메뉴 건너뛰기




Volumn 35, Issue 1, 2014, Pages 2-13

Cancer stemness in Wnt-driven mammary tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA1 INTEGRIN; CANCER GROWTH FACTOR; CD24 ANTIGEN; MEMBRANE ANTIGEN; PROTEIN P53; SMOOTH MUSCLE ACTIN; SONIC HEDGEHOG PROTEIN; UVOMORULIN;

EID: 84891364732     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt279     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • Visvader,J.E. et al. (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer, 8, 755-768.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1
  • 2
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya,T. et al. (2001) Stem cells, cancer, and cancer stem cells. Nature, 414, 105-111.
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1
  • 3
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya,T. et al. (2005) Wnt signalling in stem cells and cancer. Nature, 434, 843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1
  • 4
    • 78651339164 scopus 로고    scopus 로고
    • A Wnt-ow of opportunity: targeting the Wnt/ beta-catenin pathway in breast cancer
    • Prosperi,J.R. et al. (2010) A Wnt-ow of opportunity: targeting the Wnt/ beta-catenin pathway in breast cancer. Curr. Drug Targets, 11, 1074-1088.
    • (2010) Curr. Drug Targets , vol.11 , pp. 1074-1088
    • Prosperi, J.R.1
  • 5
    • 77953183234 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    • Khramtsov,A.I. et al. (2010) Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am. J. Pathol., 176, 2911-2920.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2911-2920
    • Khramtsov, A.I.1
  • 6
    • 74549167752 scopus 로고    scopus 로고
    • Cytoplasmic localization of beta-catenin is a marker of poor outcome in breast cancer patients
    • López-Knowles,E. et al. (2010) Cytoplasmic localization of beta-catenin is a marker of poor outcome in breast cancer patients. Cancer Epidemiol. Biomarkers Prev., 19, 301-309.
    • (2010) Cancer Epidemiol. Biomarkers Prev. , vol.19 , pp. 301-309
    • López-Knowles, E.1
  • 7
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou,C.M. et al. (2000) Molecular portraits of human breast tumours. Nature, 406, 747-752.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1
  • 8
    • 21044455192 scopus 로고    scopus 로고
    • Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer
    • Gusterson,B.A. et al. (2005) Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer. Breast Cancer Res., 7, 143-148.
    • (2005) Breast Cancer Res. , vol.7 , pp. 143-148
    • Gusterson, B.A.1
  • 9
    • 58849100464 scopus 로고    scopus 로고
    • Do 'basal-like' breast cancers really exist?
    • Gusterson,B. (2009) Do 'basal-like' breast cancers really exist? Nat. Rev. Cancer, 9, 128-134.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 128-134
    • Gusterson, B.1
  • 10
    • 66249109653 scopus 로고    scopus 로고
    • Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
    • Hennessy,B.T. et al. (2009) Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res., 69, 4116-4124.
    • (2009) Cancer Res. , vol.69 , pp. 4116-4124
    • Hennessy, B.T.1
  • 11
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann,B.D. et al. (2011) Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J. Clin. Invest., 121, 2750-2767.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1
  • 12
    • 77950394022 scopus 로고    scopus 로고
    • LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
    • Liu,C.C. et al. (2010) LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc. Natl Acad. Sci. USA, 107, 5136-5141.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 5136-5141
    • Liu, C.C.1
  • 13
    • 80055040407 scopus 로고    scopus 로고
    • FZD7 has a critical role in cell proliferation in triple negative breast cancer
    • Yang,L. et al. (2011) FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene, 30, 4437-4446.
    • (2011) Oncogene , vol.30 , pp. 4437-4446
    • Yang, L.1
  • 14
    • 47149097853 scopus 로고    scopus 로고
    • Epigenetic gene silencing in the Wnt pathway in breast cancer
    • Klarmann,G.J. et al. (2008) Epigenetic gene silencing in the Wnt pathway in breast cancer. Epigenetics, 3, 59-63.
    • (2008) Epigenetics , vol.3 , pp. 59-63
    • Klarmann, G.J.1
  • 15
    • 40849116461 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer
    • Suzuki,H. et al. (2008) Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br. J. Cancer, 98, 1147-1156.
    • (2008) Br. J. Cancer , vol.98 , pp. 1147-1156
    • Suzuki, H.1
  • 16
    • 0021270667 scopus 로고
    • Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15
    • Nusse,R. et al. (1984) Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature, 307, 131-136.
