The AKT/mTOR pathway mediates neuronal protective effects of erythropoietin in sepsis

Molecular and Cellular Biochemistry

Volumn 385, Issue 1-2, 2014, Pages 125-132

  Wang, Guo Bin ^a   Ni, Yun Lan ^a   Zhou, Xin Ping ^a   Zhang, Wei Fang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

AKT mTOR signaling; Apoptosis; Cognitive dysfunction; Hippocampus; rhEPO; Sepsis

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; RECOMBINANT ERYTHROPOIETIN; S6 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DISEASE; BRAIN DYSFUNCTION; BRAIN PROTECTION; COGNITIVE DEFECT; CONTROLLED STUDY; EMBRYO; LOCOMOTION; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SEPSIS;

ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BRAIN; CECUM; COGNITION; EMOTIONS; ERYTHROPOIETIN; HUMANS; LIGATION; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PUNCTURES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SEPSIS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84890539919     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1821-5     Document Type: Article

References (39)

1. Iacobone E, Bailly-Salin J, Polito A, Friedman D, Stevens RD, Sharshar T (2009) Sepsis-associated encephalopathy and its differential diagnosis. Crit Care Med 37:S331-S336
2. Siami S, Annane D, Sharshar T (2008) The encephalopathy in sepsis. Crit Care Clin 24:67-82
3. Comim CM, Rezin GT, Scaini G, Di-Pietro PB, Cardoso MR, Petronilho FC, Ritter C, Streck EL, Quevedo J, Dal-Pizzol F (2008) Mitochondrial respiratory chain and creatine kinase activities in rat brain after sepsis induced by cecal ligation and perforation. Mitochondrion 8:313-318
4. Joana da Costa P, Santiago APS, Amâncio RT, Galina A, Oliveira MF, Bozza FA (2008) Sepsis induces brain mitochondrial dysfunction. Crit Care Med 36:1925-1932
5. Weberpals M, Hermes M, Hermann S, Kummer MP, Terwel D, Semmler A, Berger M, Schäfers M, Heneka MT (2009) NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci 29:14177-14184
6. Morishita E, Masuda S, Nagao M, Yasuda Y, Sasaki R (1997) Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76:105-116
7. Morishita E, Narita H, Nishida M, Kawashima N, Yamagishi K, Masuda S, Nagao M, Hatta H, Sasaki R (1996) Anti-erythropoietin receptor monoclonal antibody: epitope mapping, quantification of the soluble receptor, and detection of the solubilized transmembrane receptor and the receptor-expressing cells. Blood 88:465-471
8. Digicaylioglu M, Bichet S, Marti H, Wenger R, Rivas L, Bauer C, Gassmann M (1995) Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci USA 92:3717-3720
9. McPherson RJ, Juul SE (2008) Recent trends in erythropoietin-mediated neuroprotection. Int J Dev Neurosci 26:103-111
10. Kao R, Xenocostas A, Rui T, Yu P, Huang W, Rose J, Martin CM (2007) Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model. Crit Care 11:R58
11. Koroglu T, Yilmaz O, Ozer E, Baskin H, Gokmen N, Kumral A, Duman M, Ozkan H (2006) Erythropoietin attenuates lipopolysaccharide-induced splenic and thymic apoptosis in rats. Physiol Res 55:309
12. Kumral A, Baskin H, Yesilirmak DC, Ergur BU, Aykan S, Genc S, Genc K, Yilmaz O, Tugyan K, Giray O (2007) Erythropoietin attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain. Neonatology 92:269-278
13. Mitra A, Bansal S, Wang W, Falk S, Zolty E, Schrier RW (2007) Erythropoietin ameliorates renal dysfunction during endotoxaemia. Nephrol Dial Transplant 22:2349-2353
14. Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129:1261-1274
15. Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149:274-293
