A randomized, controlled trial of the effects of adding vitamin B 12 and folate to erythropoietin for the treatment of anemia of prematurity

Pediatrics

Volumn 118, Issue 1, 2006, Pages 180-188

  Haiden, Nadja ^a   Klebermass, Katrin ^a   Cardona, Francesco ^a   Schwindt, Jens ^a   Berger, Angelika ^a   Kohlhauser Vollmuth, Christina ^a   Jilma, Bernd ^a   Pollak, Arnold ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Anemia of prematurity; Erythropoietin; Folic acid; Vitamin B12

Indexed keywords

ALPHA TOCOPHEROL; CYANOCOBALAMIN; ERYTHROPOIETIN; FOLIC ACID; FOLICOBALAMINE; HEMOGLOBIN; IRON DEXTRAN; IRON POLYMALTOSE; MALTOFER; RECOMBINANT ERYTHROPOIETIN; SOLUVIT; UNCLASSIFIED DRUG; VITAMIN B COMPLEX;

ABSENCE OF SIDE EFFECTS; ANEMIA; ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG POTENTIATION; ENTERIC FEEDING; ERYTHROCYTE COUNT; ERYTHROPOIESIS; FEMALE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFANT; IRON THERAPY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; VITAMIN BLOOD LEVEL; BLOOD TRANSFUSION; DRUG COMBINATION; GESTATIONAL AGE; MEAN CORPUSCULAR VOLUME; NEWBORN; NEWBORN ANEMIA; PARENTERAL NUTRITION;

ANEMIA, NEONATAL; BLOOD TRANSFUSION; DRUG THERAPY, COMBINATION; ERYTHROCYTE INDICES; ERYTHROPOIESIS; ERYTHROPOIETIN; FOLIC ACID; GESTATIONAL AGE; HEMATOCRIT; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; PARENTERAL NUTRITION; VITAMIN B 12; VITAMIN B COMPLEX;

EID: 33746810188     PISSN: 00314005     EISSN: 02105721     Source Type: Journal    
DOI: 10.1542/peds.2005-2475     Document Type: Article

References (42)

