Total synthesis and biological evaluation of phidianidines a and b uncovers unique pharmacological profiles at CNS targets

ACS Chemical Neuroscience

Volumn 3, Issue 9, 2012, Pages 658-664

  Brogan, John T ^a,b   Stoops, Sydney L ^a   Lindsley, Craig W ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; MU OPIATE RECEPTOR; OXADIAZOLE DERIVATIVE; PHIDIANIDINE A; PHIDIANIDINE B; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; PRIORITY JOURNAL; REACTION ANALYSIS;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM AGENTS; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GASTROPODA; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEK293 CELLS; HUMANS; INDICATORS AND REAGENTS; INDOLE ALKALOIDS; LIGANDS; OXADIAZOLES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

PHIDIANA;

EID: 84866393196     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn300064r     Document Type: Article

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