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Volumn 82, Issue 1, 2014, Pages 445-452

Cyclic Di-GMP receptor PlzA controls virulence gene expression through RpoS in Borrelia burgdorferi

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BINDING PROTEIN; CYCLIC DI GUANOSINE MONOPHOSPHATE; CYCLIC GMP DERIVATIVE; GENOMIC DNA; MESSENGER RNA; PROTEIN PLZA; SIGMA FACTOR RPOS; UNCLASSIFIED DRUG;

EID: 84890820130     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01238-13     Document Type: Article
Times cited : (39)

References (56)
  • 1
    • 2142660806 scopus 로고    scopus 로고
    • The emergence of Lyme disease
    • Steere AC, Coburn J, Glickstein L. 2004. The emergence of Lyme disease. J. Clin. Invest. 113:1093-1101. http://dx.doi.org/10.1172/JCI21681.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1093-1101
    • Steere, A.C.1    Coburn, J.2    Glickstein, L.3
  • 2
    • 80053278392 scopus 로고    scopus 로고
    • Gene regulation in Borrelia burgdorferi
    • Samuels DS. 2011. Gene regulation in Borrelia burgdorferi. Annu. Rev. Microbiol. 65:479-499. http://dx.doi.org/10.1146/annurev.micro.112408.134040.
    • (2011) Annu. Rev. Microbiol. , vol.65 , pp. 479-499
    • Samuels, D.S.1
  • 3
    • 84855900042 scopus 로고    scopus 로고
    • Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
    • Radolf JD, Caimano MJ, Stevenson B, Hu LT. 2012. Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nat. Rev. Microbiol. 10:87-99. http://dx.doi.org/10.1038/nrmicro2714.
    • (2012) Nat. Rev. Microbiol. , vol.10 , pp. 87-99
    • Radolf, J.D.1    Caimano, M.J.2    Stevenson, B.3    Hu, L.T.4
  • 5
    • 0033759350 scopus 로고    scopus 로고
    • Genome analyses of spirochetes: a study of the protein structures, functions and metabolic pathways in Treponema pallidum and Borrelia burgdorferi
    • Das R, Hegyi H, Gerstein M. 2000. Genome analyses of spirochetes: a study of the protein structures, functions and metabolic pathways in Treponema pallidum and Borrelia burgdorferi. J. Mol. Microbiol. Biotechnol. 2:387-392.
    • (2000) J. Mol. Microbiol. Biotechnol. , vol.2 , pp. 387-392
    • Das, R.1    Hegyi, H.2    Gerstein, M.3
  • 6
    • 51949106515 scopus 로고    scopus 로고
    • Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi
    • Boardman BK, He M, Ouyang Z, Xu H, Pang X, Yang XF. 2008. Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi. Infect. Immun. 76:3844-3853. http://dx.doi.org/10.1128/IAI.00467-08.
    • (2008) Infect. Immun. , vol.76 , pp. 3844-3853
    • Boardman, B.K.1    He, M.2    Ouyang, Z.3    Xu, H.4    Pang, X.5    Yang, X.F.6
  • 7
    • 34547879640 scopus 로고    scopus 로고
    • Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle
    • Caimano MJ, Iyer R, Eggers CH, Gonzalez C, Morton EA, Gilbert MA, Schwartz I, Radolf JD. 2007. Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle. Mol. Microbiol. 65:1193-1217. http://dx.doi.org/10.1111/j.1365-2958.2007.05860.x.
