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Volumn 79, Issue 8, 2011, Pages 3273-3283

Analysis of the HD-GYP domain cyclic dimeric gmp phosphodiesterase reveals a role in motility and the enzootic life cycle of Borrelia burgdorferi

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CYCLIC GMP PHOSPHODIESTERASE; DIMER; HD GYP PROTEIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE A; PHOSPHODIESTERASE B; PILZ PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

EID: 79961113805     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05153-11     Document Type: Article
Times cited : (78)

References (102)
  • 1
    • 33749180794 scopus 로고    scopus 로고
    • The HD-GYP domain of RpfG mediates a direct linkage between the Rpf quorum-sensing pathway and a subset of diguanylate cyclase proteins in the phytopathogen Xanthomonas axonopodis pv citri
    • Andrade, M. O., et al. 2006. The HD-GYP domain of RpfG mediates a direct linkage between the Rpf quorum-sensing pathway and a subset of diguanylate cyclase proteins in the phytopathogen Xanthomonas axonopodis pv citri. Mol. Microbiol. 62:537-551.
    • (2006) Mol. Microbiol. , vol.62 , pp. 537-551
    • Andrade, M.O.1
  • 2
    • 0032408864 scopus 로고    scopus 로고
    • The HD domain defines a new superfamily of metal-dependent phosphohydrolases
    • Aravind, L., and E. V. Koonin. 1998. The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Trends Biochem. Sci. 23:469-472.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 469-472
    • Aravind, L.1    Koonin, E.V.2
  • 3
    • 77950952363 scopus 로고    scopus 로고
    • Time for bacteria to slow down
    • Armitage, J. P., and R. M. Berry. 2010. Time for bacteria to slow down. Cell 141:24-26.
    • (2010) Cell , vol.141 , pp. 24-26
    • Armitage, J.P.1    Berry, R.M.2
  • 4
    • 17644379542 scopus 로고    scopus 로고
    • Synthesis of autoinducer 2 by the lyme disease spirochete, Borrelia burgdorferi
    • Babb, K., K. von Lackum, R. L. Wattier, S. P. Riley, and B. Stevenson. 2005. Synthesis of autoinducer 2 by the lyme disease spirochete, Borrelia burgdorferi. J. Bacteriol. 187:3079-3087.
    • (2005) J. Bacteriol. , vol.187 , pp. 3079-3087
    • Babb, K.1    von Lackum, K.2    Wattier, R.L.3    Riley, S.P.4    Stevenson, B.5
  • 5
    • 33847235021 scopus 로고    scopus 로고
    • Identification of specific chemoattractants and genetic complementation of a Borrelia burgdorferi chemotaxis mutant: flow cytometry-based capillary tube chemotaxis assay
    • Bakker, R. G., C. Li, M. R. Miller, C. Cunningham, and N. W. Charon. 2007. Identification of specific chemoattractants and genetic complementation of a Borrelia burgdorferi chemotaxis mutant: flow cytometry-based capillary tube chemotaxis assay. Appl. Environ. Microbiol. 73:1180-1188.
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 1180-1188
    • Bakker, R.G.1    Li, C.2    Miller, M.R.3    Cunningham, C.4    Charon, N.W.5
  • 6
    • 55849126646 scopus 로고    scopus 로고
    • Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector
    • Battisti, J. M., et al. 2008. Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector. Infect. Immun. 76:5228-5237.
    • (2008) Infect. Immun. , vol.76 , pp. 5228-5237
    • Battisti, J.M.1
  • 7
    • 77950928649 scopus 로고    scopus 로고
    • Second messenger-mediated adjustment of bacterial swimming velocity
    • Boehm, A., et al. 2010. Second messenger-mediated adjustment of bacterial swimming velocity. Cell 141:107-116.
    • (2010) Cell , vol.141 , pp. 107-116
    • Boehm, A.1
  • 8
    • 0034119460 scopus 로고    scopus 로고
    • Isolation and characterization of nonchemotactic CheZ mutants of Escherichia coli
    • Boesch, K. C., R. E. Silversmith, and R. B. Bourret. 2000. Isolation and characterization of nonchemotactic CheZ mutants of Escherichia coli. J. Bacteriol. 182:3544-3552.
    • (2000) J. Bacteriol. , vol.182 , pp. 3544-3552
    • Boesch, K.C.1    Silversmith, R.E.2    Bourret, R.B.3
  • 9
    • 33845501160 scopus 로고    scopus 로고
    • Identification of potential virulence determinants by Himar1 transposition of infectious Borrelia burgdorferi B31
    • Botkin, D. J., et al. 2006. Identification of potential virulence determinants by Himar1 transposition of infectious Borrelia burgdorferi B31. Infect. Immun. 74:6690-6699.
    • (2006) Infect. Immun. , vol.74 , pp. 6690-6699
    • Botkin, D.J.1
  • 10
    • 1842737591 scopus 로고    scopus 로고
    • Both chemotaxis and net motility greatly influence the infectivity of Vibrio cholerae
    • Butler, S. M., and A. Camilli. 2004. Both chemotaxis and net motility greatly influence the infectivity of Vibrio cholerae. Proc. Natl. Acad. Sci. U. S. A. 101:5018-5023.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 5018-5023
    • Butler, S.M.1    Camilli, A.2
  • 11
    • 79960955642 scopus 로고    scopus 로고
    • The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks
    • Caimano, M. J., et al. 2011. The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect. Immun. 79:3117-3130.