1. Ebert BL, Bunn HF. Regulation of the erythropoietin gene. Blood. 1999;94:1864-1877
2. Kling PJ, Schmidt RL, Roberts RA, Widness JA. Serum erythropoietin levels during infancy: associations with erythropoiesis. J Pediatr. 1996;128:791-796
3. Ohls RK. The use of erythropoietin in neonates. Clin Perinatol. 2000;27:681-696
4. Brown MS, Garcia JF, Phibbs RH, Dallman PR. Decreased response of plasma immunoreactive erythropoietin to "available oxygen" in anemia of prematurity. J Pediatr. 1984;105:793-798
5. Goodnough LT, Skikne B, Brugnara C. Erythropoietin, iron, and erythropoiesis. Blood. 2000;96:823-833
6. Spivak JL. Recombinant human erythropoietin and the anemia of cancer. Blood. 1994;84:997-1004
7. Cazzola M, Mercuriali F, Brugnara C. Use of recombinant human erythropoietin outside the setting of uremia. Blood. 1997;89:4248-4267
8. Vamvakas EC, Strauss RG. Meta-analysis of controlled clinical trials studying the efficacy of rHuEPO in reducing blood transfusions in the anemia of prematurity. Transfusion. 2001;41:406-415
9. Kotto-Kome AC, Garcia MG, Calhoun DA, Christensen RD. Effect of beginning recombinant erythropoietin treatment within the first week of life, among very-low-birth-weight neonates, on "early" and "late" erythrocyte transfusions: a meta-analysis. J Perinatol. 2004;24:24-29
10. Garcia MG, Hutson AD, Christensen RD. Effect of recombinant erythropoietin on "late" transfusions in the neonatal intensive care unit: a meta-analysis. J Perinatol. 2002;22:108-111
11. Neu J, Valentine C, Meetze W. Scientifically-based strategies for nutrition of the high-risk low birth weight infant. Eur J Pediatr. 1990;150:2-13
12. Brown MS, Shapiro H. Effect of protein intake on erythropoiesis during erythropoietin treatment of anemia of prematurity. J Pediatr. 1996;128:512-517
13. 12 deficiency in pregnancy and in the neonatal period. Clin Perinatol. 1984;11:433-459
14. Gallagher PG, Ehrenkranz RA. Nutritional anemias in infancy. Clin Perinatol. 1995;22:671-692
15. Pollak A, Hayde M, Hayn M, et al. Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants. Pediatrics. 2001;107:78-85
16. Maier RF, Obladen M, Muller-Hansen I, et al. Early treatment with erythropoietin β ameliorates anemia and reduces transfusion requirements in infants with birth weights below 1000 g. J Pediatr. 2002;141:8-15
17. Ohls RK, Ehrenkranz RA, Wright LL, et al. Effects of early erythropoietin therapy on the transfusion requirements of preterm infants below 1250 grams birth weight: a multicenter, randomized, controlled trial. Pediatrics. 2001;108:934-942
18. Donato H, Vain N, Rendo P, et al. Effect of early versus late administration of human recombinant erythropoietin on transfusion requirements in premature infants: results of a randomized, placebo-controlled, multicenter trial. Pediatrics. 2000;105:1066-1072
19. 12 to reduce the severity of the anemia of prematurity. Am J Clin Nutr. 1994;60:930-935
20. 12 supplementation in very low birth weight infants treated with erythropoietin: a cautionary note. Pediatrics. 2001;108:217
21. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529-534
22. Afzali B, Goldsmith DJ. Intravenous iron therapy in renal failure: friend and foe? J Nephrol. 2004;17:487-495
23. Sunder-Plassmann G, Patruta SI, Horl WH. Pathobiology of the role of iron in infection. Am J Kidney Dis. 1999;34(suppl 2):S25-S29
24. Shannon KM, Keith JF III, Mentzer WC, et al. Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants. Pediatrics. 1995;95:1-8
25. Walker WA, Watkins JB. Nutrition in Pediatrics: Basic Science and Clinical Applications. 2nd ed. London, United Kingdom: BC Decker; 1997
26. Stolley PD, Strom BL. Sample size calculations for clinical pharmacology studies. Clin Pharmacol Ther. 1986;39:489-490
27. Oster O. Reference values. In: Lentze MJ, Schulte FJ, Schaub J, Spranger J, eds. Pädiatrie. 3rd ed. Berlin, Germany: Springer; 2003:1806
28. Emmerson AJ, Coles HJ, Stern CM, Pearson TC. Double blind trial of recombinant human erythropoietin in preterm infants. Arch Dis Child. 1993;68:291-296
29. Campbell NR. How safe are folic acid supplements? Arch Intern Med. 1996;156:1638-1644
30. Stevens D, Burman D, Strelling MK, Morris A. Folic acid supplementation in low birth weight infants. Pediatrics. 1979;64:333-335
31. Newell SJ. Enteral feeding of the micropreemie. Clin Perinatol. 2000;27:221-234
32. Weaver LT, Lucas A. Development of bowel habit in preterm infants. Arch Dis Child. 1993;68:317-320
33. 12. Folia Haematol Int Mag Klin Morphol Blutforsch. 1956;74:273-275
34. Patel A, Chanarin I. Restoration of normal red cell size after treatment in megaloblastic anaemia. Br J Haematol. 1975;30:57-63
35. Kling PJ, Winzerling JJ. Iron status and the treatment of the anemia of prematurity. Clin Perinatol. 2002;29:283-294
36. Lundstrom U, Siimes MA, Dallman PR. At what age does iron supplementation become necessary in low-birth-weight infants? J Pediatr. 1977;91:878-883
37. Morris KP, Watson S, Reid MM, Hamilton PJ, Coulthard MG. Assessing iron status in children with chronic renal failure on erythropoietin: which measurements should we use? Pediatr Nephrol. 1994;8:51-56
38. Bader D, Blondheim O, Jonas R, et al. Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity. Acta Paediatr. 1996;85:496-501
39. Beguin Y, Clemons GK, Pootrakul P, Fillet G. Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood. 1993;81:1067-1076
40. Kohgo Y, Niitsu Y, Kondo H, et al. Serum transferrin receptor as a new index of erythropoiesis. Blood. 1987;70:1955-1958
41. Kivivuori SM, Heikinheimo M, Teppo AM, Siimes MA. Early rise in serum concentration of transferrin receptor induced by recombinant human erythropoietin in very-low-birth-weight infants. Pediatr Res. 1994;36:85-89
42. Beguin Y, Loo M, R'Zik S, et al. Early prediction of response to recombinant human erythropoietin in patients with the anemia of renal failure by serum transferrin receptor and fibrinogen. Blood. 1993;82:2010-2016