메뉴 건너뛰기




Volumn 22, Issue 21, 2013, Pages 2496-2502

Pharmacological activities and possible mechanism of effective components in Ophiopogonis radix

Author keywords

Effective components; Ophiopogon japonicus; Pharmacological effects; Research progress

Indexed keywords

AMINO ACID DERIVATIVE; ANTICOAGULANT AGENT; ANTIDIABETIC AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ANTITUSSIVE AGENT; CARDIOVASCULAR AGENT; CHINESE DRUG; FLAVONOID; OPHIOPOGONIS RADIX; POLYSACCHARIDE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84891362397     PISSN: 10033734     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (13)

References (39)
  • 1
    • 84891356402 scopus 로고    scopus 로고
    • Chinese source
    • 2010: 25, 144.
    • (2010)
  • 2
    • 84891361804 scopus 로고    scopus 로고
    • Chinese source
    • 2007, 5(1): 10-14.
    • (2007) , vol.5 , Issue.1 , pp. 10-14
  • 3
    • 77952317641 scopus 로고    scopus 로고
    • A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart
    • WANG S, ZHANG Z, LIN X, et al. A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart[J]. Glycobiology, 2010, 20(4): 473-484.
    • (2010) Glycobiology , vol.20 , Issue.4 , pp. 473-484
    • Wang, S.1    Zhang, Z.2    Lin, X.3
  • 4
    • 84857794793 scopus 로고    scopus 로고
    • A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression
    • WANG S, LIN X, WANG L Y, et al. A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression[J]. Int J Biol Macromol, 2012, 50(3): 734-740.
    • (2012) Int J Biol Macromol , vol.50 , Issue.3 , pp. 734-740
    • Wang, S.1    Lin, X.2    Wang, L.Y.3
  • 5
    • 66349117714 scopus 로고    scopus 로고
    • Influence of sulfation on anti-myocardial ischemic activity of Ophiopogon japonicus polysaccharide
    • ZHENG Q, FENG Y, XU D S, et al. Influence of sulfation on anti-myocardial ischemic activity of Ophiopogon japonicus polysaccharide[J]. J Asian Nat Prd Res, 2009, 11(4): 306-321.
    • (2009) J Asian Nat Prd Res , vol.11 , Issue.4 , pp. 306-321
    • Zheng, Q.1    Feng, Y.2    Xu, D.S.3
  • 6
    • 24944469438 scopus 로고    scopus 로고
    • Effects of saponin monomer 13 of dwarf lilyturf tuber on L-type calcium currents in adult rat ventricular myocytes
    • TAO J, WANG H, CHEN J, et al. Effects of saponin monomer 13 of dwarf lilyturf tuber on L-type calcium currents in adult rat ventricular myocytes[J]. Am J Chin Med, 2005, 33(5): 797-806.
    • (2005) Am J Chin Med , vol.33 , Issue.5 , pp. 797-806
    • Tao, J.1    Wang, H.2    Chen, J.3
  • 7
    • 26444531635 scopus 로고    scopus 로고
    • The saponin monomer of dwarf lilyturf tuber, DT-13, reduces L-type calcium currents during hypoxia in adult rat ventricular myocytes
    • TAO J, WANG H, ZHOU H, et al. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces L-type calcium currents during hypoxia in adult rat ventricular myocytes[J]. Life Sci, 2005, 77(24): 3021-3030.
    • (2005) Life Sci , vol.77 , Issue.24 , pp. 3021-3030
    • Tao, J.1    Wang, H.2    Zhou, H.3
  • 8
    • 23844509645 scopus 로고    scopus 로고
    • Inhibitory effects of ethanol extract from Radix Ophiopogon japonicus on venous thrombosis linked with its endothelium-protective and anti-adhesive activities
    • KOU J P, YU B Y, XU Q. Inhibitory effects of ethanol extract from Radix Ophiopogon japonicus on venous thrombosis linked with its endothelium-protective and anti-adhesive activities[J]. Vasc Pharmacol, 2005, 43(3): 157-163.
