Microbiological investigation in male infertility: A practical overview

Journal of Medical Microbiology

Volumn 63, Issue PART 1, 2013, Pages 1-14

  La Vignera, Sandro ^a   Condorelli, Rosita A ^a   Vicari, Enzo ^a   Salmeri, Mario ^a   Morgia, Giuseppe ^a   Favilla, Vincenzo ^a   Cimino, Sebastiano ^a   Calogero, Aldo E ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE MIGRATION INHIBITION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

BALANOPREPUTIAL SWAB; BIOCHEMISTRY; HUMAN; LEUKOCYTE; MALE INFERTILITY; MICROBIOLOGICAL EXAMINATION; OXIDATIVE STRESS; PAPILLOMAVIRUS INFECTION; PRIORITY JOURNAL; REVIEW; SPERM; URETHRAL SWAB; URINE CULTURE; UROGENITAL TRACT INFECTION; WART VIRUS;

EID: 84890760018     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.062968-0     Document Type: Review

References (85)

1. Aitken, R. J., Clarkson, J. S., Hargreave, T. B., Irvine, D. S. & Wu, F. C. (1989). Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl 10, 214-220.
2. Aitken, R. J., Gordon, E., Harkiss, D., Twigg, J. P., Milne, P., Jennings, Z. & Irvine, D. S. (1998). Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. Biol Reprod 59, 1037-1046.
3. Aljabari, B., Calogero, A. E., Perdichizzi, A., Vicari, E., Karaki, R., Lahloub, T., Zatari, R., El-Abed, K., Nicoletti, F. & other authors (2007). Imbalance in seminal fluid MIF indicates male infertility. Mol Med 13, 199-202.
4. Allam, J. P., Fronhoffs, F., Fathy, A., Novak, N., Oltermann, I., Bieber, T., Schuppe, H. C. & Haidl, G. (2008). High percentage of apoptotic spermatozoa in ejaculates from men with chronic genital tract inflammation. Andrologia 40, 329-334.
5. Askienazy-Elbhar, M. (2005). [Male genital tract infection: the point of view of the bacteriologist]. Gynecol Obstet Fertil 33, 691-697 (in French).
6. Aydemir, B., Onaran, I., Kiziler, A. R., Alici, B. & Akyolcu, M. C. (2008). The influence of oxidative damage on viscosity of seminal fluid in infertile men. J Androl 29, 41-46.
7. Barroso, G., Morshedi, M. & Oehninger, S. (2000). Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa. Hum Reprod 15, 1338-1344.
8. Bian, S. L., Jin, H. B., Wang, S. Z., Zhang, H. F., Gu, C. R., Zhang, W. & Yu, X. G. (2007). [Effects of interferon-gamma and tumor necrosis factor-alpha on the fertilizing capacity of human sperm and their mechanisms]. Zhonghua Nan Ke Xue 13, 681-684 (in Chinese).
9. Boitrelle, F., Robin, G., Lefebvre, C., Bailly, M., Selva, J., Courcol, R., Lornage, J. & Albert, M. (2012). [Bacteriospermia in Assisted Reproductive Techniques: effects of bacteria on spermatozoa and seminal plasma, diagnosis and treatment]. Gynecol Obstet Fertil 40, 226-234 (in French).
10. Budía, A., Luis Palmero, J., Broseta, E., Tejadillos, S., Benedicto, A., Queipo, J. A., Gobernado, M. & Fernando Jiménez Cruz, J. (2006). Value of semen culture in the diagnosis of chronic bacterial prostatitis: a simplified method. Scand J Urol Nephrol 40, 326-331.
11. Camejo, M. I., Segnini, A. & Proverbio, F. (2001). Interleukin-6 (IL-6) in seminal plasma of infertile men, and lipid peroxidation of their sperm. Arch Androl 47, 97-101.
12. Carli, C., Leclerc, P., Metz, C. N. & Akoum, A. (2007). Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility. Fertil Steril 88 (Suppl), 1240-1247.
13. Comhaire, F., Verschraegen, G. & Vermeulen, L. (1980). Diagnosis of accessory gland infection and its possible role in male infertility. Int J Androl 3, 32-45.