    • (2007) Mol. Microbiol. , vol.65 , pp. 1193-1217
    • Caimano, M.J.1    Iyer, R.2    Eggers, C.H.3    Gonzalez, C.4    Morton, E.A.5    Gilbert, M.A.6    Schwartz, I.7    Radolf, J.D.8
  • 8
    • 0141814623 scopus 로고    scopus 로고
    • The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi
    • Yang XF, Alani SM, Norgard MV. 2003. The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi. Proc. Natl. Acad. Sci. U.S.A. 100:11001-11006. http://dx.doi.org/10.1073/pnas.1834315100.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 11001-11006
    • Yang, X.F.1    Alani, S.M.2    Norgard, M.V.3
  • 9
    • 53449090658 scopus 로고    scopus 로고
    • Transcriptional interplay among the regulators Rrp2, RpoN, and RpoS in Borrelia burgdorferi
    • Ouyang Z, Blevins JS, Norgard MV. 2008. Transcriptional interplay among the regulators Rrp2, RpoN, and RpoS in Borrelia burgdorferi. Microbiology 154:2641-2658. http://dx.doi.org/10.1099/mic.0.2008/019992-0.
    • (2008) Microbiology , vol.154 , pp. 2641-2658
    • Ouyang, Z.1    Blevins, J.S.2    Norgard, M.V.3
  • 11
    • 72049101202 scopus 로고    scopus 로고
    • The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete
    • Hyde JA, Shaw DK, Smith Iii R, Trzeciakowski JP, Skare JT. 2009. The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. Mol. Microbiol. 74:1344-1355. http://dx.doi.org/10.1111/j.1365-2958.2009.06951.x.
    • (2009) Mol. Microbiol. , vol.74 , pp. 1344-1355
    • Hyde, J.A.1    Shaw, D.K.2    Smith Iii, R.3    Trzeciakowski, J.P.4    Skare, J.T.5
  • 12
    • 72049128621 scopus 로고    scopus 로고
    • BosR (BB0647) governs virulence expression in Borrelia burgdorferi
    • Ouyang Z, Kumar M, Kariu T, Haq S, Goldberg M, Pal U, Norgard MV. 2009. BosR (BB0647) governs virulence expression in Borrelia burgdorferi. Mol. Microbiol. 74:1331-1343. http://dx.doi.org/10.1111/j.1365-2958.2009.06945.x.
    • (2009) Mol. Microbiol. , vol.74 , pp. 1331-1343
    • Ouyang, Z.1    Kumar, M.2    Kariu, T.3    Haq, S.4    Goldberg, M.5    Pal, U.6    Norgard, M.V.7
  • 13
    • 79952237303 scopus 로고    scopus 로고
    • BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism
    • Ouyang Z, Deka RK, Norgard MV. 2011. BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathog. 7:e1001272. http://dx.doi.org/10.1371/journal.ppat.1001272.
    • (2011) PLoS Pathog. , vol.7
    • Ouyang, Z.1    Deka, R.K.2    Norgard, M.V.3
  • 15
    • 0141482029 scopus 로고    scopus 로고
    • Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activator
    • Boylan JA, Posey JE, Gherardini FC. 2003. Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activator. Proc. Natl. Acad. Sci. U.S.A. 100:11684-11689. http://dx.doi.org/10.1073/pnas.2032956100.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 11684-11689
    • Boylan, J.A.1    Posey, J.E.2    Gherardini, F.C.3
  • 16
    • 9644291859 scopus 로고    scopus 로고
    • A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi
    • Seshu J, Boylan JA, Hyde JA, Swingle KL, Gherardini FC, Skare JT. 2004. A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi. Mol. Microbiol. 54:1352-1363. http://dx.doi.org/10.1111/j.1365-2958.2004.04352.x.
    • (2004) Mol. Microbiol. , vol.54 , pp. 1352-1363
    • Seshu, J.1    Boylan, J.A.2    Hyde, J.A.3    Swingle, K.L.4    Gherardini, F.C.5    Skare, J.T.6
  • 17
    • 84884287311 scopus 로고    scopus 로고
    • Borrelia burgdorferi oxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection
    • Wang P, Dadhwal P, Cheng Z, Zianni MR, Rikihisa Y, Liang FT, Li X. 2013. Borrelia burgdorferi oxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection. Mol. Microbiol. 89:1140-1153. http://dx.doi.org/10.1111/mmi.12337.