    • (2011) Infect. Immun. , vol.79 , pp. 3117-3130
    • Caimano, M.J.1
  • 12
    • 0033975239 scopus 로고    scopus 로고
    • A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi
    • Casjens, S., et al. 2000. A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol. Microbiol. 35:490-516.
    • (2000) Mol. Microbiol. , vol.35 , pp. 490-516
    • Casjens, S.1
  • 13
    • 0036948288 scopus 로고    scopus 로고
    • Genetics of motility and chemotaxis of a fascinating group of bacteria: the spirochetes
    • Charon, N. W., and S. F. Goldstein. 2002. Genetics of motility and chemotaxis of a fascinating group of bacteria: the spirochetes. Annu. Rev. Genet. 36:47-73.
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 47-73
    • Charon, N.W.1    Goldstein, S.F.2
  • 14
    • 58649114723 scopus 로고    scopus 로고
    • The flat ribbon configuration of the periplasmic flagella of Borrelia burgdorferi and its relationship to motility and morphology
    • Charon, N. W., et al. 2009. The flat ribbon configuration of the periplasmic flagella of Borrelia burgdorferi and its relationship to motility and morphology. J. Bacteriol. 191:600-607.
    • (2009) J. Bacteriol. , vol.191 , pp. 600-607
    • Charon, N.W.1
  • 15
    • 34247213819 scopus 로고    scopus 로고
    • DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus
    • Christen, M., et al. 2007. DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus. Proc. Natl. Acad. Sci. U. S. A. 104:4112-4117.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 4112-4117
    • Christen, M.1
  • 16
    • 24744457756 scopus 로고    scopus 로고
    • Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP
    • Christen, M., B. Christen, M. Folcher, A. Schauerte, and U. Jenal. 2005. Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP. J. Biol. Chem. 280:30829-30837.
    • (2005) J. Biol. Chem. , vol.280 , pp. 30829-30837
    • Christen, M.1    Christen, B.2    Folcher, M.3    Schauerte, A.4    Jenal, U.5
  • 17
    • 0026695713 scopus 로고
    • Characterization of antigenic determinants of Borrelia burgdorferi shared by other bacteria
    • Coleman, J. L., and J. L. Benach. 1992. Characterization of antigenic determinants of Borrelia burgdorferi shared by other bacteria. J. Infect. Dis. 165:658-666.
    • (1992) J. Infect. Dis. , vol.165 , pp. 658-666
    • Coleman, J.L.1    Benach, J.L.2
  • 18
    • 33846847846 scopus 로고    scopus 로고
    • c-di-GMP-mediated regulation of virulence and biofilm formation
    • Cotter, P. A., and S. Stibitz. 2007. c-di-GMP-mediated regulation of virulence and biofilm formation. Curr. Opin. Microbiol. 10:17-23.
    • (2007) Curr. Opin. Microbiol. , vol.10 , pp. 17-23
    • Cotter, P.A.1    Stibitz, S.2
  • 19
    • 68949119913 scopus 로고    scopus 로고
    • The elastic basis for the shape of Borrelia burgdorferi
    • Dombrowski, C., et al. 2009. The elastic basis for the shape of Borrelia burgdorferi. Biophys. J. 96:4409-4417.
    • (2009) Biophys. J. , vol.96 , pp. 4409-4417
    • Dombrowski, C.1
  • 20
    • 72849134856 scopus 로고    scopus 로고
    • Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks
    • Dunham-Ems, S. M., et al. 2009. Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks. J. Clin. Invest. 119:3652-3665.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3652-3665
    • Dunham-Ems, S.M.1
  • 21
    • 0345491594 scopus 로고    scopus 로고
    • New antibiotic resistance cassettes suitable for genetic studies in Borrelia burgdorferi
    • Elias, A. F., et al. 2003. New antibiotic resistance cassettes suitable for genetic studies in Borrelia burgdorferi. J. Mol. Microbiol. Biotechnol. 6:29-40.
    • (2003) J. Mol. Microbiol. Biotechnol. , vol.6 , pp. 29-40
    • Elias, A.F.1
  • 22
    • 0036126988 scopus 로고    scopus 로고
    • Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background
    • Elias, A. F., et al. 2002. Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background. Infect. Immun. 70:2139-2150.
    • (2002) Infect. Immun. , vol.70 , pp. 2139-2150
    • Elias, A.F.1
  • 23
    • 77952813357 scopus 로고    scopus 로고
    • A posttranslational, c-di-GMP-dependent mechanism regulating flagellar motility
    • Fang, X., and M. Gomelsky. 2010. A posttranslational, c-di-GMP-dependent mechanism regulating flagellar motility. Mol. Microbiol. 76:1295-1305.
    • (2010) Mol. Microbiol. , vol.76 , pp. 1295-1305
    • Fang, X.1    Gomelsky, M.2
  • 24
    • 0023990266 scopus 로고
    • Motility and chemotaxis of Spirochaeta aurantia: computer-assisted motion analysis
    • Fosnaugh, K., and E. P. Greenberg. 1988. Motility and chemotaxis of Spirochaeta aurantia: computer-assisted motion analysis. J. Bacteriol. 170: 1768-1774.
    • (1988) J. Bacteriol. , vol.170 , pp. 1768-1774
    • Fosnaugh, K.1    Greenberg, E.P.2
  • 26
    • 0031470826 scopus 로고    scopus 로고
    • Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
    • Fraser, C. M., et al. 1997. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390:580-586.
    • (1997) Nature , vol.390 , pp. 580-586
    • Fraser, C.M.1
  • 27
    • 76349103493 scopus 로고    scopus 로고
    • Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi
    • Freedman, J. C., et al. 2010. Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi. FEMS Immunol. Med. Microbiol. 58:285-294.
