Mutating a Conserved Proline Residue within the Trimerization Domain Modifies Na+ Binding to Excitatory Amino Acid Transporters and Associated Conformational Changes

Journal of Biological Chemistry

Volumn 288, Issue 51, 2013, Pages 36492-36501

  Hotzy, Jasmin ^a   Schneider, Nicole ^a,b,c   Kovermann, Peter ^a,b   Fahlke, Christoph ^a,b,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; EXCITATORY AMINO ACIDS; FLUORESCENCE SIGNALS; NATURALLY OCCURRING; PROLINE RESIDUES; SODIUM BINDING; TRANSPORT FUNCTION; VOLTAGE CLAMP;

AMINO ACIDS; FLUORESCENCE;

SODIUM;

EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMIC ACID;

AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT; ANIMAL CELL; ANION CONDUCTION; ANION TRANSPORT; ARTICLE; BINDING AND RELATED PHENOMENA; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOFLUOROMETRY; DISSOCIATION; FEMALE; GAIN OF FUNCTION MUTATION; GLUTAMATE UPTAKE; ION CONDUCTANCE; MOLECULAR DYNAMICS; NONHUMAN; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SODIUM BINDING; STRUCTURE ACTIVITY RELATION; TRIMERIZATION DOMAIN; VOLTAGE CLAMP TECHNIQUE; XENOPUS LAEVIS;

ANION TRANSPORT; ATAXIA; GLUTAMATE; NEUROLOGICAL DISEASES; NEUROTRANSMITTER TRANSPORT; VOLTAGE CLAMP FLUOROMETRY;

ANIMALS; CONSERVED SEQUENCE; EXCITATORY AMINO ACID TRANSPORTER 1; GLUTAMIC ACID; HEK293 CELLS; HUMANS; MUTATION, MISSENSE; PROLINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SODIUM; XENOPUS;

EID: 84890895187     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.489385     Document Type: Article

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