Microphthalmia transcription factor regulates pancreatic β-Cell function

Diabetes

Volumn 62, Issue 8, 2013, Pages 2834-2842

  Mazur, Magdalena A ^a   Winkler, Marcus ^a   Ganić, Elvira ^a   Colberg, Jesper K ^a   Johansson, Jenny K ^a   Bennet, Hedvig ^a   Fex, Malin ^a   Nuber, Ulrike A ^a   Artner, Isabella ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PAX6; EYE PROTEIN; HOMEODOMAIN PROTEIN; MITF PROTEIN, MOUSE; PAIRED BOX TRANSCRIPTION FACTOR; PAX4 PROTEIN, MOUSE; REPRESSOR PROTEIN; GLUCOSE BLOOD LEVEL;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOCRINE CELL; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; INSULIN RELEASE; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; WILD TYPE; ANIMAL; GENETICS; METABOLISM; MUTATION; PANCREAS ISLET; SECRETION (PROCESS); TRANSCRIPTION INITIATION;

ANIMALS; BLOOD GLUCOSE; EYE PROTEINS; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MUTATION; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS; TRANSCRIPTIONAL ACTIVATION;

EID: 84890872273     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1464     Document Type: Article

References (37)

1. Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994;371:606-609
2. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H. beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998;12:1763-1768
3. Ashery-Padan R, Zhou X, Marquardt T, et al. Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Dev Biol 2004;269: 479-488
4. Gu C, Stein GH, Pan N, et al. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab 2010;11:298-310
5. Stoffers DA, Ferrer J, Clarke WL, Habener JF. Early-onset type-2 diabetes mellitus (MODY4) linked to IPF1. Nat Genet 1997;17:138-139
6. Yasuda T, Kajimoto Y, Fujitani Y, et al. PAX6 mutation as a genetic factor common to aniridia and glucose intolerance. Diabetes 2002;51:224-230
7. Malecki MT, Jhala US, Antonellis A, et al. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet 1999;23:323-328
8. Hole RL, Pian-Smith MC, Sharp GW. Development of the biphasic response to glucose in fetal and neonatal rat pancreas. Am J Physiol 1988;254:E167- E174
9. Matsuoka T, Zhao L, Artner I, et al. Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. 2003;23:6049- 6062
10. Matsuoka TA, Kaneto H, Stein R, et al. MafA regulates expression of genes important to islet beta-cell function. Mol Endocrinol 2007;21:2764-2774
11. Artner I, Blanchi B, Raum JC, et al. MafB is required for islet beta cell maturation. Proc Natl Acad Sci USA 2007;104:3853-3858
12. Artner I, Hang Y, Mazur M, et al. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes 2010;59:2530-2539
13. Shibahara S, Yasumoto K, Amae S, et al. Regulation of pigment cell-specific gene expression by MITF. Pigment Cell Res 2000;13(Suppl. 8):98-102
14. Spence JR, Madhavan M, Aycinena J-C, Del Rio-Tsonis K. Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6. Mol Vis 2007;13:57-65
15. Bharti K, Gasper M, Ou J, et al. A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. PLoS Genet 2012;8:e1002757
16. McGill GG, Horstmann M, Widlund HR, et al. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 2002;109:707-718
17. Du J, Widlund HR, Horstmann MA, et al. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell 2004;6:565-576
18. Loercher AE, Tank EMH, Delston RB, Harbour JW. MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J Cell Biol 2005;168:35-40
19. Hemesath TJ, Steingrímsson E, McGill G, et al. microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev 1994;8:2770-2780
20. Johansson JK, Voss U, Kesavan G, et al. N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis 2010;48:374-381
21. Ahlenius H, Devaraju K, Monni E, et al. Adaptor protein LNK is a negative regulator of brain neural stem cell proliferation after stroke. J Neurosci 2012;32:5151-5164
22. Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L. Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS ONE 2012;7:e52026
23. Mochii M, Mazaki Y, Mizuno N, Hayashi H, Eguchi G. Role of Mitf in differentiation and transdifferentiation of chicken pigmented epithelial cell. Dev Biol 1998;193:47-62
24. Morgan R. Conservation of sequence and function in the Pax6 regulatory elements. Trends Genet 2004;20:283-287
25. Carbe C, Hertzler-Schaefer K, Zhang X. The functional role of the Meis/ Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol 2012;363:320-329
26. Steingrímsson E, Copeland NG, Jenkins NA. Melanocytes and the microphthalmia transcription factor network. Annu Rev Genet 2004;38:365-411
27. White P, May CL, Lamounier RN, Brestelli JE, Kaestner KH. Defining pancreatic endocrine precursors and their descendants. Diabetes 2008;57:654-668
28. Johnson SL, Nguyen AN, Lister JA. mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell. Dev Biol 2011;350:405-413
29. Orci L, Thorens B, Ravazzola M, Lodish HF. Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. Science 1989;245:295-297
30. Guillam MT, Dupraz P, Thorens B. Glucose uptake, utilization, and signaling in GLUT2-null islets. Diabetes 2000;49:1485-1491
31. Gosmain Y, Katz LS, Masson MH, Cheyssac C, Poisson C, Philippe J. Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion. Mol Endocrinol 2012;26:696-709
32. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P. The Pax4 gene is essential for differentiation of insulin-producing b cells in the mammalian pancreas. Nature 1997;386:399-402
33. Hu He KH, Lorenzo PI, Brun T, et al. In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice. Diabetes 2011;60:1705-1715
34. Goding CR. Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage. Genes Dev 2000;14:1712- 1728
35. Planque N, Raposo G, Leconte L, Anezo O, Martin P, Saule S. Microphthalmia transcription factor induces both retinal pigmented epithelium and neural crest melanocytes from neuroretina cells. J Biol Chem 2004; 279:41911-41917
36. Zhang X, Friedman A, Heaney S, Purcell P, Maas RL. Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev 2002;16:2097-2107
37. Planque N, Leconte L, Coquelle FM, Martin P, Saule S. Specific Pax- /microphthalmia transcription factor interactions involve their DNA-binding domains and inhibit transcriptional properties of both proteins. J Biol Chem 2001;276:29330-29337