-
1
-
-
0033151510
-
The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa- associated lymphoid tissue lymphomas
-
Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, et al. The apoptosis inhibit or gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21; q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999;93:3601-9. (Pubitemid 29249804)
-
(1999)
Blood
, vol.93
, Issue.11
, pp. 3601-3609
-
-
Dierlamm, J.1
Baens, M.2
Wlodarska, I.3
Stefanova-Ouzounova, M.4
Hernandez, J.M.5
Hossfeld, D.K.6
De Wolf-Peeters, C.7
Hagemeijer, A.8
Van Den Berghe, H.9
Marynen, P.10
-
2
-
-
0012605299
-
MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma
-
DOI 10.1182/blood-2002-10-3236
-
Sanchez-Izquierdo D, Buchonnet G, Siebert R, Gascoyne RD, Climent J, Karran L, et al. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Blood 2003;101:4539-46. (Pubitemid 36857825)
-
(2003)
Blood
, vol.101
, Issue.11
, pp. 4539-4546
-
-
Sanchez-Izquierdo, D.1
Buchonnet, G.2
Siebert, R.3
Gascoyne, R.D.4
Climent, J.5
Karran, L.6
Marin, M.7
Blesa, D.8
Horsman, D.9
Rosenwald, A.10
Staudt, L.M.11
Albertson, D.G.12
Du, M.-Q.13
Ye, H.14
Marynen, P.15
Garcia-Conde, J.16
Pinkel, D.17
Dyer, M.J.S.18
Martinez-Climent, J.A.19
-
3
-
-
0037443498
-
T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma
-
DOI 10.1182/blood-2002-09-2963
-
Streubel B, Lamprecht A, Dierlamm J, Cerroni L, Stolte M, Ott G, et al. T (14;18)(q32;q21) involving IGHand MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood 2003;101:2335-9. (Pubitemid 36302078)
-
(2003)
Blood
, vol.101
, Issue.6
, pp. 2335-2339
-
-
Streubel, B.1
Lamprecht, A.2
Dierlamm, J.3
Cerroni, L.4
Stolte, M.5
Ott, G.6
Raderer, M.7
Chott, A.8
-
4
-
-
84862990370
-
Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
-
Vicente-Duenas C, Fontan L, Gonzalez-Herrero I, Romero-Camar-ero I, Segura V, Aznar MA, et al. Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice. Proc Natl Acad Sci USA 2012;109: 10534-9.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 10534-10539
-
-
Vicente-Duenas, C.1
Fontan, L.2
Gonzalez-Herrero, I.3
Romero-Camar-Ero, I.4
Segura, V.5
Aznar, M.A.6
-
5
-
-
70449713757
-
Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells
-
Ferch U, Kloo B, Gewies A, Pfander V, Duwel M, Peschel C, et al. Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 2009;206: 2313-20.
-
(2009)
J Exp Med
, vol.206
, pp. 2313-2320
-
-
Ferch, U.1
Kloo, B.2
Gewies, A.3
Pfander, V.4
Duwel, M.5
Peschel, C.6
-
6
-
-
73949114883
-
Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
-
Hailfinger S, Lenz G, Ngo V, Posvitz-Fejfar A, Rebeaud F, Guzzardi M, et al. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. Proc Natl Acad Sci USA 2009;106: 19946-51.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 19946-19951
-
-
Hailfinger, S.1
Lenz, G.2
Ngo, V.3
Posvitz-Fejfar, A.4
Rebeaud, F.5
Guzzardi, M.6
-
7
-
-
33645306041
-
A loss-of-function RNA interference screen for molecular targets in cancer
-
Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G, et al. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 2006;441:106-10.
-
(2006)
Nature
, vol.441
, pp. 106-110
-
-
Ngo, V.N.1
Davis, R.E.2
Lamy, L.3
Yu, X.4
Zhao, H.5
Lenz, G.6
-
8
-
-
80455144540
-
MALT1 protease: A new therapeutic target in B lymphoma and beyond?
