Dynamics of docosahexaenoic acid metabolism in the central nervous system: Lack of effect of chronic lithium treatment

Neurochemical Research

Volumn 24, Issue 3, 1999, Pages 399-406

  Chang, Michael C J ^a   Bell, Jane M ^a   Purdon, A David ^a   Chikhale, Elsbeth G ^a   Grange, Eric ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Acyl CoA; Arachidonate; Brain; Docosahexaenoate; Fatty acids; In vivo incorporation; Lithium; Palmitate; Phospholipase A2; Phospholipids; Rat; Signal transduction; Turnover

Indexed keywords

DOCOSAHEXAENOIC ACID; LITHIUM; PHOSPHOLIPASE A2;

ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ACYL COENZYME A; ANIMALS; ARACHIDONIC ACID; BRAIN; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, NONESTERIFIED; LIPID METABOLISM; LITHIUM; MALE; PHOSPHOLIPASES A; PHOSPHOLIPIDS; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0032940177     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020989701330     Document Type: Article

References (46)

1. Robinson, P.J., Noronha, J.G., DeGeorge, J.J., Freed, L.M., Nariai, T., and Rapoport, S.I. 1992. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res. Rev. 17:187-214.
2. 14C]arachidonate in awake rats, with or without cholinergic stimulation, following unilateral lesioning of nucleus basalis magnocellularis. Brain Res. 559:1-9.
3. Wakabayashi, S., Freed, L.M., Bell, J.M., and Rapoport, S.I. 1994. In vivo cerebral incorporation of radiolabeled fatty acids after acute unilateral orbital enucleation in adult hooded Long-Evans rats. J. Cereb. Blood Flow Metab. 14:312-323.
4. Arai, T., Wakabayashi, S., Charming, M.A., Dunn, B.B., Der, M.G., Bell, J.M., Herscovitch, P., Eckelman, W.C., Rapoport, S.I., and Chang, M.C.J. 1995. Incorporation of [1-carbon-11]palmitate in monkey brain using PET. J. Nuc. Med. 36:2261-2267.
5. 11C]arachidonate in normocapnic and hypercapnic monkeys, measured by positron emission tomography. Brain Res. 755:74-83.
6. Rapoport, S.I., Purdon, A., Shetty, H.U., Grange, E., Smith, Q., Jones, C., and Chang, M.C.J. 1997. In vivo imaging of fatty acid incorporation into brain to examine signal transduction and neuroplasticity involving phospholipids. Ann. N.Y. Acad. Sci. 820: 56-74.
7. 3H]arachidonate in the anesthetized rat. J. Neurochem. 63:727-736.
8. 3H]palmitate in plasma and brain palmitoyl-CoA pool. J. Neurochem. 65:2290-2298.
9. Chang, M.C.J., Grange, E., Rabin, O., Bell, J.M., Allen, D.D., and Rapoport, S.I. 1996. Lithium decreases turnover of arachidonate in several brain phospholipids. Neurosci. Lett. 220:171-174. Corrigendum 222 (1997) 141.
10. Purdon, A.D., Arai, T., and Rapoport, S.I. 1997. No direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rats. J. Lipid Res. 38:158-162.
11. Neuringer, M., Andersen, G.J., and Connor, W.E. 1988. The essentiality of n-3 fatty acids for the development and function of the retina and brain. Ann. Rev. Nurr. 8:517-541.
12. Salem, N. Jr., Kim, H.Y., and Yergey, J.A. 1986. Docosahexaenoic acid: Membrane function and metabolism, in The Health Effects of Polyunsaturated Fatty Acids in Seafoods (Simopoulos A.P., Kifer R.R., and Martin R., eds.), pp. 263-317. Academic Press, New York.
13. Gazzah, N., Gharib, A., Croset, M., Bobillier, P., Lagarde, N. 1995. Decrease in brain phospholipid synthesis in free-moving n-3 fatty acid deficient rats. J. Neurochem. 64:908-918.
14. Rapoport, S.I. 1995. Matters Arising. Docosahexaenoate turnover in brain phospholipids. J. Neurochem. 65:1903-1904.
15. Folch, J., Lees, M., and Sloane-Stanley, G.H. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509.
16. Deutsch, J., Grange, E., Rapoport, S.I., and Purdon, A.D. 1994. Isolation and quantification of acyl-CoA esters in brain tissue by solid phase extraction. Anal. Biochem. 220:321-323.
