Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a Mouse model of generalized inflammation

Blood

Volumn 116, Issue 26, 2010, Pages 6072-6081

  Millot, Sarah ^a,b,c   Andrieu, Valérie ^d   Letteron, Philippe ^a   Lyoumi, Saïd ^a   Hurtado Nedelec, Margarita ^d   Karim, Zoubida ^a   Thibaudeau, Olivier ^d   Bennada, Samira ^d   Charrier, Jean Luc ^b,c   Lasocki, Sigismond ^a,d   Beaumont, Carole ^a  

^a CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^b Paris 5 Descartes University EA 2496 U F R of Odontology   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; GAMMA INTERFERON; RECOMBINANT ERYTHROPOIETIN;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BURST FORMING UNIT E; CELL MATURATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; ERYTHROBLAST; ERYTHROCYTE; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; HALF LIFE TIME; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; STRESS;

EID: 78650643140     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-04-281840     Document Type: Article

References (30)

1. Lenox LE, Perry JM, Paulson RF. BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood. 2005;105(7):2741-2748.
2. Lenox LE, Shi L, Hegde S, Paulson RF. Ex-tramedullary erythropoiesis in the adult liver requires BMP-4/Smad5-dependent signaling. Exp Hematol. 2009;37(5):549-558.
3. Porayette P, Paulson RF. BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development. Dev Biol. 2008;317(1):24-35.
4. Perry JM, Harandi OF, Paulson RF. BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors. Blood. 2007;109(10):4494-4502.
5. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011-1023.
6. Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hep-cidin. J Clin Invest. 2004;113(9):1271-1276.
7. Theurl I, Aigner E, Theurl M, et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood. 2009;113(21):5277-5286.
8. Felli N, Pedini F, Zeuner A, et al. Multiple members of the TNF superfamily contribute to IFN-gamma-mediated inhibition of erythropoiesis. J Immunol. 2005;175(3):1464-1472.
9. Taniguchi S, Dai CH, Price JO, Krantz SB. Inter-feron gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells. Blood. 1997;90(6):2244-2252.
10. Wang CQ, Udupa KB, Lipschitz DA. Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development. J Cell Physiol. 1995;162(1):134-138.
11. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin: results of a combined phase I and II clinical trial. N Engl J Med. 1987;316(2):73-78.
12. Zarychanski R, Turgeon AF, McIntyre L, Fergusson DA. Erythropoietin- receptor agonists in critically ill patients: a meta-analysis of randomized controlled trials. CMAJ. 2007;177(6):725-734.
13. Bateman AP, McArdle F, Walsh TS. Time course of anemia during six months follow up following intensive care discharge and factors associated with impaired recovery of erythropoiesis. Crit Care Med. 2009;37(6):1906-1912.
14. Lasocki S, Millot S, Andrieu V, et al. Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia. Crit Care Med. 2008;36(8):2388-2394.
15. Volman TJ, Hendriks T, Goris RJ. Zymosan-induced generalized inflammation: experimental studies into mechanisms leading to multiple organ dysfunction syndrome. Shock. 2005;23(4):291-297.
16. Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a (-/-) 5b (-/-) mice due to decreased survival of early erythroblasts. Blood. 2001;98(12):3261-3273.
17. Rivera S, Ganz T. Animal models of anemia of inflammation. Semin Hematol. 2009;46(4):351-357.
18. Schubert TE, Obermaier F, Ugocsai P, et al. Murine models of anaemia of inflammation: extramedullary haematopoiesis represents a species specific difference to human anaemia of inflammation that can be eliminated by splenectomy. Int J Immunopathol Pharmacol. 2008;21(3):577-584.
19. Chasis JA, Mohandas N. Erythroblastic islands: niches for erythropoiesis. Blood. 2008;112(3):470-478.
20. Sadahira Y, Yasuda T, Yoshino T, et al. Impaired splenic erythropoiesis in phlebotomized mice injected with CL2MDP-liposome: an experimental model for studying the role of stromal macro-phages in erythropoiesis. J Leukoc Biol. 2000;68(4):464-470.
21. Perry JM, Harandi OF, Porayette P, Hegde S, Kannan AK, Paulson RF. Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling. Blood. 2009;113(4):911-918.
22. Wu DC, Paulson RF. Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. PLoS One;5 (6):e11303.
23. Konstantinopoulos PA, Karamouzis MV, Papavassiliou AG. Selective modulation of the erythropoietic and tissue-protective effects of erythropoietin: time to reach the full therapeutic potential of erythropoietin. Biochim Biophys Acta. 2007;1776(1):1-9.
24. Bailey DM, Robach P, Thomsen JJ, Lundby C. Erythropoietin depletes iron stores: antioxidant neuroprotection for ischemic stroke? Stroke. 2006;37(10):2453.
25. Barany P, Muller HJ. Maintaining control over haemoglobin levels: optimizing the management of anaemia in chronic kidney disease. Nephrol Dial Transplant. 2007;22(suppl 4): iv10-iv18.
26. Silverberg DS, Wexler D, Iaina A, Schwartz D. The correction of anemia in patients with the combination of chronic kidney disease and congestive heart failure may prevent progression of both conditions. Clin Exp Nephrol. 2009;13(2):101-106.
27. Sasu BJ, Cooke KS, Arvedson TL, et al. Anti-hep-cidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia. Blood. 2010;115(17):3616-3627.
28. Cavill I, Auerbach M, Bailie GR, et al. Iron and the anaemia of chronic disease: a review and strategic recommendations. Curr Med Res Opin. 2006;22(4):731-737.
29. Goldman DC, Bailey AS, Pfaffle DL, Al Masri A, Christian JL, Fleming WH. BMP4 regulates the hematopoietic stem cell niche. Blood. 2009;114(20):4393-4401.
30. Luck L, Zeng L, Hiti AL, Weinberg KI, Malik P. Human CD34 (+) and CD34 (+) CD38 (-) hematopoietic progenitors in sickle cell disease differ phenotypically and functionally from normal and suggest distinct subpopulations that generate F cells. Exp Hematol. 2004;32(5):483-493.