-
McAllister-Lucas LM, Baens M, Lucas PC. MALT1 protease: a new therapeutic target in B lymphoma and beyond? Clin Cancer Res 2011;17:6623-31.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6623-6631
-
-
McAllister-Lucas, L.M.1
Baens, M.2
Lucas, P.C.3
-
9
-
-
78650901943
-
NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins
-
Blonska M, Lin X. NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res 2011;21:55-70.
-
(2011)
Cell Res
, vol.21
, pp. 55-70
-
-
Blonska, M.1
Lin, X.2
-
10
-
-
2442612540
-
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
-
Thome M. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat Rev Immunol 2004;4:348-59. (Pubitemid 38649277)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.5
, pp. 348-359
-
-
Thome, M.1
-
11
-
-
33846228444
-
Antigen-Receptor Signaling to Nuclear Factor B
-
DOI 10.1016/j.immuni.2006.10.010, PII S1074761306004821
-
Schulze-Luehrmann J, Ghosh S. Antigen-receptor signaling to nuclear factor kappa B. Immunity 2006;25:701-15. (Pubitemid 46107295)
-
(2006)
Immunity
, vol.25
, Issue.5
, pp. 701-715
-
-
Schulze-Luehrmann, J.1
Ghosh, S.2
-
12
-
-
34548136086
-
MALT1 directs B cell receptor-induced canonical nuclear factor-B signaling selectively to the c-Rel subunit
-
DOI 10.1038/ni1493, PII NI1493
-
Ferch U, zum Buschenfelde CM, Gewies A, Wegener E, Rauser S, Peschel C, et al. MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit. Nat Immunol 2007;8:984-91. (Pubitemid 47300013)
-
(2007)
Nature Immunology
, vol.8
, Issue.9
, pp. 984-991
-
-
Ferch, U.1
Buschenfelde, C.M.Z.2
Gewies, A.3
Wegener, E.4
Rauser, S.5
Peschel, C.6
Krappmann, D.7
Ruland, J.8
-
13
-
-
84870856936
-
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo
-
Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 2012;22:812-24.
-
(2012)
Cancer Cell
, vol.22
, pp. 812-824
-
-
Fontan, L.1
Yang, C.2
Kabaleeswaran, V.3
Volpon, L.4
Osborne, M.J.5
Beltran, E.6
-
14
-
-
79551547792
-
Selective C-Rel activation via Malt1 controls antifungal T(H)-17 immunity by dectin-1 and dectin-2
-
Gringhuis SI, Wevers BA, Kaptein TM, van Capel TM, Theelen B, Boekhout T, et al. Selective C-Rel activation via Malt1 controls antifungal T(H)-17 immunity by dectin-1 and dectin-2. PLoS Pathogens 2011;7:e1001259.
-
(2011)
PLoS Pathogens
, vol.7
-
-
Gringhuis, S.I.1
Wevers, B.A.2
Kaptein, T.M.3
Van Capel, T.M.4
Theelen, B.5
Boekhout, T.6
-
15
-
-
0345374583
-
Regulation of NF-B-Dependent Lymphocyte Activation and Development by Paracaspase
-
DOI 10.1126/science.1090769
-
Ruefli-Brasse AA, French DM, Dixit VM. Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 2003;302:1581-4. (Pubitemid 37475705)
-
(2003)
Science
, vol.302
, Issue.5650
, pp. 1581-1584
-
-
Ruefli-Brasse, A.A.1
French, D.M.2
Dixit, V.M.3
-
16
-
-
0345358541
-
Differential requirement for Malt1 in T and B cell antigen receptor signaling
-
DOI 10.1016/S1074-7613(03)00293-0
-
Ruland J, Duncan GS, Wakeham A, Mak TW. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 2003;19:749-58. (Pubitemid 37490799)
-
(2003)
Immunity
, vol.19
, Issue.5
, pp. 749-758
-
-
Ruland, J.U.1
Duncan, G.S.2
Wakeham, A.3
Mak, T.W.4
-
17
-
-
33748752805
-
The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-B from toll-like receptor 4
-
DOI 10.1074/jbc.M513057200
-
Dong W, Liu Y, Peng J, Chen L, Zou T, Xiao H, et al. The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 2006;281:26029-40. (Pubitemid 44401809)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.36
, pp. 26029-26040
-
-
Dong, W.1
Liu, Y.2
Peng, J.3
Chen, L.4
Zou, T.5
Xiao, H.6
Liu, Z.7
Li, W.8
Bu, Y.9
Qi, Y.10
-
18
-
-
0033638182
-
Identification of paracaspases and metacaspases: Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
-
Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, et al. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell 2000;6:961-7.
