Non-celiac gluten sensitivity. Is it in the gluten or the grain?

Journal of Gastrointestinal and Liver Diseases

Volumn 22, Issue 4, 2013, Pages 435-440

  Nijeboer, Petula ^a   Bontkes, Hetty J ^a   Mulder, Chris J J ^a   Bouma, Gerd ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Celiac Disease; Gluten free diet; Gluten sensitivity; Grain; IBS; Irritable bowel syndrome; NCGS; Non celiac gluten sensitivity; Wheat; Wheat allergy

Indexed keywords

ENDOMYSIUM ANTIBODY; GAMMA INTERFERON; GLIADIN ANTIBODY; GLUTEN; HLA DQ2 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 21; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; T LYMPHOCYTE RECEPTOR;

BIOPSY; CELIAC DISEASE; DIARRHEA; DIGESTIVE SYSTEM DISEASE; GLUTEN FREE DIET; GRAIN; HUMAN; INNATE IMMUNITY; IRRITABLE COLON; NON CELIAC GLUTEN SENSITIVITY; PATHOGENESIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; WHEAT ALLERGY;

ANIMALS; CELIAC DISEASE; DIAGNOSIS, DIFFERENTIAL; DIET, GLUTEN-FREE; FOOD HYPERSENSITIVITY; GLUTENS; HUMANS; IRRITABLE BOWEL SYNDROME; PREDICTIVE VALUE OF TESTS; RISK FACTORS; WHEAT HYPERSENSITIVITY;

EID: 84890529454     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Di Sabatino, Corazza GR. Celiac disease. Lancet 2009;373:1480-1493.
2. Green PH, Cellier C. Celiac disease. N Engl J Med 2007;357:1731-1743.
3. Tatham AS, Shewry PR. Allergens to wheat and related cereals. Clin Exp Allergy 2008;38:1712-1726.
4. Kaukinen K, Turjanmaa K, Maki M, et al. Intolerance to cereals is not specific for celiac disease. Scand J Gastroenterol 2000;35:942-946.
5. Troncone R, Jabri B. Celiac disease and gluten sensitivity. J Intern Med 2011;269:582-590.
6. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006;130:1480-1491.
7. Di Sabatino, Corazza GR. Nonceliac gluten sensitivity: sense or sensibility? Ann Intern Med 2012;156:309-311.
8. Sapone A, Bai JC, Ciacci C, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012;10:13.
9. Aziz I, Sanders DS. Emerging concepts: from celiac disease to non-celiac gluten sensitivity. Proc Nutr Soc 2012;71:576-580.
10. Ferch CC, Chey WD. Irritable bowel syndrome and gluten sensitivity without celiac disease: separating the wheat from the chaff. Gastroenterology 2012;142:664-666.
11. William Davis. Wheat belly: lose the wheat, lose the weight and find your path back to health. Rodale, New York 2011.
12. Verdu EF. Editorial: Can gluten contribute to irritable bowel syndrome? Am J Gastroenterol 2011;106:516-518.
13. Volta U, De Georgio R. New understanding of gluten sensitivity. Nat Rev Gastroenterol Hepatol 2012;9:295-299.
14. Ludvigsson JF, Leer DA, Bai JC, et al. The Oslo definitions for celiac disease and related terms. Gut 2013;62:43-52.
15. Di Sabatino, Corazza GR. Some clarification is necessary on the Oslo definitions for celiac disease-related terms. Gut 2013;62:182.
16. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses 2009;73:438-440.
17. Dickerson F, Stallings C, Origoni A, et al. Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia. Biol Psychiatry 2010;68:100-104.
18. Spiller R. Clinical update: irritable bowel syndrome. Lancet 2007;369:1586-1588.
19. Spiller R, Aziz Q, Creed F, et al. Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 2007;56:1770-1798.
20. Wahnschafle U, Ullrich R, Riecken EO, Schulzke JD. Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome. Gastroenterology 2001;121:1329-1338.
21. Ellis A, Linaker BD. Non-celiac gluten sensitivity? Lancet 1978;1:1358-1359.
22. Cooper BT, Holmes GK, Ferguson R, Thompson RA, Allan RN, Cooke WT. Gluten-sensitive diarrhea without evidence of celiac disease. Gastroenterology 1980;79:801-806.
23. Verdu EF, Armstrong D, Murray JA. Between celiac disease and irritable bowel syndrome: the "no man's land" of gluten sensitivity. Am J Gastroenterol 2009;104:1587-1594.
24. Campanella J, Biagi F, Bianchi PI, Zanellati G, Marchese A, Corazza GR. Clinical response to gluten withdrawal is not an indicator of celiac disease. Scand J Gastroenterol 2008;43:1311-1314.
25. Vazquez-Roque MI, Camilleri M, Smyrk T, et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 2013;144:903-911.
26. Biesiekierski JR, Newnham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011;106:508-514.
27. Carroccio A, Mansueto P, Iacono G, et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol 2012;107:1898-1906.
28. Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. No effects of gluten in patients with self-reported non-celiac gluten sensitivity aTher dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 2013;145:320-328.
29. Gibson PR, Shepherd SJ. Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach. J Gastroenterol Hepatol 2010;25:252-258.
30. Wahnschafle U, Schulzke JD, Zeitz M, Ullrich R. Predictors of clinical response to gluten-free diet in patients diagnosed with diarrheapredominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2007.5:844-850.
31. Volta U, Tovoli F, Cicola R, et al. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol 2012;46:680-685.
32. Monsuur AJ, Wijmenga C. Understanding the molecular basis of celiac disease: what genetic studies reveal. Ann Med 2006;38:578-591.
33. Sapone A, Lammers KM, Casolaro V, et al. Divergence of gut permeability and mucosal immune gene expression in two glutenassociated conditions: celiac disease and gluten sensitivity. BMC Med 2011;9:23.
34. Sapone A, Lammers KM, Mazzarella G, et al. DiTherential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol 2010;152:75-80.
35. Jabri B, Sollid LM. Tissue-mediated control of immunopathology in celiac disease. Nat Rev Immunol 2009;9:858-870.
36. Freed DL. Do dietary lectins cause disease? BMJ 1999;318:1023-1024.
37. Haas H, Falcone FH, Schramm G, et al. Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils. Eur J Immunol 1999;29:918-927.
38. Dalla Pellegrina C, Perbellini O, Scupoli MT, et al. Effects of wheat germ agglutinin on human gastrointestinal epithelium: insights from an experimental model of immune/epithelial cell interaction. Toxicol Appl Pharmacol 2009;237:146-153.
39. Junker Y, Zeissig S, Kim SJ, et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 2012;209:2395-2408.
40. Not T, Ziberna F, Vatta S, et al. Cryptic genetic gluten intolerance revealed by intestinal antitransglutaminase antibodies and response to gluten-free diet. Gut 2011;60:1487-1493.