Anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines

Anticancer Research

Volumn 33, Issue 10, 2013, Pages 4365-4372

  Yunos, Nurhanan Murni ^a   Mutalip, Siti S M ^a   Jauri, Muhammad H ^a   Yu, Jun Q ^b   Huq, Fazlul ^b  

^a FOREST RESEARCH INSTITUTE MALAYSIA   (Malaysia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Andrographolide; Anti proliferative; Apoptosis; Cisplatin; Ovarian cancer; Synergism

Indexed keywords

ANDROGRAPHOLIDE; CISPLATIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DOSE RESPONSE; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC 50; MONOTHERAPY; OVARY CANCER; PRIORITY JOURNAL;

ANDROGRAPHOLIDE; ANTI-PROLIFERATIVE; APOPTOSIS; CISPLATIN; OVARIAN CANCER; SYNERGISM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; DITERPENES; DNA FRAGMENTATION; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; FEMALE; HUMANS; OVARIAN NEOPLASMS;

EID: 84891348114     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Shah MA and Schwartz GK: The relevance of drug sequence in combination chemotherapy. Drug Resist Update 3: 335-336, 2000.
2. Sharma A, Lal K and Handa SS: Standardization of the indian crude drug kalmegh by high-pressure liquid-chromatographic determination of andrographolide. Phytochem Anal 3(3): 129-131, 1992.
3. Nanduri S, Nyavanandi VK, Thunuguntla SSR, Kasu S, Pallerla MK, Ram PS, Rajagopal S, Kumar RA, Ramanujam R, Babu JM, Vyas K, Devi AS, Reddy GO and Akella V: Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents. Bioorg Medicinal Chem Lett 14(18): 4711-4717, 2004.
4. Huq F and Yunos NM: Molecular modelling analysis of the metabolism of andrographolide. IJPAC 2: 359-369, 2007.
5. Kumar RA, Sridevi K, Kumar NV, Nanduri S and Rajagopal S: Anticancer and immunostimulatory compounds from Andrographis paniculata: J Ethnopharmacol 92(2-3): 291-295, 2004.
6. Shen KK, Liu TY, Xu C, Ji LL and Wang ZT: Andrographolide inhibits hepatoma cells growth and affects the expression of cell cycle related proteins. Yao Xue Xue Bao 44(9): 973-979.
7. Lippard SJ: Chemistry and molecular biology of platinum anticancer drugs. Pure Appl Chem 59(6): 731-742, 1987.
8. 2]. Indian J Chem 8: 193-94, 1970.
9. Yunos NM, Beale P, Yu JQ and Huq F: Synergism from the sequence combinations of curcumin and epigallocatechin-3-gallate with cisplatin in the killing of human ovarian cancer cells. Anticancer Res 31: 1131-1140, 2011.
10. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65(1-2): 55-63, 1983.
11. Chou TC and Talalay P: Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55, 1984.
12. Chou TC: Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58(3): 621-812, 2006.
13. Al Batran R, Al-Bayaty F, Al-Obaidi MM and Abdulla MA: Acute Toxicity and the effect of andrographolide on porphyromonas gingivalis-induced hyperlipidemia in rats. Biomed Res Int 2013: 594012, 2013.
14. Nessa MN, Beale P, Chan C, Yu JQ and Huq F: Synergism from combinations of cisplatin and oxaliplatin with quercetin and thymoquinone in human ovarian tumour models, Anticancer Res 31: 3789-3798, 2011.
15. Ghosh N, Ghosh R, Mandal V and Mandal SC: Recent advances in herbal medicine for treatment of liver diseases. Pharmaceut Biol 49(9): 970-988, 2011.
16. Liu J, Wang ZT, Ji Li and Ge BX: Inhibitory effects of neoandrographolide on nitric oxide and prostaglandin E2 production in LPS-stimulated murine macrophage, Mol Cell Biochem 298: 49-57, 2007.
17. Zhou J, Hu Se, Tan SH, Cao R, Chen Y, Xia D, Zhu X, Yang XF, Ong CN and Shen HM: Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysome fusion in human cancer cells. Autophagy 8(3): 338-349, 2012.
18. Yang L, Wu D, Luo K, Wu S and Wu P: Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells. Cancer Lett 276(2): 180-188, 2009.
19. Shi MD, Lin HH, Lee YC, Chao JK, Lin RA and Chen JH: Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. Chem Biol Interact 174(3): 201-210, 2008.
20. Cheung HY, Cheung SH, Li J, Cheung CS, Lai WP, Fong WF and Leung FM: Andrographolide isolated from Andrographispaniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells. Planta Medic 71(12):1106-1111.
21. Zhou J, Zhang S, Ong CN and Shen HM Critical role of proapoptotic Bcl-2 family members in andrographolide induced apoptosis in human cancer cells. Biochem Pharmacol 72: 132-144, 2006.
22. Li Y, Zhang P, Qiu F, Chen L, Miao C, Li J, Xiao W and Ma E: Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells. Life Sci 90(25- 26): 962-967.
23. Singh M, Chaudhry P, Fabi F and Asselin E: 2013: Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: A potential mechanism of chemoresistance. BMC Cancer 13: 233-241, 2013.
24. Tee TT and Azimahtol HL: Induction of apoptosis by Eurycoma longifolia jack extracts. Anticancer Res 25(3B): 2205-2213, 2005.
25. Bao GQ, Shen BY, Pan CP, Zhang YJ, Shi MM and Peng CH: Andrographolide causes apoptosis via activation of STAT3 and AKT. Toxicol Lett 222(1): 23-35, 2013.