-
(2000)
Mol Cell
, vol.6
, pp. 961-967
-
-
Uren, A.G.1
O'Rourke, K.2
Aravind, L.A.3
Pisabarro, M.T.4
Seshagiri, S.5
Koonin, E.V.6
-
19
-
-
39449131430
-
T cell antigen receptor stimulation induces MALT1 paracaspase - Mediated cleavage of the NF-B inhibitor A20
-
DOI 10.1038/ni1561, PII NI1561
-
Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol 2008;9:263-71. (Pubitemid 351267323)
-
(2008)
Nature Immunology
, vol.9
, Issue.3
, pp. 263-271
-
-
Coornaert, B.1
Baens, M.2
Heyninck, K.3
Bekaert, T.4
Haegman, M.5
Staal, J.6
Sun, L.7
Chen, Z.J.8
Marynen, P.9
Beyaert, R.10
-
20
-
-
39449085547
-
The proteolytic activity of the paracaspase MALT1 is key in T cell activation
-
DOI 10.1038/ni1568, PII NI1568
-
Rebeaud F, Hailfinger S, Posevitz-Fejfar A, Tapernoux M, Moser R, Rueda D, et al. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat Immunol 2008;9:272-81. (Pubitemid 351267324)
-
(2008)
Nature Immunology
, vol.9
, Issue.3
, pp. 272-281
-
-
Rebeaud, F.1
Hailfinger, S.2
Posevitz-Fejfar, A.3
Tapernoux, M.4
Moser, R.5
Rueda, D.6
Gaide, O.7
Guzzardi, M.8
Iancu, E.M.9
Rufer, N.10
Fasel, N.11
Thome, M.12
-
21
-
-
79955592698
-
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
-
Staal J, Driege Y, Bekaert T, Demeyer A, Muyllaert D, Van Damme P, et al. T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J 2011;30:1742-52.
-
(2011)
EMBO J
, vol.30
, pp. 1742-1752
-
-
Staal, J.1
Driege, Y.2
Bekaert, T.3
Demeyer, A.4
Muyllaert, D.5
Van Damme, P.6
-
22
-
-
80052282195
-
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines
-
Hailfinger S, Nogai H, Pelzer C, Jaworski M, Cabalzar K, Charton JE, et al. Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc Natl Acad Sci USA 2011;108:14596-601.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14596-14601
-
-
Hailfinger, S.1
Nogai, H.2
Pelzer, C.3
Jaworski, M.4
Cabalzar, K.5
Charton, J.E.6
-
23
-
-
84878315256
-
Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation
-
Uehata T, Iwasaki H, Vandenbon A, Matsushita K, Hernandez-Cuellar E, Kuniyoshi K, et al. Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation. Cell 2013; 153:1036-49.
-
(2013)
Cell
, vol.153
, pp. 1036-1049
-
-
Uehata, T.1
Iwasaki, H.2
Vandenbon, A.3
Matsushita, K.4
Hernandez-Cuellar, E.5
Kuniyoshi, K.6
-
24
-
-
79251574621
-
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation
-
Rosebeck S, Madden L, Jin X, Gu S, Apel IJ, Appert A, et al. Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. Science 2011;331:468-72.
-
(2011)
Science
, vol.331
, pp. 468-472
-
-
Rosebeck, S.1
Madden, L.2
Jin, X.3
Gu, S.4
Apel, I.J.5
Appert, A.6
-
25
-
-
78650915537
-
Deubiquitinases in the regulation of NF-kappaB signaling
-
Harhaj EW, Dixit VM. Deubiquitinases in the regulation of NF-kappaB signaling. Cell Res 2011;21:22-39.
