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Volumn 55, Issue 1, 2014, Pages 62-74

Whole body synthesis rates of DHA from -linolenic acid are greater than brain DHA accretion and uptake rates in adult rats

Author keywords

A linolenic acid; Brain; Conversion; Docosahexaenoic acid; Kinetics; Liver; Synthesis

Indexed keywords

DOCOSAHEXAENOIC ACID; LINOLENIC ACID; OMEGA 3 FATTY ACID;

EID: 84891367872     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M042275     Document Type: Article
Times cited : (80)

References (57)
  • 1
    • 79955455705 scopus 로고    scopus 로고
    • Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century
    • Blasbalg, T. L., J. R. Hibbeln, C. E. Ramsden, S. F. Majchrzak, and R. R. Rawlings . 2011 . Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am. J. Clin. Nutr. 93 : 950-962 .
    • (2011) Am. J. Clin. Nutr , vol.93 , pp. 950-962
    • Blasbalg, T.L.1    Hibbeln, J.R.2    Ramsden, C.E.3    Majchrzak, S.F.4    Rawlings, R.R.5
  • 3
    • 30844456607 scopus 로고    scopus 로고
    • One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats
    • DeMar, J. C., Jr ., K. Ma, J. M. Bell, M. Igarashi, D. Greenstein, and S. I. Rapoport . 2006 . One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats. J. Lipid Res. 47 : 172-180 .
    • (2006) J. Lipid Res , vol.47 , pp. 172-180
    • DeMar Jr., J.C.1    Ma, K.2    Bell, J.M.3    Igarashi, M.4    Greenstein, D.5    Rapoport, S.I.6
  • 7
    • 70350059182 scopus 로고    scopus 로고
    • Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefi ts for human health and a role in maintaining tissue n-3 fatty acid levels
    • Barceló-Coblijn, G., and E. J. Murphy . 2009 . Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefi ts for human health and a role in maintaining tissue n-3 fatty acid levels. Prog. Lipid Res. 48 : 355-374 .
    • (2009) Prog. Lipid Res , vol.48 , pp. 355-374
    • Barceló-Coblijn, G.1    Murphy, E.J.2
  • 8
    • 0042062317 scopus 로고    scopus 로고
    • Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C] alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men
    • Burdge, G. C., Y. E. Finnegan, A. M. Minihane, C. M. Williams, and S. A. Wootton . 2003 . Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C] alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. Br. J. Nutr. 90 : 311-321 .
    • (2003) Br. J. Nutr , vol.90 , pp. 311-321
    • Burdge, G.C.1    Finnegan, Y.E.2    Minihane, A.M.3    Williams, C.M.4    Wootton, S.A.5
  • 9
    • 0036774711 scopus 로고    scopus 로고
    • Eicosapentaenoic and docosapentaenoic acids are the principal products of alphalinolenic acid metabolism in young men
    • Burdge, G. C., A. E. Jones, and S. A. Wootton . 2002 . Eicosapentaenoic and docosapentaenoic acids are the principal products of alphalinolenic acid metabolism in young men. Br. J. Nutr. 88 : 355-363 .
    • (2002) Br. J. Nutr , vol.88 , pp. 355-363
    • Burdge, G.C.1    Jones, A.E.2    Wootton, S.A.3
  • 10
    • 0036774671 scopus 로고    scopus 로고
    • Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women
    • Burdge, G. C., and S. A. Wootton . 2002 . Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br. J. Nutr. 88 : 411-420 .
    • (2002) Br. J. Nutr , vol.88 , pp. 411-420
    • Burdge, G.C.1    Wootton, S.A.2
  • 11
    • 0032870832 scopus 로고    scopus 로고
    • Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope-labeled oleic, linoleic, and linolenic acids by male subjects
    • Emken, E. A., R. O. Adlof, S. M. Duval, and G. J. Nelson . 1999 . Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope-labeled oleic, linoleic, and linolenic acids by male subjects. Lipids . 34 : 785-791 .
    • (1999) Lipids , vol.34 , pp. 785-791
    • Emken, E.A.1    Adlof, R.O.2    Duval, S.M.3    Nelson, G.J.4
  • 12
    • 0028068555 scopus 로고
    • Dietary linoleic acid infl uences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males
    • Emken, E. A., R. O. Adlof, and R. M. Gulley . 1994 . Dietary linoleic acid infl uences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochim. Biophys. Acta . 1213 : 277-288 .
