A mouse strain where basal connective tissue growth factor gene expression can be switched from low to high

PLoS ONE

Volumn 5, Issue 9, 2010, Pages 1-14

  Doherty, Heather E ^a,b   Kim, Hyung Suk ^b   Hiller, Sylvia ^b   Sulik, Kathleen K ^a,b   Maeda, Nobuyo ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; PROTEIN C FOS; TAMOXIFEN; GROWTH HORMONE; PEPTIDE FRAGMENT; SOMATOTROPIN FRAGMENT 96 133; SOMATOTROPIN FRAGMENT 96-133;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRANIOFACIAL MALFORMATION; CTGF LO HI MUTANT MOUSE; DEVELOPMENT; DEVELOPMENTAL DISORDER; EMBRYO; EMBRYO DEATH; EXTRACELLULAR MATRIX; FEMALE; FIBROSIS; GENE CASSETTE; GENE CONSTRUCT; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ENGINEERING; GENETIC VARIABILITY; IN VIVO STUDY; MALE; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; ONCOGENE C FOS; ORGAN INJURY; OSTEOSARCOMA; PERINATAL PERIOD; PROTEIN EXPRESSION; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CATTLE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PRENATAL DEVELOPMENT; PROMOTER REGION;

BOVINAE; MUS;

ANIMALS; CATTLE; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GROWTH HORMONE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SPECIFICITY; PEPTIDE FRAGMENTS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-FOS;

EID: 77958492749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012909     Document Type: Article

References (55)

1. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, et al. (2006) Heart disease and stroke statistics-2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113: e85-151.
2. González A, López B, Díez J (2002) Myocardial fibrosis in arterial hypertension. European Heart Journal Supplements 4: D18-D22.
3. Sun Y, Weber KT (2000) Infarct scar: a dynamic tissue. Cardiovasc Res 46: 250-256.
4. Sun Y, Zhang JQ, Zhang J, Lamparter S (2000) Cardiac remodeling by fibrous tissue after infarction in rats. J Lab Clin Med 135: 316-323.
5. Sun Y, Zhang JQ, Zhang J, Ramires FJ (1998) Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heart. J Mol Cell Cardiol 30: 1559-1569.
6. Gordois A, Scuffham P, Shearer A, Oglesby A (2004) The health care costs of diabetic nephropathy in the United States and the United Kingdom. J Diabetes Complications 18: 18-26.
7. Williams EJ, Iredale JP (1998) Liver cirrhosis. Postgrad Med J 74: 193-202.
8. Leask A, Abraham DJ (2003) The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology. Biochem Cell Biol 81: 355-363.
9. Ryseck RP, Macdonald-Bravo H, Mattei MG, Bravo R (1991) Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ 2: 225-233.
10. Surveyor GA, Brigstock DR (1999) Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation. Growth Factors 17: 115-124.
11. Leask A, Abraham DJ (2006) All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci 119: 4803-4810.
12. Shi-Wen X, Leask A, Abraham D (2008) Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev 19: 133-144.
13. Riser BL, Cortes P, DeNichilo M, Deshmukh PV, Chahal PS, et al. (2003) Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary report. Kidney Int 64: 451-458.
14. Yang DH, Kim HS, Wilson EM, Rosenfeld RG, Oh Y (1998) Identification of glycosylated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF-beta in Hs578T human breast cancer cells. J Clin Endocrinol Metab 83: 2593-2596.
15. Blom IE, Goldschmeding R, Leask A (2002) Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 21: 473-482.
16. Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, et al. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130: 2779-2791.
17. Nakanishi T, Yamaai T, Asano M, Nawachi K, Suzuki M, et al. (2001) Overexpression of connective tissue growth factor/hypertrophic chondrocytespecific gene product 24 decreases bone density in adult mice and induces dwarfism. Biochem Biophys Res Commun 281: 678-681.
18. Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Canalis E (2008) Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Endocrinology 149: 4374-4381.
19. Panek AN, Posch MG, Alenina N, Ghadge SK, Erdmann B, et al. (2009) Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload. PLoS One 4: e6743.
20. Yokoi H, Mukoyama M, Mori K, Kasahara M, Suganami T, et al. (2008) Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice. Kidney Int 73: 446-455.
21. Tong Z, Chen R, Alt DS, Kemper S, Perbal B, et al. (2009) Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes. Hepatology 50: 939-947.
22. Wu S, Platteau A, Chen S, McNamara G, Whitsett J, et al. Conditional overexpression of connective tissue growth factor disrupts postnatal lung development. Am J Respir Cell Mol Biol 42: 552-563.
23. Sonnylal S, Shi-Wen X, Leoni P, Naff K, Van Pelt CS, et al. Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum 62: 1523-1532.
24. Kakoki M, Tsai YS, Kim HS, Hatada S, Ciavatta DJ, et al. (2004) Altering the expression in mice of genes by modifying their 39 regions. Dev Cell 6: 597-606.
25. Makhanova N, Hagaman J, Kim HS, Smithies O (2008) Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension 51: 134-140.
26. Tsai YS, Tsai PJ, Jiang MJ, Chou TY, Pendse A, et al. (2009) Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. Mol Endocrinol 23: 1787-1798.
27. Tsai YS, Xu L, Smithies O, Maeda N (2009) Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure. Proc Natl Acad Sci U S A 106: 19084-19089.
28. Hayashi S, McMahon AP (2002) Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244: 305-318.
29. Cheng O, Thuillier R, Sampson E, Schultz G, Ruiz P, et al. (2006) Connective tissue growth factor is a biomarker and mediator of kidney allograft fibrosis. Am J Transplant 6: 2292-2306.
30. Kovalenko E, Tacke F, Gressner OA, Zimmermann HW, Lahme B, et al. (2009) Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. J Viral Hepat 16: 612-620.
31. Kwon S, Munroe X, Crawley SC, Lee HY, Spong S, et al. (2007) Expression of connective tissue growth factor in pancreatic cancer cell lines. Int J Oncol 31: 693-703.
32. Tikellis C, Cooper ME, Twigg SM, Burns WC, Tolcos M (2004) Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition. Endocrinology 145: 860-866.
33. Jacobsson C, Granstrom G (1997) Clinical appearance of spontaneous and induced first and second branchial arch syndromes. Scand J Plast Reconstr Surg Hand Surg 31: 125-136.
34. Gupta AK, Kumar S, Jain A (2008) Bilateral first and second branchial cleft fistulas: a case report. Ear Nose Throat J 87: 291-293.
35. Chai Y, Maxson RE Jr (2006) Recent advances in craniofacial morphogenesis. Dev Dyn 235: 2353-2375.
36. Sanford LP, Ormsby I, Gittenberger-de Groot AC, Sariola H, Friedman R, et al. (1997) TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124: 2659-2670.
37. Tucker RP (2004) Neural crest cells: a model for invasive behavior. Int J Biochem Cell Biol 36: 173-177.
38. Igarashi A, Okochi H, Bradham DM, Grotendorst GR (1993) Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell 4: 637-645.
39. Ren S, Babelova A, Moreth K, Xin C, Eberhardt W, et al. (2009) Transforming growth factor-beta2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-beta2 by impeding CTGF expression. Kidney Int 76: 857-867.
40. Walls JR, Coultas L, Rossant J, Henkelman RM (2008) Three-dimensional analysis of vascular development in the mouse embryo. PLoS One 3: e2853.
41. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, et al. (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380: 435-439.
42. Suzuma K, Naruse K, Suzuma I, Takahara N, Ueki K, et al. (2000) Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem 275: 40725-40731.
43. Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, et al. (2002) Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J 16: 219-221.
44. Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH (1996) Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A 93: 12355-12358.
45. Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (2001) Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell 105: 863-875.
46. Wakimoto K, Kobayashi K, Kuro OM, Yao A, Iwamoto T, et al. (2000) Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. J Biol Chem 275: 36991-36998.
47. Holzenberger M, Lenzner C, Leneuve P, Zaoui R, Hamard G, et al. (2000) Cremediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene. Nucleic Acids Res 28: E92.
48. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, et al. (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93: 5860-5865.
49. Heffner C (2010) Strain Name: FVB/N-Tg(EIIa-cre)C5379Lmgd/J. Bar Harbor, ME: Jackson Laboratories.
50. Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, et al. (1999) Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. J Cell Physiol 181: 153-159.
51. Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A 89: 4471-4475.
52. Leamy LJ, Elo K, Nielsen MK, Dale Van Vleck L, Pomp D (2005) Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice. Genet Sel Evol 37: 151-173.
53. Brocard J, Warot X, Wendling O, Messaddeq N, Vonesch JL, et al. (1997) Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. Proc Natl Acad Sci U S A 94: 14559-14563.
54. Metzger D, Clifford J, Chiba H, Chambon P (1995) Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase. Proc Natl Acad Sci U S A 92: 6991-6995.
55. Sulik KK, Johnston MC (1982) Embryonic origin of holoprosencephaly: interrelationship of the developing brain and face. Scan Electron Microsc: 309-322.