-
(2011)
Cell Res
, vol.21
, pp. 22-39
-
-
Harhaj, E.W.1
Dixit, V.M.2
-
26
-
-
67649229160
-
A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains
-
Duwel M, Welteke V, Oeckinghaus A, Baens M, Kloo B, Ferch U, et al. A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J Immunol 2009;182: 7718-28.
-
(2009)
J Immunol
, vol.182
, pp. 7718-7728
-
-
Duwel, M.1
Welteke, V.2
Oeckinghaus, A.3
Baens, M.4
Kloo, B.5
Ferch, U.6
-
27
-
-
77951010885
-
Aggressive lymphomas
-
Lenz G, Staudt LM. Aggressive lymphomas. N Engl J Med 2010;362: 1417-29.
-
(2010)
N Engl J Med
, vol.362
, pp. 1417-1429
-
-
Lenz, G.1
Staudt, L.M.2
-
28
-
-
43449099189
-
Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma
-
DOI 10.3324/haematol.12057
-
Dierlamm J, Murga Penas EM, Bentink S, Wessendorf S, Berger H, Hummel M, et al. Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma. Haematologica 2008; 93:688-96. (Pubitemid 351669308)
-
(2008)
Haematologica
, vol.93
, Issue.5
, pp. 688-696
-
-
Dierlamm, J.1
Murga Penas, E.M.2
Bentink, S.3
Wessendorf, S.4
Berger, H.5
Hummel, M.6
Klapper, W.7
Lenze, D.8
Rosenwald, A.9
Haralambieva, E.10
Ott, G.11
Cogliatti, S.B.12
Moller, P.13
Schwaenen, C.14
Stein, H.15
Loffler, M.16
Spang, R.17
Trumper, L.18
Siebert, R.19
-
29
-
-
73849145729
-
Chronic active B-cell-receptor signalling in diffuse large B-cell lym-phoma
-
Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lym-phoma. Nature 2010;463:88-92.
-
(2010)
Nature
, vol.463
, pp. 88-92
-
-
Davis, R.E.1
Ngo, V.N.2
Lenz, G.3
Tolar, P.4
Young, R.M.5
Romesser, P.B.6
-
30
-
-
41149136296
-
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
-
DOI 10.1126/science.1153629
-
Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, et al. Oncogenic CARD11 mutations in human diffuse large B cell lympho-ma. Science 2008;319:1676-9. (Pubitemid 351432507)
-
(2008)
Science
, vol.319
, Issue.5870
, pp. 1676-1679
-
-
Lenz, G.1
Davis, R.E.2
Ngo, V.N.3
Lam, L.4
George, T.C.5
Wright, G.W.6
Dave, S.S.7
Zhao, H.8
Xu, W.9
Rosenwald, A.10
Ott, G.11
Muller-Hermelink, H.K.12
Gascoyne, R.D.13
Connors, J.M.14
Rimsza, L.M.15
Campo, E.16
Jaffe, E.S.17
Delabie, J.18
Smeland, E.B.19
Fisher, R.I.20
Chan, W.C.21
Staudt, L.M.22
more..
-
31
-
-
79551686422
-
Oncogenically active MYD88 mutations in human lymphoma
-
Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, et al. Oncogenically active MYD88 mutations in human lymphoma. Nature 2011;470:115-9.
-
(2011)
Nature
, vol.470
, pp. 115-119
-
-
Ngo, V.N.1
Young, R.M.2
Schmitz, R.3
Jhavar, S.4
Xiao, W.5
Lim, K.H.6
-
32
-
-
84870769441
-
Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL
-
Nagel D, Spranger S, Vincendeau M, Grau M, Raffegerst S, Kloo B, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell 2012;22:825-37.
-
(2012)
Cancer Cell
, vol.22
, pp. 825-837
-
-
Nagel, D.1
Spranger, S.2
Vincendeau, M.3
Grau, M.4
Raffegerst, S.5
Kloo, B.6
-
33
-
-
0017068246
-
Antipsychotic drug doses and neuroleptic/dopamine receptors
-
Seeman P, Lee T, Chau-Wong M, Wong K. Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 1976;261:717-9.