    • (1994) Biochim. Biophys. Acta , vol.1213 , pp. 277-288
    • Emken, E.A.1    Adlof, R.O.2    Gulley, R.M.3
  • 13
    • 13944270939 scopus 로고    scopus 로고
    • Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men
    • Hussein, N., E. Ah-Sing, P. Wilkinson, C. Leach, B. A. Griffi n, and D. J. Millward . 2005 . Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. J. Lipid Res. 46 : 269-280 .
    • (2005) J. Lipid Res , vol.46 , pp. 269-280
    • Hussein, N.1    Ah-Sing, E.2    Wilkinson, P.3    Leach, C.4    Griffin, B.A.5    Millward, D.J.6
  • 14
    • 33646696917 scopus 로고    scopus 로고
    • Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula
    • Mayes, C., G. C. Burdge, A. Bingham, J. L. Murphy, R. Tubman, and S. A. Wootton . 2006 . Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. Pediatr. Res. 59 : 271-275 .
    • (2006) Pediatr. Res , vol.59 , pp. 271-275
    • Mayes, C.1    Burdge, G.C.2    Bingham, A.3    Murphy, J.L.4    Tubman, R.5    Wootton, S.A.6
  • 15
    • 1542409270 scopus 로고    scopus 로고
    • A comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women
    • McCloy, U., M. A. Ryan, P. B. Pencharz, R. J. Ross, and S. C. Cunnane . 2004 . A comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women. J. Lipid Res. 45 : 474-485 .
    • (2004) J. Lipid Res , vol.45 , pp. 474-485
    • McCloy, U.1    Ryan, M.A.2    Pencharz, P.B.3    Ross, R.J.4    Cunnane, S.C.5
  • 17
    • 0034884757 scopus 로고    scopus 로고
    • Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans
    • Pawlosky, R. J., J. R. Hibbeln, J. A. Novotny, and N. Salem, Jr . 2001 . Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J. Lipid Res. 42 : 1257-1265 .
    • (2001) J. Lipid Res , vol.42 , pp. 1257-1265
    • Pawlosky, R.J.1    Hibbeln, J.R.2    Novotny, J.A.3    Salem Jr., N.4
  • 18
    • 78149265344 scopus 로고    scopus 로고
    • Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fi sh-eating and non-fi sh-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of - -linolenic acid to long-chain n-3 polyunsaturated fatty acids: Results from the EPIC-Norfolk cohort
    • Welch, A. A., S. Shakya-Shrestha, M. A. Lentjes, N. J. Wareham, and K. T. Khaw . 2010 . Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fi sh-eating and non-fi sh-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of - -linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. Am. J. Clin. Nutr. 92 : 1040-1051 .
    • (2010) Am. J. Clin. Nutr , vol.92 , pp. 1040-1051
    • Welch, A.A.1    Shakya-Shrestha, S.2    Lentjes, M.A.3    Wareham, N.J.4    Khaw, K.T.5
  • 19
    • 33749610980 scopus 로고    scopus 로고
    • Fatty acid composition of habitual omnivore and vegetarian diets
    • Mann, N., Y. Pirotta, S. O'Connell, D. Li, F. Kelly, and A. Sinclair . 2006 . Fatty acid composition of habitual omnivore and vegetarian diets. Lipids . 41 : 637-646 .
    • (2006) Lipids , vol.41 , pp. 637-646
    • Mann, N.1    Pirotta, Y.2    O'connell, S.3    Li, D.4    Kelly, F.5    Sinclair, A.6
  • 20
    • 77952827955 scopus 로고    scopus 로고
    • Vegetarian diets are associated with healthy mood states: A cross-sectional study in seventh day adventist adults
    • Beezhold, B. L., C. S. Johnston, and D. R. Daigle . 2010 . Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. Nutr. J. 9 : 26 .
    • (2010) Nutr. J , vol.9 , pp. 26
    • Beezhold, B.L.1    Johnston, C.S.2    Daigle, D.R.3
  • 21
    • 0034837314 scopus 로고    scopus 로고
    • Does a vegan diet reduce risk for Parkinson's disease?
    • McCarty, M. F. 2001 . Does a vegan diet reduce risk for Parkinson's disease? Med. Hypotheses . 57 : 318-323 .