    • (2013) Mol. Microbiol. , vol.89 , pp. 1140-1153
    • Wang, P.1    Dadhwal, P.2    Cheng, Z.3    Zianni, M.R.4    Rikihisa, Y.5    Liang, F.T.6    Li, X.7
  • 18
    • 84875626787 scopus 로고    scopus 로고
    • Borrelia host adaptation regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi
    • Miller CL, Karna SLR, Seshu J. 2013. Borrelia host adaptation regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi. Mol. Microbiol. 88:105-124. http://dx.doi.org/10.1111/mmi.12171.
    • (2013) Mol. Microbiol. , vol.88 , pp. 105-124
    • Miller, C.L.1    Karna, S.L.R.2    Seshu, J.3
  • 19
    • 34248398787 scopus 로고    scopus 로고
    • Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferi
    • Lybecker MC, Samuels DS. 2007. Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferi. Mol. Microbiol. 64:1075-1089. http://dx.doi.org/10.1111/j.1365-2958.2007.05716.x.
    • (2007) Mol. Microbiol. , vol.64 , pp. 1075-1089
    • Lybecker, M.C.1    Samuels, D.S.2
  • 20
    • 14244254898 scopus 로고    scopus 로고
    • Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain
    • Ryjenkov DA, Tarutina M, Moskvin OV, Gomelsky M. 2005. Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain. J. Bacteriol. 187:1792-1798. http://dx.doi.org/10.1128/JB.187.5.1792-1798.2005.
    • (2005) J. Bacteriol. , vol.187 , pp. 1792-1798
    • Ryjenkov, D.A.1    Tarutina, M.2    Moskvin, O.V.3    Gomelsky, M.4
  • 21
    • 79961113805 scopus 로고    scopus 로고
    • Analysis of the HD-GYP domain cyclic dimeric GMP phosphodiesterase reveals a role in motility and the enzootic life cycle of Borrelia burgdorferi
    • Sultan SZ, Pitzer JE, Boquoi T, Hobbs G, Miller MR, Motaleb MA. 2011. Analysis of the HD-GYP domain cyclic dimeric GMP phosphodiesterase reveals a role in motility and the enzootic life cycle of Borrelia burgdorferi. Infect. Immun. 79:3273-3283. http://dx.doi.org/10.1128/IAI.05153-11.
    • (2011) Infect. Immun. , vol.79 , pp. 3273-3283
    • Sultan, S.Z.1    Pitzer, J.E.2    Boquoi, T.3    Hobbs, G.4    Miller, M.R.5    Motaleb, M.A.6
  • 22
    • 77953988576 scopus 로고    scopus 로고
    • Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-diguanosine monophosphate in motility and virulence
    • Sultan SZ, Pitzer JE, Miller MR, Motaleb MA. 2010. Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-diguanosine monophosphate in motility and virulence. Mol. Microbiol. 77:128-142. http://dx.doi.org/10.1111/j.1365-2958.2010.07191.x.
    • (2010) Mol. Microbiol. , vol.77 , pp. 128-142
    • Sultan, S.Z.1    Pitzer, J.E.2    Miller, M.R.3    Motaleb, M.A.4
  • 24
    • 79960955642 scopus 로고    scopus 로고
    • The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks
    • Caimano MJ, Kenedy MR, Kairu T, Desrosiers DC, Harman M, Dunham-Ems S, Akins DR, Pal U, Radolf JD. 2011. The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect. Immun. 79:3117-3130. http://dx.doi.org/10.1128/IAI.05136-11.
    • (2011) Infect. Immun. , vol.79 , pp. 3117-3130
    • Caimano, M.J.1    Kenedy, M.R.2    Kairu, T.3    Desrosiers, D.C.4    Harman, M.5    Dunham-Ems, S.6    Akins, D.R.7    Pal, U.8    Radolf, J.D.9
  • 25
    • 79959551165 scopus 로고    scopus 로고
    • The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes
    • Kostick JL, Szkotnicki LT, Rogers EA, Bocci P, Raffaelli N, Marconi RT. 2011. The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes. Mol. Microbiol. 81:219-231. http://dx.doi.org/10.1111/j.1365-2958.2011.07687.x.
