Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 287, Issue 1 31-1, 2004, Pages

  O'Malley, Yunxia Q ^a   Reszka, Krzysztof J ^a,b   Spitz, Douglas R ^a   Denning, Gerene M ^a,b   Britigan, Bradley E ^a,b,c  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Glutathione; Human bronchial epithelial cells; Lung; Type 11 alveolar epithelial cells

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; BACTERIAL PROTEIN; CATALASE; CYSTEINE; FREE RADICAL; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROGEN PEROXIDE; METHIONINE; OXYGEN; OXYGEN RADICAL; PYOCYANINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL DERIVATIVE;

ARTICLE; BACTERIAL VIRULENCE; BRONCHUS MUCOSA; CELL FUNCTION; CELL STRAIN A549; CONCENTRATION RESPONSE; CYTOTOXICITY; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL TYPE 2; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATARY EPITHELIUM CELL; RESPIRATORY EPITHELIUM;

CELLS, CULTURED; EPITHELIAL CELLS; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; PSEUDOMONAS AERUGINOSA; PULMONARY ALVEOLI; PYOCYANINE; SULFHYDRYL COMPOUNDS;

EID: 2342640597     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00025.2004     Document Type: Article

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