    • (2010) FEMS Immunol. Med. Microbiol. , vol.58 , pp. 285-294
    • Freedman, J.C.1
  • 28
    • 2642554922 scopus 로고    scopus 로고
    • Bacterial signal transduction network in a genomic perspective
    • Galperin, M. Y. 2004. Bacterial signal transduction network in a genomic perspective. Environ. Microbiol. 6:552-567.
    • (2004) Environ. Microbiol. , vol.6 , pp. 552-567
    • Galperin, M.Y.1
  • 29
    • 23944523895 scopus 로고    scopus 로고
    • A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts
    • Galperin, M. Y. 2005. A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts. BMC Microbiol. 5:35.
    • (2005) BMC Microbiol , vol.5 , pp. 35
    • Galperin, M.Y.1
  • 30
    • 77949911836 scopus 로고    scopus 로고
    • Diversity of structure and function of response regulator output domains
    • Galperin, M. Y. 2010. Diversity of structure and function of response regulator output domains. Curr. Opin. Microbiol. 13:150-159.
    • (2010) Curr. Opin. Microbiol. , vol.13 , pp. 150-159
    • Galperin, M.Y.1
  • 31
    • 0033222409 scopus 로고    scopus 로고
    • A specialized version of the HD hydrolase domain implicated in signal transduction
    • Galperin, M. Y., D. A. Natale, L. Aravind, and E. V. Koonin. 1999. A specialized version of the HD hydrolase domain implicated in signal transduction. J. Mol. Microbiol. Biotechnol. 1:303-305.
    • (1999) J. Mol. Microbiol. Biotechnol. , vol.1 , pp. 303-305
    • Galperin, M.Y.1    Natale, D.A.2    Aravind, L.3    Koonin, E.V.4
  • 32
    • 0035845587 scopus 로고    scopus 로고
    • Novel domains of the prokaryotic two-component signal transduction systems
    • Galperin, M. Y., A. N. Nikolskaya, and E. V. Koonin. 2001. Novel domains of the prokaryotic two-component signal transduction systems. FEMS Microbiol. Lett. 203:11-21.
    • (2001) FEMS Microbiol. Lett. , vol.203 , pp. 11-21
    • Galperin, M.Y.1    Nikolskaya, A.N.2    Koonin, E.V.3
  • 33
    • 77952166427 scopus 로고    scopus 로고
    • The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission
    • Gilmore, R. D., Jr, et al. 2010. The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission. Proc. Natl. Acad. Sci. U. S. A. 107:7515-7520.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 7515-7520
    • Gilmore Jr., R.D.1
  • 34
    • 0028201319 scopus 로고
    • Borrelia burgdorferi swims with a planar waveform similar to that of eukaryotic flagella
    • Goldstein, S. F., N. W. Charon, and J. A. Kreiling. 1994. Borrelia burgdorferi swims with a planar waveform similar to that of eukaryotic flagella. Proc. Natl. Acad. Sci. U. S. A. 91:3433-3437.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 3433-3437
    • Goldstein, S.F.1    Charon, N.W.2    Kreiling, J.A.3
  • 35
    • 77957925160 scopus 로고    scopus 로고
    • The chic motility and chemotaxis of Borrelia burgdorferi
    • D. S. Samuels and J. D. Radolf (ed.), Caister Academic Press. Norfolk, United Kingdom
    • Goldstein, S. F., et al. 2010. The chic motility and chemotaxis of Borrelia burgdorferi, p. 161-181. In D. S. Samuels and J. D. Radolf (ed.), Borrelia: molecular biology, host interactions and pathogenesis. Caister Academic Press. Norfolk, United Kingdom.
    • (2010) Borrelia: molecular biology, host interactions and pathogenesis , pp. 161-181
    • Goldstein, S.F.1
  • 36
    • 58149511939 scopus 로고    scopus 로고
    • Distinct sensory pathways in Vibrio cholerae El Tor and classical biotypes modulate cyclic dimeric GMP levels to control biofilm formation
    • Hammer, B. K., and B. L. Bassler. 2009. Distinct sensory pathways in Vibrio cholerae El Tor and classical biotypes modulate cyclic dimeric GMP levels to control biofilm formation. J. Bacteriol. 191:169-177.
    • (2009) J. Bacteriol. , vol.191 , pp. 169-177
    • Hammer, B.K.1    Bassler, B.L.2
  • 37
    • 79959856937 scopus 로고    scopus 로고
    • Cyclic-di-GMP is essential for the survival of the Lyme disease spirochete in ticks
    • in press
    • He, M., et al. Cyclic-di-GMP is essential for the survival of the Lyme disease spirochete in ticks. PLoS Pathog., in press.
    • PLoS Pathog.
    • He, M.1
  • 38
    • 63049137897 scopus 로고    scopus 로고
    • Principles of c-di-GMP signalling in bacteria
    • Hengge, R. 2009. Principles of c-di-GMP signalling in bacteria. Nat. Rev. Microbiol. 7:263-273.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 263-273
    • Hengge, R.1
  • 39
    • 47249089614 scopus 로고    scopus 로고
    • Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor
    • Hickman, J. W., and C. S. Harwood. 2008. Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor. Mol. Microbiol. 69:376-389.
