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Volumn 7, Issue 4, 2013, Pages 253-263

Cysteine-rich protein 61 (CCN1) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy

Author keywords

CCN1; CCN2; Extracellular matrix; Ischemia; Neovascularization; Retinopathy

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CYSTEINE RICH PROTEIN 61; INTEGRIN; VASCULOTROPIN; WNT PROTEIN;

EID: 84891371068     PISSN: 18739601     EISSN: 1873961X     Source Type: Journal    
DOI: 10.1007/s12079-013-0206-6     Document Type: Review
Times cited : (35)

References (92)
  • 3
    • 0037360164 scopus 로고    scopus 로고
    • Thrombospondins 1 and 2 function as inhibitors of angiogenesis
    • 1:CAS:528:DC%2BD3sXjtVKgtLw%3D 12714043 10.1016/S0945-053X(03)00005-2
    • Armstrong LC, Bornstein P (2003) Thrombospondins 1 and 2 function as inhibitors of angiogenesis. Matrix Biol 22:63-71
    • (2003) Matrix Biol , vol.22 , pp. 63-71
    • Armstrong, L.C.1    Bornstein, P.2
  • 5
    • 0032913069 scopus 로고    scopus 로고
    • Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo
    • 1:CAS:528:DyaK1MXit1alsbk%3D 84090 10082563
    • Babic AM, Chen CC, Lau LF (1999) Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 19:2958-2966
    • (1999) Mol Cell Biol , vol.19 , pp. 2958-2966
    • Babic, A.M.1    Chen, C.C.2    Lau, L.F.3
  • 6
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
    • 1:CAS:528:DyaK1cXns1ektrY%3D 9827803 10.1016/S0092-8674(00)81618-9
    • Bader BL, Rayburn H, Crowley D, Hynes RO (1998) Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell 95:507-519
    • (1998) Cell , vol.95 , pp. 507-519
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 8
    • 0036775425 scopus 로고    scopus 로고
    • Matricellular proteins: Extracellular modulators of cell function
    • 1:CAS:528:DC%2BD38XmvVCrtbg%3D 12231357 10.1016/S0955-0674(02)00361-7
    • Bornstein P, Sage EH (2002) Matricellular proteins: Extracellular modulators of cell function. Curr Opin Cell Biol 14:608-616
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 608-616
    • Bornstein, P.1    Sage, E.H.2
  • 9
    • 2942574688 scopus 로고    scopus 로고
    • Extra-cellular matrix in vascular networks
    • 1:CAS:528:DC%2BD2cXltFygtr4%3D 15144498 10.1111/j.1365-2184.2004.00306.x
    • Bou-Gharios G, Ponticos M, Rajkumar V, Abraham D (2004) Extra-cellular matrix in vascular networks. Cell Prolif 37:207-220
    • (2004) Cell Prolif , vol.37 , pp. 207-220
    • Bou-Gharios, G.1    Ponticos, M.2    Rajkumar, V.3    Abraham, D.4
  • 10
    • 0042855012 scopus 로고    scopus 로고
    • The CCN family: A new stimulus package
    • 1:CAS:528:DC%2BD3sXmvFGns7o%3D 12904165 10.1677/joe.0.1780169
    • Brigstock DR (2003) The CCN family: A new stimulus package. J Endocrinol 178:169-175
    • (2003) J Endocrinol , vol.178 , pp. 169-175
    • Brigstock, D.R.1
  • 11
    • 24944578655 scopus 로고    scopus 로고
    • Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor
    • 1:CAS:528:DC%2BD2MXhtVejs7fF 16138907 10.1111/j.1600-0854.2005.00332.x
    • Bryant DM, Stow JL (2005) Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor. Traffic 6:947-954
    • (2005) Traffic , vol.6 , pp. 947-954
    • Bryant, D.M.1    Stow, J.L.2
  • 12
    • 79956005855 scopus 로고    scopus 로고
    • Selective blockade of cytoskeletal actin remodeling reduces experimental choroidal neovascularization
    • 1:CAS:528:DC%2BC3MXmslSqtL0%3D 3088545 21178140 10.1167/iovs.10-6351
    • Caballero S, Yang R, Grant MB, Chaqour B (2011) Selective blockade of cytoskeletal actin remodeling reduces experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 52:2490-2496
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 2490-2496
    • Caballero, S.1    Yang, R.2    Grant, M.B.3    Chaqour, B.4
  • 13
    • 0033895534 scopus 로고    scopus 로고
    • Retinal and choroidal neovascularization
    • 1:CAS:528:DC%2BD3cXlsl2mu74%3D 10911360 10.1002/1097-4652(200009)184: 3<301: AID-JCP3>3.0.CO;2-H
    • Campochiaro PA (2000) Retinal and choroidal neovascularization. J Cell Physiol 184:301-310
    • (2000) J Cell Physiol , vol.184 , pp. 301-310
    • Campochiaro, P.A.1
  • 14
    • 84857127780 scopus 로고    scopus 로고
    • From oxygen to erythropoietin: Relevance of hypoxia for retinal development, health and disease
    • 1:CAS:528:DC%2BC3MXhs1emtrrP 22108059 10.1016/j.preteyeres.2011.11.003
