Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 1, 2014, Pages 91-103

  Vignjević, Sanja ^a   Budeč, Mirela ^a   Marković, Dragana ^a   Dikić, Dragoslava ^a   Mitrović, Olivera ^a   Mojsilović, Slavko ^a   Durić, Sanja Vranješ ^b   Koko, Vesna ^a   Čokić, Bojana Beleslin ^c   Čokić, Vladan ^a   Jovčić, Gordana ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c CLINICAL CENTER OF SERBIA   (Serbia)

Author keywords

BMP4; Erythropoiesis; Spleen; Stress

Indexed keywords

ANIMALIA; MUS;

BMP4 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR; CORTICOSTERONE; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; GLUCOCORTICOID RECEPTOR; HEMOGLOBIN; IRON; MESSENGER RNA;

ANIMAL; ARTICLE; BLOOD; CBA MOUSE; CHRONIC DISEASE; DOWN REGULATION; ERYTHROPOIESIS; EXERCISE; GENETICS; MALE; MENTAL STRESS; METABOLISM; MOUSE; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPLEEN; STRESS;

BMP4; ERYTHROPOIESIS; SPLEEN; STRESS;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTORS; CHRONIC DISEASE; CORTICOSTERONE; DOWN-REGULATION; ERYTHROPOIESIS; ERYTHROPOIETIN; HEMOGLOBINS; IRON; MALE; MICE; MICE, INBRED CBA; ORGAN SIZE; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, GLUCOCORTICOID; RESTRAINT, PHYSICAL; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPLEEN; STRESS, PSYCHOLOGICAL;

EID: 84891371102     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12167     Document Type: Article

References (44)