    • (2001) Med. Hypotheses , vol.57 , pp. 318-323
    • McCarty, M.F.1
  • 22
    • 0033065886 scopus 로고    scopus 로고
    • Comparison of bolus versus fractionated oral applications of [13C]- linoleic acid in humans
    • Demmelmair, H., B. Iser, A. Rauh-Pfeiffer, and B. Koletzko . 1999 . Comparison of bolus versus fractionated oral applications of [13C]- linoleic acid in humans. Eur. J. Clin. Invest. 29 : 603-609 .
    • (1999) Eur. J. Clin. Invest , vol.29 , pp. 603-609
    • Demmelmair, H.1    Iser, B.2    Rauh-Pfeiffer, A.3    Koletzko, B.4
  • 24
    • 67449127220 scopus 로고    scopus 로고
    • Whole-body synthesis-secretion rates of longchain n-3 PUFAs from circulating unesterifi ed alpha-linolenic acid in unanesthetized rats
    • Gao, F., D. Kiesewetter, L. Chang, K. Ma, J. M. Bell, S. I. Rapoport, and M. Igarashi . 2009 . Whole-body synthesis-secretion rates of longchain n-3 PUFAs from circulating unesterifi ed alpha-linolenic acid in unanesthetized rats. J. Lipid Res. 50 : 749-758 .
    • (2009) J. Lipid Res , vol.50 , pp. 749-758
    • Gao, F.1    Kiesewetter, D.2    Chang, L.3    Ma, K.4    Bell, J.M.5    Rapoport, S.I.6    Igarashi, M.7
  • 25
    • 0031026550 scopus 로고    scopus 로고
    • The majority of dietary linoleate in growing rats is beta-oxidized or stored in visceral fat
    • Cunnane, S. C., and M. J. Anderson . 1997 . The majority of dietary linoleate in growing rats is beta-oxidized or stored in visceral fat. J. Nutr. 127 : 146-152 .
    • (1997) J. Nutr , vol.127 , pp. 146-152
    • Cunnane, S.C.1    Anderson, M.J.2
  • 26
    • 0026463926 scopus 로고
    • A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: Review and critical analysis
    • Robinson, P. J., J. Noronha, J. J. DeGeorge, L. M. Freed, T. Nariai, and S. I. Rapoport . 1992 . A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res. Brain Res. Rev. 17 : 187-214 .
    • (1992) Brain Res. Brain Res. Rev , vol.17 , pp. 187-214
    • Robinson, P.J.1    Noronha, J.2    Degeorge, J.J.3    Freed, L.M.4    Nariai, T.5    Rapoport, S.I.6
  • 27
    • 9744284920 scopus 로고    scopus 로고
    • Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids
    • DeMar, J. C., Jr ., K. Ma, J. M. Bell, and S. I. Rapoport . 2004 . Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. J. Neurochem. 91 : 1125-1137 .
    • (2004) J. Neurochem , vol.91 , pp. 1125-1137
    • DeMar Jr., J.C.1    Ma, K.2    Bell, J.M.3    Rapoport, S.I.4
  • 28
    • 70449158340 scopus 로고
    • A simple method for the isolation and purifi cation of total lipides from animal tissues
    • Folch, J., M. Lees, and G. H. Sloane Stanley . 1957 . A simple method for the isolation and purifi cation of total lipides from animal tissues. J. Biol. Chem. 226 : 497-509 .
    • (1957) J. Biol. Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 30
    • 33846540379 scopus 로고    scopus 로고
    • Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex
    • Rao, J. S., R. N. Ertley, J. C. DeMar, Jr ., S. I. Rapoport, R. P. Bazinet, and H. J. Lee . 2007 . Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol. Psychiatry . 12 : 151-157 .
    • (2007) Mol. Psychiatry , vol.12 , pp. 151-157
    • Rao, J.S.1    Ertley, R.N.2    Demar Jr., J.C.3    Rapoport, S.I.4    Bazinet, R.P.5    Lee, H.J.6
  • 31
    • 33845775752 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPKdependent mechanism
    • Rao, J. S., R. N. Ertley, H. J. Lee, J. C. DeMar, Jr ., J. T. Arnold, S. I. Rapoport, and R. P. Bazinet . 2007 . n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPKdependent mechanism. Mol. Psychiatry . 12 : 36-46 .