    • Caprara C, Grimm C (2012) From oxygen to erythropoietin: Relevance of hypoxia for retinal development, health and disease. Prog Retin Eye Res 31:89-119
    • (2012) Prog Retin Eye Res , vol.31 , pp. 89-119
    • Caprara, C.1    Grimm, C.2
  • 15
    • 59649107705 scopus 로고    scopus 로고
    • Functions and mechanisms of action of CCN matricellular proteins
    • 1:CAS:528:DC%2BD1MXitFSmtL0%3D 2668982 18775791 10.1016/j.biocel.2008.07. 025
    • Chen CC, Lau LF (2009) Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 41:771-783
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 771-783
    • Chen, C.C.1    Lau, L.F.2
  • 16
    • 6344220061 scopus 로고    scopus 로고
    • Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells
    • 1:CAS:528:DC%2BD2cXot1yns7c%3D 15308622 10.1074/jbc.M406813200
    • Chen N, Leu SJ, Todorovic V, Lam SC, Lau LF (2004) Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells. J Biol Chem 279:44166-44176
    • (2004) J Biol Chem , vol.279 , pp. 44166-44176
    • Chen, N.1    Leu, S.J.2    Todorovic, V.3    Lam, S.C.4    Lau, L.F.5
  • 17
    • 34047180464 scopus 로고    scopus 로고
    • Functional properties and intracellular signaling of CCN1/Cyr61
    • 1:CAS:528:DC%2BD2sXjvVSlsbg%3D 17171641 10.1002/jcb.21194
    • Chen Y, Du XY (2007) Functional properties and intracellular signaling of CCN1/Cyr61. J Cell Biochem 100:1337-1345
    • (2007) J Cell Biochem , vol.100 , pp. 1337-1345
    • Chen, Y.1    Du, X.Y.2
  • 18
    • 84870044156 scopus 로고    scopus 로고
    • Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene
    • 1:CAS:528:DC%2BC38XhslansbfK 3504771 23048035 10.1074/jbc.M112.386565
    • Chintala H, Liu H, Parmar R, Kamalska M, Kim YJ, Lovett D, Grant MB, Chaqour B (2012) Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene. J Biol Chem 287:40570-40585
    • (2012) J Biol Chem , vol.287 , pp. 40570-40585
    • Chintala, H.1    Liu, H.2    Parmar, R.3    Kamalska, M.4    Kim, Y.J.5    Lovett, D.6    Grant, M.B.7    Chaqour, B.8
  • 19
    • 33749235728 scopus 로고    scopus 로고
    • Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway
    • 1:CAS:528:DC%2BD28Xht1Wgs7jL 17093396
    • Chudgar SM, Deng P, Maddala R, Epstein DL, Rao PV (2006) Regulation of connective tissue growth factor expression in the aqueous humor outflow pathway. Mol Vis 12:1117-1126
    • (2006) Mol Vis , vol.12 , pp. 1117-1126
    • Chudgar, S.M.1    Deng, P.2    Maddala, R.3    Epstein, D.L.4    Rao, P.V.5
  • 20
    • 84879691074 scopus 로고    scopus 로고
    • Therapeutic uses of prostaglandin F(2alpha) analogues in ocular disease and novel synthetic strategies
    • Dams I, Wasyluk J, Prost M, Kutner A (2013) Therapeutic uses of prostaglandin F(2alpha) analogues in ocular disease and novel synthetic strategies. Prostaglandins Other Lipid Mediat.
    • (2013) Prostaglandins Other Lipid Mediat.
    • Dams, I.1    Wasyluk, J.2    Prost, M.3    Kutner, A.4
  • 21
    • 0142122287 scopus 로고    scopus 로고
    • Retinal and choroidal angiogenesis: Pathophysiology and strategies for inhibition
    • 1:CAS:528:DC%2BD3sXot1GlsLs%3D 14575722 10.1016/j.preteyeres.2003.08.001
    • Das A, McGuire PG (2003) Retinal and choroidal angiogenesis: Pathophysiology and strategies for inhibition. Prog Retin Eye Res 22:721-748
    • (2003) Prog Retin Eye Res , vol.22 , pp. 721-748
    • Das, A.1    McGuire, P.G.2
  • 22
    • 19644367119 scopus 로고    scopus 로고
    • VEGF-integrin interplay controls tumor growth and vascularization
    • 1:CAS:528:DC%2BD2MXkslOntbY%3D 1129024 15897451 10.1073/pnas.0502935102
    • De S, Razorenova O, McCabe NP, O'Toole T, Qin J, Byzova TV (2005) VEGF-integrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci U S A 102:7589-7594
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7589-7594
    • De, S.1    Razorenova, O.2    McCabe, N.P.3    O'Toole, T.4    Qin, J.5    Byzova, T.V.6
  • 23
    • 77958492749 scopus 로고    scopus 로고
    • A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high
    • 2943916 20877562 10.1371/journal.pone.0012909
    • Doherty HE, Kim HS, Hiller S, Sulik KK, Maeda N (2010) A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high. PLoS One 5:e12909
    • (2010) PLoS One , vol.5 , pp. 12909
    • Doherty, H.E.1    Kim, H.S.2    Hiller, S.3    Sulik, K.K.4    Maeda, N.5
