ERK1/2 activation modulates pyocyanin-induced toxicity in A549 respiratory epithelial cells

Chemico-Biological Interactions

Volumn 208, Issue 1, 2014, Pages 58-63

  Forbes, Amanda ^a   Davey, Andrew K ^a   Perkins, Anthony V ^a   Grant, Gary D ^a   McFarland, Amelia J ^a   McDermott, Catherine M ^b   Anoopkumar Dukie, Shailendra ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b BOND UNIVERSITY   (Australia)

Author keywords

A549 cells; Extracellular signal regulated kinase (ERK); Mitogen activated protein kinases (MAPK); Oxidative stress; Pyocyanin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 6; PYOCYANINE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PSEUDOMONAS AERUGINOSA; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION;

A549 CELLS; CF; CYSTIC FIBROSIS; DMEM; DULBECCO'S MODIFIED EAGLE MEDIUM; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK); GSH; GSSG; MAPK; MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES (MAPK); N-ACETYLCYTEINE; NAC; OXIDATIVE STRESS; OXIDISED GLUTATHIONE; PCN; PYOCYANIN; REACTIVE OXYGEN SPECIES; REDUCED GLUTATHIONE; ROS; SIRNA; SMALL INTERFERING RNA;

APOPTOSIS; CELL LINE, TUMOR; EPITHELIAL CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATION-REDUCTION; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYOCYANINE; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION;

EID: 84890831520     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.11.016     Document Type: Article

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