    • (2008) Mol. Microbiol. , vol.69 , pp. 376-389
    • Hickman, J.W.1    Harwood, C.S.2
  • 40
    • 0242416998 scopus 로고    scopus 로고
    • Expression of a luxS gene is not required for Borrelia burgdorferi infection of mice via needle inoculation
    • Hübner, A., A. T. Revel, D. M. Nolen, K. E. Hagman, and M. V. Norgard. 2003. Expression of a luxS gene is not required for Borrelia burgdorferi infection of mice via needle inoculation. Infect. Immun. 71:2892-2896.
    • (2003) Infect. Immun. , vol.71 , pp. 2892-2896
    • Hübner, A.1    Revel, A.T.2    Nolen, D.M.3    Hagman, K.E.4    Norgard, M.V.5
  • 41
    • 33845403359 scopus 로고    scopus 로고
    • Mechanisms of cyclic-di-GMP signaling in bacteria
    • Jenal, U., and J. Malone. 2006. Mechanisms of cyclic-di-GMP signaling in bacteria. Annu. Rev. Genet. 40:385-407.
    • (2006) Annu. Rev. Genet. , vol.40 , pp. 385-407
    • Jenal, U.1    Malone, J.2
  • 42
    • 34249820286 scopus 로고    scopus 로고
    • The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi
    • Jewett, M. W., et al. 2007. The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi. Mol. Microbiol. 64:1358-1374.
    • (2007) Mol. Microbiol. , vol.64 , pp. 1358-1374
    • Jewett, M.W.1
  • 43
    • 70350440467 scopus 로고    scopus 로고
    • GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle
    • Jewett, M. W., et al. 2009. GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle. J. Bacteriol. 191:6231-6241.
    • (2009) J. Bacteriol. , vol.191 , pp. 6231-6241
    • Jewett, M.W.1
  • 44
    • 0036221572 scopus 로고    scopus 로고
    • The role of motility as a virulence factor in bacteria
    • Josenhans, C., and S. Suerbaum. 2002. The role of motility as a virulence factor in bacteria. Int. J. Med. Microbiol. 291:605-614.
    • (2002) Int. J. Med. Microbiol. , vol.291 , pp. 605-614
    • Josenhans, C.1    Suerbaum, S.2
  • 45
    • 9244239222 scopus 로고    scopus 로고
    • BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype
    • Kawabata, H., S. J. Norris, and H. Watanabe. 2004. BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype. Infect. Immun. 72:7147-7154.
    • (2004) Infect. Immun. , vol.72 , pp. 7147-7154
    • Kawabata, H.1    Norris, S.J.2    Watanabe, H.3
  • 46
    • 0025087320 scopus 로고
    • Motility of Lyme disease spirochetes in fluids as viscous as the extracellular matrix
    • Kimsey, R. B., and A. Spielman. 1990. Motility of Lyme disease spirochetes in fluids as viscous as the extracellular matrix. J. Infect. Dis. 162:1205-1208.
    • (1990) J. Infect. Dis. , vol.162 , pp. 1205-1208
    • Kimsey, R.B.1    Spielman, A.2
  • 47
    • 79959551165 scopus 로고    scopus 로고
    • The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes
    • 4 May, posting date. [Epub ahead of print.] doi:10.1111/j.1365-2958.2011.07687.x
    • Kostick, J. L., et al. 4 May 2011, posting date. The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes. Mol. Microbiol. [Epub ahead of print.] doi:10.1111/j.1365-2958.2011.07687.x.
    • (2011) Mol. Microbiol.
    • Kostick, J.L.1
  • 48
    • 62449236570 scopus 로고    scopus 로고
    • Comparative cryo-electron tomography of pathogenic Lyme disease spirochetes
    • Kudryashev, M., et al. 2009. Comparative cryo-electron tomography of pathogenic Lyme disease spirochetes. Mol. Microbiol. 71:1415-1434.
    • (2009) Mol. Microbiol. , vol.71 , pp. 1415-1434
    • Kudryashev, M.1
  • 49
    • 33644516891 scopus 로고    scopus 로고
    • Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence
    • Kulasakara, H., et al. 2006. Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence. Proc. Natl. Acad. Sci. U. S. A. 103:2839-2844.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 2839-2844
    • Kulasakara, H.1
  • 50
    • 77749308350 scopus 로고    scopus 로고
    • BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts
    • Kumar, M., X. Yang, A. S. Coleman, and U. Pal. 2010. BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts. J. Infect. Dis. 201:1084-1095.
    • (2010) J. Infect. Dis. , vol.201 , pp. 1084-1095
    • Kumar, M.1    Yang, X.2    Coleman, A.S.3    Pal, U.4
  • 51
    • 63449138218 scopus 로고    scopus 로고
    • The Anaplasma phagocytophilum PleC histidine kinase and PleD diguanylate cyclase two-component system and role of cyclic di-GMP in host cell infection
    • Lai, T. H., Y. Kumagai, M. Hyodo, Y. Hayakawa, and Y. Rikihisa. 2009. The Anaplasma phagocytophilum PleC histidine kinase and PleD diguanylate cyclase two-component system and role of cyclic di-GMP in host cell infection. J. Bacteriol. 191:693-700.
    • (2009) J. Bacteriol. , vol.191 , pp. 693-700
    • Lai, T.H.1    Kumagai, Y.2    Hyodo, M.3    Hayakawa, Y.4    Rikihisa, Y.5
  • 52
    • 0037197987 scopus 로고    scopus 로고
    • Asymmetrical flagellar rotation in Borrelia burgdorferi nonchemotactic mutants
    • Li, C., et al. 2002. Asymmetrical flagellar rotation in Borrelia burgdorferi nonchemotactic mutants. Proc. Natl. Acad. Sci. U. S. A. 99:6169-6174.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 6169-6174
    • Li, C.1
  • 54
    • 77949392836 scopus 로고    scopus 로고
    • Inactivation of a putative flagellar motor switch protein FliG1 prevents Borrelia burgdorferi from swimming in highly viscous media and blocks its infectivity
    • Li, C., H. Xu, K. Zhang, and F. T. Liang. 2010. Inactivation of a putative flagellar motor switch protein FliG1 prevents Borrelia burgdorferi from swimming in highly viscous media and blocks its infectivity. Mol. Microbiol. 75:1563-1576.