    • (2005) Vasc Pharmacol , vol.43 , Issue.3 , pp. 157-163
    • Kou, J.P.1    Yu, B.Y.2    Xu, Q.3
  • 9
    • 33744924862 scopus 로고    scopus 로고
    • Antithrombotic activities of aqueous extract from radix ophiopogon japonicus and its two constituents
    • KOU J P, TIAN Y Q, TANG K Y, et al. Antithrombotic activities of aqueous extract from radix ophiopogon japonicus and its two constituents[J]. Biol Pharm Bull, 2006, 29(6): 1267-1270.
    • (2006) Biol Pharm Bull , vol.29 , Issue.6 , pp. 1267-1270
    • Kou, J.P.1    Tian, Y.Q.2    Tang, K.Y.3
  • 10
    • 24944443737 scopus 로고    scopus 로고
    • Anti-inflammatory activities of aqueous extract from radix ophiopogon japonicus and its two constituents
    • KOU J P, SUN Y, LIN Y W, et al. Anti-inflammatory activities of aqueous extract from radix ophiopogon japonicus and its two constituents[J]. Biol Pharm Bull, 2005, 28(7): 1234-1238.
    • (2005) Biol Pharm Bull , vol.28 , Issue.7 , pp. 1234-1238
    • Kou, J.P.1    Sun, Y.2    Lin, Y.W.3
  • 11
    • 0035990593 scopus 로고    scopus 로고
    • Ruscogenin glycoside (Lm-3) isolated from Liriope muscari inhibits lymphocyte adhesion to extracellular matrix
    • LIU J L, CHEN T, YU B Y, et al. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari inhibits lymphocyte adhesion to extracellular matrix[J]. J Pharm Pharmacol, 2002, 54(7): 959-965.
    • (2002) J Pharm Pharmacol , vol.54 , Issue.7 , pp. 959-965
    • Liu, J.L.1    Chen, T.2    Yu, B.Y.3
  • 12
    • 55549083200 scopus 로고    scopus 로고
    • Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB
    • HUANG Y L, KOU J P, MA L, et al. Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB[J]. J Pharmacol Sci, 2008, 108(2): 198-205.
    • (2008) J Pharmacol Sci , vol.108 , Issue.2 , pp. 198-205
    • Huang, Y.L.1    Kou, J.P.2    Ma, L.3
  • 13
    • 77956213919 scopus 로고    scopus 로고
    • Ruscogenin mainly inhibits nuclear factor-kappaB but not Akt and mitogen-activated protein kinase signaling pathways in human umbilical vein endothelial cells
    • SONG J, KOU J, HUANG Y, et al. Ruscogenin mainly inhibits nuclear factor-kappaB but not Akt and mitogen-activated protein kinase signaling pathways in human umbilical vein endothelial cells[J]. J Pharmacol Sci, 2010, 113(4): 409-413.
    • (2010) J Pharmacol Sci , vol.113 , Issue.4 , pp. 409-413
    • Song, J.1    Kou, J.2    Huang, Y.3
  • 14
    • 79956043638 scopus 로고    scopus 로고
    • Anti-inflammatory effects of aqueous extract from radix liriope muscari and its major active fraction and component
    • TIAN Y Q, KOU J P, ZHOU L L, et al. Anti-inflammatory effects of aqueous extract from radix liriope muscari and its major active fraction and component[J]. Chin J Nat Med, 2011, 9(3): 222-226.
    • (2011) Chin J Nat Med , vol.9 , Issue.3 , pp. 222-226
    • Tian, Y.Q.1    Kou, J.P.2    Zhou, L.L.3
  • 15
    • 77950063625 scopus 로고    scopus 로고
    • Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammolation activity
    • HUNG T M, THU C V, DAT N T, et al. Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammolation activity[J]. Bioorg Med Chem Lett, 2010, 20(8): 2412-2416.