-
(1976)
Nature
, vol.261
, pp. 717-719
-
-
Seeman, P.1
Lee, T.2
Chau-Wong, M.3
Wong, K.4
-
34
-
-
0035150202
-
Antipsychotic drugs: Prolonged QTc interval, torsade de pointes, and sudden death
-
DOI 10.1176/appi.ajp.158.11.1774
-
Glassman AH, Bigger JT Jr. Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am J Psychiatry 2001;158:1774-82. (Pubitemid 33054769)
-
(2001)
American Journal of Psychiatry
, vol.158
, Issue.11
, pp. 1774-1782
-
-
Glassman, A.H.1
Bigger Jr., J.T.2
-
35
-
-
84875452974
-
The protease activity of the paracaspase MALT1 is controlled by mono-ubiquitination
-
Pelzer C, Cabalzar K, Wolf A, Gonzalez M, Lenz G, Thome M. The protease activity of the paracaspase MALT1 is controlled by mono-ubiquitination. Nat Immunol 2013;14:337-45.
-
(2013)
Nat Immunol
, vol.14
, pp. 337-345
-
-
Pelzer, C.1
Cabalzar, K.2
Wolf, A.3
Gonzalez, M.4
Lenz, G.5
Thome, M.6
-
36
-
-
16844381831
-
Mechanisms of B-cell lymphoma pathogenesis
-
DOI 10.1038/nrc1589
-
Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 2005;5:251-62. (Pubitemid 40488631)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.4
, pp. 251-262
-
-
Kuppers, R.1
-
37
-
-
84879748062
-
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
-
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum KA, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013;369:32-42.
-
(2013)
N Engl J Med
, vol.369
, pp. 32-42
-
-
Byrd, J.C.1
Furman, R.R.2
Coutre, S.E.3
Flinn, I.W.4
Burger, J.A.5
Blum, K.A.6
-
38
-
-
84881225049
-
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma
-
Wang ML, Rule S, Martin P, Goy A, Auer R, Kahl BS, et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med 2013;369:507-516.
-
(2013)
N Engl J Med
, vol.369
, pp. 507-516
-
-
Wang, M.L.1
Rule, S.2
Martin, P.3
Goy, A.4
Auer, R.5
Kahl, B.S.6
-
39
-
-
84874585216
-
The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (PCI-32765) has preferential activity in the ABC subtype of relapsed/refractory de novo diffuse large B-cell lymphoma (DLBCL): Interim results of a multicenter open-label phase 2 study [abstract]
-
2012 Dec 8-11; Atlanta, GA. Abstract nr 686
-
Wilson WH, Gerecitano JF, Goy A, de Vos S, Kenkre VP, Barr PM, et al. The Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib (PCI-32765), has preferential activity in the ABC subtype of relapsed/refractory de novo diffuse large B-cell lymphoma (DLBCL): interim results of a multicenter, open-label, phase 2 study [abstract]. In: Proceedings of the 54th ASH Annual Meeting and Exposition; 2012 Dec 8-11; Atlanta, GA. Abstract nr 686.
-
Proceedings of the 54th ASH Annual Meeting and Exposition
-
-
Wilson, W.H.1
Gerecitano, J.F.2
Goy, A.3
De Vos, S.4
Kenkre, V.P.5
Barr, P.M.6
-
40
-
-
77951002653
-
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
-
Friedberg JW, Sharman J, Sweetenham J, Johnston PB, Vose JM, Lacasce A, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 2010;115:2578-85.
-
(2010)
Blood
, vol.115
, pp. 2578-2585
-
-
Friedberg, J.W.1
Sharman, J.2
Sweetenham, J.3
Johnston, P.B.4
Vose, J.M.5
Lacasce, A.6
-
41
-
-
84881082520
-
Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-kappaB activation in diffuse large B-cell lymphoma
-
Qu C, Liu Y, Kunkalla K, Singh RR, Blonska M, Lin X, et al. Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-kappaB activation in diffuse large B-cell lymphoma. Blood 2013;121:4718-28.
