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Volumn 82, Issue 1, 2014, Pages 92-100

Insulin treatment modulates the host immune system to enhance Pseudomonas aeruginosa wound biofilms

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DEOXYRIBONUCLEASE; GENOMIC DNA; GENTAMICIN; HUMAN INSULIN; ISOPHANE INSULIN; MYELOPEROXIDASE; RNA;

EID: 84890851760     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00651-13     Document Type: Article
Times cited : (52)

References (59)
  • 2
    • 0017521787 scopus 로고
    • Epidemiology of nosocomial infection due to Gram-negative bacilli: aspects relevant to development and use of vaccines
    • Stamm WE, Martin SM, Bennett JV. 1977. Epidemiology of nosocomial infection due to Gram-negative bacilli: aspects relevant to development and use of vaccines. J. Infect. Dis. 136(Suppl):S151-S160. http://dx.doi.org/10.1093/infdis/136.Supplement.S151.
    • (1977) J. Infect. Dis. , vol.136 , Issue.SUPPL.
    • Stamm, W.E.1    Martin, S.M.2    Bennett, J.V.3
  • 5
    • 1342304447 scopus 로고    scopus 로고
    • Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system
    • Vuong C, Voyich JM, Fischer ER, Braughton KR, Whitney AR, DeLeo FR, Otto M. 2004. Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system. Cell. Microbiol. 6:269-275. http://dx.doi.org/10.1046/j.1462-5822.2004.00367.x.
    • (2004) Cell. Microbiol. , vol.6 , pp. 269-275
    • Vuong, C.1    Voyich, J.M.2    Fischer, E.R.3    Braughton, K.R.4    Whitney, A.R.5    DeLeo, F.R.6    Otto, M.7
  • 6
    • 78751681579 scopus 로고    scopus 로고
    • Biofilms: do they affect wound healing? Int
    • Thomson CH. 2011. Biofilms: do they affect wound healing? Int. Wound J. 8:63-67. http://dx.doi.org/10.1111/j.1742-481X.2010.00749.x.
    • (2011) Wound J. , vol.8 , pp. 63-67
    • Thomson, C.H.1
  • 7
    • 78751691645 scopus 로고    scopus 로고
    • Investigating the humoral immune response in chronic venous leg ulcer patients colonised with Pseudomonas aeruginosa
    • Jacobsen JN, Andersen AS, Sonnested MK, Laursen I, Jorgensen B, Krogfelt KA. 2011. Investigating the humoral immune response in chronic venous leg ulcer patients colonised with Pseudomonas aeruginosa. Int. Wound J. 8:33-43. http://dx.doi.org/10.1111/j.1742-481X.2010.00741.x.
    • (2011) Int. Wound J. , vol.8 , pp. 33-43
    • Jacobsen, J.N.1    Andersen, A.S.2    Sonnested, M.K.3    Laursen, I.4    Jorgensen, B.5    Krogfelt, K.A.6
  • 8
    • 44949093604 scopus 로고    scopus 로고
    • Biofilms and chronic infections
    • Wolcott RD, Ehrlich GD. 2008. Biofilms and chronic infections. JAMA 299:2682-2684. http://dx.doi.org/10.1001/jama.299.22.2682.
    • (2008) JAMA , vol.299 , pp. 2682-2684
    • Wolcott, R.D.1    Ehrlich, G.D.2
  • 9
    • 78751545483 scopus 로고    scopus 로고
    • Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms
    • Percival SL, Hill KE, Malic S, Thomas DW, Williams DW. 2011. Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair Regen. 19:1-9. http://dx.doi.org/10.1111/j.1524-475X.2010.00651.x.
    • (2011) Wound Repair Regen. , vol.19 , pp. 1-9
    • Percival, S.L.1    Hill, K.E.2    Malic, S.3    Thomas, D.W.4    Williams, D.W.5
  • 10
    • 0025147735 scopus 로고
    • Testing the susceptibility of bacteria in biofilms to antibacterial agents
    • Anwar H, Dasgupta MK, Costerton JW. 1990. Testing the susceptibility of bacteria in biofilms to antibacterial agents. Antimicrob. Agents Chemother. 34:2043-2046. http://dx.doi.org/10.1128/AAC.34.11.2043.