14. Comhaire, F. H., Vermeulen, L. & Pieters, O. (1989). Study of the accuracy of physical and biochemical markers in semen to detect infectious dysfunction of the accessory sex glands. J Androl 10, 50-53.
15. Comhaire, F. H., Mahmoud, A. M. A., Depuydt, C. E., Zalata, A. A. & Christophe, A. B. (1999). Mechanisms and effects of male genital tract infection on sperm quality and fertilizing potential: the andrologist's viewpoint. Hum Reprod Update 5, 393-398.
16. Cooper, T. G., Weidner, W. & Nieschlag, E. (1990). The influence of inflammation of the human male genital tract on secretion of the seminal markers alpha-glucosidase, glycerophosphocholine, carnitine, fructose and citric acid. Int J Androl 13, 329-336.
17. De Francesco, M. A., Negrini, R., Ravizzola, G., Galli, P. & Manca, N. (2011). Bacterial species present in the lower male genital tract: a fiveyear retrospective study. Eur J Contracept Reprod Health Care 16, 47-53.
18. Dimitrov, D. G. & Petrovská, M. (1996). Effects of products of activated immune cells and recombinant cytokines on spontaneous and ionophore-induced acrosome reaction. Am J Reprod Immunol 36, 150-156.
19. Dousset, B., Hussenet, F., Daudin, M., Bujan, L., Foliguet, B. & Nabet, P. (1997). Seminal cytokine concentrations (IL-1beta, IL-2, IL-6, sR IL-2, sR IL-6), semen parameters and blood hormonal status in male infertility. Hum Reprod 12, 1476-1479.
20. Eggert-Kruse, W., Boit, R., Rohr, G., Aufenanger, J., Hund, M. & Strowitzki, T. (2001). Relationship of seminal plasma interleukin (IL)-8 and IL-6 with semen quality. Hum Reprod 16, 517-528.
21. Estrada, L. S., Champion, H. C., Wang, R., Rajasekaran, M., Hellstrom, W. J., Aggarwal, B. & Sikka, S. C. (1997). Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters. Int J Androl 20, 237-242.
22. Fedder, J. & Ellermann-eriksen, S. (1995). Effect of cytokines on sperm motility and ionophore-stimulated acrosome reaction. Arch Androl 35, 173-185.
23. Foresta, C., Pizzol, D., Bertoldo, A., Menegazzo, M., Barzon, L. & Garolla, A. (2011). Semen washing procedures do not eliminate human papilloma virus sperm infection in infertile patients. Fertil Steril 96, 1077-1082.
24. Fraczek, M. & Kurpisz, M. (2007). Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa. J Androl 28, 325-333.
25. Fraczek, M., Sanocka, D., Kamieniczna, M. & Kurpisz, M. (2008). Proinflammatory cytokines as an intermediate factor enhancing lipid sperm membrane peroxidation in in vitro conditions. J Androl 29, 85-92.
26. Frenette, G., Légaré, C., Saez, F. & Sullivan, R. (2005). Macrophage migration inhibitory factor in the human epididymis and semen. Mol Hum Reprod 11, 575-582.
27. Garolla, A., Pizzol, D. & Foresta, C. (2011). The role of human papillomavirus on sperm function. Curr Opin Obstet Gynecol 23, 232-237.
28. Girling, J. E. & Hedger, M. P. (2007). Toll-like receptors in the gonads and reproductive tract: emerging roles in reproductive physiology and pathology. Immunol Cell Biol 85, 481-489.
29. Griveau, J. F. & Lannou, D. L. E. (1997). Reactive oxygen species and human spermatozoa: physiology and pathology. Int J Androl 20, 61-69.
30. Gruschwitz, M. S., Brezinschek, R. & Brezinschek, H. P. (1996). Cytokine levels in the seminal plasma of infertile males. J Androl 17, 158-163.
31. Hill, J. A., Haimovici, F., Politch, J. A. & Anderson, D. J. (1987). Effects of soluble products of activated lymphocytes and macrophages (lymphokines and monokines) on human sperm motion parameters. Fertil Steril 47, 460-465.
32. Hill, J. A., Cohen, J. & Anderson, D. J. (1989). The effects of lymphokines and monokines on human sperm fertilizing ability in the zona-free hamster egg penetration test. Am J Obstet Gynecol 160, 1154-1159.