    • (2007) Mol. Psychiatry , vol.12 , pp. 36-46
    • Rao, J.S.1    Ertley, R.N.2    Lee, H.J.3    Demar Jr., J.C.4    Arnold, J.T.5    Rapoport, S.I.6    Bazinet, R.P.7
  • 32
    • 34548431107 scopus 로고    scopus 로고
    • Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas
    • Kothapalli, K. S., J. C. Anthony, B. S. Pan, A. T. Hsieh, P. W. Nathanielsz, and J. T. Brenna . 2007 . Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PLoS ONE . 2 : e370 .
    • (2007) PLoS ONE , vol.2
    • Kothapalli, K.S.1    Anthony, J.C.2    Pan, B.S.3    Hsieh, A.T.4    Nathanielsz, P.W.5    Brenna, J.T.6
  • 34
    • 51649111510 scopus 로고    scopus 로고
    • Altered expression of key dopaminergic regulatory proteins in the postnatal brain following perinatal n-3 fatty acid dietary defi ciency
    • Kuperstein, F., R. Eilam, and E. Yavin . 2008 . Altered expression of key dopaminergic regulatory proteins in the postnatal brain following perinatal n-3 fatty acid dietary defi ciency. J. Neurochem. 106 : 662-671 .
    • (2008) J. Neurochem , vol.106 , pp. 662-671
    • Kuperstein, F.1    Eilam, R.2    Yavin, E.3
  • 35
    • 77953626742 scopus 로고    scopus 로고
    • Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats
    • Dyall, S. C., G. J. Michael, and A. T. Michael-Titus . 2010 . Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J. Neurosci. Res. 88 : 2091-2102 .
    • (2010) J. Neurosci. Res , vol.88 , pp. 2091-2102
    • Dyall, S.C.1    Michael, G.J.2    Michael-Titus, A.T.3
  • 36
    • 78651292670 scopus 로고    scopus 로고
    • Docosahexaenoic acid suppresses neuroinfl ammatory responses and induces heme oxygenase- 1 expression in BV-2 microglia: Implications of antidepressant effects for - -3 fatty acids
    • Lu, D. Y., Y. Y. Tsao, Y. M. Leung, and K. P. Su . 2010 . Docosahexaenoic acid suppresses neuroinfl ammatory responses and induces heme oxygenase- 1 expression in BV-2 microglia: implications of antidepressant effects for - -3 fatty acids . Neuropsychopharmacology . 35 : 2238-2248 .
    • (2010) Neuropsychopharmacology , vol.35 , pp. 2238-2248
    • Lu, D.Y.1    Tsao, Y.Y.2    Leung, Y.M.3    Su, K.P.4
  • 37
    • 79251595761 scopus 로고    scopus 로고
    • Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain
    • Kim, H. W., J. S. Rao, S. I. Rapoport, and M. Igarashi . 2011 . Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain. Biochim. Biophys. Acta . 1811 : 111-117 .
    • (2011) Biochim. Biophys. Acta , vol.1811 , pp. 111-117
    • Kim, H.W.1    Rao, J.S.2    Rapoport, S.I.3    Igarashi, M.4
  • 38
    • 77951975834 scopus 로고    scopus 로고
    • Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis
    • Rapoport, S. I., M. Igarashi, and F. Gao . 2010 . Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. Prostaglandins Leukot. Essent. Fatty Acids . 82 : 273-276 .
    • (2010) Prostaglandins Leukot. Essent. Fatty Acids , vol.82 , pp. 273-276
    • Rapoport, S.I.1    Igarashi, M.2    Gao, F.3
  • 40
    • 0021289035 scopus 로고
    • Stable isotope labelled 5-lipoxygenase metabolites of arachidonic acid: Analysis by negative ion chemical ionization mass spectrometry
    • Strife, R. J., and R. C. Murphy . 1984 . Stable isotope labelled 5-lipoxygenase metabolites of arachidonic acid: analysis by negative ion chemical ionization mass spectrometry. Prostaglandins Leukot. Med. 13 : 1-8 .
    • (1984) Prostaglandins Leukot. Med , vol.13 , pp. 1-8
    • Strife, R.J.1    Murphy, R.C.2
  • 41
    • 0026448076 scopus 로고
    • High sensitivity negative ion GC-MS method for detection of desaturated and chain-elongated products of deuterated linoleic and linolenic acids
    • Pawlosky, R. J., H. W. Sprecher, and N. Salem, Jr . 1992 . High sensitivity negative ion GC-MS method for detection of desaturated and chain-elongated products of deuterated linoleic and linolenic acids. J. Lipid Res. 33 : 1711-1717 .