-
(2013)
Blood
, vol.121
, pp. 4718-4728
-
-
Qu, C.1
Liu, Y.2
Kunkalla, K.3
Singh, R.R.4
Blonska, M.5
Lin, X.6
-
42
-
-
84878969076
-
SYK inhibition modulates distinct PI3K/AKT-dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas
-
Chen L, Monti S, Juszczynski P, Ouyang J, Chapuy B, Neuberg D, et al. SYK inhibition modulates distinct PI3K/AKT-dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas. Cancer Cell 2013;23:826-38.
-
(2013)
Cancer Cell
, vol.23
, pp. 826-838
-
-
Chen, L.1
Monti, S.2
Juszczynski, P.3
Ouyang, J.4
Chapuy, B.5
Neuberg, D.6
-
43
-
-
80855145502
-
MALT lymphomas: Pathogenesis can drive treatment
-
47
-
Bertoni F, Coiffier B, Salles G, Stathis A, Traverse-Glehen A, Thieble-mont C, et al. MALT lymphomas: pathogenesis can drive treatment. Oncology (Williston Park) 2011;25:1134-42, 47.
-
(2011)
Oncology (Williston Park)
, vol.25
, pp. 1134-1142
-
-
Bertoni, F.1
Coiffier, B.2
Salles, G.3
Stathis, A.4
Traverse-Glehen, A.5
Thieble-Mont, C.6
-
44
-
-
84870521827
-
The NF-kappaB regulator MALT1 determines the enceph-alitogenic potential of Th17 cells
-
Brustle A, Brenner D, Knobbe CB, Lang PA, Virtanen C, Hershenfield BM, et al. The NF-kappaB regulator MALT1 determines the enceph-alitogenic potential of Th17 cells. J Clin Invest 2012;122:4698-709.
-
(2012)
J Clin Invest
, vol.122
, pp. 4698-4709
-
-
Brustle, A.1
Brenner, D.2
Knobbe, C.B.3
Lang, P.A.4
Virtanen, C.5
Hershenfield, B.M.6
-
45
-
-
84874928867
-
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination
-
Mc Guire C, Wieghofer P, Elton L, Muylaert D, Prinz M, Beyaert R, et al. Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination. J Immunol 2013;190:2896-903.
-
(2013)
J Immunol
, vol.190
, pp. 2896-2903
-
-
Mc Guire, C.1
Wieghofer, P.2
Elton, L.3
Muylaert, D.4
Prinz, M.5
Beyaert, R.6
-
46
-
-
80051684615
-
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
-
Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011; 476:214-9.
-
(2011)
Nature
, vol.476
, pp. 214-219
-
-
Sawcer, S.1
Hellenthal, G.2
Pirinen, M.3
Spencer, C.C.4
Patsopoulos, N.A.5
Moutsianas, L.6
-
47
-
-
84881244147
-
Association of POL1, MALT1, MC4R, PHLPP and DSEL single nucle-otide polymorphisms in chromosome 18q region with type 2 diabetes in Tunisians
-
Turki A, Mahjoub T, Mtiraoui N, Abdelhedi M, Frih A, Almawi WY. Association of POL1, MALT1, MC4R, PHLPP and DSEL single nucle-otide polymorphisms in chromosome 18q region with type 2 diabetes in Tunisians. Gene 2013;527:243-7.
-
(2013)
Gene
, vol.527
, pp. 243-247
-
-
Turki, A.1
Mahjoub, T.2
Mtiraoui, N.3
Abdelhedi, M.4
Frih, A.5
Almawi, W.Y.6
-
48
-
-
68149139538
-
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
-
Vereecke L, Beyaert R, van Loo G. The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology. Trends Immunol 2009;30:383-91.
-
(2009)
Trends Immunol
, vol.30
, pp. 383-391
-
-
Vereecke, L.1
Beyaert, R.2
Van Loo, G.3
-
49
-
-
84857389911
-
The c-Rel transcription factor in development and disease
-
Gilmore TD, Gerondakis S. The c-Rel transcription factor in development and disease. Genes Cancer 2011;2:695-711.