  • 24
    • 84864460655 scopus 로고    scopus 로고
    • Microvascular remodeling and wound healing: A role for pericytes
    • 1:CAS:528:DC%2BC38XhtlKrs7zM 3455116 22750474 10.1016/j.biocel.2012.06. 031
    • Dulmovits BM, Herman IM (2012) Microvascular remodeling and wound healing: A role for pericytes. Int J Biochem Cell Biol 44:1800-1812
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 1800-1812
    • Dulmovits, B.M.1    Herman, I.M.2
  • 25
    • 77949674681 scopus 로고    scopus 로고
    • Cyr61/CCN1 Displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin
    • 2829074 20195466 10.1371/journal.pone.0009356
    • Francischetti IM, Kotsyfakis M, Andersen JF, Lukszo J (2010) Cyr61/CCN1 Displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin. PLoS One 5:e9356
    • (2010) PLoS One , vol.5 , pp. 9356
    • Francischetti, I.M.1    Kotsyfakis, M.2    Andersen, J.F.3    Lukszo, J.4
  • 26
    • 67349115359 scopus 로고    scopus 로고
    • Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling
    • 1:CAS:528:DC%2BD1MXmtVCjsbo%3D 3014319 19450457 10.1016/j.exer.2009.01. 002
    • Fuchshofer R, Stephan DA, Russell P, Tamm ER (2009) Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling. Exp Eye Res 88:1020-1032
    • (2009) Exp Eye Res , vol.88 , pp. 1020-1032
    • Fuchshofer, R.1    Stephan, D.A.2    Russell, P.3    Tamm, E.R.4
  • 27
    • 0242690484 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells
    • 1:CAS:528:DC%2BD3sXosVyksrk%3D 14585398 10.1016/S1386-6346(03)00241-9
    • Gao R, Brigstock DR (2003) Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res 27:214-220
    • (2003) Hepatol Res , vol.27 , pp. 214-220
    • Gao, R.1    Brigstock, D.R.2
  • 30
    • 0042928454 scopus 로고    scopus 로고
    • Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways
    • 1:CAS:528:DC%2BD3sXmvFWktLY%3D 12899698 10.1046/j.1432-1033.2003.03723.x
    • Han JS, Macarak E, Rosenbloom J, Chung KC, Chaqour B (2003) Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways. Eur J Biochem 270:3408-3421
    • (2003) Eur J Biochem , vol.270 , pp. 3408-3421
    • Han, J.S.1    MacArak, E.2    Rosenbloom, J.3    Chung, K.C.4    Chaqour, B.5
  • 31
    • 69249107729 scopus 로고    scopus 로고
    • Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase
    • 1:CAS:528:DC%2BD1MXpvFKiu7s%3D 2755718 19542562 10.1074/jbc.M109.019059
    • Hanna M, Liu H, Amir J, Sun Y, Morris SW, Siddiqui MA, Lau LF, Chaqour B (2009) Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase. J Biol Chem 284:23125-23136
    • (2009) J Biol Chem , vol.284 , pp. 23125-23136
    • Hanna, M.1    Liu, H.2    Amir, J.3    Sun, Y.4    Morris, S.W.5    Siddiqui, M.A.6    Lau, L.F.7    Chaqour, B.8
  • 32
    • 84871689012 scopus 로고    scopus 로고
    • Mechanisms and management of retinopathy of prematurity
    • 1:CAS:528:DC%2BC3sXktVCnsw%3D%3D 3695731 23268666 10.1056/NEJMra1208129
    • Hartnett ME, Penn JS (2012) Mechanisms and management of retinopathy of prematurity. N Engl J Med 367:2515-2526
    • (2012) N Engl J Med , vol.367 , pp. 2515-2526
    • Hartnett, M.E.1    Penn, J.S.2
  • 33
    • 79953215255 scopus 로고    scopus 로고
    • The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy
    • 1:CAS:528:DC%2BC3MXjtFOit70%3D 3059032 21212276 10.1074/jbc.M110.198689
    • Hasan A, Pokeza N, Shaw L, Lee HS, Lazzaro D, Chintala H, Rosenbaum D, Grant MB, Chaqour B (2011) The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy. J Biol Chem 286:9542-9554
    • (2011) J Biol Chem , vol.286 , pp. 9542-9554
    • Hasan, A.1    Pokeza, N.2    Shaw, L.3    Lee, H.S.4    Lazzaro, D.5    Chintala, H.6    Rosenbaum, D.7    Grant, M.B.8    Chaqour, B.9
  • 34
    • 0141833839 scopus 로고    scopus 로고
    • A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization
    • 1:CAS:528:DC%2BD3sXnvFars7Y%3D 12963611 10.1001/archopht.121.9.1283
    • He S, Jin ML, Worpel V, Hinton DR (2003) A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol 121:1283-1288
    • (2003) Arch Ophthalmol , vol.121 , pp. 1283-1288
    • He, S.1    Jin, M.L.2    Worpel, V.3    Hinton, D.R.4
  • 35
    • 43149111611 scopus 로고    scopus 로고
    • Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene
    • 2275724 18289368 10.1186/1471-213X-8-18
    • Heath E, Tahri D, Andermarcher E, Schofield P, Fleming S, Boulter CA (2008) Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene. BMC Dev Biol 8:18