    • (1992) J. Lipid Res , vol.33 , pp. 1711-1717
    • Pawlosky, R.J.1    Sprecher, H.W.2    Salem Jr., N.3
  • 42
    • 0021473919 scopus 로고
    • Comparison of body fl uid compartment sizes in Brattleboro homozygous and Long-Evans rats
    • Robinson, D. H., K. P. Conrad, and B. R. Edwards . 1984 . Comparison of body fl uid compartment sizes in Brattleboro homozygous and Long-Evans rats. Am. J. Physiol. 247 : F234-F239 .
    • (1984) Am. J. Physiol , vol.247
    • Robinson, D.H.1    Conrad, K.P.2    Edwards, B.R.3
  • 43
    • 79959373565 scopus 로고    scopus 로고
    • Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but alpha-LNA-containing n-3 PUFA adequate diet
    • Gao, F., H. W. Kim, M. Igarashi, D. Kiesewetter, L. Chang, K. Ma, and S. I. Rapoport . 2011 . Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but alpha-LNA-containing n-3 PUFA adequate diet. Biochim. Biophys. Acta . 1811 : 484-489 .
    • (2011) Biochim. Biophys. Acta , vol.1811 , pp. 484-489
    • Gao, F.1    Kim, H.W.2    Igarashi, M.3    Kiesewetter, D.4    Chang, L.5    Ma, K.6    Rapoport, S.I.7
  • 44
    • 84880548071 scopus 로고    scopus 로고
    • Aging decreases rate of docosahexaenoic acid synthesis- secretion from circulating unesterifi ed alpha-linolenic acid by rat liver
    • Gao, F., A. Y. Taha, K. Ma, L. Chang, D. Kiesewetter, and S. I. Rapoport . 2013 . Aging decreases rate of docosahexaenoic acid synthesis- secretion from circulating unesterifi ed alpha-linolenic acid by rat liver . Age (Dordr.) . 35 : 597-608 .
    • (2013) Age (Dordr.) , vol.35 , pp. 597-608
    • Gao, F.1    Taha, A.Y.2    Ma, K.3    Chang, L.4    Kiesewetter, D.5    Rapoport, S.I.6
  • 45
    • 0028178224 scopus 로고
    • Liver delta 5 and delta 6 desaturase activity differs among laboratory rat strains
    • de Antueno, R. J., M. Elliot, and D. F. Horrobin . 1994 . Liver delta 5 and delta 6 desaturase activity differs among laboratory rat strains. Lipids . 29 : 327-331 .
    • (1994) Lipids , vol.29 , pp. 327-331
    • De Antueno, R.J.1    Elliot, M.2    Horrobin, D.F.3
  • 46
    • 0033773192 scopus 로고    scopus 로고
    • Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain
    • Contreras, M. A., R. S. Greiner, M. C. Chang, C. S. Myers, N. Salem, Jr ., and S. I. Rapoport . 2000 . Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain. J. Neurochem. 75 : 2392-2400 .
    • (2000) J. Neurochem , vol.75 , pp. 2392-2400
    • Contreras, M.A.1    Greiner, R.S.2    Chang, M.C.3    Myers, C.S.4    Salem Jr., N.5    Rapoport, S.I.6
  • 47
    • 0032940177 scopus 로고    scopus 로고
    • Dynamics of docosahexaenoic acid metabolism in the central nervous system: Lack of effect of chronic lithium treatment
    • Chang, M. C., J. M. Bell, A. D. Purdon, E. G. Chikhale, and E. Grange . 1999 . Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment. Neurochem. Res. 24 : 399-406 .
    • (1999) Neurochem. Res , vol.24 , pp. 399-406
    • Chang, M.C.1    Bell, J.M.2    Purdon, A.D.3    Chikhale, E.G.4    Grange, E.5
  • 48
    • 77953288863 scopus 로고    scopus 로고
    • The fat-1 mouse has brain docosahexaenoic acid levels achievable through fi sh oil feeding
    • Orr, S. K., J. Y. Tong, J. X. Kang, D. W. Ma, and R. P. Bazinet . 2010 . The fat-1 mouse has brain docosahexaenoic acid levels achievable through fi sh oil feeding. Neurochem. Res. 35 : 811-819 .
    • (2010) Neurochem. Res , vol.35 , pp. 811-819
    • Orr, S.K.1    Tong, J.Y.2    Kang, J.X.3    Ma, D.W.4    Bazinet, R.P.5
  • 49
    • 0033055142 scopus 로고    scopus 로고
    • The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig
    • Abedin, L., E. L. Lien, A. J. Vingrys, and A. J. Sinclair . 1999 . The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig. Lipids . 34 : 475-482 .
