MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function

Molecular Endocrinology

Volumn 26, Issue 10, 2012, Pages 1682-1693

  Griffin III, Alfred C ^a   Kern, Michael J ^a,b   Kirkwood, Keith L ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CYTOCHROME P450; CYTOCHROME P450 24A1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; OSTEOCLAST DIFFERENTIATION FACTOR; RETINOID X RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; BONE MARROW CELL; BONE MARROW STROMAL CELL; CELL FRACTIONATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE TARGETING; GENE TRANSLOCATION; GENOME; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; NUCLEAR IMPORT; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SIGNAL TRANSDUCTION; STROMA CELL; WESTERN BLOTTING; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BASE SEQUENCE; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL NUCLEUS; CELLS, CULTURED; COCULTURE TECHNIQUES; DUAL SPECIFICITY PHOSPHATASE 1; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOCLASTS; PROMOTER REGIONS, GENETIC; RANK LIGAND; RECEPTORS, CALCITRIOL; RETINOID X RECEPTOR ALPHA; SIGNAL TRANSDUCTION; STEROID HYDROXYLASES; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; VITAMIN D; VITAMIN D RESPONSE ELEMENT;

MUS;

EID: 84867013608     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1033     Document Type: Review

References (51)

1. Bickle DA, Christakos S 2008 Vitamin D: production, metabolism, mechanism of action, and clinical requirements. In: Rosen CJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. Washington, DC: American Society for Bone and Mineral Research; 141-147
2. Pettifor JM 2005 Rickets and vitamin D deficiency in children and adolescents. Endocrinol Metab Clin North Am 34:537-553
3. Bordier P, Pechet MM, Hesse R, Marie P, Rasmussen H 1974 Response of adult patients with osteomalacia to treatment with crystalline 1_-hydroxy vitamin D3. N Engl J Med 291:866-871
4. Kristjansson K, Rut AR, Hewison M, O'Riordan JL, Hughes MR 1993 Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3. J Clin Invest 92:12-16
5. Pike JW, Shevde NK 2005 The Vitamin D Receptor. In: Feldman D, Pike JW, Glorieux FH, eds. Vitamin D. 2nd ed. San Diego: Elsevier; 167-191
6. Kim S, Shevde NK, Pike JW 2005 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. J Bone Miner Res 20:305-317
7. Mangelsdorf DJ, Evans RM 1995 The RXR heterodimers and orphan receptors. Cell 83:841-850
8. Prüfer K, Racz A, Lin GC, Barsony J 2000 Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting of vitamin D receptors. J Biol Chem 275:41114-41123
9. Pike JW, Meyer MB, Watanuki M, Kim S, Zella LA, Fretz JA, Yamazaki M, Shevde NK 2007 Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor. J Steroid Biochem Mol Biol 103:389-395
10. Zella LA, Kim S, Shevde NK, Pike JW 2006 Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3. Mol Endocrinol 20:1231-1247
11. Kim S, Yamazaki M, Zella LA, Shevde NK, Pike JW 2006 Activation of receptor activator of NF-_B ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers. Mol Cell Biol 26:6469-6486
12. Pike JW, Zella LA, Meyer MB, Fretz JA, Kim S 2007 Molecular actions of,25-dihydroxyvitamin D3 on genes involved in calcium homeostasis. J Bone Miner Res 22(Suppl 2):V16-V19
13. Boyle WJ, Simonet WS, Lacey DL 2003 Osteoclast differentiation and activation. Nature 423:337-342
14. Kim S, Yamazaki M, Zella LA, Meyer MB, Fretz JA, Shevde NK, Pike JW 2007 Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 103:430-434
15. Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V 2007 Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep)158:1-235
16. Ishizuka S, Kurihara N, Reddy SV, Cornish J, Cundy T, Roodman GD 2005 (23S)-25-Dehydro-1_-hydroxyvitamin D3-26,23-lactone, a vitamin D receptor antagonist that inhibits osteoclast formation and bone resorption in bone marrow cultures from patients with Paget's disease. Endocrinology 146:2023-2030
17. Kurihara N, Reddy SV, Araki N, Ishizuka S, Ozono K, Cornish J, Cundy T, Singer FR, Roodman GD 2004 Role of TAFII-17, a VDR binding protein, in The increased osteoclast formation in Paget's disease. J Bone Miner Res 19:1154-1164
18. Carlson J, Cui W, Zhang Q, Xu X, Mercan F, Bennett AM, Vignery A 2009 Role of MKP-1 in osteoclasts and bone homeostasis. Am J Pathol 175:1564-1573
19. Zhang Y, Leung DY, Richers BN, Liu Y, Remigio LK, Riches DW, Goleva E 2012 Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol 188:2127-2135
20. Abraham SM, Clark AR 2006 Dual-specificity phosphatase 1: a critical regulator of innate immune responses. Biochem Soc Trans 34:1018-1023
21. Dickinson RJ, Keyse SM 2006 Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci 119:4607-4615