    • (2010) Mol. Microbiol. , vol.75 , pp. 1563-1576
    • Li, C.1    Xu, H.2    Zhang, K.3    Liang, F.T.4
  • 55
    • 33846217722 scopus 로고    scopus 로고
    • The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks
    • Li, X., et al. 2007. The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Mol. Microbiol. 63:694-710.
    • (2007) Mol. Microbiol. , vol.63 , pp. 694-710
    • Li, X.1
  • 56
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 57
    • 70350464919 scopus 로고    scopus 로고
    • A novel regulatory protein involved in motility of Vibrio cholerae
    • Moisi, M., et al. 2009. A novel regulatory protein involved in motility of Vibrio cholerae. J. Bacteriol. 191:7027-7038.
    • (2009) J. Bacteriol. , vol.191 , pp. 7027-7038
    • Moisi, M.1
  • 58
    • 0034718538 scopus 로고    scopus 로고
    • Borrelia burgdorferi periplasmic flagella have both skeletal and motility functions
    • Motaleb, M. A., et al. 2000. Borrelia burgdorferi periplasmic flagella have both skeletal and motility functions. Proc. Natl. Acad. Sci. U. S. A. 97: 10899-10904.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 10899-10904
    • Motaleb, M.A.1
  • 59
    • 85058203355 scopus 로고    scopus 로고
    • Isolation and characterization of chemotaxis mutants of the Lyme disease spirochete Borrelia burgdorferi using allelic exchange mutagenesis, flow cytometry, and cell tracking
    • Motaleb, M. A., M. R. Miller, R. G. Bakker, C. Li, and N. W. Charon. 2007. Isolation and characterization of chemotaxis mutants of the Lyme disease spirochete Borrelia burgdorferi using allelic exchange mutagenesis, flow cytometry, and cell tracking. Methods Enzymol. 422:421-437.
    • (2007) Methods Enzymol , vol.422 , pp. 421-437
    • Motaleb, M.A.1    Miller, M.R.2    Bakker, R.G.3    Li, C.4    Charon, N.W.5
  • 60
    • 28044460791 scopus 로고    scopus 로고
    • CheX is a phosphorylated CheY phosphatase essential for Borrelia burgdorferi chemotaxis
    • Motaleb, M. A., et al. 2005. CheX is a phosphorylated CheY phosphatase essential for Borrelia burgdorferi chemotaxis. J. Bacteriol. 187:7963-7969.
    • (2005) J. Bacteriol. , vol.187 , pp. 7963-7969
    • Motaleb, M.A.1
  • 61
    • 79959326635 scopus 로고    scopus 로고
    • A novel gene inactivation system reveals an altered periplasmic flagellar orientation in a Borrelia burgdorferi fliL mutant
    • 25 March, posting date [Epub ahead of print.]
    • Motaleb, M. A., J. E. Pitzer, S. Z. Sultan, and J. Liu. 25 March 2011, posting date. A novel gene inactivation system reveals an altered periplasmic flagellar orientation in a Borrelia burgdorferi fliL mutant. J. Bacteriol. [Epub ahead of print.].
    • (2011) J. Bacteriol.
    • Motaleb, M.A.1    Pitzer, J.E.2    Sultan, S.Z.3    Liu, J.4
  • 62
    • 2942605826 scopus 로고    scopus 로고
    • The decrease in FlaA observed in a flaB mutant of Borrelia burgdorferi occurs posttranscriptionally
    • Motaleb, M. A., M. S. Sal, and N. W. Charon. 2004. The decrease in FlaA observed in a flaB mutant of Borrelia burgdorferi occurs posttranscriptionally. J. Bacteriol. 186:3703-3711.
    • (2004) J. Bacteriol. , vol.186 , pp. 3703-3711
    • Motaleb, M.A.1    Sal, M.S.2    Charon, N.W.3
  • 63
    • 79959326874 scopus 로고    scopus 로고
    • CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated intermediate
    • 29 April, posting date. [Epub ahead of print.]
    • Motaleb, M. A., S. Z. Sultan, M. R. Miller, C. Li, and N. W. Charon. 29 April 2011, posting date. CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated intermediate. J. Bacteriol. [Epub ahead of print.].
    • (2011) J. Bacteriol.
    • Motaleb, M.A.1    Sultan, S.Z.2    Miller, M.R.3    Li, C.4    Charon, N.W.5
  • 64
    • 0036128606 scopus 로고    scopus 로고
    • Helicobacter pylori uses motility for initial colonization and to attain robust infection
    • Ottemann, K. M., and A. C. Lowenthal. 2002. Helicobacter pylori uses motility for initial colonization and to attain robust infection. Infect. Immun. 70:1984-1990.
    • (2002) Infect. Immun. , vol.70 , pp. 1984-1990
    • Ottemann, K.M.1    Lowenthal, A.C.2
  • 65
    • 72049128621 scopus 로고    scopus 로고
    • BosR (BB0647) governs virulence expression in Borrelia burgdorferi
    • Ouyang, Z., et al. 2009. BosR (BB0647) governs virulence expression in Borrelia burgdorferi. Mol. Microbiol. 74:1331-1343.