    • (1990) Antimicrob. Agents Chemother. , vol.34 , pp. 2043-2046
    • Anwar, H.1    Dasgupta, M.K.2    Costerton, J.W.3
  • 11
    • 66749179869 scopus 로고    scopus 로고
    • The importance of being persistent: heterogeneity of bacterial populations under antibiotic stress
    • Gefen O, Balaban NQ. 2009. The importance of being persistent: heterogeneity of bacterial populations under antibiotic stress. FEMS Microbiol. Rev. 33:704-717. http://dx.doi.org/10.1111/j.1574-6976.2008.00156.x.
    • (2009) FEMS Microbiol. Rev. , vol.33 , pp. 704-717
    • Gefen, O.1    Balaban, N.Q.2
  • 16
    • 0034915177 scopus 로고    scopus 로고
    • Insulin inhibits intranuclear nuclear factor kappa B and stimulates I kappa B in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J
    • Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, Ahmad S. 2001. Insulin inhibits intranuclear nuclear factor kappa B and stimulates I kappa B in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J. Clin. Endocrinol. Metabolism 86:3257-3265. http://dx.doi.org/10.1210/jc.86.7.3257.
    • (2001) Clin. Endocrinol. Metabolism , vol.86 , pp. 3257-3265
    • Dandona, P.1    Aljada, A.2    Mohanty, P.3    Ghanim, H.4    Hamouda, W.5    Assian, E.6    Ahmad, S.7
  • 17
    • 51149105270 scopus 로고    scopus 로고
    • Insulin suppresses LPS-induced iNOS and COX-2 expression and NFkappa B activation in alveolar macrophages
    • Martins JO, Ferracini M, Ravanelli N, Landgraf RG, Jancar S. 2008. Insulin suppresses LPS-induced iNOS and COX-2 expression and NFkappa B activation in alveolar macrophages. Cell. Physiol. Biochem. 22: 279-286. http://dx.doi.org/10.1159/000149806.
    • (2008) Cell. Physiol. Biochem. , vol.22 , pp. 279-286
    • Martins, J.O.1    Ferracini, M.2    Ravanelli, N.3    Landgraf, R.G.4    Jancar, S.5
  • 18
    • 45749127808 scopus 로고    scopus 로고
    • Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharideinduced inflammation in mice
    • Kidd LB, Schabbauer GA, Luyendyk JP, Holscher TD, Tilley RE, Tencati M, Mackman N. 2008. Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharideinduced inflammation in mice. J. Pharmacol. Exp. Ther. 326:348-353. http://dx.doi.org/10.1124/jpet.108.138891.
    • (2008) J. Pharmacol. Exp. Ther. , vol.326 , pp. 348-353
    • Kidd, L.B.1    Schabbauer, G.A.2    Luyendyk, J.P.3    Holscher, T.D.4    Tilley, R.E.5    Tencati, M.6    Mackman, N.7
  • 20
    • 0028849833 scopus 로고
    • Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family
    • Brint JM, Ohman DE. 1995. Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J. Bacteriol. 177:7155-7163.
    • (1995) J. Bacteriol. , vol.177 , pp. 7155-7163
    • Brint, J.M.1    Ohman, D.E.2
  • 21
    • 18144388695 scopus 로고    scopus 로고
    • Mouse models to study wound closure and topical treatment of infected wounds in healing-impaired and normal healing hosts
    • Brown RL, Greenhalgh DG. 1997. Mouse models to study wound closure and topical treatment of infected wounds in healing-impaired and normal healing hosts. Wound Repair Regen. 5:198-204. http://dx.doi.org/10.1046/j.1524-475X.1997.50213.x.
