Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Matsuzaki, Hirokazu ^a   Shimizu, Yuta ^a   Iwata, Naohiro ^a   Kamiuchi, Shinya ^a   Suzuki, Fumiko ^b   Iizuka, Hiroshi ^b   Hibino, Yasuhide ^a   Okazaki, Mari ^a  

^a JOSAI UNIVERSITY   (Japan)

^b Noda Shokukin kogyo Co Ltd   (Japan)

Author keywords

5 HT2A receptors; Anxiety; Depression; Ganoderma lucidum mycelia; Locomotion; Memory

Indexed keywords

5 HYDROXYTRYPTOPHAN; ANTIDEPRESSANT AGENT; GANODERMA LUCIDUM EXTRACT; IMIPRAMINE; SEROTONIN 2A AGONIST;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; CLIMBING; CONDITIONING; CONTROLLED STUDY; CULTURE MEDIUM; ELEVATED PLUS MAZE TEST; FEAR; FORCED SWIM TEST; GANODERMA LUCIDUM; HEAD TWITCH; IMMOBILITY; LOCOMOTION; MALE; MYCELIUM; NONHUMAN; OPEN FIELD TEST; RAT; TRANQUILIZING ACTIVITY;

5-HYDROXYTRYPTOPHAN; ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CULTURE MEDIA, CONDITIONED; FEAR; MALE; MYCELIUM; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REISHI; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL; TICS;

EID: 84890941902     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-370     Document Type: Article

References (41)