33. Horner, P. J. & Taylor-Robinson, D. (2011). Association of Mycoplasma genitalium with balanoposthitis in men with nongonococcal urethritis. Sex Transm Infect 87, 38-40.
34. Hussenet, F., Dousset, B., Cordonnier, J. L., Jacob, C., Foliguet, B., Grignon, G. & Nabet, P. (1993). Tumour necrosis factor alpha and interleukin 2 in normal and infected human seminal fluid. Hum Reprod 8, 409-411.
35. Isemberg, H. D. (editor) (1998). Essential Procedures for Clinical Microbiology. Washington, DC: American Society for Microbiology.
36. Jensen, I. P., Fogh, H. & Prag, J. (2003). Diagnosis of Chlamydia trachomatis infections in a sexually transmitted disease clinic: evaluation of a urine sample tested by enzyme immunoassay and polymerase chain reaction in comparison with a cervical and/or a urethral swab tested by culture and polymerase chain reaction. Clin Microbiol Infect 9, 194-201.
37. Koçak, I., Yenisey, C., Dündar, M., Okyay, P. & Serter, M. (2002). Relationship between seminal plasma interleukin-6 and tumor necrosis factor alpha levels with semen parameters in fertile and infertile men. Urol Res 30, 263-267.
38. Krieger, J. N., Nyberg, L., Jr & Nickel, J. C. (1999). NIH consensus definition and classification of prostatitis. JAMA 282, 236-237.
39. La Vignera, S., Calogero, A. E., Arancio, A., Castiglione, R., De Grande, G. & Vicari, E. (2008). Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia. Asian J Androl 10, 731-740.
40. La Vignera, S., Vicari, E., Condorelli, R. A., D'Agata, R. & Calogero, A. E. (2011). Male accessory gland infection and sperm parameters (review). Int J Androl 34, e330-e347.
41. La Vignera, S., Condorelli, R., Vicari, E., D'Agata, R. & Calogero, A. E. (2012a). High frequency of sexual dysfunction in patients with male accessory gland infections. Andrologia 44 (Suppl 1), 438-446.
42. La Vignera, S., Calogero, A. E., Condorelli, R. A., Vicari, L. O., Catanuso, M., D'Agata, R. & Vicari, E. (2012b). Ultrasonographic evaluation of patients with male accessory gland infection. Andrologia 44 (Suppl 1), 26-31.
43. La Vignera, S., Condorelli, R. A., Calogero, A. E., Bellanca, S., Salmeri, M. & Vicari, E. (2012c). Persistence of ultrasound alterations after antibiotic treatment with levofloxacin in patients with male accessory gland infection. Asian J Androl 14, 879-883.
44. Lampiao, F. & du Plessis, S. S. (2008). TNF-alpha and IL-6 affect human sperm function by elevating nitric oxide production. Reprod Biomed Online 17, 628-631.
45. Lampiao, F. & du Plessis, S. S. (2009). Effects of tumour necrosis factor alpha and interleukin-6 on progesterone and calcium ionophore-induced acrosome reaction. Int J Androl 32, 274-277.
46. Lanzafame, F. M., La Vignera, S., Vicari, E. & Calogero, A. E. (2009). Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online 19, 638-659.
47. Leterrier, M., Fréour, T., Guillouzouic, A., Juvin, M. E., Barriere, P., Reynaud, A. & Corvec, S. (2011). Semen cultures analysis: retrospective study during a 6-year period and interest in the management of infertility. Eur J Clin Microbiol Infect Dis 30, 401-406.
48. Letkiewicz, S., Mie{ogonek}dzybrodzki, R., Kłak, M., Jończyk, E., Weber-Da{ogonek}browska, B. & Górski, A. (2010). The perspectives of the application of phage therapy in chronic bacterial prostatitis. FEMS Immunol Med Microbiol 60, 99-112.
49. Lewis, S. E. M., Donnelly, E. T., Sterling, E. S. L., Kennedy, M. S., Thompson, W. & Chakravarthy, U. (1996). Nitric oxide synthase and nitrite production in human spermatozoa: evidence that endogenous nitric oxide is beneficial to sperm motility. Mol Hum Reprod 2, 873-878.