22. Liu Y, Shepherd EG, Nelin LD 2007 MAPK phosphatases-regulating the immune response. Nat Rev Immunol 7:202-212
23. Franklin CC, Kraft AS 1997 Conditional expression of the mitogenactivated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J Biol Chem 272:16917-16923
24. Sartori R, Li F, Kirkwood KL 2009 MAP kinase phosphatase-1 protects against inflammatory bone loss. J Dent Res 88:1125-1130
25. Roth Flach RJ, BennettAM2010 Mitogen-activated protein kinase phosphatase-1-a potential therapeutic target in metabolic disease. Expert Opin Ther Targets 14:1323-1332
26. Solomon C, White JH, Kremer R 1999 Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor _. J Clin Invest 103:1729-1735
27. Zhang Z, Kovalenko P, Cui M, Desmet M, Clinton SK, Fleet JC 2010 Constitutive ac ivation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells. J Cell Physiol 224:433-442
28. Derberg O, Gullberg M, Jarvius M, Ridderstråle K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG, Landegren U. 2006 Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 3:995-1000
29. Hayashi H, Nakahama K, Sato T, Tuchiya T, Asakawa Y, Maemura T, Tanaka M, Morita M, Morita I 2008 The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-_B ligand. FEBS Lett 582:3243-3248
30. Wali RK, Kong J, Sitrin MD, Bissonnette M, Li YC 2003 Vitamin Dreceptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts. J Cell Biochem 88:794-801
31. Atkins GJ, Anderson PH, Findlay DM, Welldon KJ, Vincent C, Zannettino AC, O'Loughlin PD, Morris HA 2007 Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 α,25-dihydroxyvitamin D3. Bone 40:1517-1528
32. Fu Q, Manolagas SC, O'Brien CA 2006 Parathyroid hormone controls receptor activator of NF-κB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol 26:6453-6468
33. Noda M, Vogel RL, Craig AM, Prahl J, DeLuca HF, Denhardt DT 1990 Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitaminD3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Proc Natl Acad Sci USA 87:9995-9999.
34. Rossa Jr C, Liu M, Kirkwood KL 2008 A dominant function of p38 mitogen-activated protein kinase signaling in receptor activator of nuclear factor-_B ligand expression and osteoclastogenesis induction by Aggregatibacter actinomycetemcomitans and Escherichia coli lipopolysaccharide. J Periodontal Res 43:201-211
35. Patil CS, Liu M, Zhao W, Coatney DD, Li F, VanTubergen EA, D'Silva NJ, Kirkwood KL 2008 Targeting mRNA stability arrests inflammatory bone loss. Mol Ther 16:1657-1664
36. Teitelbaum SL 2000 Bone resorption by osteoclasts. Science 289: 1504-1508
37. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176
38. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ 1999 Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96: 3540-3545
39. Nakashima T, Takayanagi H 2009 Osteoimmunology: crosstalk between the immune and bone systems. J Clin Immunol 29:555-567
40. Mahalingam CD, Datta T, Patil RV, Kreider J, Bonfil RD, Kirkwood KL, Goldstein SA, Abou-Samra AB, Datta NS 2011 Mitogen activated protein kinase phosphatase 1 regulates bone mass, osteoblast gene expression, and responsiveness to parathyroid hormone. J Endocrinol 211:145-156
41. Leenders JJ, Pinto YM, Creemers EE 2011 Tapping the brake on cardiac growth-endogenous repressors of hypertrophic signaling. J Mol Cell Cardiol 51:156-167
42. Manetsch M, Che W, Seidel P, Chen Y, Ammit AJ 2012 MKP-1: A negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells. Cell Signal 24:907-913
43. Franklin CC, Srikanth S, Kraft AS 1998 Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Proc Natl Acad Sci USA 95:3014-3019
44. Yu H, Li Q, Herbert B, Zinna R, Martin K, Junior CR, Kirkwood KL 2011 An i-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss. Gene Ther 18:344-353
45. Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA 2006 Dynamic regulation of proand anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci USA 103:2274-2279
46. Salojin KV, Owusu IB, Millerchip KA, Potter M, Platt KA, Oravecz T 2006 Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol 176:1899-1907
47. Galli C, Fu Q, Wang W, Olsen BR, Manolagas SC, Jilka RL, O'Brien CA 2009 Commitment to the osteoblast lineage is not required for RANKL gene expression. J Biol Chem 284:12654-12662
48. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T 1998 Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95:3597-3602
49. Sutton AL, MacDonald PN 2003 Vitamin D: more than a "bonea-fide" hormone. Mol Endocrinol 17:777-791
50. Nagpal S, Na S, Rathnachalam R 2005 Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 26:662-687
51. Yasmin R, Williams RM, Xu M, NoyN2005 Nuclear import of the retinoid X receptor, the vitamin D receptorand their mutual heterodimer. J Biol Chem 280:40152-40160