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.8 , pp. 2412-2416
    • Hung, T.M.1    Thu, C.V.2    Dat, N.T.3
  • 16
    • 84863987076 scopus 로고    scopus 로고
    • Anti-inflammatory homoisflavonoids from the tuberous roots of Ophiopogon japonicus
    • LI N, ZHANG J Y, ZENG K W, et al. Anti-inflammatory homoisflavonoids from the tuberous roots of Ophiopogon japonicus[J]. Fitoterapia, 2012, 83(6): 1042-1045.
    • (2012) Fitoterapia , vol.83 , Issue.6 , pp. 1042-1045
    • Li, N.1    Zhang, J.Y.2    Zeng, K.W.3
  • 17
    • 79952361298 scopus 로고    scopus 로고
    • Two new benzofuran derivatives with anti-inflammolatory activity from Liriope spicata var. prolifera
    • HU Z F, CHEN L L, QI J, et al. Two new benzofuran derivatives with anti-inflammolatory activity from Liriope spicata var. prolifera[J]. Fitoterapia, 2011, 82(2): 190-192.
    • (2011) Fitoterapia , vol.82 , Issue.2 , pp. 190-192
    • Hu, Z.F.1    Chen, L.L.2    Qi, J.3
  • 18
    • 84870709202 scopus 로고    scopus 로고
    • Immunomodulatory effects of Liriope Platyphylla water extract on lipopolysaccharide-activated mouse macrophage
    • KIM H K, LEE J Y, HAN H S, et al. Immunomodulatory effects of Liriope Platyphylla water extract on lipopolysaccharide-activated mouse macrophage[J]. Nutrients, 2012, 4(12): 1887-1897.
    • (2012) Nutrients , vol.4 , Issue.12 , pp. 1887-1897
    • Kim, H.K.1    Lee, J.Y.2    Han, H.S.3
  • 19
    • 69949105088 scopus 로고    scopus 로고
    • Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice
    • BAI X, CHEN X, LIU Y, et al. Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice[J]. J Ethnopharmacol, 2009, 125(3): 482-486.
    • (2009) J Ethnopharmacol , vol.125 , Issue.3 , pp. 482-486
    • Bai, X.1    Chen, X.2    Liu, Y.3
  • 20
    • 73349096929 scopus 로고    scopus 로고
    • Hypoglycemic polysaccharides from the tuberous root of Liriope spicata
    • CHEN X, LIU Y, BAI X, et al. Hypoglycemic polysaccharides from the tuberous root of Liriope spicata[J]. J Nat Prod, 2009, 72(11): 1988-1992.
    • (2009) J Nat Prod , vol.72 , Issue.11 , pp. 1988-1992
    • Chen, X.1    Liu, Y.2    Bai, X.3
  • 21
    • 84855684945 scopus 로고    scopus 로고
    • Mechanistic studies on the antidiabetic activity of a polysaccharide-rich extract of Radix Ophiopogonis
    • DING L W, LI P B, LIU B S, et al. Mechanistic studies on the antidiabetic activity of a polysaccharide-rich extract of Radix Ophiopogonis[J]. Phytother Res, 2012, 26(1): 101-105.
    • (2012) Phytother Res , vol.26 , Issue.1 , pp. 101-105
    • Ding, L.W.1    Li, P.B.2    Liu, B.S.3
  • 22
    • 80052303770 scopus 로고    scopus 로고
    • Hypoglycemic effects of MDG-1, a polysaccharide derived from Ophiopogon japonicas, in the ob/ob mouse model of type 2 diabetes mellitus
    • XU J, WANG Y, XU D S, et al. Hypoglycemic effects of MDG-1, a polysaccharide derived from Ophiopogon japonicas, in the ob/ob mouse model of type 2 diabetes mellitus[J]. Int J Biol Macromol, 2011, 49(4): 657-662.
    • (2011) Int J Biol Macromol , vol.49 , Issue.4 , pp. 657-662
    • Xu, J.1    Wang, Y.2    Xu, D.S.3
  • 23
    • 84864697477 scopus 로고    scopus 로고
    • MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model
    • WANG L Y, WANG Y, XU D S, et al. MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model[J]. J Ethnopharmacol, 2012, 143(1): 347-354.