    • (2009) Mol. Microbiol. , vol.74 , pp. 1331-1343
    • Ouyang, Z.1
  • 66
    • 39349089426 scopus 로고    scopus 로고
    • A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks
    • Pal, U., et al. 2008. A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks. J. Infect. Dis. 197:148-155.
    • (2008) J. Infect. Dis. , vol.197 , pp. 148-155
    • Pal, U.1
  • 67
    • 78650238422 scopus 로고    scopus 로고
    • Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism
    • Parveen, N., and K. A. Cornell. 2011. Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism. Mol. Microbiol. 79:7-20.
    • (2011) Mol. Microbiol. , vol.79 , pp. 7-20
    • Parveen, N.1    Cornell, K.A.2
  • 68
    • 77950370030 scopus 로고    scopus 로고
    • The c-di-GMP binding protein YcgR controls flagellar motor direction and speed to affect chemotaxis by a "backstop brake" mechanism
    • Paul, K., V. Nieto, W. C. Carlquist, D. F. Blair, and R. M. Harshey. 2010. The c-di-GMP binding protein YcgR controls flagellar motor direction and speed to affect chemotaxis by a "backstop brake" mechanism. Mol. Cell 38:128-139.
    • (2010) Mol. Cell , vol.38 , pp. 128-139
    • Paul, K.1    Nieto, V.2    Carlquist, W.C.3    Blair, D.F.4    Harshey, R.M.5
  • 69
    • 76649097688 scopus 로고    scopus 로고
    • Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate
    • Pazy, Y., et al. 2010. Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate. Proc. Natl. Acad. Sci. U. S. A. 107:1924-1929.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 1924-1929
    • Pazy, Y.1
  • 70
    • 79959410913 scopus 로고    scopus 로고
    • Analysis of the Borrelia burgdorferi cyclic-di-GMP binding protein PlzA reveals a role in motility and virulence
    • Pitzer, J. E., et al. 2011. Analysis of the Borrelia burgdorferi cyclic-di-GMP binding protein PlzA reveals a role in motility and virulence. Infect. Immun. 79:1815-1825.
    • (2011) Infect. Immun. , vol.79 , pp. 1815-1825
    • Pitzer, J.E.1
  • 71
    • 0142026236 scopus 로고    scopus 로고
    • Experimental infection of Ixodes scapularis larvae (Acari: Ixodidae) by immersion in low passage cultures of Borrelia burgdorferi
    • Policastro, P. F., and T. G. Schwan. 2003. Experimental infection of Ixodes scapularis larvae (Acari: Ixodidae) by immersion in low passage cultures of Borrelia burgdorferi. J. Med. Entomol. 40:364-370.
    • (2003) J. Med. Entomol. , vol.40 , pp. 364-370
    • Policastro, P.F.1    Schwan, T.G.2
  • 72
    • 0034610332 scopus 로고    scopus 로고
    • Correlation between plasmid content and infectivity in Borrelia burgdorferi
    • Purser, J. E., and S. J. Norris. 2000. Correlation between plasmid content and infectivity in Borrelia burgdorferi. Proc. Natl. Acad. Sci. U. S. A. 97: 13865-13870.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 13865-13870
    • Purser, J.E.1    Norris, S.J.2
  • 73
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27:493-497.
    • (1938) Am. J. Hyg. , vol.27 , pp. 93-497
    • Reed, L.J.1    Muench, H.2
  • 74
    • 79951591754 scopus 로고    scopus 로고
    • Defining the plasmid-encoded restriction-modification systems of the Lyme disease spirochete Borrelia burgdorferi
    • Rego, R. O., A. Bestor, and P. A. Rosa. 2011. Defining the plasmid-encoded restriction-modification systems of the Lyme disease spirochete Borrelia burgdorferi. J. Bacteriol. 193:1161-1171.
    • (2011) J. Bacteriol. , vol.193 , pp. 1161-1171
    • Rego, R.O.1    Bestor, A.2    Rosa, P.A.3
  • 75
    • 18744400258 scopus 로고    scopus 로고
    • bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector
    • Revel, A. T., et al. 2005. bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector. Proc. Natl. Acad. Sci. U. S. A. 102:6972-6977.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 6972-6977
    • Revel, A.T.1
  • 76
    • 34447527747 scopus 로고    scopus 로고
    • Genetic and physiological characterization of the Borrelia burgdorferi ORF BB0374-pfs-metK-luxS operon
    • Riley, S. P., T. Bykowski, K. Babb, K. von Lackum, and B. Stevenson. 2007. Genetic and physiological characterization of the Borrelia burgdorferi ORF BB0374-pfs-metK-luxS operon. Microbiology 153:2304-2311.
    • (2007) Microbiology , vol.153 , pp. 2304-2311
    • Riley, S.P.1    Bykowski, T.2    Babb, K.3    von Lackum, K.4    Stevenson, B.5
  • 77
    • 62449269945 scopus 로고    scopus 로고
    • Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions
    • Rogers, E. A., et al. 2009. Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions. Mol. Microbiol. 71:1551-1573.
    • (2009) Mol. Microbiol. , vol.71 , pp. 1551-1573
    • Rogers, E.A.1
  • 78
    • 67651215871 scopus 로고    scopus 로고
    • Prevailing concepts of c-di-GMP signaling
    • Römling, U., and R. Simm. 2009. Prevailing concepts of c-di-GMP signaling. Contrib. Microbiol. 16:161-181.