    • (1984) Nature , vol.307 , pp. 131-136
    • Nusse, R.1
  • 17
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • Tsukamoto,A.S. et al. (1988) Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell, 55, 619-625.
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.S.1
  • 18
    • 0035939818 scopus 로고    scopus 로고
    • Beta-catenin is a downstream effector of Wntmediated tumorigenesis in the mammary gland
    • Michaelson,J.S. et al. (2001) Beta-catenin is a downstream effector of Wntmediated tumorigenesis in the mammary gland. Oncogene, 20, 5093-5099.
    • (2001) Oncogene , vol.20 , pp. 5093-5099
    • Michaelson, J.S.1
  • 19
    • 0035972159 scopus 로고    scopus 로고
    • Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland
    • Imbert,A. et al. (2001) Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J. Cell Biol., 153, 555-568.
    • (2001) J. Cell Biol. , vol.153 , pp. 555-568
    • Imbert, A.1
  • 20
    • 61449101684 scopus 로고    scopus 로고
    • Genetic mechanisms in Apc-mediated mammary tumorigenesis
    • Kuraguchi,M. et al. (2009) Genetic mechanisms in Apc-mediated mammary tumorigenesis. PLoS Genet., 5, e1000367.
    • (2009) PLoS Genet. , vol.5
    • Kuraguchi, M.1
  • 21
    • 68249083454 scopus 로고    scopus 로고
    • A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis
    • Gaspar,C. et al. (2009) A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PLoS Genet., 5, e1000547.
    • (2009) PLoS Genet. , vol.5
    • Gaspar, C.1
  • 22
    • 33645289670 scopus 로고    scopus 로고
    • Biphasic metaplastic sarcomatoid carcinoma of the breast
    • Hennessy,B.T. et al. (2006) Biphasic metaplastic sarcomatoid carcinoma of the breast. Ann. Oncol., 17, 605-613.
    • (2006) Ann. Oncol. , vol.17 , pp. 605-613
    • Hennessy, B.T.1
  • 23
    • 32944465996 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the breast
    • Hennessy,B.T. et al. (2005) Squamous cell carcinoma of the breast. J. Clin. Oncol., 23, 7827-7835.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7827-7835
    • Hennessy, B.T.1
  • 24
    • 30144433093 scopus 로고    scopus 로고
    • Generation of a functional mammary gland from a single stem cell
    • Shackleton,M. et al. (2006) Generation of a functional mammary gland from a single stem cell. Nature, 439, 84-88.
    • (2006) Nature , vol.439 , pp. 84-88
    • Shackleton, M.1
  • 25
    • 49649085001 scopus 로고    scopus 로고
    • Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    • Zhang,M. et al. (2008) Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res., 68, 4674-4682.
    • (2008) Cancer Res. , vol.68 , pp. 4674-4682
    • Zhang, M.1
  • 26
    • 54249086214 scopus 로고    scopus 로고
    • The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
    • Vaillant,F. et al. (2008) The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res., 68, 7711-7717.
    • (2008) Cancer Res. , vol.68 , pp. 7711-7717
    • Vaillant, F.1
  • 27
    • 40949116308 scopus 로고    scopus 로고
    • Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors
    • Cho,R.W. et al. (2008) Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells, 26, 364-371.
    • (2008) Stem Cells , vol.26 , pp. 364-371
    • Cho, R.W.1
  • 28
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar,R. et al. (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res., 30, 207-210.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 207-210
    • Edgar, R.1
  • 29
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin,M. et al. (2007) Molecular definition of breast tumor heterogeneity. Cancer Cell, 11, 259-273.
    • (2007) Cancer Cell , vol.11 , pp. 259-273
    • Shipitsin, M.1
  • 30
    • 33750470097 scopus 로고    scopus 로고
    • CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells
    • Sleeman,K.E. et al. (2006) CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Res., 8, R7.
    • (2006) Breast Cancer Res. , vol.8
    • Sleeman, K.E.1
  • 32
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker,N. et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449, 1003-1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 33
    • 33751261643 scopus 로고    scopus 로고
    • Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer
    • Ivshina,A.V. et al. (2006) Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res., 66, 10292-10301.
    • (2006) Cancer Res. , vol.66 , pp. 10292-10301
    • Ivshina, A.V.1
  • 34
    • 44949121510 scopus 로고    scopus 로고
    • Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen
    • Loi,S. et al. (2008) Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen. BMC Genomics, 9, 239.