1. Charney DS. Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry 1998, 59(Suppl 1):11-14.
2. Papakostas GI. Tolerability of modern antidepressants. J Clin Psychiatry 2008, 69(Suppl E):8-13.
3. Xu C, Teng J, Chen W, Ge Q, Yang Z, Yu C, Yang Z, Jia W. 20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests. Prog Neuropsychopharmacol Biol Psychiatry 2010, 34:1402-1411. 10.1016/j.pnpbp.2010.07.010, 20647027.
4. Singh GK, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S. Antidepressant activity of Asparagus racemosus in rodent models. Pharmacol Biochem Behav 2009, 91:283-290. 10.1016/j.pbb.2008.07.010, 18692086.
5. Machado DG, Bettio LEB, Cunha MP, Capra JC, Dalmarco JB, Pizzolatti MG, Rodrigues ALS. Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:642-650. 10.1016/j.pnpbp.2009.03.004, 19286446.
6. Grundmann OLVY, Kelber O, Butterweck V. Mechanism of St. John's wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine system. Neuropharmacology 2010, 58:767-773. 10.1016/j.neuropharm.2009.12.014, 20036263.
7. Sanodiya B, Thakur G, Baghel R, Prasad G, Bisen P. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol 2009, 10:717-742. 10.2174/138920109789978757, 19939212.
8. Lu H, Uesaka T, Katoh O, Kyo E, Watanabe H. Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats. Oncol Rep 2001, 8:1341-1345.
9. Kubo N, Myojin Y, Shimamoto F, Kashimoto N, Kyo E, Kamiya K, Watanabe H. Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: increased small intestinal crypt survival and prolongation of average time to animal. Int J Mol Med 2005, 15:401-416.
10. Iwata N, Okazaki M, Kasahara C, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y. Protective effects of a water-soluble extract from culture medium of ganoderma lucidum mycelia against neuronal damage after cerebral ischemia/reperfusion in diabetic rats. J Jpn Soc Nutr Food Sci 2008, 61:119-127.
11. Okazaki M, Iwata N, Horiuchi S, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y. Protective effects of a water-soluble extract from culture medium of ganoderma lucidum mycelia against neuronal damage after hypoxia-ischemia in mice. Jpn J Compl Altern Med 2008, 5:153-162.
12. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978, 47:379-391. 10.1016/0014-2999(78)90118-8, 204499.
13. Detke MJ, Rickels M, Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 1995, 121:66-72. 10.1007/BF02245592, 8539342.
14. Yamaguchi T, Tsujimatsu A, Kumamoto H, Izumi T, Ohmura Y, Yoshida T, Yoshioka M. Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress. J Ethnopharmacol 2012, 143:533-539. 10.1016/j.jep.2012.07.007, 22819689.
15. Bertoglio LJ, Joca SRL, Guimarães FS. Further evidence that anxiety and memory are regionally dissociated within the hippocampus. Behav Brain Res 2006, 175:183-188. 10.1016/j.bbr.2006.08.021, 16996146.
16. Fanselow MS. Conditioned and unconditional components of post-shock freezing. Pavlov J Biol Sci 1973, 15:177-182.
17. Rojas Corrales MO, Gibert Rahola J, Mico JA. Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior. Psychopharmacology (Berl) 2007, 190:221-231.
18. Cryan JF, Valentino RJ, Lucki I. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 2005, 29:547-569. 10.1016/j.neubiorev.2005.03.008, 15893822.
19. Rudy JW, Huff NC, Matus-Amat P. Understanding contextual fear conditioning: insights from a two-process model. Neurosci Biobehav Rev 2004, 28:675-685. 10.1016/j.neubiorev.2004.09.004, 15555677.
20. Carobrez AP, Bertoglio LJ. Ethological and temporal analyses of anxiety-like behavior: the elevated plus-maze model 20 years on. Neurosci Biobehav Rev 2005, 29:1193-1205. 10.1016/j.neubiorev.2005.04.017, 16084592.
21. Fanselow MS, Helmstetter FJ. Conditional analgesia, defensive freezing, and benzodiazepines. Behav Neurosci 1988, 102:233-243.
22. Hashimoto S, Inoue T, Koyama T. Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats. Eur J Pharmacol 1999, 378:23-30. 10.1016/S0014-2999(99)00441-0, 10478561.
23. Pellow S, Chopin P, File SE, Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 1985, 14:149-167. 10.1016/0165-0270(85)90031-7, 2864480.
24. Handley SL, McBlane JW, Critchley MA, Njung EK. Multiple serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive factors. Behav Brain Res 1993, 58:203-210. 10.1016/0166-4328(93)90104-X, 8136047.
25. Griebel G, Rodgers RJ, Perrault G, Sanger DJ. Risk assessment behaviour: evaluation of utility in the study of 5-HT-related drugs in the rat elevated plus-maze test. Pharmacol Biochem Behav 1997, 57:817-827. 10.1016/S0091-3057(96)00402-9, 9259011.
26. Griebel G, Perrault G, Sanger DJ. A comparative study of the effects of selective and non-selective 5-HT2 receptor subtype antagonists in rat and mouse models of anxiety. Neuropharmacology 1997, 36:793-802. 10.1016/S0028-3908(97)00034-8, 9225307.
27. Nic Dhonnchadha BA, Bourin M, Hascoët M. Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety. Behav Brain Res 2003, 140:203-214. 10.1016/S0166-4328(02)00311-X, 12644293.
28. Corne SJ, Pickering RW, Warner BT. A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine. Br J Pharmacol Chemother 1963, 20:106-120. 10.1111/j.1476-5381.1963.tb01302.x, 1703746, 14023050.
29. Schreiber R, Brocco M, Audinot V, Gobert A, Veiga S, Millan MJ. (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. J Pharmacol Exp Ther 1995, 273:101-112.
30. Pawłowski L, Melzacka M. Inhibition of head twitch response to quipazine in rats by chronic amitriptyline but not fluvoxamine or citalopram. Psychopharmacology (Berl) 1986, 88:279-284. 10.1007/BF00180825, 3083448.
31. Canal CE, Morgan D. Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model. Drug Test Anal 2012, 4:556-576. 10.1002/dta.1333, 3722587, 22517680.
32. Bel N, Artigas F. Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: an in vivo microdialysis study. Eur J Pharmacol 1992, 229:101-103. 10.1016/0014-2999(92)90292-C, 1282104.
33. Zhang Q, Andoh T, Konno M, Lee J-B, Hattori M, Kuraishi Y. Inhibitory effect of methanol extract of ganoderma lucidum on acute itch-associated responses in mice. Biol Pharm Bull 2010, 33:909-911. 10.1248/bpb.33.909, 20460776.
34. Maes M, Galecki P, Chang YS, Berk M. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35:676-692. 10.1016/j.pnpbp.2010.05.004, 20471444.
35. Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J Neurochem 2006, 97:1634-1658. 10.1111/j.1471-4159.2006.03907.x, 16805774.
36. Bilici M, Efe H, Köroǧlu MA, Uydu HA, Bekaroǧlu M, Deǧer O. Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J Affect Disord 2001, 64:43-51. 10.1016/S0165-0327(00)00199-3, 11292519.
37. Zafir A, Ara A, Banu N. Invivo antioxidant status: a putative target of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:220-228. 10.1016/j.pnpbp.2008.11.010, 19059298.
38. Okazaki M, Tanaka A, Hatta Y, Kawahara Y, Kamiuchi S, Iwata N, Asano S, Suzuki F, Iizuka H, Hibino Y. Antioxidant properties of a water-soluble extract from culture medium of ganoderma lucidum (Rei-shi) mycelia and antidiabetic effects in streptozotocin-treated mice. Jpn J Compl Altern Med 2008, 5:209-218.
39. Zhou Y, Shen Y-H, Zhang C, Su J, Liu R-H, Zhang W-D. Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models. J Nat Prod 2007, 70:652-655. 10.1021/np060470s, 17343408.
40. Liang X, Yan Ni H, Si Wei C, Wen Juan W, Xu N, Cui S, Liu XH, Zhang H, Yue Nan L, Liu S, Yang M, Dong Y. Antidepressant-like effect of asiaticoside in mice. Pharmacol Biochem Behav 2008, 89:444-449. 10.1016/j.pbb.2008.01.020, 18325568.
41. Wang J, Flaisher-Grinberg S, Li S, Liu H, Sun L, Zhou Y, Einat H. Antidepressant-like effects of the active acidic polysaccharide portion of ginseng in mice. J Ethnopharmacol 2010, 132:65-69. 10.1016/j.jep.2010.07.042, 20673793.