-
(2011)
Genes Cancer
, vol.2
, pp. 695-711
-
-
Gilmore, T.D.1
Gerondakis, S.2
-
50
-
-
84882912219
-
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency
-
Jabara HH, Ohsumi T, Chou J, Massaad MJ, Benson H, Megarbane A, et al. A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency. J Allergy Clin Immunol 2013;132:151-8.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 151-158
-
-
Jabara, H.H.1
Ohsumi, T.2
Chou, J.3
Massaad, M.J.4
Benson, H.5
Megarbane, A.6
-
51
-
-
80052029516
-
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
-
Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 2011;476:298-303.
-
(2011)
Nature
, vol.476
, pp. 298-303
-
-
Morin, R.D.1
Mendez-Lago, M.2
Mungall, A.J.3
Goya, R.4
Mungall, K.L.5
Corbett, R.D.6
-
52
-
-
84865736998
-
Targeting the B-cell lymphoma/leukemia 2 family in cancer
-
Davids MS, Letai A. Targeting the B-cell lymphoma/leukemia 2 family in cancer. J Clin Oncol 2012;30:3127-35.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3127-3135
-
-
Davids, M.S.1
Letai, A.2
-
53
-
-
77955949060
-
BCL6: Master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis
-
Basso K, Dalla-Favera R. BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis. Adv Immunol 2010;105:193-210.
-
(2010)
Adv Immunol
, vol.105
, pp. 193-210
-
-
Basso, K.1
Dalla-Favera, R.2
-
54
-
-
47149096182
-
B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma
-
Ci W, Polo JM, Melnick A. B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma. Curr Opin Hematol 2008;15:381-90.
-
(2008)
Curr Opin Hematol
, vol.15
, pp. 381-390
-
-
Ci, W.1
Polo, J.M.2
Melnick, A.3
-
55
-
-
77950486830
-
A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo
-
Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, et al. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell 2010;17:400-11.
-
(2010)
Cancer Cell
, vol.17
, pp. 400-411
-
-
Cerchietti, L.C.1
Ghetu, A.F.2
Zhu, X.3
Da Silva, G.F.4
Zhong, S.5
Matthews, M.6
-
56
-
-
65349119454
-
A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo
-
Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, et al. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood 2009;113:3397-405.
-
(2009)
Blood
, vol.113
, pp. 3397-3405
-
-
Cerchietti, L.C.1
Yang, S.N.2
Shaknovich, R.3
Hatzi, K.4
Polo, J.M.5
Chadburn, A.6
-
57
-
-
11144277489
-
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
-
DOI 10.1038/nm1134
-
Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF, et al. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med 2004;10: 1329-35. (Pubitemid 40022714)
-
(2004)
Nature Medicine
, vol.10
, Issue.12
, pp. 1329-1335
-
-
Polo, J.M.1
Dell'Oso, T.2
Ranuncolo, S.M.3
Cerchietti, L.4
Beck, D.5
Da Silva, G.F.6
Prive, G.G.7
Licht, J.D.8
Melnick, A.9
-
58
-
-
84878030010
-
MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma
-
Horn H, Ziepert M, Becher C, Barth TF, Bernd HW, Feller AC, et al. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood 2013;121:2253-63.
-
(2013)
Blood
, vol.121
, pp. 2253-2263
-
-
Horn, H.1
Ziepert, M.2
Becher, C.3
Barth, T.F.4
Bernd, H.W.5
Feller, A.C.6
-
59
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011;146:904-17.
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
-
60
-
-
80053651202
-
Targeting MYC dependence in cancer by inhibiting BET bromodomains
-
Mertz JA, Conery AR, Bryant BM, Sandy P, Balasubramanian S, Mele DA, et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci USA 2011;108:16669-74.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16669-16674
-
-
Mertz, J.A.1
Conery, A.R.2
Bryant, B.M.3
Sandy, P.4
Balasubramanian, S.5
Mele, D.A.6
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