    • (2011) Mol. Microbiol. , vol.81 , pp. 219-231
    • Kostick, J.L.1    Szkotnicki, L.T.2    Rogers, E.A.3    Bocci, P.4    Raffaelli, N.5    Marconi, R.T.6
  • 26
    • 62449269945 scopus 로고    scopus 로고
    • Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions
    • Rogers EA, Terekhova D, Zhang H, Hovis KM, Schwartz I, Marconi RT. 2009. Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions. Mol. Microbiol. 71:1551-1573. http://dx.doi.org/10.1111/j.1365-2958.2009.06621.x.
    • (2009) Mol. Microbiol. , vol.71 , pp. 1551-1573
    • Rogers, E.A.1    Terekhova, D.2    Zhang, H.3    Hovis, K.M.4    Schwartz, I.5    Marconi, R.T.6
  • 27
    • 79960963391 scopus 로고    scopus 로고
    • Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle
    • Pappas CJ, Iyer R, Petzke MM, Caimano MJ, Radolf JD, Schwartz I. 2011. Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle. PLoS Pathog. 7:e1002102. http://dx.doi.org/10.1371/journal.ppat.1002102.
    • (2011) PLoS Pathog. , vol.7
    • Pappas, C.J.1    Iyer, R.2    Petzke, M.M.3    Caimano, M.J.4    Radolf, J.D.5    Schwartz, I.6
  • 28
    • 0023490966 scopus 로고
    • A rapid cold-hardening process in insects
    • Lee RE, Chen CP, Denlinger DL. 1987. A rapid cold-hardening process in insects. Science 238:1415-1417. http://dx.doi.org/10.1126/science.238.4832.1415.
    • (1987) Science , vol.238 , pp. 1415-1417
    • Lee, R.E.1    Chen, C.P.2    Denlinger, D.L.3
  • 29
    • 67650569077 scopus 로고    scopus 로고
    • Chitobiose utilization in Borrelia burgdorferi is dually regulated by RpoD and RpoS
    • Rhodes R, Coy W, Nelson D. 2009. Chitobiose utilization in Borrelia burgdorferi is dually regulated by RpoD and RpoS.BMCMicrobiol. 9:108. http://dx.doi.org/10.1186/1471-2180-9-108.
    • (2009) BMC Microbiol. , vol.9 , pp. 108
    • Rhodes, R.1    Coy, W.2    Nelson, D.3
  • 30
    • 77649306815 scopus 로고    scopus 로고
    • The chitobiose transporter, chbC, is required for chitin utilization in Borrelia burgdorferi
    • Rhodes R, Atoyan J, Nelson D. 2010. The chitobiose transporter, chbC, is required for chitin utilization in Borrelia burgdorferi. BMC Microbiol. 10:21. http://dx.doi.org/10.1186/1471-2180-10-21.
    • (2010) BMC Microbiol. , vol.10 , pp. 21
    • Rhodes, R.1    Atoyan, J.2    Nelson, D.3
  • 31
    • 0034823641 scopus 로고    scopus 로고
    • Genetics and regulation of chitobiose utilization in Borrelia burgdorferi
    • Tilly K, Elias A, Errett J, Fischer E, Iyer R, Schwartz I, Bono J, Rosa P. 2001. Genetics and regulation of chitobiose utilization in Borrelia burgdorferi. J. Bacteriol. 183:5544-5553. http://dx.doi.org/10.1128/JB.183.19.5544-5553.2001.
    • (2001) J. Bacteriol. , vol.183 , pp. 5544-5553
    • Tilly, K.1    Elias, A.2    Errett, J.3    Fischer, E.4    Iyer, R.5    Schwartz, I.6    Bono, J.7    Rosa, P.8
  • 32
    • 84877796869 scopus 로고    scopus 로고
    • Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi
    • Sze CW, Smith A, Choi YH, Yang X, Pal U, Yu A, Li C. 2013. Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi. Infect. Immun. 81:1775-1787. http://dx.doi.org/10.1128/IAI.00050-13.
