Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 51, 2013, Pages 20503-20508

  Guillén, Jaime ^a   Ferrer Orta, Cristina ^b   Buxaderas, Mònica ^b   Pérez Sánchez, Dolores ^a   Guerrero Valero, Marta ^a   Luengo Gil, Ginés ^a   Pous, Joan ^b,c   Guerra, Pablo ^b   Gómez Fernández, Juan C ^a   Verdaguer, Nuria ^b   Corbalán García, Senena ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^c INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

Calcium; PIP2; Vesicle fusion

Indexed keywords

CALCIUM ION; GLUTAMIC ACID; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN; RABPHILIN 3A; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; CALCIUM; NERVE PROTEIN; RABPHILIN-3A; SIGNAL TRANSDUCING ADAPTOR PROTEIN; VESICULAR TRANSPORT PROTEIN;

ARTICLE; BETA SHEET; BINDING KINETICS; CALCIUM BINDING; COMPARATIVE STUDY; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN C2 DOMAIN; PROTEIN C2A DOMAIN; PROTEIN C2B DOMAIN; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; CELL MEMBRANE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; PIP2; VESICLE FUSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CALCIUM; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; HUMANS; NERVE TISSUE PROTEINS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOTAGMIN I; VESICULAR TRANSPORT PROTEINS;

CALCIUM; PIP2; VESICLE FUSION;

EID: 84890835772     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1316179110     Document Type: Article

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