    • (2009) Contrib. Microbiol. , vol.16 , pp. 161-181
    • Römling, U.1    Simm, R.2
  • 79
    • 33646249963 scopus 로고    scopus 로고
    • Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover
    • Ryan, R. P., et al. 2006. Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover. Proc. Natl. Acad. Sci. U. S. A. 103:6712-6717.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 6712-6717
    • Ryan, R.P.1
  • 80
    • 65349134696 scopus 로고    scopus 로고
    • HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa
    • Ryan, R. P., et al. 2009. HD-GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa. Environ. Microbiol. 11: 1126-1136.
    • (2009) Environ. Microbiol. , vol.11 , pp. 1126-1136
    • Ryan, R.P.1
  • 81
    • 77950547731 scopus 로고    scopus 로고
    • Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris
    • Ryan, R. P., et al. 2010. Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris. Proc. Natl. Acad. Sci. U. S. A. 107:5989-5994.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 5989-5994
    • Ryan, R.P.1
  • 82
    • 33750044865 scopus 로고    scopus 로고
    • The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria
    • Ryjenkov, D. A., R. Simm, U. Römling, and M. Gomelsky. 2006. The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria. J. Biol. Chem. 281:30310-30314.
    • (2006) J. Biol. Chem. , vol.281 , pp. 30310-30314
    • Ryjenkov, D.A.1    Simm, R.2    Römling, U.3    Gomelsky, M.4
  • 83
    • 14244254898 scopus 로고    scopus 로고
    • Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain
    • Ryjenkov, D. A., M. Tarutina, O. V. Moskvin, and M. Gomelsky. 2005. Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain. J. Bacteriol. 187:1792-1798.
    • (2005) J. Bacteriol. , vol.187 , pp. 1792-1798
    • Ryjenkov, D.A.1    Tarutina, M.2    Moskvin, O.V.3    Gomelsky, M.4
  • 84
    • 40449134876 scopus 로고    scopus 로고
    • Borrelia burgdorferi uniquely regulates its motility genes and has an intricate flagellar hook-basal body structure
    • Sal, M. S., et al. 2008. Borrelia burgdorferi uniquely regulates its motility genes and has an intricate flagellar hook-basal body structure. J. Bacteriol. 190:1912-1921.
    • (2008) J. Bacteriol. , vol.190 , pp. 1912-1921
    • Sal, M.S.1
  • 85
    • 70349274104 scopus 로고    scopus 로고
    • Structural and mechanistic determinants of c-di-GMP signalling
    • Schirmer, T., and U. Jenal. 2009. Structural and mechanistic determinants of c-di-GMP signalling. Nat. Rev. Microbiol. 7:724-735.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 724-735
    • Schirmer, T.1    Jenal, U.2
  • 86
    • 67549109657 scopus 로고    scopus 로고
    • A role for the EAL-like protein STM1344 in regulation of CsgD expression and motility in Salmonella enterica serovar Typhimurium
    • Simm, R., U. Remminghorst, I. Ahmad, K. Zakikhany, and U. Römling. 2009. A role for the EAL-like protein STM1344 in regulation of CsgD expression and motility in Salmonella enterica serovar Typhimurium. J. Bacteriol. 191:3928-3937.
    • (2009) J. Bacteriol. , vol.191 , pp. 3928-3937
    • Simm, R.1    Remminghorst, U.2    Ahmad, I.3    Zakikhany, K.4    Römling, U.5
  • 87
    • 0025977648 scopus 로고
    • Antibody to a 39-kilodalton Borrelia burgdorferi antigen (P39) as a marker for infection in experimentally and naturally inoculated animals
    • Simpson, W. J., W. Burgdorfer, M. E. Schrumpf, R. H. Karstens, and T. G. Schwan. 1991. Antibody to a 39-kilodalton Borrelia burgdorferi antigen (P39) as a marker for infection in experimentally and naturally inoculated animals. J. Clin. Microbiol. 29:236-243.
    • (1991) J. Clin. Microbiol. , vol.29 , pp. 236-243
    • Simpson, W.J.1    Burgdorfer, W.2    Schrumpf, M.E.3    Karstens, R.H.4    Schwan, T.G.5
  • 89
    • 42949083309 scopus 로고    scopus 로고
    • A tightly regulated surface protein of Borrelia burgdorferi is not essential to the mouse-tick infectious cycle
    • Stewart, P. E., A. Bestor, J. N. Cullen, and P. A. Rosa. 2008. A tightly regulated surface protein of Borrelia burgdorferi is not essential to the mouse-tick infectious cycle. Infect. Immun. 76:1970-1978.
    • (2008) Infect. Immun. , vol.76 , pp. 1970-1978
    • Stewart, P.E.1    Bestor, A.2    Cullen, J.N.3    Rosa, P.A.4
  • 90
    • 0035131631 scopus 로고    scopus 로고
    • Isolation of a circular plasmid region sufficient for autonomous replication and transformation of infectious Borrelia burgdorferi
    • Stewart, P. E., R. Thalken, J. L. Bono, and P. Rosa. 2001. Isolation of a circular plasmid region sufficient for autonomous replication and transformation of infectious Borrelia burgdorferi. Mol. Microbiol. 39:714-721.
    • (2001) Mol. Microbiol. , vol.39 , pp. 714-721
    • Stewart, P.E.1    Thalken, R.2    Bono, J.L.3    Rosa, P.4
  • 91
    • 23644454421 scopus 로고    scopus 로고
    • Role of Borrelia burgdorferi linear plasmid 25 in infection of Ixodes scapularis ticks
    • Strother, K. O., and A. de Silva. 2005. Role of Borrelia burgdorferi linear plasmid 25 in infection of Ixodes scapularis ticks. J. Bacteriol. 187:5776-5781.