    • (2013) Infect. Immun. , vol.81 , pp. 1775-1787
    • Sze, C.W.1    Smith, A.2    Choi, Y.H.3    Yang, X.4    Pal, U.5    Yu, A.6    Li, C.7
  • 33
    • 84874914744 scopus 로고    scopus 로고
    • Cyclic di-GMP: the first 25 years of a universal bacterial second messenger
    • Römling U, Galperin MY, Gomelsky M. 2013. Cyclic di-GMP: the first 25 years of a universal bacterial second messenger. Microbiol. Mol. Biol. Rev. 71:1-52. http://dx.doi.org/10.1128/MMBR.00043-12.
    • (2013) Microbiol. Mol. Biol. Rev. , vol.71 , pp. 1-52
    • Römling, U.1    Galperin, M.Y.2    Gomelsky, M.3
  • 34
    • 33750044865 scopus 로고    scopus 로고
    • The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria
    • Ryjenkov DA, Simm R, Romling U, Gomelsky M. 2006. The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria. J. Biol. Chem. 281: 30310-30314. http://dx.doi.org/10.1074/jbc.C600179200.
    • (2006) J. Biol. Chem. , vol.281 , pp. 30310-30314
    • Ryjenkov, D.A.1    Simm, R.2    Romling, U.3    Gomelsky, M.4
  • 35
    • 79959410913 scopus 로고    scopus 로고
    • Analysis of the Borrelia burgdorferi cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulence
    • Pitzer JE, Sultan SZ, Hayakawa Y, Hobbs G, Miller MR, Motaleb MA. 2011. Analysis of the Borrelia burgdorferi cyclic-di-GMP-binding protein PlzA reveals a role in motility and virulence. Infect. Immun. 79:1815-1825. http://dx.doi.org/10.1128/IAI.00075-11.
    • (2011) Infect. Immun. , vol.79 , pp. 1815-1825
    • Pitzer, J.E.1    Sultan, S.Z.2    Hayakawa, Y.3    Hobbs, G.4    Miller, M.R.5    Motaleb, M.A.6
  • 36
    • 76349103493 scopus 로고    scopus 로고
    • Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi
    • Freedman JC, Rogers EA, Kostick JL, Zhang H, Iyer R, Schwartz I, Marconi RT. 2010. Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi. FEMS Immunol. Med. Microbiol. 58:285-294. http://dx.doi.org/10.1111/j.1574-695X.2009.00635.x.
    • (2010) FEMS Immunol. Med. Microbiol. , vol.58 , pp. 285-294
    • Freedman, J.C.1    Rogers, E.A.2    Kostick, J.L.3    Zhang, H.4    Iyer, R.5    Schwartz, I.6    Marconi, R.T.7
  • 37
    • 9244239222 scopus 로고    scopus 로고
    • BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype
    • Kawabata H, Norris SJ, Watanabe H. 2004. BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype. Infect. Immun. 72:7147-7154. http://dx.doi.org/10.1128/IAI.72.12.7147-7154.2004.
    • (2004) Infect. Immun. , vol.72 , pp. 7147-7154
    • Kawabata, H.1    Norris, S.J.2    Watanabe, H.3
  • 38
    • 0029200874 scopus 로고
    • Electrotransformation of the spirochete Borrelia burgdorferi
    • Samuels DS. 1995. Electrotransformation of the spirochete Borrelia burgdorferi. Methods Mol. Biol. 45:253-259.
    • (1995) Methods Mol. Biol. , vol.45 , pp. 253-259
    • Samuels, D.S.1
  • 39
    • 1542283705 scopus 로고    scopus 로고
    • Essential role for OspA/B in the life cycle of the Lyme disease spirochete
    • Yang XF, Pal U, Alani SM, Fikrig E, Norgard MV. 2004. Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J. Exp. Med. 199:641-648. http://dx.doi.org/10.1084/jem.20031960.