    • (2008) BMC Dev Biol , vol.8 , pp. 18
    • Heath, E.1    Tahri, D.2    Andermarcher, E.3    Schofield, P.4    Fleming, S.5    Boulter, C.A.6
  • 37
    • 41649116120 scopus 로고    scopus 로고
    • Non-conventional frizzled ligands and Wnt receptors
    • 1:CAS:528:DC%2BD1cXmtFyntbs%3D 18366384 10.1111/j.1440-169X.2008.01016.x
    • Hendrickx M, Leyns L (2008) Non-conventional frizzled ligands and Wnt receptors. Dev Growth Differ 50:229-243
    • (2008) Dev Growth Differ , vol.50 , pp. 229-243
    • Hendrickx, M.1    Leyns, L.2
  • 39
    • 1442348817 scopus 로고    scopus 로고
    • Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy
    • 1:CAS:528:DC%2BD2cXisFKnsL4%3D 14988298 10.2337/diacare.27.3.758
    • Hinton DR, Spee C, He S, Weitz S, Usinger W, LaBree L, Oliver N, Lim JI (2004) Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care 27:758-764
    • (2004) Diabetes Care , vol.27 , pp. 758-764
    • Hinton, D.R.1    Spee, C.2    He, S.3    Weitz, S.4    Usinger, W.5    Labree, L.6    Oliver, N.7    Lim, J.I.8
  • 40
    • 62449084935 scopus 로고    scopus 로고
    • Alternative splicing of Cyr61 is regulated by hypoxia and significantly changed in breast cancer
    • 1:CAS:528:DC%2BD1MXisFSrurg%3D 19244129 10.1158/0008-5472.CAN-08-1997
    • Hirschfeld M, zur Hausen A, Bettendorf H, Jager M, Stickeler E (2009) Alternative splicing of Cyr61 is regulated by hypoxia and significantly changed in breast cancer. Cancer Res 69:2082-2090
    • (2009) Cancer Res , vol.69 , pp. 2082-2090
    • Hirschfeld, M.1    Zur Hausen, A.2    Bettendorf, H.3    Jager, M.4    Stickeler, E.5
  • 41
    • 67349113882 scopus 로고    scopus 로고
    • Proteins on the catwalk: Modelling the structural domains of the CCN family of proteins
    • 2686754 19424823 10.1007/s12079-009-0048-4
    • Holbourn KP, Perbal B, Ravi AK (2009) Proteins on the catwalk: Modelling the structural domains of the CCN family of proteins. J Cell Commun Signal 3:25-41
    • (2009) J Cell Commun Signal , vol.3 , pp. 25-41
    • Holbourn, K.P.1    Perbal, B.2    Ravi, A.K.3
  • 42
    • 34147117767 scopus 로고    scopus 로고
    • Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina
    • 1:CAS:528:DC%2BD2sXjvV2msL4%3D 1914292 17333105 10.1007/s00125-007-0621-4
    • Hughes JM, Kuiper EJ, Klaassen I, Canning P, Stitt AW, Van BJ, Schalkwijk CG, Van Noorden CJ, Schlingemann RO (2007) Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina. Diabetologia 50:1089-1098
    • (2007) Diabetologia , vol.50 , pp. 1089-1098
    • Hughes, J.M.1    Kuiper, E.J.2    Klaassen, I.3    Canning, P.4    Stitt, A.W.5    Van, B.J.6    Schalkwijk, C.G.7    Van Noorden, C.J.8    Schlingemann, R.O.9
  • 43
    • 0036481769 scopus 로고    scopus 로고
    • Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis
    • 1:CAS:528:DC%2BD38XhsVeqt7c%3D 11744618
    • Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, Takata S, Kobayashi K, Okada Y (2002) Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J 16:219-221
    • (2002) FASEB J , vol.16 , pp. 219-221
    • Inoki, I.1    Shiomi, T.2    Hashimoto, G.3    Enomoto, H.4    Nakamura, H.5    Makino, K.6    Ikeda, E.7    Takata, S.8    Kobayashi, K.9    Okada, Y.10
  • 44
    • 0037902889 scopus 로고    scopus 로고
    • Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
    • 1:CAS:528:DC%2BD3sXktFOnu7o%3D 12730690 10.1038/nm877
    • Ishida S, Yamashiro K, Usui T, Kaji Y, Ogura Y, Hida T, Honda Y, Oguchi Y, Adamis AP (2003) Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease. Nat Med 9:781-788
    • (2003) Nat Med , vol.9 , pp. 781-788
    • Ishida, S.1    Yamashiro, K.2    Usui, T.3    Kaji, Y.4    Ogura, Y.5    Hida, T.6    Honda, Y.7    Oguchi, Y.8    Adamis, A.P.9
  • 45
    • 0038093327 scopus 로고    scopus 로고
    • Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    • 1:CAS:528:DC%2BD3sXltFart7k%3D 3360973 12736220 10.1242/dev.00505
    • Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130:2779-2791
    • (2003) Development , vol.130 , pp. 2779-2791
    • Ivkovic, S.1    Yoon, B.S.2    Popoff, S.N.3    Safadi, F.F.4    Libuda, D.E.5    Stephenson, R.C.6    Daluiski, A.7    Lyons, K.M.8
  • 46
    • 0028071526 scopus 로고
    • Nuclear signaling pathways for polypeptide ligands and their membrane receptors?