    • (2012) J Ethnopharmacol , vol.143 , Issue.1 , pp. 347-354
    • Wang, L.Y.1    Wang, Y.2    Xu, D.S.3
  • 24
    • 84866562692 scopus 로고    scopus 로고
    • Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats
    • LI P B, LIN W L, WANG Y G, et al. Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats[J]. Int J Biol Macromol, 2012, 51(5): 749-755.
    • (2012) Int J Biol Macromol , vol.51 , Issue.5 , pp. 749-755
    • Li, P.B.1    Lin, W.L.2    Wang, Y.G.3
  • 25
    • 79957956348 scopus 로고    scopus 로고
    • Fermentation effects of oligosaccharides of Radix Ophiopogonis on alloxan-induced diabetes in mice
    • LIN W L, SU W W, CAI X Y, et al. Fermentation effects of oligosaccharides of Radix Ophiopogonis on alloxan-induced diabetes in mice[J]. Int J Biol Macromol, 2011, 49(2): 194-200.
    • (2011) Int J Biol Macromol , vol.49 , Issue.2 , pp. 194-200
    • Lin, W.L.1    Su, W.W.2    Cai, X.Y.3
  • 26
    • 84891362253 scopus 로고    scopus 로고
    • The saponin monomer of dwarf lilyturf tuber, DT-13, exhibits anti-cancer activity by reducing CCR5 and VEGF in vitro and inhibits tumor growth and metastasis in vivo
    • Accepted
    • ZHAO R P, LIN S S, YUAN S T, et al. The saponin monomer of dwarf lilyturf tuber, DT-13, exhibits anti-cancer activity by reducing CCR5 and VEGF in vitro and inhibits tumor growth and metastasis in vivo[J]. Chin J Nat Med, Accepted.
    • Chin J Nat Med
    • Zhao, R.P.1    Lin, S.S.2    Yuan, S.T.3
  • 27
    • 84874755348 scopus 로고    scopus 로고
    • The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi-targeting activity
    • ZHAO R P, SUN L, LIN S S, et al. The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi-targeting activity[J]. Oncol Rep, 2013, 29(4): 1379-1386.
    • (2013) Oncol Rep , vol.29 , Issue.4 , pp. 1379-1386
    • Zhao, R.P.1    Sun, L.2    Lin, S.S.3
  • 28
    • 84866469822 scopus 로고    scopus 로고
    • DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway
    • ZHANG Y Y, LIU J H, KOU J P, et al. DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway[J]. Mol Med Report, 2012, 6(5): 1121-1125.
    • (2012) Mol Med Report , vol.6 , Issue.5 , pp. 1121-1125
    • Zhang, Y.Y.1    Liu, J.H.2    Kou, J.P.3
  • 29
    • 77954473120 scopus 로고    scopus 로고
    • The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor
    • SUN L, LIN S S, ZHAO R P, et al. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor[J]. Biol Pharm Bull, 2010, 33(7): 1192-1198.
    • (2010) Biol Pharm Bull , vol.33 , Issue.7 , pp. 1192-1198
    • Sun, L.1    Lin, S.S.2    Zhao, R.P.3
  • 30
    • 84872788950 scopus 로고    scopus 로고
    • Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway
    • CHEN M J, DU Y H, QUI M, et al. Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway[J]. Oncol Rep, 2013, 29(2): 430-436.
    • (2013) Oncol Rep , vol.29 , Issue.2 , pp. 430-436
    • Chen, M.J.1    Du, Y.H.2    Qui, M.3
  • 31
    • 67349118806 scopus 로고    scopus 로고
    • Bioinformatics analyses of the mannose-binding lectins from polygonatum cyrtonema, ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities
    • LIU B, PENG H, YAO Q, et al. Bioinformatics analyses of the mannose-binding lectins from polygonatum cyrtonema, ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities[J]. Phytomedicine, 2009, 16(6-7): 601-608.
    • (2009) Phytomedicine , vol.16 , Issue.6-7 , pp. 601-608
    • Liu, B.1    Peng, H.2    Yao, Q.3
  • 32
    • 84879889808 scopus 로고    scopus 로고
    • Preparation and biological activity of saponin from Ophiopogon japonicus
    • XIONG S L, HOU D B, HANG N, et al. Preparation and biological activity of saponin from Ophiopogon japonicus[J]. Afr J Pharm Pharmacol, 2012, 6(26): 1964-1970.