    • (1997) Wound Repair Regen. , vol.5 , pp. 198-204
    • Brown, R.L.1    Greenhalgh, D.G.2
  • 23
    • 0029861676 scopus 로고    scopus 로고
    • Quantitation of eosinophil and neutrophil infiltration into rat lung by specific assays for eosinophil peroxidase and myeloperoxidase. Application in a Brown Norway rat model of allergic pulmonary inflammation
    • Schneider T, Issekutz AC. 1996. Quantitation of eosinophil and neutrophil infiltration into rat lung by specific assays for eosinophil peroxidase and myeloperoxidase. Application in a Brown Norway rat model of allergic pulmonary inflammation. J. Immunol. Methods 198:1-14.
    • (1996) J. Immunol. Methods , vol.198 , pp. 1-14
    • Schneider, T.1    Issekutz, A.C.2
  • 24
    • 84864024867 scopus 로고    scopus 로고
    • Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo
    • van Gennip M, Christensen LD, Alhede M, Qvortrup K, Jensen PO, Hoiby N, Givskov M, Bjarnsholt T. 2012. Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo. Infect. Immun. 80:2601-2607. http://dx.doi.org/10.1128/IAI.06215-11.
    • (2012) Infect. Immun. , vol.80 , pp. 2601-2607
    • van Gennip, M.1    Christensen, L.D.2    Alhede, M.3    Qvortrup, K.4    Jensen, P.O.5    Hoiby, N.6    Givskov, M.7    Bjarnsholt, T.8
  • 26
    • 0037154837 scopus 로고    scopus 로고
    • Extracellular DNA required for bacterial biofilm formation
    • Whitchurch CB, Tolker-Nielsen T, Ragas PC, Mattick JS. 2002. Extracellular DNA required for bacterial biofilm formation. Science 295:1487. http://dx.doi.org/10.1126/science.295.5559.1487.
    • (2002) Science , vol.295 , pp. 1487
    • Whitchurch, C.B.1    Tolker-Nielsen, T.2    Ragas, P.C.3    Mattick, J.S.4
  • 27
    • 33645887831 scopus 로고    scopus 로고
    • Quorum sensing and DNA release in bacterial biofilms
    • Spoering AL, Gilmore MS. 2006. Quorum sensing and DNA release in bacterial biofilms. Curr. Opin. Microbiol. 9:133-137. http://dx.doi.org/10.1016/j.mib.2006.02.004.
    • (2006) Curr. Opin. Microbiol. , vol.9 , pp. 133-137
    • Spoering, A.L.1    Gilmore, M.S.2
  • 28
    • 62949140725 scopus 로고    scopus 로고
    • Effect of DNase and antibiotics on biofilm characteristics
    • Tetz GV, Artemenko NK, Tetz VV. 2009. Effect of DNase and antibiotics on biofilm characteristics. Antimicrob. Agents Chemother. 53:1204-1209. http://dx.doi.org/10.1128/AAC.00471-08.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1204-1209
    • Tetz, G.V.1    Artemenko, N.K.2    Tetz, V.V.3
  • 29
    • 57149111485 scopus 로고    scopus 로고
    • Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms
    • Mulcahy H, Charron-Mazenod L, Lewenza S. 2008. Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms. PLoS Pathog. 4:e1000213. http://dx.doi.org/10.1371/journal.ppat.1000213.
    • (2008) PLoS Pathog. , vol.4
    • Mulcahy, H.1    Charron-Mazenod, L.2    Lewenza, S.3
  • 31
    • 84890816284 scopus 로고    scopus 로고
    • The role of alginate and extracellular DNA in biofilm-meditated Pseudomonas aeruginosa gentamicin
    • Aspe M, Jensen L, Melegrito J, Sun M. 2012. The role of alginate and extracellular DNA in biofilm-meditated Pseudomonas aeruginosa gentamicin. J. Exp. Microbiol. Immunol. 16:42-48.
    • (2012) J. Exp. Microbiol. Immunol. , vol.16 , pp. 42-48
    • Aspe, M.1    Jensen, L.2    Melegrito, J.3    Sun, M.4
  • 32
    • 2542478053 scopus 로고    scopus 로고
    • Wound healing: an overview of acute,fibrotic and delayed healing
    • Diegelmann RF, Evans MC. 2004. Wound healing: an overview of acute,fibrotic and delayed healing. Front. Biosci. 9:283-289. http://dx.doi.org/10.2741/1184.