    • (2004) J. Exp. Med. , vol.199 , pp. 641-648
    • Yang, X.F.1    Pal, U.2    Alani, S.M.3    Fikrig, E.4    Norgard, M.V.5
  • 40
    • 0034610332 scopus 로고    scopus 로고
    • Correlation between plasmid content and infectivity in Borrelia burgdorferi Proc
    • Purser JE, Norris SJ. 2000. Correlation between plasmid content and infectivity in Borrelia burgdorferi Proc. Natl. Acad. Sci. U.S.A. 97:13865-13870. http://dx.doi.org/10.1073/pnas.97.25.13865.
    • (2000) Natl. Acad. Sci. U.S.A. , vol.97 , pp. 13865-13870
    • Purser, J.E.1    Norris, S.J.2
  • 42
    • 46449086457 scopus 로고    scopus 로고
    • Real-time high resolution 3D imaging of the Lyme disease spirochete adhering to and escaping from the vasculature of a living host
    • Moriarty TJ, Norman MU, Colarusso P, Bankhead T, Kubes P, Chaconas G. 2008. Real-time high resolution 3D imaging of the Lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLoS Pathog. 4:e1000090. http://dx.doi.org/10.1371/journal.ppat.1000090.
    • (2008) PLoS Pathog. , vol.4
    • Moriarty, T.J.1    Norman, M.U.2    Colarusso, P.3    Bankhead, T.4    Kubes, P.5    Chaconas, G.6
  • 43
    • 84879745505 scopus 로고    scopus 로고
    • Manganese and zinc regulate virulence determinants in Borrelia burgdorferi
    • Troxell B, Ye M, Yang Y, Carrasco SE, Lou Y, Yang XF. 2013. Manganese and zinc regulate virulence determinants in Borrelia burgdorferi. Infect. Immun. 81:2743-2752. http://dx.doi.org/10.1128/IAI.00507-13.
    • (2013) Infect. Immun. , vol.81 , pp. 2743-2752
    • Troxell, B.1    Ye, M.2    Yang, Y.3    Carrasco, S.E.4    Lou, Y.5    Yang, X.F.6
  • 44
    • 0032523936 scopus 로고    scopus 로고
    • A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state
    • Akins DR, Bourell KW, Caimano MJ, Norgard MV, Radolf JD. 1998. A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J. Clin. Invest. 101:2240-2250. http://dx.doi.org/10.1172/JCI2325.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2240-2250
    • Akins, D.R.1    Bourell, K.W.2    Caimano, M.J.3    Norgard, M.V.4    Radolf, J.D.5
  • 45
    • 77953952245 scopus 로고    scopus 로고
    • Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi
    • Xu H, He M, He JJ, Yang XF. 2010. Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi. Infect. Immun. 78:2910-2918. http://dx.doi.org/10.1128/IAI.00372-10.
    • (2010) Infect. Immun. , vol.78 , pp. 2910-2918
    • Xu, H.1    He, M.2    He, J.J.3    Yang, X.F.4
  • 46
    • 0035940482 scopus 로고    scopus 로고
    • Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway
    • Hubner A, Yang X, Nolen DM, Popova TG, Cabello FC, Norgard MV. 2001. Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway. Proc. Natl. Acad. Sci. U.S.A. 98:12724-12729. http://dx.doi.org/10.1073/pnas.231442498.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 12724-12729
    • Hubner, A.1    Yang, X.2    Nolen, D.M.3    Popova, T.G.4    Cabello, F.C.5    Norgard, M.V.6
  • 47
    • 7044233312 scopus 로고    scopus 로고
    • RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants
    • Caimano MJ, Eggers CH, Hazlett KR, Radolf JD. 2004. RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect. Immun. 72:6433-6445. http://dx.doi.org/10.1128/IAI.72.11.6433-6445.2004.