50. Lipperheide, V., Andraka, L., Pontón, J. & Quindós, G. (1993). Evaluation of the albicans IDR plate method for the rapid identification of Candida albicans. Mycoses 36, 417-420.
51. Lotti, F. & Maggi, M. (2013). Interleukin 8 and the male genital tract. J Reprod Immunol [Epub ahead of print].
52. Lotti, F., Corona, G., Mancini, M., Filimberti, E., Degli Innocenti, S., Colpi, G. M., Baldi, E., Noci, I., Forti, G. & other authors (2011). Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility. Int J Androl 34, 600-613.
53. Ludwig, M., Vidal, A., Diemer, T., Pabst, W., Failing, K. & Weidner, W. (2002). Seminal secretory capacity of the male accessory sex glands in chronic pelvic pain syndrome (CPPS)/chronic prostatitis with special focus on the new prostatitis classification. Eur Urol 42, 24-28.
54. Mahmoud, A. M., Geslevich, J., Kint, J., Depuydt, C., Huysse, L., Zalata, A. & Comhaire, F. H. (1998). Seminal plasma alphaglucosidase activity and male infertility. Hum Reprod 13, 591-595.
55. Marconi, M., Pilatz, A., Wagenlehner, F., Diemer, T. & Weidner, W. (2009). Impact of infection on the secretory capacity of the male accessory glands. Int Braz J Urol 35, 299-308, discussion 308-309.
56. Martínez, P., Proverbio, F. & Camejo, M. I. (2007). Sperm lipid peroxidation and pro-inflammatory cytokines. Asian J Androl 9, 102-107.
57. Meares, E. M. & Stamey, T. A. (1968). Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest Urol 5, 492-518.
58. Murray, P. R., Baron, E. J., Jorgensen, J. H. & other authors (editors) (2003). Manual of Clinical Microbiology, 8th edn. Washington, DC: American Society for Microbiology.
59. Nickel, J. C. (1997). The Pre and Post Massage Test (PPMT): a simple screen for prostatitis. Tech Urol 3, 38-43.
60. Nickel, J. C., Nyberg, L. M. & Hennenfent, M. (1999). Research guidelines for chronic prostatitis: consensus report from the first National Institutes of Health International Prostatitis Collaborative Network. Urology 54, 229-233.
61. Nickel, J. C., Shoskes, D., Wang, Y., Alexander, R. B., Fowler, J. E., Jr, Zeitlin, S., O'Leary, M. P., Pontari, M. A., Schaeffer, A. J. & other authors (2006). How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome? J Urol 176, 119-124.
62. Okamura, N., Tajima, Y., Ishikawa, H., Yoshii, S., Koiso, K. & Sugita, Y. (1986). Lowered levels of bicarbonate in seminal plasma cause the poor sperm motility in human infertile patients. Fertil Steril 45, 265-272.
63. Omu, A. E., Al-Qattan, F., Al-Abdul-Hadi, F. M., Fatinikun, M. T. & Fernandes, S. (1999). Seminal immune response in infertile men with leukocytospermia: effect on antioxidant activity. Eur J Obstet Gynecol Reprod Biol 86, 195-202.
64. Orellana, M. A., Gómez, Ml., Sánchez, M. T. & Fernández-Chacón, T. (2009). [Diagnosis of urethritis in men. A 3-year review]. Rev Esp Quimioter 22, 83-87 (in Spanish).
65. Pakendorf, U. W., Bornman, M. S. & Du Plessis, D. J. (1998). Prevalence of human papilloma virus in men attending the infertility clinic. Andrologia 30, 11-14.
66. Patel, S. R., Wiese, W., Patel, S. C., Ohl, C., Byrd, J. C. & Estrada, C. A. (2000). Systematic review of diagnostic tests for vaginal trichomoniasis. Infect Dis Obstet Gynecol 8, 248-257.
67. Perdichizzi, A., Nicoletti, F., La Vignera, S., Barone, N., D'Agata, R., Vicari, E. & Calogero, A. E. (2007). Effects of tumour necrosis factoralpha on human sperm motility and apoptosis. J Clin Immunol 27, 152-162.