    • (1999) Lipids , vol.34 , pp. 475-482
    • Abedin, L.1    Lien, E.L.2    Vingrys, A.J.3    Sinclair, A.J.4
  • 50
    • 35848960339 scopus 로고    scopus 로고
    • Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain
    • Igarashi, M., K. Ma, L. Chang, J. M. Bell, and S. I. Rapoport . 2007 . Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. J. Lipid Res. 48 : 2463-2470 .
    • (2007) J. Lipid Res , vol.48 , pp. 2463-2470
    • Igarashi, M.1    Ma, K.2    Chang, L.3    Bell, J.M.4    Rapoport, S.I.5
  • 51
    • 69549103671 scopus 로고    scopus 로고
    • Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA?
    • Rapoport, S. I., and M. Igarashi . 2009 . Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? Prostaglandins Leukot. Essent. Fatty Acids . 81 : 119-123 .
    • (2009) Prostaglandins Leukot. Essent. Fatty Acids , vol.81 , pp. 119-123
    • Rapoport, S.I.1    Igarashi, M.2
  • 52
    • 0034804695 scopus 로고    scopus 로고
    • Comparative bioavailability of dietary alpha-linolenic and docosahexaenoic acids in the growing rat
    • Poumes-Ballihaut, C., B. Langelier, F. Houlier, J. M. Alessandri, G. Durand, C. Latge, and P. Guesnet . 2001 . Comparative bioavailability of dietary alpha-linolenic and docosahexaenoic acids in the growing rat. Lipids . 36 : 793-800 .
    • (2001) Lipids , vol.36 , pp. 793-800
    • Poumes-Ballihaut, C.1    Langelier, B.2    Houlier, F.3    Alessandri, J.M.4    Durand, G.5    Latge, C.6    Guesnet, P.7
  • 53
    • 84871987938 scopus 로고    scopus 로고
    • Dietary oils and FADS1- FADS2 genetic variants modulate [13C]alpha-linolenic acid metabolism and plasma fatty acid composition
    • Gillingham, L. G., S. V. Harding, T. C. Rideout, N. Yurkova, S. C. Cunnane, P. K. Eck, and P. J. Jones . 2013 . Dietary oils and FADS1- FADS2 genetic variants modulate [13C]alpha-linolenic acid metabolism and plasma fatty acid composition. Am. J. Clin. Nutr. 97 : 195-207 .
    • (2013) Am. J. Clin. Nutr , vol.97 , pp. 195-207
    • Gillingham, L.G.1    Harding, S.V.2    Rideout, T.C.3    Yurkova, N.4    Cunnane, S.C.5    Eck, P.K.6    Jones, P.J.7
  • 54
    • 0028021727 scopus 로고
    • Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants
    • Makrides, M., M. A. Neumann, R. W. Byard, K. Simmer, and R. A. Gibson . 1994 . Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am. J. Clin. Nutr. 60 : 189-194 .
    • (1994) Am. J. Clin. Nutr , vol.60 , pp. 189-194
    • Makrides, M.1    Neumann, M.A.2    Byard, R.W.3    Simmer, K.4    Gibson, R.A.5
  • 55
    • 0008572648 scopus 로고
    • Effect of lipemia and heparin on free fatty acid concentration of serum in humans
    • Grossman, M. I., H. C. Moeller, and L. Palm . 1955 . Effect of lipemia and heparin on free fatty acid concentration of serum in humans. Proc. Soc. Exp. Biol. Med. 90 : 106-109 .
    • (1955) Proc. Soc. Exp. Biol. Med , vol.90 , pp. 106-109
    • Grossman, M.I.1    Moeller, H.C.2    Palm, L.3
  • 56
    • 84946379467 scopus 로고
    • Effect of lipemia and heparin on free fatty acid content of rat plasma
    • Grossman, M. I., L. Palm, G. H. Becker, and H. C. Moeller . 1954 . Effect of lipemia and heparin on free fatty acid content of rat plasma. Proc. Soc. Exp. Biol. Med. 87 : 312-315 .
    • (1954) Proc. Soc. Exp. Biol. Med , vol.87 , pp. 312-315
    • Grossman, M.I.1    Palm, L.2    Becker, G.H.3    Moeller, H.C.4


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