    • (2004) Infect. Immun. , vol.72 , pp. 6433-6445
    • Caimano, M.J.1    Eggers, C.H.2    Hazlett, K.R.3    Radolf, J.D.4
  • 48
    • 33846706457 scopus 로고    scopus 로고
    • Artificial regulation of ospC expression in Borrelia burgdorferi
    • Gilbert MA, Morton EA, Bundle SF, Samuels DS. 2007. Artificial regulation of ospC expression in Borrelia burgdorferi. Mol. Microbiol. 63:1259-1273. http://dx.doi.org/10.1111/j.1365-2958.2007.05593.x.
    • (2007) Mol. Microbiol. , vol.63 , pp. 1259-1273
    • Gilbert, M.A.1    Morton, E.A.2    Bundle, S.F.3    Samuels, D.S.4
  • 51
    • 0026529325 scopus 로고
    • Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22 kDa protein (pC) in Escherichia coli
    • Fuchs R, Jauris S, Lottspeich F, Preac-Mursic V, Wilske B, Soutschek E. 1992. Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22 kDa protein (pC) in Escherichia coli. Mol. Microbiol. 6:503-509. http://dx.doi.org/10.1111/j.1365-2958.1992.tb01495.x.
    • (1992) Mol. Microbiol. , vol.6 , pp. 503-509
    • Fuchs, R.1    Jauris, S.2    Lottspeich, F.3    Preac-Mursic, V.4    Wilske, B.5    Soutschek, E.6
  • 52
    • 55949120483 scopus 로고    scopus 로고
    • The two-component network and the general stress sigma factor RpoS (sigma S) in Escherichia coli
    • Hengge R. 2008. The two-component network and the general stress sigma factor RpoS (sigma S) in Escherichia coli. Adv. Exp. Med. Biol. 631:40-53. http://dx.doi.org/10.1007/978-0-387-78885-2_4.
    • (2008) Adv. Exp. Med. Biol. , vol.631 , pp. 40-53
    • Hengge, R.1
  • 53
    • 79952300932 scopus 로고    scopus 로고
    • BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle
    • Banik S, Terekhova D, Iyer R, Pappas CJ, Caimano MJ, Radolf JD, Schwartz I. 2011. BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle. Infect. Immun. 79:1208-1217. http://dx.doi.org/10.1128/IAI.01156-10.
    • (2011) Infect. Immun. , vol.79 , pp. 1208-1217
    • Banik, S.1    Terekhova, D.2    Iyer, R.3    Pappas, C.J.4    Caimano, M.J.5    Radolf, J.D.6    Schwartz, I.7
  • 54
    • 56549092142 scopus 로고    scopus 로고
    • Borrelia burgdorferi expression of the bba64, bba65, bba66, and bba73 genes in tissues during persistent infection in mice
    • Gilmore RD Jr., Howison RR, Schmit VL, Carroll JA. 2008. Borrelia burgdorferi expression of the bba64, bba65, bba66, and bba73 genes in tissues during persistent infection in mice. Microb. Pathog. 45:355-368. http://dx.doi.org/10.1016/j.micpath.2008.08.006.
    • (2008) Microb. Pathog. , vol.45 , pp. 355-368
    • Gilmore Jr., R.D.1    Howison, R.R.2    Schmit, V.L.3    Carroll, J.A.4
  • 55
    • 33846247458 scopus 로고    scopus 로고
    • Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels
    • Hyde JA, Trzeciakowski JP, Skare JT. 2007. Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels. J. Bacteriol. 189:437-445. http://dx.doi.org/10.1128/JB.01109-06.
    • (2007) J. Bacteriol. , vol.189 , pp. 437-445
    • Hyde, J.A.1    Trzeciakowski, J.P.2    Skare, J.T.3
  • 56
    • 84858725678 scopus 로고    scopus 로고
    • Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi
    • Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard M. 2012. Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi. BMC Microbiol. 12:44. http://dx.doi.org/10.1186/1471-2180-12-44.
    • (2012) BMC Microbiol. , vol.12 , pp. 44
    • Ouyang, Z.1    Narasimhan, S.2    Neelakanta, G.3    Kumar, M.4    Pal, U.5    Fikrig, E.6    Norgard, M.7


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