    • (2004) Front. Biosci. , vol.9 , pp. 283-289
    • Diegelmann, R.F.1    Evans, M.C.2
  • 33
    • 32644439432 scopus 로고    scopus 로고
    • Polymorphonuclear neutrophil dysfunctions in streptozotocin-induced type 1 diabetic rats
    • Nabi AH, Islam LN, Rahman MM, Biswas KB. 2005. Polymorphonuclear neutrophil dysfunctions in streptozotocin-induced type 1 diabetic rats. J. Biochem. Mol. Biol. 38:661-667. http://dx.doi.org/10.5483/BMBRep.2005.38.6.661.
    • (2005) J. Biochem. Mol. Biol. , vol.38 , pp. 661-667
    • Nabi, A.H.1    Islam, L.N.2    Rahman, M.M.3    Biswas, K.B.4
  • 34
    • 0018908508 scopus 로고
    • Depressed immunological defence mechanisms in mice with experimentally induced diabetes
    • Saiki O, Negoro S, Tsuyuguchi I, Yamamura Y. 1980. Depressed immunological defence mechanisms in mice with experimentally induced diabetes. Infect. Immun. 28:127-131.
    • (1980) Infect. Immun. , vol.28 , pp. 127-131
    • Saiki, O.1    Negoro, S.2    Tsuyuguchi, I.3    Yamamura, Y.4
  • 35
    • 0023218545 scopus 로고
    • Impairment of monocyte "lectin-like" receptor activity in type 1 (insulin-dependent) diabetic patients
    • Glass EJ, Stewart J, Matthews DM, Collier A, Clarke BF, Weir DM. 1987. Impairment of monocyte "lectin-like" receptor activity in type 1 (insulin-dependent) diabetic patients. Diabetologia 30:228-231. http://dx.doi.org/10.1007/BF00270420.
    • (1987) Diabetologia , vol.30 , pp. 228-231
    • Glass, E.J.1    Stewart, J.2    Matthews, D.M.3    Collier, A.4    Clarke, B.F.5    Weir, D.M.6
  • 36
    • 0022626462 scopus 로고
    • Neutrophil phagocytosis and killing in insulin-dependent diabetes
    • Wilson RM, Reeves WG. 1986. Neutrophil phagocytosis and killing in insulin-dependent diabetes. Clin. Exp. Immunol. 63:478-484.
    • (1986) Clin. Exp. Immunol. , vol.63 , pp. 478-484
    • Wilson, R.M.1    Reeves, W.G.2
  • 37
    • 0017240322 scopus 로고
    • Studies on the chlorinating activity of myeloperoxidase
    • Harrison JE, Schultz J. 1976. Studies on the chlorinating activity of myeloperoxidase. J. Biol. Chem. 251:1371-1374.
    • (1976) J. Biol. Chem. , vol.251 , pp. 1371-1374
    • Harrison, J.E.1    Schultz, J.2
  • 38
    • 0036043876 scopus 로고    scopus 로고
    • TUNEL assay. An overview of techniques
    • Loo DT. 2002. TUNEL assay. An overview of techniques. Methods Mol. Biol. 203:21-30. http://dx.doi.org/10.1385/1-59259-179-5:21.
    • (2002) Methods Mol. Biol. , vol.203 , pp. 21-30
    • Loo, D.T.1
  • 39
    • 0031564831 scopus 로고    scopus 로고
    • Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain
    • de Torres C, Munell F, Ferrer I, Reventos J, Macaya A. 1997. Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain. Neurosci. Lett. 230:1-4. http://dx.doi.org/10.1016/S0304-3940(97)00445-X.
