, 224-228.
10. KAMIJO, R., HARADA, H. MATSUYAMA, T., BOSLAND, M., GERECITANO, J., SHAPIRO, D., LE, J., KOH, S.I., KIMURA, T., GREEN, S.J., MAK, T.W., TANIGUCHI, T. & VILCEK, J. (1994). Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science ( Wash.), 263, 1612-1615.
11. KANNO, K., HIRATA, Y., IMAI, T & MARUMO, F. (1993). Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells. Hypertension, 22, 34-39.
12. KWON, G., CORBETT, J.A., RODI, C.P., SULLIVAN, P & MCDANIEL, M.L. (1995). Interleukin-1β-induced nitric oxide synthase expression by rat pancreatic β-cells: evidence for the involvement of nuclear factor κB in the signaling mechanism. Endocrinology, 136, 4790-4795.
13. LOWENSTEIN, C.J., ALLEY, E.W., RAVAL, P., SNOWMAN, A.M., SNYDER, S.H., RUSSELL, S.W. & MURPHY, W.J. (1993). Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc. Natl. Acad. Sci. U.S.A., 90, 9730-9734.
14. MARCZIN, N., PAPAPETROPOULOS, A. & CATRAVA, J.D. (1993). Tyrosine kinase inhibitors suppress endoxotin- and IL-1β-induced NO synthesis in aortic smooth muscle cells. Am. J. Physiol., 265, H1014-H1018.
15. MARTIN, E., NATHAN, C. & XIE, Q.-W. (1994). Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med.. 180, 977-984.
16. MORITOKI, H., HISAYAMA, T., TAKEGUCHI, S., KONDOH, W. & TAKEJI, Y. (1995). Possible involvement of tyrosine kinase in the LPS-promoted initiation of the L-arginine-induced relaxation of rat aorta mediated by induction of NO synthase. Life Sci., 57, 125-130.
17. MORRIS, S.M. & BILLIAR, T.R. (1994). New insights into the regulation of inducible nitric oxide synthesis. Am. J. Physiol., 266, E829-E839.
18. MÜHL, H. & PFEILSCHIFTER, J. (1994). Possible role of protein kinase C-ε isoenzyme in inhibition of interleukin 1β induction of nitric oxide synthase in rat renal mesangial cells. Biochem. J., 303, 607-612.
19. NAKAYAMA, I., KAWAHARA, Y., TSUDA, T, OKUDA, M. & YOKOYAMA, M. (1994). Angiotensin II inhibits cytokine-stimulated inducible nitric oxide synthase expression in vascular smooth muscle cells. J. Biol. Chem., 269, 11628-11633.
20. RAMAMOORTHY, J.D., RAMAMOORTHY, S . PAPAPETROPOULOS, A., CATRAVAS, J.D., LEIHBACH, F.H. & GANAPATHY, V. (1995). Cyclic AMP-independent up-regulation of the human serotonin transporter by staurosporine in choricarcinoma cells. J. Biol. Chem., 270, 17189-17195.
21. SAVILLE, B. (1958). A scheme for the colorimetric determination of microgram amounts of thiols. Analyst, 83, 670-672.
22. SCHINI-KERTH, V.B., BOESE, M., BUSSE, R., FISSLTHALER, B. & MÜLSCH, A. (1996). N-α-tosyl-L-lysine chloromethylketone prevents the expression of the inducible nitric oxide synthase in vascular smooth muscle by blocking activation of nuclear factor κB. Art. Thromb. Vasc. Biol., (in press).
23. SCHINI-KERTH, V.B., BARA, A., MÜLSCH, A. & BUSSE, R. (1995). Pyrrolidine dithiocarbamate selectively prevents the expression of inducible nitric oxide synthase in the rat aorta. Eur. J. Pharmacol., 265, 83-87.
24. SCHREIBER, E., MATTHIAS, P., MÜLLER, M.M. & SCHAFENER, W. (1989). Rapid detection of octamer binding proteins with 'mini-extracts' prepared from a smaller number of cells. Nucl. Acad Res., 17, 6419.
25. SCOTT-BURDEN, T., ELIZONDO, E., GE, T., BOULANGER, C.M. & VANHOUTTE, P.M. (1994). Simultaneous activation of adenylyl cyclase and protein kinase C induces production of nitric oxide by vascular smooth muscle cells. Mol. Pharmacol., 46, 274-282.
26. SOWA, G. & PRZEWLOCKI, R. (1995). Enhancing effect of staurosporine on NO production in rat peritoneal macrophages via a protein kinase C-independent mechanism. Br. J. Pharmacol., 116, 1711-1712.
27. STEIN, B. & BALDWIN, A. (1993). Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and co-operativity between C/EBP and NF-κB. Mol. Cell. Biol., 13, 7191-7198.
28. TETSUKA, T., SRIVASTAVA, S.K. & MORRISON, A.R. (1996). Tyrosine kinase inhibitors, genistein and herbimycin A, do not block interleukin-1β-induced activation of NF-κB in rat mesangial cells. Biochem. Biophys, Res. Commun., 218, 808-812.
29. WEDEL, A. & ZIEGLER-HEITBROCK, H.W.L. (1995). The C/EBP family of transcription factors. Immunobiology, 193, 171-185.
30. WEGNER, M., CAO, Z & ROSENFELD, M.G. (1992). Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. Science, 256, 370-373.
31. XIE, Q.-W., KASHIWABARA, Y. & NATHAN, C. (1994). Role of transcription factor NF-κB/Rel in the induction of nitric oxide synthase. J. Biol. Chem., 269, 4705-4708.
32. XIE, Q.-W., WISHNAN, R. & NATHAN, C. (1993). Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J. Exp. Med., 177, 1779-1784.