    • (2012) Afr J Pharm Pharmacol , vol.6 , Issue.26 , pp. 1964-1970
    • Xiong, S.L.1    Hou, D.B.2    Hang, N.3
  • 33
    • 77649189826 scopus 로고    scopus 로고
    • 2-induced injury in primary human umbilical vein endothelial cells
    • 2-induced injury in primary human umbilical vein endothelial cells[J]. J Ethnopharmacol, 2010, 128(2): 438-445.
    • (2010) J Ethnopharmacol , vol.128 , Issue.2 , pp. 438-445
    • Qian, J.1    Jiang, F.2    Wang, B.3
  • 34
    • 84863150046 scopus 로고    scopus 로고
    • Phenolic compounds and antioxidant activities of liriope muscari
    • LI W J, CHENG X L, LIU J, et al. Phenolic compounds and antioxidant activities of liriope muscari[J]. Molecules, 2012, 17(2): 1797-1808.
    • (2012) Molecules , vol.17 , Issue.2 , pp. 1797-1808
    • Li, W.J.1    Cheng, X.L.2    Liu, J.3
  • 35
    • 0034999160 scopus 로고    scopus 로고
    • Ruscogenin glycoside (Lm-3) isolated from Liriope muscari improves liver injury by dysfunctioning liver-infiltrating lymphocytes
    • WU F, CAO J, JIANG J, et al. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari improves liver injury by dysfunctioning liver-infiltrating lymphocytes[J]. J Pharm Pharmacol, 2001, 53(5): 681-688.
    • (2001) J Pharm Pharmacol , vol.53 , Issue.5 , pp. 681-688
    • Wu, F.1    Cao, J.2    Jiang, J.3
  • 36
    • 84856087476 scopus 로고    scopus 로고
    • Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB
    • SUN Q, CHEN L, GAO M Y, et al. Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB[J]. Int Immunopharmacol, 2012, 12(1): 88-93.
    • (2012) Int Immunopharmacol , vol.12 , Issue.1 , pp. 88-93
    • Sun, Q.1    Chen, L.2    Gao, M.Y.3
  • 37
    • 0035128892 scopus 로고    scopus 로고
    • Activation of potassium conductance by ophiopogonin-D in acutely dissociated rat paratracheal neurons
    • ISHIBASHI H, MOCHIDOME T, OKAI J, et al. Activation of potassium conductance by ophiopogonin-D in acutely dissociated rat paratracheal neurons[J]. Br J Pharmacol, 2001, 132(2): 461-466.
    • (2001) Br J Pharmacol , vol.132 , Issue.2 , pp. 461-466
    • Ishibashi, H.1    Mochidome, T.2    Okai, J.3
  • 38
    • 85027930354 scopus 로고    scopus 로고
    • A new furostanol glycoside with fatty acid synthase inhibitory activity from Ophiopogon japonicusa
    • DUAN C L, WANG Y, MA X F, et al. A new furostanol glycoside with fatty acid synthase inhibitory activity from Ophiopogon japonicusa[J]. Chem Nat Compd, 2012, 48(4): 613-615.
    • (2012) Chem Nat Compd , vol.48 , Issue.4 , pp. 613-615
    • Duan, C.L.1    Wang, Y.2    Ma, X.F.3
  • 39
    • 84870062966 scopus 로고    scopus 로고
    • Antimicrobial activities of endophytic fungi isolated from Ophiopogon japonicus (Liliaceae)
    • LIANG H Q, XING Y M, JUAN C, et al. Antimicrobial activities of endophytic fungi isolated from Ophiopogon japonicus (Liliaceae)[J]. BMC Complem Altern M, 2012, 12: 238-243.
    • (2012) BMC Complem Altern M , vol.12 , pp. 238-243
    • Liang, H.Q.1    Xing, Y.M.2    Juan, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.