Acute toxicity and the effect of andrographolide on porphyromonas gingivalis -induced hyperlipidemia in rats

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Al Batran, Rami ^a   Al Bayaty, Fouad ^a   Al Obaidi, Mazen M Jamil ^a   Abdulla, Mahmood A ^b  

^a UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGRAPHOLIDE; CARBOXYMETHYLCELLULOSE; CHOLESTEROL; FAT DROPLET; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; PHOSPHATE BUFFERED SALINE; SIMVASTATIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; ANTIOXIDANT; BIOLOGICAL MARKER; DITERPENE; LIPID;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BACTERIAL CELL; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; HISTOPATHOLOGY; HYPERLIPIDEMIA; LIPID PEROXIDATION; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PORPHYROMONAS GINGIVALIS; RAT; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; DRUG EFFECTS; KIDNEY; LIVER; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TOXICITY; TOXICITY TESTING; DRUG EFFECT;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; DITERPENES; GLUTATHIONE PEROXIDASE; HYPERLIPIDEMIAS; KIDNEY; LIPID PEROXIDATION; LIPIDS; LIVER; MALE; MALONDIALDEHYDE; PORPHYROMONAS GINGIVALIS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TOXICITY TESTS, ACUTE;

EID: 84880088630     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/594012     Document Type: Article

References (23)

1. Al-Bayaty F. H., Taiyeb-Ali T. B., Abdulla M. A., Mahmud Z. B., Antibacterial effects of Oradex, Gengigel and Salviathymol-n mouthwash on dental biofilm bacteria. African Journal of Microbiology Research 2011 5 6 636 642 2-s2.0-79957830755
2. Genco R. J., Current view of risk factors for periodontal diseases. Journal of Periodontology 1996 67 10 1041 1049 2-s2.0-0030256974
3. Lamont R. J., Jenkinson H. F., Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiology and Molecular Biology Reviews 1998 62 4 1244 1263 2-s2.0-0031766801
4. Wang P.-L., Ohura K., Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and toll-like receptors. Critical Reviews in Oral Biology and Medicine 2002 13 2 132 142 2-s2.0-0036073921
5. Zhang C. Y., Tan B., Hypotensive activity of aqueous extract of Andrographis paniculata in rats. Clinical and Experimental Pharmacology and Physiology 1996 23 8 675 678 2-s2.0-0029852445
6. Zhang X.-F., Tan B. K.-H., Antihyperglycaemic and anti-oxidant properties of Andrographis paniculata in normal and diabetic rats. Clinical and Experimental Pharmacology and Physiology 2000 27 5-6 358 363 2-s2.0-0034073761 10.1046/j.1440-1681.2000.03253.x
7. Al-Bayaty F., Abdulla M., Mohamed I., Hussein S., Effects of Malaysian medicinal plants on macrophage functions in vitro study. Journal of Medicinal Plants Research 2010 4 14 1459 1463
8. Al-Bayaty F. H., Abdulla M. A., Hassan M. I. A., Ali H. M., Effect of Andrographis paniculata leaf extract on wound healing in rats. Natural Product Research 2012 26 5 423 429 2-s2.0-84857583842 10.1080/14786419.2010.496114
9. Wasman S. Q., Mahmood A. A., Chua L. S., Alshawsh M. A., Hamdan S., Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats. Indian Journal of Experimental Biology 2011 49 10 767 772 2-s2.0-80054048498
10. Amroyan E., Gabrielian E., Panossian A., Wikman G., Wagner H., Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999 6 1 27 31 2-s2.0-0033091643
11. Buschmann J., The OECD guidelines for the testing of chemicals and pesticides. Methods in Molecular Biology 2013 947 37 56
12. Cass J. S., Campbell I. R., Lange L., A guide to production, care and use of laboratory animals. An annotated bibliography. 7. Special techniques; preparation of animals for use; handling; anesthesia, euthanasia, resuscitation; surgical techniques. Federation Proceedings 1963 22 2 115 144 2-s2.0-75549115644
13. Gibson F. C. III, Yumoto H., Takahashi Y., Chou H.-H., Genco C. A., Innate immune signaling and Porphyromonas gingivalis -accelerated atherosclerosis. Journal of Dental Research 2006 85 2 106 121 2-s2.0-33744823520 10.1177/154405910608500202
14. Lalla E., Lamster I. B., Hofmann M. A., Bucciarelli L., Jerud A. P., Tucker S., Lu Y., Papapanou P. N., Schmidt A. M., Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 8 1405 1411 2-s2.0-0042490523 10.1161/01.ATV.0000082462.26258.FE
15. Cutler C. W., Shinedling E. A., Nunn M., Jotwani R., Kim B.-O., Nares S., Iacopino A. M., Association between periodontitis and hyperlipidemia: cause or effect? Journal of Periodontology 1999 70 12 1429 1434 2-s2.0-0033251463
16. Draper H. H., Hadley M., Malondialdehyde determination as index of lipid peroxidation. Methods in Enzymology 1990 186 421 431 2-s2.0-0025142672 10.1016/0076-6879(90)86135-I
17. Choudhary M. I., Naheed S., Jalil S., Alam J. M., Atta-Ur-Rahman A.-U., Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet. Journal of Ethnopharmacology 2005 98 1-2 217 220 2-s2.0-14844332742 10.1016/j.jep.2005.01.013
18. Woo M.-N., Bok S.-H., Choi M.-S., Hypolipidemic and body fat-lowering effects of Fatclean in rats fed a high-fat diet. Food and Chemical Toxicology 2009 47 8 2076 2082 2-s2.0-68649110691 10.1016/j.fct.2009.05.041
19. Bolkent S., Yanardag R., Karabulut-Bulan O., Yesilyaprak B., Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: a morphological and biochemical study. Journal of Ethnopharmacology 2005 99 3 391 398 2-s2.0-20744439442 10.1016/j.jep.2005.02.038
20. Hou Y., Shao W., Xiao R., Xu K., Ma Z., Johnstone B. H., Du Y., Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model. Experimental Gerontology 2009 44 6-7 434 439 2-s2.0-67349180637 10.1016/j.exger.2009.03.007
21. Mantha S. V., Prasad M., Kalra J., Prasad K., Antioxidant enzymes in hypercholesterolemia and effects of vitamin E in rabbits. Atherosclerosis 1993 101 2 135 144 2-s2.0-0027199071
22. Iliskovic N., Singal P. K., Lipid lowering: an important factor in preventing adriamycin-induced heart failure. American Journal of Pathology 1997 150 2 727 734 2-s2.0-0031029638
23. Del Boccio G., Lapenna D., Porreca E., Pennelli A., Savini F., Feliciani P., Ricci G., Cuccurullo F., Aortic antioxidant defence mechanisms: time-related changes in cholesterol-fed rabbits. Atherosclerosis 1990 81 2 127 135 2-s2.0-0025269968