1. Bowers SL, Bilbo SD, Dhabhar FS, et al. Stressor-specific alterations in corticosterone and immune responses in mice. Brain Behav Immun. 2008; 22: 105-13.
2. Chida Y, Hamer M, Wardle J, et al. Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol. 2008; 5: 466-75.
3. Barbieri A, Palma G, Rosati A, et al. Role of endothelial nitric oxide synthase (eNOS) in chronic stress-promoted tumour growth. J Cell Mol Med. 2012; 16: 920-6.
4. Feng Z, Liu L, Zhang C, et al. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci USA. 2012; 109: 7013-8.
5. Buynitsky T, Mostofsky DI. Restraint stress in biobehavioral research: recent developments. Neurosci Biobehav Rev. 2009; 33: 1089-98.
6. Souza Queiroz J, Malacrida SA, Justo GZ, et al. Myelopoietic response in mice exposed to acute cold/restraint stress: modulation by Chlorella vulgaris prophylactic treatment. Immunopharmacol Immunotoxicol. 2004; 26: 455-67.
7. Sherstoboev EY, Minakova MY. Hemopoietic precursors: mechanisms of regulation under conditions of chronic stress. Bull Exp Biol Med. 2005; 140: 616-20.
8. Socolovsky M. Molecular insights into stress erythropoiesis. Curr Opin Hematol. 2007; 14: 215-24.
9. Lau CI, Outram SV, Saldaña JI, et al. Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog. Blood. 2012; 119: 4741-51.
10. Prakash S, Hoffman R, Barouk S, et al. Splenic extramedullary hematopoietic proliferation in Philadelphia chromosome-negative myeloproliferative neoplasms: heterogeneous morphology and cytological composition. Mod Pathol. 2012; 25: 815-27.
11. Perry JM, Harandi OF, Paulson RF. BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors. Blood. 2007; 109: 4494-502.
12. Lenox LE, Shi L, Hegde S, et al. Extramedullary erythropoiesis in the adult liver requires BMP-4/Smad5-dependent signaling. Exp Hematol. 2009; 37: 549-58.
13. Lenox LE, Perry JM, Paulson RF. BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood. 2005; 105: 2741-8.
14. Harandi OF, Hedge S, Wu DC, et al. Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors. J Clin Invest. 2010; 120: 4507-19.
15. O'Neill HC. Niches for extramedullary hematopoiesis in the spleen. Niche. 2012; 1: 12-6.
16. Kolbus A, Blázquez-Domingo M, Carotta S, et al. Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling. Blood. 2003; 102: 3136-46.
17. Hattangadi SM, Wong P, Zhang L, et al. From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood. 2011; 118: 6258-68.
18. Paulson RF, Shi L, Wu DC. Stress erythropoiesis: new signals and new stress progenitor cells. Curr Opin Hematol. 2011; 18: 139-45.
19. Subramanian A, Hegde S, Porayette P, et al. Friend virus utilizes the BMP4-dependent stress erythropoiesis pathway to induce erythroleukemia. J Virol. 2008; 82: 382-93.
20. Dumitriu B, Bhattaram P, Dy P, et al. Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions. PLoS ONE. 2010; 5: e12088. doi:10.1371/journal.pone.0012088.
21. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002; 30: e36.
22. Trovato GM, Catalano D, Martines GF, et al. Psychological stress measure in type 2 diabetes. Eur Rev Med Pharmacol Sci. 2006; 10: 69-74.
23. Wei C, Zhou J, Huang X, et al. Effects of psychological stress on serum iron and erythropoiesis. Int J Hematol. 2008; 1: 52-6.
24. Millot S, Andrieu V, Letteron P, et al. Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation. Blood. 2010; 116: 6072-81.
25. Valtieri M, Gabbianelli M, Pelosi E, et al. Erythropoietin alone induces erythroid burst formation by human embryonic but not adult BFU-E in unicellular serum-free culture. Blood. 1989; 74: 460-70.
26. Palis J, Segel GB. Developmental biology of erythropoiesis. Blood Rev. 1998; 12: 106-14.
27. Liu Y, Pop R, Sadegh C, et al. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006; 108: 123-33.
28. Bauer A, Tronche F, Wessely O, et al. The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev. 1999; 13: 2996-3002.
29. Menon MP, Karur V, Bogacheva O, et al. Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. J Clin Invest. 2006; 116: 683-94.
30. Wessely O, Deiner EM, Beug H, et al. The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors. EMBO J. 1997; 16: 267-80.
31. Gursoy A, Dogruk Unal A, Ayturk S, et al. Polycythemia as the first manifestation of Cushing's disease. J Endocrinol Invest. 2006; 29: 742-4.
32. von Lindern M, Zauner W, Mellitzer G, et al. The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro. Blood. 1999; 94: 550-9.
33. Stellacci E, Di Noia A, Di Baldassarre A, et al. Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009; 37: 559-72.
34. Chiba S, Numakawa T, Ninomiya M, et al. Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2012; 39: 112-9.
35. Agosti V, Karur V, Sathyanarayana P, et al. A KIT juxtamembrane PY567-directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Exp Hematol. 2009; 37: 159-71.
36. Perry JM, Harandi OF, Porayette P, et al. Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling. Blood. 2009; 113: 911-8.
37. Sieber C, Kopf J, Hiepen C, et al. Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev. 2009; 20: 343-55.
38. Alarmo EL, Huhtala H, Korhonen T, et al. Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development. Mod Pathol. 2013; 26: 10-21.
39. Stamatoyannopoulos G, Veith R, Galanello R, et al. Hb F production in stressed erythropoiesis: observations and kinetic models. Ann N Y Acad Sci. 1985; 445: 188-97.
40. Teng WF, Sun WM, Shi LF, et al. Effects of restraint stress on iron, zinc, calcium, and magnesium whole blood levels in mice. Biol Trace Elem Res. 2008; 121: 243-8.
41. Chen J, Shen H, Chen C, et al. The effect of psychological stress on iron absorption in rats. BMC Gastroenterol. 2009; 9: 83.
42. Li H, Ginzburg YZ. Crosstalk between iron metabolism and erythropoiesis. Adv Hematol. 2010; 2010: 605435.
43. von Lindern M, Deiner EM, Dolznig H, et al. Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis. Oncogene. 2001; 20: 3651-64.
44. Shaked Y, Cervi D, Neuman M, et al. The splenic microenvironment is a source of proangiogenesis/inflammatory mediators accelerating the expansion of murine erythroleukemic cells. Blood. 2005; 105: 4500-7.