    • 1:CAS:528:DyaK2cXmt1CgtrY%3D 8070633
    • Jans DA (1994) Nuclear signaling pathways for polypeptide ligands and their membrane receptors? FASEB J 8:841-847
    • (1994) FASEB J , vol.8 , pp. 841-847
    • Jans, D.A.1
  • 47
    • 24344446240 scopus 로고    scopus 로고
    • Cyr61 Protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells
    • 1:CAS:528:DC%2BD2MXhtVSkurjK 15961723 10.1165/rcmb.2005-0144OC
    • Jin Y, Kim HP, Ifedigbo E, Lau LF, Choi AM (2005) Cyr61 Protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. Am J Respir Cell Mol Biol 33:297-302
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 297-302
    • Jin, Y.1    Kim, H.P.2    Ifedigbo, E.3    Lau, L.F.4    Choi, A.M.5
  • 48
    • 82455198983 scopus 로고    scopus 로고
    • Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
    • 1:CAS:528:DC%2BC3MXhsFGkur7O 3663145 22129992 10.1038/nrd3599
    • Jun JI, Lau LF (2011) Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov 10:945-963
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 945-963
    • Jun, J.I.1    Lau, L.F.2
  • 49
    • 84857154364 scopus 로고    scopus 로고
    • TNFalpha-induced apoptosis enabled by CCN1/CYR61: Pathways of reactive oxygen species generation and cytochrome c release
    • 1:CAS:528:DC%2BC38Xjt1Snur8%3D 3281933 22363611 10.1371/journal.pone. 0031303
    • Juric V, Chen CC, Lau LF (2012) TNFalpha-induced apoptosis enabled by CCN1/CYR61: Pathways of reactive oxygen species generation and cytochrome c release. PLoS One 7:e31303
    • (2012) PLoS One , vol.7 , pp. 31303
    • Juric, V.1    Chen, C.C.2    Lau, L.F.3
  • 51
    • 84878975251 scopus 로고    scopus 로고
    • The Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts
    • Kim KH, Chen CC, Monzon RI, Lau LF (2013). The Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Mol Cell Biol.
    • (2013) Mol Cell Biol.
    • Kim, K.H.1    Chen, C.C.2    Monzon, R.I.3    Lau, L.F.4
  • 52
    • 33847076868 scopus 로고    scopus 로고
    • Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: Possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor
    • 1:CAS:528:DC%2BD2sXhtVWltL0%3D 17192487 10.2337/db06-0581
    • Kita T, Hata Y, Kano K, Miura M, Nakao S, Noda Y, Shimokawa H, Ishibashi T (2007) Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: Possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor. Diabetes 56:231-238
    • (2007) Diabetes , vol.56 , pp. 231-238
    • Kita, T.1    Hata, Y.2    Kano, K.3    Miura, M.4    Nakao, S.5    Noda, Y.6    Shimokawa, H.7    Ishibashi, T.8
  • 55
    • 62349090894 scopus 로고    scopus 로고
    • Primary open-angle glaucoma
    • 1:CAS:528:DC%2BD1MXjtFygtrc%3D 3700399 19279343 10.1056/NEJMra0804630
    • Kwon YH, Fingert JH, Kuehn MH, Alward WL (2009) Primary open-angle glaucoma. N Engl J Med 360:1113-1124
    • (2009) N Engl J Med , vol.360 , pp. 1113-1124
    • Kwon, Y.H.1    Fingert, J.H.2    Kuehn, M.H.3    Alward, W.L.4
  • 56
    • 33845906843 scopus 로고    scopus 로고
    • All in the CCN family: Essential matricellular signaling modulators emerge from the bunker
    • 1:CAS:528:DC%2BD2sXivFejsw%3D%3D 17130294 10.1242/jcs.03270
    • Leask A, Abraham DJ (2006) All in the CCN family: Essential matricellular signaling modulators emerge from the bunker. J Cell Sci 119:4803-4810
    • (2006) J Cell Sci , vol.119 , pp. 4803-4810
    • Leask, A.1    Abraham, D.J.2
  • 57
    • 33847020702 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia
    • 1:CAS:528:DC%2BD2sXhsF2rsrw%3D 17234971 10.1161/01.RES.0000257945.97958. 77
    • Lee HY, Chung JW, Youn SW, Kim JY, Park KW, Koo BK, Oh BH, Park YB, Chaqour B, Walsh K, Kim HS (2007) Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res 100:372-380
    • (2007) Circ Res , vol.100 , pp. 372-380
    • Lee, H.Y.1    Chung, J.W.2    Youn, S.W.3    Kim, J.Y.4    Park, K.W.5    Koo, B.K.6    Oh, B.H.7    Park, Y.B.8    Chaqour, B.9    Walsh, K.10    Kim, H.S.11
  • 58
    • 84869014083 scopus 로고    scopus 로고
    • Hypoxia-induced oxidative stress in ischemic retinopathy
    • 3483772 23125893
    • Li SY, Fu ZJ, Lo AC (2012) Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev 2012:426769
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 426769
    • Li, S.Y.1    Fu, Z.J.2    Lo, A.C.3
  • 59
    • 0037697095 scopus 로고    scopus 로고
    • Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression
    • 1:CAS:528:DC%2BD3sXltlOjsrs%3D 12724323 10.1074/jbc.M301009200
    • Liang Y, Li C, Guzman VM, Evinger AJ III, Protzman CE, Krauss AH, Woodward DF (2003) Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression. J Biol Chem 278:27267-27277
    • (2003) J Biol Chem , vol.278 , pp. 27267-27277
    • Liang, Y.1    Li, C.2    Guzman, V.M.3    Evinger III, A.J.4    Protzman, C.E.5    Krauss, A.H.6    Woodward, D.F.7
  • 60
    • 41549100146 scopus 로고    scopus 로고
    • Cysteine-rich protein 61 and connective tissue growth factor induce deadhesion and anoikis of retinal pericytes
    • 1:CAS:528:DC%2BD1cXktVeqsrs%3D 18187544 10.1210/en.2007-1415
    • Liu H, Yang R, Tinner B, Choudhry A, Schutze N, Chaqour B (2008) Cysteine-rich protein 61 and connective tissue growth factor induce deadhesion and anoikis of retinal pericytes. Endocrinology 149:1666-1677
    • (2008) Endocrinology , vol.149 , pp. 1666-1677
    • Liu, H.1    Yang, R.2    Tinner, B.3    Choudhry, A.4    Schutze, N.5    Chaqour, B.6
  • 63
    • 73549119945 scopus 로고    scopus 로고
    • Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it?