    • (2005) J. Bacteriol. , vol.187 , pp. 5776-5781
    • Strother, K.O.1    de Silva, A.2
  • 92
    • 47749152941 scopus 로고    scopus 로고
    • Riboswitches in eubacteria sense the second messenger cyclic di-GMP
    • Sudarsan, N., et al. 2008. Riboswitches in eubacteria sense the second messenger cyclic di-GMP. Science 321:411-413.
    • (2008) Science , vol.321 , pp. 411-413
    • Sudarsan, N.1
  • 93
    • 77953988576 scopus 로고    scopus 로고
    • Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclicdi-GMP in motility and virulence
    • Sultan, S. Z., J. E. Pitzer, M. R. Miller, and M. A. Motaleb. 2010. Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclicdi-GMP in motility and virulence. Mol. Microbiol. 77:128-142.
    • (2010) Mol. Microbiol. , vol.77 , pp. 128-142
    • Sultan, S.Z.1    Pitzer, J.E.2    Miller, M.R.3    Motaleb, M.A.4
  • 94
    • 35848951876 scopus 로고    scopus 로고
    • Roles of cyclic diguanylate in the regulation of bacterial pathogenesis
    • Tamayo, R., J. T. Pratt, and A. Camilli. 2007. Roles of cyclic diguanylate in the regulation of bacterial pathogenesis. Annu. Rev. Microbiol. 61:131-148.
    • (2007) Annu. Rev. Microbiol. , vol.61 , pp. 131-148
    • Tamayo, R.1    Pratt, J.T.2    Camilli, A.3
  • 95
    • 42149119716 scopus 로고    scopus 로고
    • Role of cyclic di-GMP during El Tor biotype Vibrio cholerae infection: characterization of the in vivo-induced cyclic di-GMP phosphodiesterase CdpA
    • Tamayo, R., S. Schild, J. T. Pratt, and A. Camilli. 2008. Role of cyclic di-GMP during El Tor biotype Vibrio cholerae infection: characterization of the in vivo-induced cyclic di-GMP phosphodiesterase CdpA. Infect. Immun. 76:1617-1627.
    • (2008) Infect. Immun. , vol.76 , pp. 1617-1627
    • Tamayo, R.1    Schild, S.2    Pratt, J.T.3    Camilli, A.4
  • 96
    • 25144489145 scopus 로고    scopus 로고
    • The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase
    • Tamayo, R., A. D. Tischler, and A. Camilli. 2005. The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase. J. Biol. Chem. 280:33324-33330.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33324-33330
    • Tamayo, R.1    Tischler, A.D.2    Camilli, A.3
  • 97
    • 33646930883 scopus 로고    scopus 로고
    • Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    • Tilly, K., et al. 2006. Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection. Infect. Immun. 74:3554-3564.
    • (2006) Infect. Immun. , vol.74 , pp. 3554-3564
    • Tilly, K.1
  • 98
    • 38749146920 scopus 로고    scopus 로고
    • Get the message out: cyclic-di-GMP regulates multiple levels of flagellum-based motility
    • Wolfe, A. J., and K. L. Visick. 2008. Get the message out: cyclic-di-GMP regulates multiple levels of flagellum-based motility. J. Bacteriol. 190:463-475.
    • (2008) J. Bacteriol. , vol.190 , pp. 463-475
    • Wolfe, A.J.1    Visick, K.L.2
  • 99
    • 77953952245 scopus 로고    scopus 로고
    • Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi
    • Xu, H., M. He, J. J. He, and X. F. Yang. 2010. Role of the surface lipoprotein BBA07 in the enzootic cycle of Borrelia burgdorferi. Infect. Immun. 78:2910-2918.
    • (2010) Infect. Immun. , vol.78 , pp. 2910-2918
    • Xu, H.1    He, M.2    He, J.J.3    Yang, X.F.4
  • 100
    • 1542283705 scopus 로고    scopus 로고
    • Essential role for OspA/B in the life cycle of the Lyme disease spirochete
    • Yang, X. F., U. Pal, S. M. Alani, E. Fikrig, and M. V. Norgard. 2004. Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J. Exp. Med. 199:641-648.
    • (2004) J. Exp. Med. , vol.199 , pp. 641-648
    • Yang, X.F.1    Pal, U.2    Alani, S.M.3    Fikrig, E.4    Norgard, M.V.5
  • 101
    • 70349428512 scopus 로고    scopus 로고
    • BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tickrodent transmission cycle
    • Zhang, X., X. Yang, M. Kumar, and U. Pal. 2009. BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tickrodent transmission cycle. J. Infect. Dis. 200:1318-1330.
    • (2009) J. Infect. Dis. , vol.200 , pp. 1318-1330
    • Zhang, X.1    Yang, X.2    Kumar, M.3    Pal, U.4
  • 102
    • 58149350102 scopus 로고    scopus 로고
    • Spent culture medium from virulent Borrelia burgdorferi increases permeability of individually perfused microvessels of rat mesentery
    • Zhou, X., M. R. Miller, M. Motaleb, N. W. Charon, and P. He. 2008. Spent culture medium from virulent Borrelia burgdorferi increases permeability of individually perfused microvessels of rat mesentery. PLoS One 3:e4101.
    • (2008) PLoS One , vol.3
    • Zhou, X.1    Miller, M.R.2    Motaleb, M.3    Charon, N.W.4    He, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.