16. Bao H, Jacobs-Helber S, Lawson A, Penta K, Wickrema A, Sawyer S (1999) Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells). Blood 93:3757-3773
17. Tramontano A, Muniyappa R, Black A, Blendea M, Cohen I, Deng L, Sowers J, Cutaia M, El-Sherif N (2003) Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway. Biochem Biophys Res Commun 308:990-994
18. Kaech S, Banker G (2007) Culturing hippocampal neurons. Nat Protoc 1:2406-2415
19. Ritter C, Andrades ME, Reinke A, Menna-Barreto S, Moreira JCF, Dal-Pizzol F (2004) Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Crit Care Med 32:342-349
20. Sakanaka M, Wen T-C, Matsuda S, Masuda S, Morishita E, Nagao M, Sasaki R (1998) In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95:4635-4640
21. Valentim AM, Di Giminiani P, Ribeiro PO, Rodrigues P, Olsson IAS, Antunes LM (2010) Lower isoflurane concentration affects spatial learning and neurodegeneration in adult mice compared with higher concentrations. Anesthesiology 113:1099-1108
22. Ebersoldt M, Sharshar T, Annane D (2007) Sepsis-associated delirium. Intensive Care Med 33:941-950
23. Maiese K, Li F, Chong ZZ (2004) Erythropoietin in the brain: can the promise to protect be fulfilled? Trends Pharmacol Sci 25:577
24. Calapai G, Marciano MC, Corica F, Allegra A, Parisi A, Frisina N, Caputi AP, Buemi M (2000) Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation. Eur J Pharmacol 401:349-356
25. Kanaan NM, Collier TJ, Marchionini DM, McGuire SO, Fleming MF, Sortwell CE (2006) Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease. Brain Res 1068:221-229
26. Assaraf MI, Diaz Z, Liberman A, Miller WH Jr, Arvanitakis Z, Li Y, Bennett DA, Schipper HM (2007) Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. J Neuropathol Exp Neurol 66:389-398
27. Aoshiba K, Onizawa S, Tsuji T, Nagai A (2009) Therapeutic effects of erythropoietin in murine models of endotoxin shock. Crit Care Med 37:889-898
28. Haiden N, Klebermass K, Cardona F, Schwindt J, Berger A, Kohlhauser-Vollmuth C, Jilma B, Pollak A (2006) A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity. Pediatrics 118:180-188
29. Ehrenreich H, Hasselblatt M, Dembowski C, Cepek L, Lewczuk P, Stiefel M, Rustenbeck H, Breiter N, Jacob S, Knerlich F (2002) Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 8:495-505
30. Aher S, Ohlsson A (2006) Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 3:CD004868
31. Yap TA, Garrett MD, Walton MI, Raynaud F, de Bono JS, Workman P (2008) Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. Curr Opin Pharmacol 8:393-412
32. Parcellier A, Tintignac LA, Zhuravleva E, Hemmings BA (2008) PKB and the mitochondria: AKTing on apoptosis. Cell Signal 20:21-30
33. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C (2003) PI3K/Akt and apoptosis: size matters. Oncogene 22:8983-8998
34. Rokutanda S, Fujita T, Kanatani N, Yoshida CA, Komori H, Liu W, Mizuno A, Komori T (2009) Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev Biol 328:78-93
35. Cai W, Rudolph JL, Harrison SM, Jin L, Frantz AL, Harrison DA, Andres DA (2011) An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. Mol Biol Cell 22:3231-3241
36. Koh P-O (2011) Nicotinamide attenuates the ischemic brain injury-induced decrease of Akt activation and Bad phosphorylation. Neurosci Lett 498:105-109
37. Maiese K, Chong ZZ, Li F, Shang YC (2008) Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol 85:194-213
38. Mendoza MC, Er EE, Blenis J (2011) The Ras-ERK and PI3 K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci 36:320-328
39. Lei G, Xia Y, Johnson KM (2007) The role of Akt-GSK-3β signaling and synaptic strength in phencyclidine-induced neurodegeneration. Neuropsychopharmacol 33:1343-1353