    • (1997) Neurosci. Lett. , vol.230 , pp. 1-4
    • de Torres, C.1    Munell, F.2    Ferrer, I.3    Reventos, J.4    Macaya, A.5
  • 40
    • 33747609826 scopus 로고    scopus 로고
    • Immunohistochemical expression of activated caspase-3 as a marker of apoptosis in glomeruli of human lupus nephritis
    • Jeruc J, Vizjak A, Rozman B, Ferluga D. 2006. Immunohistochemical expression of activated caspase-3 as a marker of apoptosis in glomeruli of human lupus nephritis. Am. J. Kidney Dis. 48:410-418. http://dx.doi.org/10.1053/j.ajkd.2006.05.019.
    • (2006) Am. J. Kidney Dis. , vol.48 , pp. 410-418
    • Jeruc, J.1    Vizjak, A.2    Rozman, B.3    Ferluga, D.4
  • 42
    • 0019784850 scopus 로고
    • F4/80, a monoclonal antibody directed specifically against the mouse macrophage
    • Austyn JM, Gordon S. 1981. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur. J. Immunol. 11:805-815. http://dx.doi.org/10.1002/eji.1830111013.
    • (1981) Eur. J. Immunol. , vol.11 , pp. 805-815
    • Austyn, J.M.1    Gordon, S.2
  • 43
    • 3242728528 scopus 로고    scopus 로고
    • Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma
    • Klein D, Schubert T, Horch RE, Jauch KW, Jeschke MG. 2004. Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma. Ann. Surg. 240:340-349. http://dx.doi.org/10.1097/01.sla.0000133353.57674.cd.
    • (2004) Ann. Surg. , vol.240 , pp. 340-349
    • Klein, D.1    Schubert, T.2    Horch, R.E.3    Jauch, K.W.4    Jeschke, M.G.5
  • 44
    • 4344645520 scopus 로고    scopus 로고
    • Insulin attenuates the systemic inflammatory response in endotoxemic rats
    • Jeschke MG, Klein D, Bolder U, Einspanier R. 2004. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology 145:4084-4093. http://dx.doi.org/10.1210/en.2004-0592.
    • (2004) Endocrinology , vol.145 , pp. 4084-4093
    • Jeschke, M.G.1    Klein, D.2    Bolder, U.3    Einspanier, R.4
  • 45
    • 1642331710 scopus 로고    scopus 로고
    • Insulin treatment improves the systemic inflammatory reaction to severe trauma
    • Jeschke MG, Klein D, Herndon DN. 2004. Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann. Surg. 239:553-560. http://dx.doi.org/10.1097/01.sla.0000118569.10289.ad.
    • (2004) Ann. Surg. , vol.239 , pp. 553-560
    • Jeschke, M.G.1    Klein, D.2    Herndon, D.N.3
  • 46
    • 33846236258 scopus 로고    scopus 로고
    • Insulin attenuates the cytokine response in a burn wound infection model
    • Przkora R, Herndon DN, Finnerty CC, Jeschke MG. 2007. Insulin attenuates the cytokine response in a burn wound infection model. Shock 27:205-208. http://dx.doi.org/10.1097/01.shk.0000238069.84826.1b.
    • (2007) Shock , vol.27 , pp. 205-208
    • Przkora, R.1    Herndon, D.N.2    Finnerty, C.C.3    Jeschke, M.G.4
  • 47
    • 84863479694 scopus 로고    scopus 로고
    • Antipathogenic properties of Lactobacillus plantarum on Pseudomonas aeruginosa: the potential use of its supernatants in the treatment of infected chronic wounds
    • Ramos AN, Cabral ME, Noseda D, Bosch A, Yantorno OM, Valdez JC. 2012. Antipathogenic properties of Lactobacillus plantarum on Pseudomonas aeruginosa: the potential use of its supernatants in the treatment of infected chronic wounds. Wound Repair Regen. 20:552-562. http://dx.doi.org/10.1111/j.1524-475X.2012.00798.x.
