MKP-1 signaling events are required for early osteoclastogenesis in lineage defined progenitor populations by disrupting RANKL-induced NFATc1 nuclear translocation

Bone

Volumn 60, Issue , 2014, Pages 16-25

  Valerio, Michael S ^a   Herbert, Bethany A ^a   Griffin, Alfred C ^a   Wan, Zhuang ^b   Hill, Elizabeth G ^a,b   Kirkwood, Keith L ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Cytokine; MAPK phosphatase; Osteoclastogenesis; Progenitors; RANKL

Indexed keywords

COLONY STIMULATING FACTOR 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; INTRACELLULAR TRANSPORT; MOUSE; NFATC1 GENE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TM7SF4 GENE;

CYTOKINE; MAPK PHOSPHATASE; OSTEOCLASTOGENESIS; PROGENITORS; RANKL;

ANIMALS; BIOLOGICAL MARKERS; CELL FUSION; CELL LINEAGE; CELL MEMBRANE; CELL NUCLEUS; DUAL SPECIFICITY PHOSPHATASE 1; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; OSTEOGENESIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; RANK LIGAND; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84890578491     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.11.012     Document Type: Article

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