    • 2721079 19214781 10.1007/s12079-009-0038-6
    • Mason RM (2009) Connective tissue growth factor(CCN2), a pathogenic factor in diabetic nephropathy. What does it do? How does it do it? J Cell Commun Signal 3:95-104
    • (2009) J Cell Commun Signal , vol.3 , pp. 95-104
    • Mason, R.M.1
  • 64
    • 84868665052 scopus 로고    scopus 로고
    • Treatment of retinopathy of prematurity with vascular endothelial growth factor inhibitors
    • 1:CAS:528:DC%2BC38XhsFSltb3M 23078830 10.1016/j.earlhumdev.2012.09.019
    • Mintz-Hittner HA (2012) Treatment of retinopathy of prematurity with vascular endothelial growth factor inhibitors. Early Hum Dev 88:937-941
    • (2012) Early Hum Dev , vol.88 , pp. 937-941
    • Mintz-Hittner, H.A.1
  • 65
    • 33750480252 scopus 로고    scopus 로고
    • The matricellular protein CCN1 is essential for cardiac development
    • 1:CAS:528:DC%2BD28XhtFSlur%2FP 1626492 17023674 10.1161/01.RES. 0000248426.35019.89
    • Mo FE, Lau LF (2006) The matricellular protein CCN1 is essential for cardiac development. Circ Res 99:961-969
    • (2006) Circ Res , vol.99 , pp. 961-969
    • Mo, F.E.1    Lau, L.F.2
  • 66
    • 0036892032 scopus 로고    scopus 로고
    • CYR61 (CCN1) Is essential for placental development and vascular integrity
    • 1:CAS:528:DC%2BD38XptlGrtr0%3D 139880 12446788 10.1128/MCB.22.24.8709- 8720.2002
    • Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF (2002) CYR61 (CCN1) Is essential for placental development and vascular integrity. Mol Cell Biol 22:8709-8720
    • (2002) Mol Cell Biol , vol.22 , pp. 8709-8720
    • Mo, F.E.1    Muntean, A.G.2    Chen, C.C.3    Stolz, D.B.4    Watkins, S.C.5    Lau, L.F.6
  • 67
    • 84857034583 scopus 로고    scopus 로고
    • The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner
    • 1:CAS:528:DC%2BC38Xit12hsLg%3D 22226979 10.1016/j.ydbio.2011.12.027
    • Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T, Kubota Y (2012) The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. Dev Biol 363:106-114
    • (2012) Dev Biol , vol.363 , pp. 106-114
    • Nakamura-Ishizu, A.1    Kurihara, T.2    Okuno, Y.3    Ozawa, Y.4    Kishi, K.5    Goda, N.6    Tsubota, K.7    Okano, H.8    Suda, T.9    Kubota, Y.10
  • 68
    • 84863836311 scopus 로고    scopus 로고
    • Choroidal neovascularization in pathological myopia
    • 1:CAS:528:DC%2BC38XhtVGntLjP 22569156 10.1016/j.preteyeres.2012.04.001
    • Neelam K, Cheung CM, Ohno-Matsui K, Lai TY, Wong TY (2012) Choroidal neovascularization in pathological myopia. Prog Retin Eye Res 31:495-525
    • (2012) Prog Retin Eye Res , vol.31 , pp. 495-525
    • Neelam, K.1    Cheung, C.M.2    Ohno-Matsui, K.3    Lai, T.Y.4    Wong, T.Y.5
  • 69
    • 84880328113 scopus 로고    scopus 로고
    • CCN proteins: A centralized communication network
    • 10.1007/s12079-013-0193-7
    • Perbal B (2013) CCN proteins: A centralized communication network. J Cell Commun Signal. doi: 10.1007/s12079-013-0193-7
    • (2013) J Cell Commun Signal
    • Perbal, B.1
  • 70
  • 71
    • 33748077425 scopus 로고    scopus 로고
    • Nuclear addressing provides a clue for the transforming activity of amino-truncated CCN3 proteins
    • 1:CAS:528:DC%2BD28XovVKqsLY%3D 16598765 10.1002/jcb.20887
    • Planque N, Long LC, Saule S, Bleau AM, Perbal B (2006) Nuclear addressing provides a clue for the transforming activity of amino-truncated CCN3 proteins. J Cell Biochem 99:105-116
    • (2006) J Cell Biochem , vol.99 , pp. 105-116
    • Planque, N.1    Long, L.C.2    Saule, S.3    Bleau, A.M.4    Perbal, B.5
  • 72
    • 0034824634 scopus 로고    scopus 로고
    • Development of the primate retinal vasculature
    • 1:STN:280:DC%2BD3MrktFChsg%3D%3D 11587918 10.1016/S1350-9462(01)00012-X
    • Provis JM (2001) Development of the primate retinal vasculature. Prog Retin Eye Res 20:799-821
    • (2001) Prog Retin Eye Res , vol.20 , pp. 799-821
    • Provis, J.M.1
  • 73
    • 79954621581 scopus 로고    scopus 로고
    • Glaucoma
    • 21453963 10.1016/S0140-6736(10)61423-7
    • Quigley HA (2011) Glaucoma. Lancet 377:1367-1377
    • (2011) Lancet , vol.377 , pp. 1367-1377
    • Quigley, H.A.1
  • 74
    • 11144348973 scopus 로고    scopus 로고
    • Development and pathology of the hyaloid, choroidal and retinal vasculature
    • 15558494 10.1387/ijdb.041895ms