68. Quintar, A. A., Roth, F. D., Paul, A. L. D, Aoki, A. & Maldonado, C. A. (2006). Toll-like receptor 4 in rat prostate: modulation by testosterone and acute bacterial infection in epithelial and stromal cells. Biol Reprod 75, 664-672.
69. Rowe, P., Comhaire, F., Hargreave, T. B. & Mellows, H. J. (editors) (1993). World Health Organization Manual for the Standardised Investigation and Diagnosis of the Infertile Couple. Cambridge: Cambridge University Press.
70. Rusz, A., Pilatz, A., Wagenlehner, F., Linn, T., Diemer, T., Schuppe, H. C., Lohmeyer, J., Hossain, H. & Weidner, W. (2012). Influence of urogenital infections and inflammation on semen quality and male fertility. World J Urol 30, 23-30.
71. Saraniya, A., Koner, B. C., Doureradjou, P., Selvaraj, N. & Shivagourou, V. (2008). Altered malondialdehyde, protein carbonyl and sialic acid levels in seminal plasma of microscopically abnormal semen. Andrologia 40, 56-57.
72. Schiefer, H. G. (1998). Microbiology of male urethroadnexitis: diagnostic procedures and criteria for aetiologic classification. Andrologia 30 (Suppl 1), 7-13.
73. Scottish Intercollegiate Guideline Network. Management of genital chlamydia trachomatis infection. A national clinical guideline. The Scottish Intercollegiate Guideline Network; 2009.
74. Sikka, S. C., Champion, H. C., Bivalacqua, T. J., Estrada, L. S., Wang, R., Rajasekaran, M., Aggarwal, B. B. & Hellstrom, W. J. (2001). Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa. Int J Androl 24, 136-141.
75. Suleiman, S. A., Ali, M. E., Zaki, Z. M., el-Malik, E. M. & Nasr, M. A. (1996). Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl 17, 530-537.
76. Twigg, J. P., Irvine, D. S. & Aitken, R. J. (1998). Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod 13, 1864-1871.
77. Vázquez, F., Carreño, F., Pérez, A. F., Cuestan, M. M., Ordóñez, M. L. & Palacio, V. (1995). Comparison of 3 culture methods for genital mycoplasmas. Enferm Infecc Microbiol Clin 13, 460-463.
78. Vesić, S., Vukićević, J., Daković, Z., Tomović, M., Dobrosavljević, D., Medenica, L. & Pavlović, M. D. (2007). Male urethritis with and without discharge: relation to microbiological findings and polymorphonuclear counts. Acta Dermatovenerol Alp Panonica Adriat 16, 53-57.
79. Vicari, E. (1999). Seminal leukocyte concentration and related specific reactive oxygen species production in patients with male accessory gland infections. Hum Reprod 14, 2025-2030.
80. Vicari, E., Mongioì, A., Speciale, A., Caccamo, F., Calogero, A., Gulizia, S., Pellegrino, M. B., Macchi, M. & D'Agata, R. (1986). Enhancing detection of gonococcus in ejaculates of adult males using sperm dilution. Arch Androl 16, 19-23.
81. Vicari, E., La Vignera, S., Castiglione, R. & Calogero, A. E. (2006). Sperm parameter abnormalities, low seminal fructose and reactive oxygen species overproduction do not discriminate patients with unilateral or bilateral post-infectious inflammatory prostato-vesiculo-epididymitis. J Endocrinol Invest 29, 18-25.
82. Wagenlehner, F. M. & Naber, K. G. (2006). Current challenges in the treatment of complicated urinary tract infections and prostatitis. Clin Microbiol Infect 12 (Suppl 3), 67-80.
83. Weidner, W., Krause, W. & Ludwig, M. (1999). Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. Hum Reprod Update 5, 421-432.
84. Wincek, T. J., Meyer, T. K., Meyer, M. R. & Kuehl, T. J. (1991). Absence of a direct effect of recombinant tumor necrosis factor-alpha on human sperm function and murine preimplantation development. Fertil Steril 56, 332-339.
85. Zermann, D. H., Wunderlich, H., Schubert, J. & Ishigooka, M. (1999). Re: The diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health Interstitial Cystitis Database Study. J Urol 162, 807.