    • (2012) Wound Repair Regen. , vol.20 , pp. 552-562
    • Ramos, A.N.1    Cabral, M.E.2    Noseda, D.3    Bosch, A.4    Yantorno, O.M.5    Valdez, J.C.6
  • 51
    • 53649100267 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa induces localized immunosuppression during pneumonia
    • Diaz MH, Shaver CM, King JD, Musunuri S, Kazzaz JA, Hauser AR. 2008. Pseudomonas aeruginosa induces localized immunosuppression during pneumonia. Infect. Immun. 76:4414-4421. http://dx.doi.org/10.1128/IAI.00012-08.
    • (2008) Infect. Immun. , vol.76 , pp. 4414-4421
    • Diaz, M.H.1    Shaver, C.M.2    King, J.D.3    Musunuri, S.4    Kazzaz, J.A.5    Hauser, A.R.6
  • 52
    • 57349184120 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetic models in mice and rats
    • Chapter 5:Unit 5.47.
    • Wu KK, Huan Y. 2008. Streptozotocin-induced diabetic models in mice and rats. Curr. Protoc. Pharmacol. Chapter 5:Unit 5.47. http://dx.doi.org/10.1002/0471141755.ph0547s40.
    • (2008) Curr. Protoc. Pharmacol.
    • Wu, K.K.1    Huan, Y.2
  • 53
    • 22144434453 scopus 로고    scopus 로고
    • Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects
    • Turina M, Fry DE, Polk HC, Jr. 2005. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Crit. Care Med. 33: 1624-1633. http://dx.doi.org/10.1097/01.CCM.0000170106.61978.D8.
    • (2005) Crit. Care Med. , vol.33 , pp. 1624-1633
    • Turina, M.1    Fry, D.E.2    Polk Jr., H.C.3
  • 54
    • 0018822437 scopus 로고
    • Infection and diabetes mellitus
    • Wheat LJ. 1980. Infection and diabetes mellitus. Diabetes Care 3:187-197. http://dx.doi.org/10.2337/diacare.3.1.187.
    • (1980) Diabetes Care , vol.3 , pp. 187-197
    • Wheat, L.J.1
  • 55
    • 0023247368 scopus 로고
    • The effect of diabetes mellitus on chemotactic and bactericidal activity of human polymorphonuclear leukocytes
    • Naghibi M, Smith RP, Baltch AL, Gates SA, Wu DH, Hammer MC, Michelsen PB. 1987. The effect of diabetes mellitus on chemotactic and bactericidal activity of human polymorphonuclear leukocytes. Diabetes Res. Clin. Pract. 4:27-35. http://dx.doi.org/10.1016/S0168-8227(87)80030-X.
    • (1987) Diabetes Res. Clin. Pract. , vol.4 , pp. 27-35
    • Naghibi, M.1    Smith, R.P.2    Baltch, A.L.3    Gates, S.A.4    Wu, D.H.5    Hammer, M.C.6    Michelsen, P.B.7
  • 56
    • 84866175158 scopus 로고    scopus 로고
    • Neutrophil extracellular traps: double-edged swords of innate immunity
    • Kaplan MJ, Radic M. 2012. Neutrophil extracellular traps: double-edged swords of innate immunity. J. Immunol. 189:2689-2695. http://dx.doi.org/10.4049/jimmunol.1201719.
    • (2012) J. Immunol. , vol.189 , pp. 2689-2695
    • Kaplan, M.J.1    Radic, M.2
  • 59
    • 65649093014 scopus 로고    scopus 로고
    • Neutrophil enhancement of Pseudomonas aeruginosa biofilm development: human F-actin and DNA as targets for therapy
    • Parks QM, Young RL, Poch KR, Malcolm KC, Vasil ML, Nick JA. 2009. Neutrophil enhancement of Pseudomonas aeruginosa biofilm development: human F-actin and DNA as targets for therapy. J. Med. Microbiol. 58:492-502. http://dx.doi.org/10.1099/jmm.0.005728-0.
    • (2009) J. Med. Microbiol. , vol.58 , pp. 492-502
    • Parks, Q.M.1    Young, R.L.2    Poch, K.R.3    Malcolm, K.C.4    Vasil, M.L.5    Nick, J.A.6


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