    • Saint-Geniez M, D'Amore PA (2004) Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol 48:1045-1058
    • (2004) Int J Dev Biol , vol.48 , pp. 1045-1058
    • Saint-Geniez, M.1    D'Amore, P.A.2
  • 75
    • 0037097845 scopus 로고    scopus 로고
    • Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): Immediate-early gene products expressed in atherosclerotic lesions
    • 1:CAS:528:DC%2BD38XksFGks7w%3D 12036876 10.1182/blood.V99.12.4457
    • Schober JM, Chen N, Grzeszkiewicz TM, Jovanovic I, Emeson EE, Ugarova TP, Ye RD, Lau LF, Lam SC (2002) Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 99:4457-4465
    • (2002) Blood , vol.99 , pp. 4457-4465
    • Schober, J.M.1    Chen, N.2    Grzeszkiewicz, T.M.3    Jovanovic, I.4    Emeson, E.E.5    Ugarova, T.P.6    Ye, R.D.7    Lau, L.F.8    Lam, S.C.9
  • 76
    • 1842556467 scopus 로고    scopus 로고
    • Current management of glaucoma
    • 15021223 10.1097/00055735-200404000-00011
    • Schwartz K, Budenz D (2004) Current management of glaucoma. Curr Opin Ophthalmol 15:119-126
    • (2004) Curr Opin Ophthalmol , vol.15 , pp. 119-126
    • Schwartz, K.1    Budenz, D.2
  • 77
    • 0035798710 scopus 로고    scopus 로고
    • The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor
    • 1:CAS:528:DC%2BD3MXosVKhtb4%3D 11518710 10.1074/jbc.M105180200
    • Segarini PR, Nesbitt JE, Li D, Hays LG, Yates JR III, Carmichael DF (2001) The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor. J Biol Chem 276:40659-40667
    • (2001) J Biol Chem , vol.276 , pp. 40659-40667
    • Segarini, P.R.1    Nesbitt, J.E.2    Li, D.3    Hays, L.G.4    Yates III, J.R.5    Carmichael, D.F.6
  • 78
    • 0032817965 scopus 로고    scopus 로고
    • Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo
    • 1:CAS:528:DyaK1MXmtlagtLo%3D 10393331 10.1093/oxfordjournals.jbchem. a022414
    • Shimo T, Nakanishi T, Nishida T, Asano M, Kanyama M, Kuboki T, Tamatani T, Tezuka K, Takemura M, Matsumura T, Takigawa M (1999) Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. J Biochem 126:137-145
    • (1999) J Biochem , vol.126 , pp. 137-145
    • Shimo, T.1    Nakanishi, T.2    Nishida, T.3    Asano, M.4    Kanyama, M.5    Kuboki, T.6    Tamatani, T.7    Tezuka, K.8    Takemura, M.9    Matsumura, T.10    Takigawa, M.11
  • 80
    • 33645816535 scopus 로고    scopus 로고
    • CCN1/Cyr61 Is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells
    • 1:CAS:528:DC%2BD28Xjs1SlsbY%3D 1446962 16581771 10.1128/MCB.26.8.2955- 2964.2006
    • Si W, Kang Q, Luu HH, Park JK, Luo Q, Song WX, Jiang W, Luo X, Li X, Yin H, Montag AG, Haydon RC, He TC (2006) CCN1/Cyr61 Is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol 26:2955-2964
    • (2006) Mol Cell Biol , vol.26 , pp. 2955-2964
    • Si, W.1    Kang, Q.2    Luu, H.H.3    Park, J.K.4    Luo, Q.5    Song, W.X.6    Jiang, W.7    Luo, X.8    Li, X.9    Yin, H.10    Montag, A.G.11    Haydon, R.C.12    He, T.C.13
  • 81
    • 34250747675 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome
    • 1:STN:280:DC%2BD2Mnltl2lug%3D%3D 16334858
    • Stalmans I (2005) Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome. Verh K Acad Geneeskd Belg 67:229-276
    • (2005) Verh K Acad Geneeskd Belg , vol.67 , pp. 229-276
    • Stalmans, I.1
  • 82
    • 64249131959 scopus 로고    scopus 로고
    • The trabecular meshwork outflow pathways: Structural and functional aspects
    • 1:CAS:528:DC%2BD1MXkslyhtL8%3D 19239914 10.1016/j.exer.2009.02.007
    • Tamm ER (2009) The trabecular meshwork outflow pathways: Structural and functional aspects. Exp Eye Res 88:648-655
    • (2009) Exp Eye Res , vol.88 , pp. 648-655
    • Tamm, E.R.1
  • 83
    • 0035204293 scopus 로고    scopus 로고
    • Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways
    • 1:CAS:528:DC%2BD3MXos1aiu78%3D 11600415
    • Tamura I, Rosenbloom J, Macarak E, Chaqour B (2001) Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways. Am J Physiol Cell Physiol 281:C1524-C1532
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Tamura, I.1    Rosenbloom, J.2    MacArak, E.3    Chaqour, B.4
  • 84
    • 0035047352 scopus 로고    scopus 로고
    • Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: A potential mechanism for expansion of extracellular matrix in diabetes mellitus