    • (2008) BMC Genomics , vol.9 , pp. 239
    • Loi, S.1
  • 35
    • 26444546442 scopus 로고    scopus 로고
    • An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
    • Miller,L.D. et al. (2005) An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc. Natl Acad. Sci. USA, 102, 13550-13555.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13550-13555
    • Miller, L.D.1
  • 36
    • 34147211281 scopus 로고    scopus 로고
    • Lung metastasis genes couple breast tumor size and metastatic spread
    • Minn,A.J. et al. (2007) Lung metastasis genes couple breast tumor size and metastatic spread. Proc. Natl Acad. Sci. USA, 104, 6740-6745.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6740-6745
    • Minn, A.J.1
  • 37
    • 34447632167 scopus 로고    scopus 로고
    • Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population- based cohorts
    • Pawitan,Y. et al. (2005) Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population- based cohorts. Breast Cancer Res., 7, R953-R964.
    • (2005) Breast Cancer Res. , vol.7
    • Pawitan, Y.1
  • 38
    • 33144462268 scopus 로고    scopus 로고
    • Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    • Sotiriou,C. et al. (2006) Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J. Natl Cancer Inst., 98, 262-272.
    • (2006) J. Natl Cancer Inst. , vol.98 , pp. 262-272
    • Sotiriou, C.1
  • 39
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver,M.J. et al. (2002) A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med., 347, 1999-2009.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1999-2009
    • van de Vijver, M.J.1
  • 40
    • 33645804773 scopus 로고    scopus 로고
    • Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors
    • Takeuchi,T. et al. (2006) Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J. Clin. Oncol., 24, 1679-1688.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 1679-1688
    • Takeuchi, T.1
  • 41
    • 0037059002 scopus 로고    scopus 로고
    • Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis
    • Leung,S.Y. et al. (2002) Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc. Natl Acad. Sci. USA, 99, 16203-16208.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 16203-16208
    • Leung, S.Y.1
  • 42
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz,T. et al. (2005) Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat. Rev. Cancer, 5, 744-749.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1
  • 43
    • 33847740988 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in cancer stemness and malignant behavior
    • Fodde,R. et al. (2007) Wnt/beta-catenin signaling in cancer stemness and malignant behavior. Curr. Opin. Cell Biol., 19, 150-158.
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 150-158
    • Fodde, R.1
  • 44
    • 72749103664 scopus 로고    scopus 로고
    • Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    • Visvader,J.E. (2009) Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev., 23, 2563-2577.
    • (2009) Genes Dev. , vol.23 , pp. 2563-2577
    • Visvader, J.E.1
  • 45
    • 30144432901 scopus 로고    scopus 로고
    • Purification and unique properties of mammary epithelial stem cells
    • Stingl,J. et al. (2006) Purification and unique properties of mammary epithelial stem cells. Nature, 439, 993-997.
    • (2006) Nature , vol.439 , pp. 993-997
    • Stingl, J.1
  • 46
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen,A. et al. (2011) Distinct stem cells contribute to mammary gland development and maintenance. Nature, 479, 189-193.
    • (2011) Nature , vol.479 , pp. 189-193
    • Van Keymeulen, A.1
  • 47
    • 84866114887 scopus 로고    scopus 로고
    • Developmental stage and time dictate the fate of Wnt/ß-catenin-responsive stem cells in the mammary gland
    • van Amerongen,R. et al. (2012) Developmental stage and time dictate the fate of Wnt/ß-catenin-responsive stem cells in the mammary gland. Cell Stem Cell, 11, 387-400.
    • (2012) Cell Stem Cell , vol.11 , pp. 387-400
    • van Amerongen, R.1
  • 48
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelialmesenchymal transition in basal-like breast cancer
    • DiMeo,T.A. et al. (2009) A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelialmesenchymal transition in basal-like breast cancer. Cancer Res., 69, 5364-5373.
    • (2009) Cancer Res. , vol.69 , pp. 5364-5373
    • DiMeo, T.A.1
  • 49
    • 77955895963 scopus 로고    scopus 로고
    • Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
    • Lim,E. et al. (2010) Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res., 12, R21.
    • (2010) Breast Cancer Res. , vol.12
    • Lim, E.1
  • 50
    • 80055090025 scopus 로고    scopus 로고
    • Most random gene expression signatures are significantly associated with breast cancer outcome
    • Venet,D. et al. (2011) Most random gene expression signatures are significantly associated with breast cancer outcome. PLoS Comput. Biol., 7, e1002240.
    • (2011) PLoS Comput. Biol. , vol.7
    • Venet, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.