17. Rabin, O., Deutsch, J., Grange, E., Chang, M.C.J., Rapoport, S.I., and Purdon, A.D. 1997. Changes in cerebral acyl-CoA concentrations following ischemia-reperfusion in awake gerbils. J. Neurochem. 68:2111-2118.
18. Corkey, B.E. 1988. Analysis of acyl-Coenzyme A esters in biological samples. Methods Enzymol. 166:55-70.
19. DeGeorge, J.J., Nariai, T., Yamazaki, S., Williams, W.M., and Rapoport, S.I. 1991. Arecoline-stimulated brain incorporation of intravenously administered fatty acids in unanesthetized rats. J. Neurochem. 56:352-355.
20. Stinson, A.M., Wiegand, R.D., and Anderson, R.E. 1991. Recycling of docosahexaenoic acid in rat retinas during n-3 fatty acid deficiency. J. Lipid Res. 32:2009-2017.
21. 2 inhibitor on arachidonate incorporation into brain lipids in vivo. Neurochem. Res. (in press).
22. 2 activity. Neurochem. Res. 23: 887-892.
23. Dawson, E., Parfitt, E., Roberts, Q., Daniels, J., Lim, L., Sham, P., Nöthen, M., Propping, P., Lanczik, M., Maier, W., Reuner, U., Weissenbach, J., Gill, M., Powell, J., McGuffin, P., Owen, M., and Craddock, N. 1995. Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1. Am. J. Med. (Neuropsychiat. Gen.) 60:94-102.
24. 2. J. Biol. Chem. 272:16709-16712.
25. 2. J. Lipid Med. Cell Signalling 12:83-117.
26. 2. Proc. Natl. Acad. Sci., U.S.A. 84:6374-6378.
27. 2 activity in bovine rod outer segments by the beta gamma sub-units of transducin and its inhibition by the alpha subunit. Proc. Natl. Acad. Sci., U.S.A. 84:3623-3627.
28. 2 and arachidonic release in signal transduction. Biochem. Soc. Trans. 18:503-507.
29. Avissar, S., Schreiber, G., Danon, A., and Belmaker, R.H. 1988. Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex. Nature 331:440-442.
30. Bunney, W.E., and Davis, J.M. 1965. Norepinephrine in depressive reactions. Arch. Gen. Psychiatry 13:483-494.
31. Nakamura, S. 1990. Antidepressants induce regeneration of catecholaminergic axon terminals in the rat cerebral cortex. Neurosci. Lett. 111:64-68.
32. Nakamura, S. 1991. Effects of mianserin and fluoxetine on axonal regeneration of brain catecholamine neurons. NeuroReport 2:525-528.
33. 2 in axonal regeneration of brain noradrenergic neurones. NeuroReport 4:371-374.
34. 2 inhibitors on the antidepressant-induced axonal regeneration of noradrenergic locus coeruleus neurons. Microscopy Res. Technique 29:204-210.
35. Torda, S.W., Yamaguchi, I., Hiarata, F., Kopin, I.J., and Axelrod, J. 1981. Quinacrine-blocked desensitization of adrenoceptors after immobilization stress or repeated injection of isoproterenol in rats. J. Pharmacol. Exp. Ther. 216:334-338.
36. Manji, H., Chen, G., Bitran, J., Gusovsky, F., and Potter, W.Z. 1990. Mepracrine blocks desipramine induced beta adrenoceptor downregulation in C6 glioma cells. Soc. Neurosci. Abst. 16:914.
37. 2 activity in schizophrenics and other psychiatric patients. Biol. Psychiatry 34:641-649.
38. 2 activity in schizophrenia. Schizophr. Res. 16:1-6.
39. 2 and the hypofrontality hypothesis of schizophrenia. Prostaglandins, Leuko. and Essent. Fatty Acids 55:109-113.
40. Horrobin, D.F., Glen, A.I., and Hudson, C.J. 1995. Possible relevance of phospholipid abnormalities and genetic interactions in psychiatric disorders: the relationship between dyslexia and schizophrenia. Med. Hypothesis 45:605-613.
41. Horrobin, D.F. 1996. Schizophrenia as a membrane lipid disorder which is expressed throughout the body. Prostaglandins, Leuko. and Essent. Fatty Acids 55:3-7.
42. 2 associated with schizophrenia. Schizophr. Res. 21:111-116.
43. 2 activity in schizophrenic patients: reduction after neuroleptic therapy. Biol. Psychiatry 22:421-426.
44. 2 activity in schizophrenia: a replication study. Biol. Psychiatry 28:495-501.
45. Yao, J.K., Van Kammen, D.P., and Welker, J.A. 1994. Red blood cell membrane dynamics in schizophrenia. Schizophr. Res. 13: 217-226.
46. 2 activity in the brain of rats. Eur. Arch. Psychiatry Clin. Neurosci. 245:179-182.