    • 1:CAS:528:DC%2BD3MXjt1akt7o%3D 11316739 10.1210/en.142.5.1760
    • Twigg SM, Chen MM, Joly AH, Chakrapani SD, Tsubaki J, Kim HS, Oh Y, Rosenfeld RG (2001) Advanced glycosylation end products up-regulate connective tissue growth factor (insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: A potential mechanism for expansion of extracellular matrix in diabetes mellitus. Endocrinology 142:1760-1769
    • (2001) Endocrinology , vol.142 , pp. 1760-1769
    • Twigg, S.M.1    Chen, M.M.2    Joly, A.H.3    Chakrapani, S.D.4    Tsubaki, J.5    Kim, H.S.6    Oh, Y.7    Rosenfeld, R.G.8
  • 85
    • 84874929596 scopus 로고    scopus 로고
    • Vitreous TIMP-1 levels associate with neovascularization and TGF-beta2 levels but not with fibrosis in the clinical course of proliferative diabetic retinopathy
    • 3590360 23054594 10.1007/s12079-012-0178-y
    • Van Geest RJ, Klaassen I, Lesnik-Oberstein SY, Tan HS, Mura M, Goldschmeding R, Van Noorden CJ, Schlingemann RO (2013) Vitreous TIMP-1 levels associate with neovascularization and TGF-beta2 levels but not with fibrosis in the clinical course of proliferative diabetic retinopathy. J Cell Commun Signal 7:1-9
    • (2013) J Cell Commun Signal , vol.7 , pp. 1-9
    • Van Geest, R.J.1    Klaassen, I.2    Lesnik-Oberstein, S.Y.3    Tan, H.S.4    Mura, M.5    Goldschmeding, R.6    Van Noorden, C.J.7    Schlingemann, R.O.8
  • 86
    • 33645780908 scopus 로고    scopus 로고
    • Mechanotransduction involving multimodular proteins: Converting force into biochemical signals
    • 1:CAS:528:DC%2BD28XmtFSksrw%3D 16689645 10.1146/annurev.biophys.35. 040405.102013
    • Vogel V (2006) Mechanotransduction involving multimodular proteins: Converting force into biochemical signals. Annu Rev Biophys Biomol Struct 35:459-488
    • (2006) Annu Rev Biophys Biomol Struct , vol.35 , pp. 459-488
    • Vogel, V.1
  • 87
    • 0035476393 scopus 로고    scopus 로고
    • Uptake and intracellular transport of the connective tissue growth factor: A potential mode of action
    • 1:STN:280:DC%2BD3MrhslWrsA%3D%3D 1222124 11563972 10.1042/0264-6021: 3590089
    • Wahab NA, Brinkman H, Mason RM (2001) Uptake and intracellular transport of the connective tissue growth factor: A potential mode of action. Biochem J 359:89-97
    • (2001) Biochem J , vol.359 , pp. 89-97
    • Wahab, N.A.1    Brinkman, H.2    Mason, R.M.3
  • 88
    • 37549046071 scopus 로고    scopus 로고
    • The Wnt signaling pathway in familial exudative vitreoretinopathy and norrie disease
    • 18097984 10.1080/08820530701745124
    • Warden SM, Andreoli CM, Mukai S (2007) The Wnt signaling pathway in familial exudative vitreoretinopathy and norrie disease. Semin Ophthalmol 22:211-217
    • (2007) Semin Ophthalmol , vol.22 , pp. 211-217
    • Warden, S.M.1    Andreoli, C.M.2    Mukai, S.3
  • 89
    • 26844504985 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor and its potential role in choroidal neovascularization
    • 16205572 10.1097/00006982-200510000-00015
    • Watanabe D, Takagi H, Suzuma K, Oh H, Ohashi H, Honda Y (2005) Expression of connective tissue growth factor and its potential role in choroidal neovascularization. Retina 25:911-918
    • (2005) Retina , vol.25 , pp. 911-918
    • Watanabe, D.1    Takagi, H.2    Suzuma, K.3    Oh, H.4    Ohashi, H.5    Honda, Y.6
  • 90
    • 79952546425 scopus 로고    scopus 로고
    • Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1
    • 1:CAS:528:DC%2BC3MXjtVSitro%3D 21308731 10.1002/jcb.23015
    • Workman G, Sage EH (2011) Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1. J Cell Biochem 112:1003-1008
    • (2011) J Cell Biochem , vol.112 , pp. 1003-1008
    • Workman, G.1    Sage, E.H.2
  • 91
    • 34249002311 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 expression and apoptogenic activity in retinal pericytes: Implications in diabetic retinopathy
    • 1:CAS:528:DC%2BD2sXmt12rtbY%3D 17332085 10.1196/annals.1394.000
    • Yang R, Liu H, Williams I, Chaqour B (2007) Matrix metalloproteinase-2 expression and apoptogenic activity in retinal pericytes: Implications in diabetic retinopathy. Ann N Y Acad Sci 1103:196-201
    • (2007) Ann N y Acad Sci , vol.1103 , pp. 196-201
    • Yang, R.1    Liu, H.2    Williams, I.3    Chaqour, B.4


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